DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NaCP60E and CATSPER4

DIOPT Version :9

Sequence 1:	NP_001261172.1	Gene:	NaCP60E / 37981	FlyBaseID:	FBgn0085434	Length:	2896	Species:	Drosophila melanogaster
Sequence 2:	NP_937770.1	Gene:	CATSPER4 / 378807	HGNCID:	23220	Length:	472	Species:	Homo sapiens

Alignment Length:	287	Identity:	76/287 - (26%)
Similarity:	120/287 - (41%)	Gaps:	74/287 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  1751 PAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFS-----FCLIFVVEMILKWLALGFS 1810
            |||:..:.:|:..::||     |.|..|..|.:..|.: ||     ...|.:.|::|.||. ||.
Human    92 PAFQLLLALLLVINAIT-----IALRTNSYLDQKHYEL-FSTIDDIVLTILLCEVLLGWLN-GFW 149

  Fly  1811 KYFTSFWTILDFIIVFVSVFSLLIEE------NENLKVLRSLRTLRALRPLRAISRWQGMRIVVN 1869
            .::...|.||:|||||:.:....|.|      |..|:.||.:....|:.||..|         :.
Human   150 IFWKDGWNILNFIIVFILLLRFFINEINIPSINYTLRALRLVHVCMAVEPLARI---------IR 205

  Fly  1870 ALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEMGELLPITEVNDKWDCIEQNYTWI 1934
            .::.::|.:.|::::.|.|.|:||:.||..||....|
Human   206 VILQSVPDMANIMVLILFFMLVFSVFGVTLFGAFVPK---------------------------- 242

  Fly  1935 NSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAY-----IYFVIFIVC 1994
                .|.::.:....|....|.:||:::.:|.          |.|...||.     |||.|||..
Human   243 ----HFQNIQVALYTLFICITQDGWVDIYSDF----------QTEKREYAMEIGGAIYFTIFITI 293

  Fly  1995 GSFFTLNLFIGVIIDNFNMLKKKYEGG 2021
            |:|..:|||:.|:..|...:.|..|.|
Human   294 GAFIGINLFVIVVTTNLEQMMKAGEQG 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	152..371	CDD:278921
		Ion_trans	705..902	CDD:278921
		Ion_trans	1768..2019	CDD:278921	68/266 (26%)
		Na_channel_gate	2009..2063	CDD:240441	4/13 (31%)
		Ion_trans	2085..2320	CDD:278921
		GPHH	2331..2386	CDD:293510
CATSPER4	NP_937770.1	Ion_trans	91..313	CDD:306908	73/278 (26%)
CATSPER4	NP_937770.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	416..438
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810