DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NaCP60E and Catsper2

DIOPT Version :9

Sequence 1:	NP_001261172.1	Gene:	NaCP60E / 37981	FlyBaseID:	FBgn0085434	Length:	2896	Species:	Drosophila melanogaster
Sequence 2:	NP_001012220.1	Gene:	Catsper2 / 366174	RGDID:	1307620	Length:	584	Species:	Rattus norvegicus

Alignment Length:	316	Identity:	74/316 - (23%)
Similarity:	152/316 - (48%)	Gaps:	55/316 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly  1747 VVDTPAFEWFVLVLIFASSITLCFEDINLDKNKT----LKRVLYWINFSFCLIFVVEMILKWLAL 1807
            |:|:..|..|::.|||.::..|..|...::...|    ||..|...::...|.|:||::|.|||
  Rat   102 VLDSSIFSNFIISLIFLNTFVLMVEIELMNSTNTSLWPLKLALEVTDWFILLSFIVEILLMWLA- 165

  Fly  1808 GFSKYFTSFWTILDFIIVFVSV---FSLLIEENENLKVLRSLRTLRALRPLRAISRWQGMRIVVN 1869
            .|..::.:.|::.||::..:|:   |.:||..:.:...|:.||..|.||.|:..:|:..:::::.
  Rat   166 SFFLFWKNAWSVFDFVVTMLSLLPEFVVLIGVSADSVWLQLLRVSRVLRSLKLFARFPQIKVILL 230

  Fly  1870 ALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEMGELLPITEVNDKWDCIEQNYTW- 1933
            ||:.|:.|:..:|::.|:|:.:|::.||.||           .|....|..|     :|.|..:
  Rat   231 ALVRALKSMTFLLMLLLIFFYVFAVAGVYFF-----------KEYSRSTIEN-----LEYNMFFS 279

  Fly  1934 --INSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGS 1996
              :||.:|          :..:.|.:.|..|:.|.       .:....:.:::.||.:::::.||
  Rat   280 DLLNSLVT----------VFILFTLDHWYAVLQDV-------WKVPEASRVFSSIYVILWLLLGS 327

  Fly  1997 FFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKR 2052
            ....|:.:.:::.||..::.:     |...:|..:..|...:.|      :::|:|
  Rat   328 IIFRNIIVAMMVTNFQNIRNE-----LHEEMTHLEVQYKADIFK------RRIIQR 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	152..371	CDD:278921
		Ion_trans	705..902	CDD:278921
		Ion_trans	1768..2019	CDD:278921	61/260 (23%)
		Na_channel_gate	2009..2063	CDD:240441	8/44 (18%)
		Ion_trans	2085..2320	CDD:278921
		GPHH	2331..2386	CDD:293510
Catsper2	NP_001012220.1	Ion_trans	138..348	CDD:278921	58/243 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	376..460
		HSP90	419..>463	CDD:278607
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	480..510
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810