DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NaCP60E and Ca-alpha1D

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster


Alignment Length:3008 Identity:579/3008 - (19%)
Similarity:992/3008 - (32%) Gaps:1291/3008 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly   104 KSLFLFYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLAM------------TETVEEAEYIF 156
            ::||.....:|.|.:|:.|...:.|::.::.||..|||.||:            .:|:|:.||:|
  Fly   746 RALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKVEYVF 810

  Fly   157 LAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATIGM-----EVGNLAGLRTFRVL 216
            |.|::.|.|:||:|.||:|:...||||.||.|||.::..|..:..:     :..::..||.||||
  Fly   811 LVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQLMKDAFDVKALRAFRVL 875

  Fly   217 RALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVPTDWT 281
            |.|:.||.:|.|:.::|::|.:...|..:..|.:|.::::|:..|:::.|:|...|..::..:  
  Fly   876 RPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKACRDEITGE-- 938

  Fly   282 NVSHTDWQIWVNDTDNWLYDEDELPVLCGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFMWSML 346
                              |:|:..|  ||  .|.: ||..|.|....:.||.|.||||||..:||
  Fly   939 ------------------YEENIRP--CG--VGYQ-CPPGYKCYGGWDGPNDGITNFDNFGLAML 980

  Fly   347 TTFQLITLDYWENV-YNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNEER 410
            |.||.:||:.|.:| |::..|........:|..:|..|:|:::||:|                  
  Fly   981 TVFQCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLIL------------------ 1027

  Fly   411 KKDLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGKEGGTNGN 475
                                                 |||...:||::.:.|             
  Fly  1028 -------------------------------------GVLSGEFSKERNKAK------------- 1042

  Fly   476 GNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQHKLAKSGSGGSNNPMAPT 540
               :.||                           .|..::.||:|:                   
  Fly  1043 ---NRGD---------------------------FQKLREKQQIEE------------------- 1058

  Fly   541 PKGRISFQDSGMGVKNPNMLYPSDYKGQL--IANSGQPSSNSSGVNRESSQDDSGVVDDHE---- 599
                                   |.:|.|  |..:.....::.|          |::.|.:    
  Fly  1059 -----------------------DLRGYLDWITQAEDIEPDAVG----------GLISDGKGKQP 1090

  Fly   600 -EQDTTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDRNCDR 663
             |.|:|.::|. ...|:.::....|.:|                 ::|           ||...|
  Fly  1091 NEMDSTENLGE-EMPEVQMTESRWRKMK-----------------KDF-----------DRVNRR 1126

  Fly   664 CVHWCTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFT 728
            ....|.             |.|:...|...|.:.:.|||..||.||:|..:...|..:..|..|.
  Fly  1127 MRRACR-------------KAVKSQAFYWLIIVLVFLNTGVLATEHYGQLDWLDNFQEYTNVFFI 1178

  Fly   729 SIFTFECIVKLMALS-KDFFLCGWNIFDLLIVTASLLDIIFELVD-----GLSVLRGLRLLRVLK 787
            .:||.|.::|:.:|. :.:|:..:|.||..:|..|:.:.:.....     |:||||.:|||||.|
  Fly  1179 GLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITETLLTNTGMMPPLGVSVLRCVRLLRVFK 1243

  Fly   788 LAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQL----FSKDYTPEKFDPDPVPRW 848
            :.:.|.::..|::.::::|.::.:|.|:|.:.|.|||::|||:    |:.|...||:      |.
  Fly  1244 VTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNFDGKEEKY------RM 1302

  Fly   849 NFNDFFHSFMMIFRILCGE-WIEPLWDCMRA---EEEQGASTCFAIFLPTLVMGNFMVLNLFLAL 909
            ||:.|:.:.:.:|:|:.|| |...::..:.|   ....||..|. .|:...:.||:::||:|||:
  Fly  1303 NFDCFWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALACI-YFIILFICGNYILLNVFLAI 1366

  Fly   910 LLNSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHA 974
            .:::.                                                         |.|
  Fly  1367 AVDNL---------------------------------------------------------ADA 1374

  Fly   975 QTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDT 1039
            .:||.     :|:.::|                                ||              
  Fly  1375 DSLSE-----VEKEEEP--------------------------------HD-------------- 1388

  Fly  1040 GDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISS 1104
                |..|.::|...||.|                                              
  Fly  1389 ----ESAQKKSHSPTPTID---------------------------------------------- 1403

  Fly  1105 GVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDE 1169
                                                                      |.::|  
  Fly  1404 ----------------------------------------------------------GMDDH-- 1408

  Fly  1170 AFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQ 1234
                             .|:|                                :.:||.| |..:
  Fly  1409 -----------------LSID--------------------------------IDMEQQE-LDDE 1423

  Fly  1235 GNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNII 1299
            ..:..|.|:  .:|:.:..:||||:                         :.|.|:         
  Fly  1424 DKMDHETLS--DEEVREMCEEEEEV-------------------------DEEGMI--------- 1452

  Fly  1300 QSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYD 1364
                          |:..|::|.:       :.|||                     :||:.|..
  Fly  1453 --------------TARPRRMSEV-------NTATK---------------------ILPIPPGT 1475

  Fly  1365 SYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAV 1429
            |:.|                                   ||.:|..|..|               
  Fly  1476 SFFL-----------------------------------FSQTNRFRVFC--------------- 1490

  Fly  1430 AATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLH 1494
                                                                             
  Fly  1491 ----------------------------------------------------------------- 1490

  Fly  1495 GPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPL 1559
                                                                             
  Fly  1491 ----------------------------------------------------------------- 1490

  Fly  1560 AALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSS 1624
                                                                             
  Fly  1491 ----------------------------------------------------------------- 1490

  Fly  1625 GAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYN 1689
                                                                             
  Fly  1491 ----------------------------------------------------------------- 1490

  Fly  1690 DPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFE 1754
                                                          ||         :.:...|.
  Fly  1491 ----------------------------------------------HW---------LCNHSNFG 1500

  Fly  1755 WFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGF----SKYFTS 1815
            ..:|..|..||..|..|: .|..|..|.:||...::.|..:|.:|:|||.::.||    ..:..|
  Fly  1501 NIILCCIMFSSAMLAAEN-PLRANDDLNKVLNKFDYFFTAVFTIELILKLISYGFVLHDGAFCRS 1564

  Fly  1816 FWTILDFIIVFVSVFSLLIEENENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFN 1880
            .:.:||.::|.||:.||:...|. :.|::.||.||.|||||||:|.:|::.||..::.|:.:|.|
  Fly  1565 AFNLLDLLVVCVSLISLVSSSNA-ISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGN 1628

  Fly  1881 VLLV-CLVFWL-----------------------------------IFSIMGVQFFGGKFFKCVN 1909
            ::|| ||:.::                                   :|:::|||.|.||||||.:
  Fly  1629 IVLVTCLLQFMFAVIGVQLFKYVVKCVVVAIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFKCTD 1693

  Fly  1910 EMGELLPITE------VNDKWDCIE---QNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMAD 1965
              |..:...|      |.|..|..:   :...|.|::..||.|..|.|.|..|:|||||..::..
  Fly  1694 --GSKMTQDECYGTYLVYDDGDVHKPRLREREWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYV 1756

  Fly  1966 AVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNF-NMLKKKYEGGVLEMFLTE 2029
            ::|:...:..|..........|::|:|:..:||.:|:|:|.:|..| |..:::|:...|:    :
  Fly  1757 SIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTFQNEGEQEYKNCDLD----K 1817

  Fly  2030 SQKH---YYTAMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYD 2091
            :|::   :....|.:.|..|:..|:..:..|:       .|..||..||:||.:|.:|:.::.|:
  Fly  1818 NQRNCIEFALKAKPVRRYIPKHGIQYKVWWFV-------TSSSFEYTIFILIMINTVTLAMKFYN 1875

  Fly  2092 QPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRY-HYFTVPWNVFDFLLVLASIFGILMEDIM--- 2152
            ||.....:|:..|..||.||.||.:.|:...|: :||...||||||::||.|...|:..:|.   
  Fly  1876 QPLWYTELLDALNMIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKD 1940

  Fly  2153 ------IDL---------PISPTLLRV--VRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNI 2200
                  .|:         .....|:.:  .|:||:.|:::|:...:|||.||:..:.|..||..:
  Fly  1941 TSQIAECDIVEGCKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYV 2005

  Fly  2201 GALLGLITFIYAILGMSLFGNVKLQG--ALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQ 2263
            ..|:.|:.||||::||.:||.:.|.|  |:....|||||.:::.:|||..|...|.:::.|...|
  Fly  2006 ALLIVLLFFIYAVVGMQVFGKIALDGGNAITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQ 2070

  Fly  2264 PP-DCDPFIHGHTNGN-CGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVED 2326
            |. .||  ::..|.|. ||.. :|..||.||.::...::||:::|:|::||:...::..| :...
  Fly  2071 PDVKCD--MNSDTPGEPCGSS-IAYPYFISFYVLCSFLIINLFVAVIMDNFDYLTRDWSI-LGPH 2131

  Fly  2327 DLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISK--PNNVA---LVSFNLPISKGNKIH 2386
            .|:.|...||:|||.|...|....:...:..:.||||..|  |:.:|   |||.|:|::....:.
  Fly  2132 HLDEFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPLNSDGTVL 2196

  Fly  2387 CLDILHALVKHVL-----GHVEETDN-----FKQLQEQMDVKFKKQF--PTRKELEIVSS----- 2434
            ....|.|:|:..|     |::::.::     .||:.::.:.|...|.  |...:.|:...     
  Fly  2197 FNATLFAVVRTSLSIKTDGNIDDANSELRATIKQIWKRTNPKLLDQVVPPPGNDDEVTVGKFYAT 2261

  Fly  2435 -------TRIWKRQEKAAK---------TIQTGWKEYLRRKREKERSNSG--DSATQTSSP---- 2477
                   .|..||:|:..|         |:|.|.:.........:|:.||  |...|...|    
  Fly  2262 YLIQDYFRRFKKRKEQEGKEGHPDSNTVTLQAGLRTLHEVSPALKRAISGNLDELDQEPEPMHRR 2326

  Fly  2478 ------GGWQSKLSALNFFHLQVSRRGTACSSRASSRKSSRASDASDLSELA------------- 2523
                  ..|.|           :.|.|.....|::...:|:::.|..:...|             
  Fly  2327 HHTLFGSVWSS-----------IRRHGNGTFRRSAKATASQSNGALAIGGSASAALGVGGSSLVL 2380

  Fly  2524 -------GPWL--NLPLMLVSGADEVVKDIKQQ--------NDELGKRGSIFVEAPRASRRRSFY 2571
                   |.:|  .|...:..|.:.:.::|.|.        .|||...||       ....|:| 
  Fly  2381 GSSDPAGGDYLYDTLNRSVADGVNNITRNIMQARLAAAGKLQDELQGAGS-------GGELRTF- 2437

  Fly  2572 NFFLRHQDAVDDSLTSPSVHRKTAMNNTTNTTSNSASTSGTASSTATAPATGCGPAATSASDSDR 2636
                      .:|::.    |..|.|.           .|.|:...|.|     |.|.:.:..:|
  Fly  2438 ----------GESISM----RPLAKNG-----------GGAATVAGTLP-----PEANAINYDNR 2472

  Fly  2637 HQAV----------GGGSAPSRKR------ASSFIRKKPPLERG------------LSAQSALRV 2673
            ::.:          ..|:.|..:|      ||.:.:::.|....            |:|:...:.
  Fly  2473 NRGILLHPYNNVYAPNGALPGHERMIQSTPASPYDQRRLPTSSDMNGLAESLIGGVLAAEGLGKY 2537

  Fly  2674 NKNAFVSEASAPEVIVTRPSPEQQ--------THPHSLSL-RPDNATLVHVLVHRESEEYKEEDE 2729
            ..:.||..|:.........:||:.        ::.||||| ...|.::.              ..
  Fly  2538 CDSEFVGTAAREMREALDMTPEEMNLAAHQILSNEHSLSLIGSSNGSIF--------------GG 2588

  Fly  2730 SSPSVSGNGNGFGVGLDMLSKQPPPQIRIT---TGSVESSMDTCAMPTVQIMVDSPKDPP-RGDF 2790
            |:..:.|.|:|...||...|     .||..   :||..||:             ||:..| .|..
  Fly  2589 SAGGLGGAGSGGVGGLGGSS-----SIRNAFGGSGSGPSSL-------------SPQHQPYSGTL 2635

  Fly  2791 SSAPIDD-----VGAPIDVNVQGDTSQVFYDYNPEKATDDQGNGQDETAQFESLPDRQRXPPVNT 2850
            :|.||.|     |......|          :.|..:.:.:..|..:..|...|   :....|...
  Fly  2636 NSPPIPDNRLRRVATVTTTN----------NNNKSQVSQNNSNSLNVRANANS---QMNMSPTGQ 2687

  Fly  2851 PLRDSEKRSSRGSRSSSS 2868
            |::.......:|:::.||
  Fly  2688 PVQQQSPLRGQGNQTYSS 2705

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 75/224 (33%)
Ion_trans 705..902 CDD:278921 63/210 (30%)
Ion_trans 1768..2019 CDD:278921 90/300 (30%)
Na_channel_gate 2009..2063 CDD:240441 10/57 (18%)
Ion_trans 2085..2320 CDD:278921 84/259 (32%)
GPHH 2331..2386 CDD:293510 20/59 (34%)
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:395416 97/354 (27%)
Ion_trans 1137..1379 CDD:395416 76/305 (25%)
Ion_trans 1496..1809 CDD:395416 95/316 (30%)
Ion_trans 1851..2126 CDD:395416 93/277 (34%)
GPHH 2135..2188 CDD:407139 19/52 (37%)
Ca_chan_IQ 2199..2271 CDD:400901 11/71 (15%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45439095
Domainoid 1 1.000 73 1.000 Domainoid score I3264
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 311 1.000 Inparanoid score I473
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
54.920

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