Protein Alignment NaCP60E and Ca-alpha1D

DIOPT Version :10

• Sequence 1: NP_001261172.1
• Gene: NaCP60E / 37981
• FlyBaseID: FBgn0085434
• Length: 2896
• Species: Drosophila melanogaster
• Sequence 2: NP_723952.2
• Gene: Ca-alpha1D / 34950
• FlyBaseID: FBgn0001991
• Length: 2705
• Species: Drosophila melanogaster
• Alignment Length: 3008
• Identity: 579/3008 - (19%)
• Similarity: 992/3008 - (32%)
• Gaps: 1291/3008 - (42%)

  Fly   104 KSLFLFYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLAM------------TETVEEAEYIF 156
            ::||.....:|.|.:|:.|...:.|::.::.||..|||.||:            .:|:|:.||:|
  Fly   746 RALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKVEYVF 810

  Fly   157 LAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATIGM-----EVGNLAGLRTFRVL 216
            |.|::.|.|:||:|.||:|:...||||.||.|||.::..|..:..:     :..::..||.||||
  Fly   811 LVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQLMKDAFDVKALRAFRVL 875

  Fly   217 RALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVPTDWT 281
            |.|:.||.:|.|:.::|::|.:...|..:..|.:|.::::|:..|:::.|:|...|..::..:
  Fly   876 RPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKACRDEITGE-- 938

  Fly   282 NVSHTDWQIWVNDTDNWLYDEDELPVLCGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFMWSML 346
                              |:|:..|  ||  .|.: ||..|.|....:.||.|.||||||..:||
  Fly   939 ------------------YEENIRP--CG--VGYQ-CPPGYKCYGGWDGPNDGITNFDNFGLAML 980

  Fly   347 TTFQLITLDYWENV-YNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNEER 410
            |.||.:||:.|.:| |::..|........:|..:|..|:|:::||:|
  Fly   981 TVFQCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLIL------------------ 1027

  Fly   411 KKDLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGKEGGTNGN 475
                                                 |||...:||::.:.|
  Fly  1028 -------------------------------------GVLSGEFSKERNKAK------------- 1042

  Fly   476 GNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQHKLAKSGSGGSNNPMAPT 540
               :.||                           .|..::.||:|:
  Fly  1043 ---NRGD---------------------------FQKLREKQQIEE------------------- 1058

  Fly   541 PKGRISFQDSGMGVKNPNMLYPSDYKGQL--IANSGQPSSNSSGVNRESSQDDSGVVDDHE---- 599
                                   |.:|.|  |..:.....::.|          |::.|.:
  Fly  1059 -----------------------DLRGYLDWITQAEDIEPDAVG----------GLISDGKGKQP 1090

  Fly   600 -EQDTTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDRNCDR 663
             |.|:|.::|. ...|:.::....|.:|                 ::|           ||...|
  Fly  1091 NEMDSTENLGE-EMPEVQMTESRWRKMK-----------------KDF-----------DRVNRR 1126

  Fly   664 CVHWCTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFT 728
            ....|.             |.|:...|...|.:.:.|||..||.||:|..:...|..:..|..|.
  Fly  1127 MRRACR-------------KAVKSQAFYWLIIVLVFLNTGVLATEHYGQLDWLDNFQEYTNVFFI 1178

  Fly   729 SIFTFECIVKLMALS-KDFFLCGWNIFDLLIVTASLLDIIFELVD-----GLSVLRGLRLLRVLK 787
            .:||.|.::|:.:|. :.:|:..:|.||..:|..|:.:.:.....     |:||||.:|||||.|
  Fly  1179 GLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITETLLTNTGMMPPLGVSVLRCVRLLRVFK 1243

  Fly   788 LAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQL----FSKDYTPEKFDPDPVPRW 848
            :.:.|.::..|::.::::|.::.:|.|:|.:.|.|||::|||:    |:.|...||:      |.
  Fly  1244 VTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNFDGKEEKY------RM 1302

  Fly   849 NFNDFFHSFMMIFRILCGE-WIEPLWDCMRA---EEEQGASTCFAIFLPTLVMGNFMVLNLFLAL 909
            ||:.|:.:.:.:|:|:.|| |...::..:.|   ....||..|. .|:...:.||:::||:|||:
  Fly  1303 NFDCFWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALACI-YFIILFICGNYILLNVFLAI 1366

  Fly   910 LLNSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHA 974
            .:::.                                                         |.|
  Fly  1367 AVDNL---------------------------------------------------------ADA 1374

  Fly   975 QTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDT 1039
            .:||.     :|:.::|                                ||
  Fly  1375 DSLSE-----VEKEEEP--------------------------------HD-------------- 1388

  Fly  1040 GDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISS 1104
                |..|.::|...||.|
  Fly  1389 ----ESAQKKSHSPTPTID---------------------------------------------- 1403

  Fly  1105 GVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDE 1169
                                                                      |.::|
  Fly  1404 ----------------------------------------------------------GMDDH-- 1408

  Fly  1170 AFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQ 1234
                             .|:|                                :.:||.| |..:
  Fly  1409 -----------------LSID--------------------------------IDMEQQE-LDDE 1423

  Fly  1235 GNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNII 1299
            ..:..|.|:  .:|:.:..:||||:                         :.|.|:
  Fly  1424 DKMDHETLS--DEEVREMCEEEEEV-------------------------DEEGMI--------- 1452

  Fly  1300 QSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYD 1364
                          |:..|::|.:       :.|||                     :||:.|..
  Fly  1453 --------------TARPRRMSEV-------NTATK---------------------ILPIPPGT 1475

  Fly  1365 SYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAV 1429
            |:.|                                   ||.:|..|..|
  Fly  1476 SFFL-----------------------------------FSQTNRFRVFC--------------- 1490

  Fly  1430 AATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLH 1494
                                                                             
  Fly  1491 ----------------------------------------------------------------- 1490

  Fly  1495 GPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPL 1559
                                                                             
  Fly  1491 ----------------------------------------------------------------- 1490

  Fly  1560 AALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSS 1624
                                                                             
  Fly  1491 ----------------------------------------------------------------- 1490

  Fly  1625 GAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYN 1689
                                                                             
  Fly  1491 ----------------------------------------------------------------- 1490

  Fly  1690 DPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFE 1754
                                                          ||         :.:...|.
  Fly  1491 ----------------------------------------------HW---------LCNHSNFG 1500

  Fly  1755 WFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGF----SKYFTS 1815
            ..:|..|..||..|..|: .|..|..|.:||...::.|..:|.:|:|||.::.||    ..:..|
  Fly  1501 NIILCCIMFSSAMLAAEN-PLRANDDLNKVLNKFDYFFTAVFTIELILKLISYGFVLHDGAFCRS 1564

  Fly  1816 FWTILDFIIVFVSVFSLLIEENENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFN 1880
            .:.:||.::|.||:.||:...|. :.|::.||.||.|||||||:|.:|::.||..::.|:.:|.|
  Fly  1565 AFNLLDLLVVCVSLISLVSSSNA-ISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGN 1628

  Fly  1881 VLLV-CLVFWL-----------------------------------IFSIMGVQFFGGKFFKCVN 1909
            ::|| ||:.::                                   :|:::|||.|.||||||.:
  Fly  1629 IVLVTCLLQFMFAVIGVQLFKYVVKCVVVAIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFKCTD 1693

  Fly  1910 EMGELLPITE------VNDKWDCIE---QNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMAD 1965
              |..:...|      |.|..|..:   :...|.|::..||.|..|.|.|..|:|||||..::..
  Fly  1694 --GSKMTQDECYGTYLVYDDGDVHKPRLREREWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYV 1756

  Fly  1966 AVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNF-NMLKKKYEGGVLEMFLTE 2029
            ::|:...:..|..........|::|:|:..:||.:|:|:|.:|..| |..:::|:...|:    :
  Fly  1757 SIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTFQNEGEQEYKNCDLD----K 1817

  Fly  2030 SQKH---YYTAMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYD 2091
            :|::   :....|.:.|..|:..|:..:..|:       .|..||..||:||.:|.:|:.::.|:
  Fly  1818 NQRNCIEFALKAKPVRRYIPKHGIQYKVWWFV-------TSSSFEYTIFILIMINTVTLAMKFYN 1875

  Fly  2092 QPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRY-HYFTVPWNVFDFLLVLASIFGILMEDIM--- 2152
            ||.....:|:..|..||.||.||.:.|:...|: :||...||||||::||.|...|:..:|.
  Fly  1876 QPLWYTELLDALNMIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKD 1940

  Fly  2153 ------IDL---------PISPTLLRV--VRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNI 2200
                  .|:         .....|:.:  .|:||:.|:::|:...:|||.||:..:.|..||..:
  Fly  1941 TSQIAECDIVEGCKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYV 2005

  Fly  2201 GALLGLITFIYAILGMSLFGNVKLQG--ALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQ 2263
            ..|:.|:.||||::||.:||.:.|.|  |:....|||||.:::.:|||..|...|.:::.|...|
  Fly  2006 ALLIVLLFFIYAVVGMQVFGKIALDGGNAITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQ 2070

  Fly  2264 PP-DCDPFIHGHTNGN-CGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVED 2326
            |. .||  ::..|.|. ||.. :|..||.||.::...::||:::|:|::||:...::..| :...
  Fly  2071 PDVKCD--MNSDTPGEPCGSS-IAYPYFISFYVLCSFLIINLFVAVIMDNFDYLTRDWSI-LGPH 2131

  Fly  2327 DLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISK--PNNVA---LVSFNLPISKGNKIH 2386
            .|:.|...||:|||.|...|....:...:..:.||||..|  |:.:|   |||.|:|::....:.
  Fly  2132 HLDEFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPLNSDGTVL 2196

  Fly  2387 CLDILHALVKHVL-----GHVEETDN-----FKQLQEQMDVKFKKQF--PTRKELEIVSS----- 2434
            ....|.|:|:..|     |::::.::     .||:.::.:.|...|.  |...:.|:...
  Fly  2197 FNATLFAVVRTSLSIKTDGNIDDANSELRATIKQIWKRTNPKLLDQVVPPPGNDDEVTVGKFYAT 2261

  Fly  2435 -------TRIWKRQEKAAK---------TIQTGWKEYLRRKREKERSNSG--DSATQTSSP---- 2477
                   .|..||:|:..|         |:|.|.:.........:|:.||  |...|...|
  Fly  2262 YLIQDYFRRFKKRKEQEGKEGHPDSNTVTLQAGLRTLHEVSPALKRAISGNLDELDQEPEPMHRR 2326

  Fly  2478 ------GGWQSKLSALNFFHLQVSRRGTACSSRASSRKSSRASDASDLSELA------------- 2523
                  ..|.|           :.|.|.....|::...:|:::.|..:...|
  Fly  2327 HHTLFGSVWSS-----------IRRHGNGTFRRSAKATASQSNGALAIGGSASAALGVGGSSLVL 2380

  Fly  2524 -------GPWL--NLPLMLVSGADEVVKDIKQQ--------NDELGKRGSIFVEAPRASRRRSFY 2571
                   |.:|  .|...:..|.:.:.::|.|.        .|||...||       ....|:|
  Fly  2381 GSSDPAGGDYLYDTLNRSVADGVNNITRNIMQARLAAAGKLQDELQGAGS-------GGELRTF- 2437

  Fly  2572 NFFLRHQDAVDDSLTSPSVHRKTAMNNTTNTTSNSASTSGTASSTATAPATGCGPAATSASDSDR 2636
                      .:|::.    |..|.|.           .|.|:...|.|     |.|.:.:..:|
  Fly  2438 ----------GESISM----RPLAKNG-----------GGAATVAGTLP-----PEANAINYDNR 2472

  Fly  2637 HQAV----------GGGSAPSRKR------ASSFIRKKPPLERG------------LSAQSALRV 2673
            ::.:          ..|:.|..:|      ||.:.:::.|....            |:|:...:.
  Fly  2473 NRGILLHPYNNVYAPNGALPGHERMIQSTPASPYDQRRLPTSSDMNGLAESLIGGVLAAEGLGKY 2537

  Fly  2674 NKNAFVSEASAPEVIVTRPSPEQQ--------THPHSLSL-RPDNATLVHVLVHRESEEYKEEDE 2729
            ..:.||..|:.........:||:.        ::.||||| ...|.::.              ..
  Fly  2538 CDSEFVGTAAREMREALDMTPEEMNLAAHQILSNEHSLSLIGSSNGSIF--------------GG 2588

  Fly  2730 SSPSVSGNGNGFGVGLDMLSKQPPPQIRIT---TGSVESSMDTCAMPTVQIMVDSPKDPP-RGDF 2790
            |:..:.|.|:|...||...|     .||..   :||..||:             ||:..| .|..
  Fly  2589 SAGGLGGAGSGGVGGLGGSS-----SIRNAFGGSGSGPSSL-------------SPQHQPYSGTL 2635

  Fly  2791 SSAPIDD-----VGAPIDVNVQGDTSQVFYDYNPEKATDDQGNGQDETAQFESLPDRQRXPPVNT 2850
            :|.||.|     |......|          :.|..:.:.:..|..:..|...|   :....|...
  Fly  2636 NSPPIPDNRLRRVATVTTTN----------NNNKSQVSQNNSNSLNVRANANS---QMNMSPTGQ 2687

  Fly  2851 PLRDSEKRSSRGSRSSSS 2868
            |::.......:|:::.||
  Fly  2688 PVQQQSPLRGQGNQTYSS 2705

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	125..371	CDD:459842	85/263 (32%)
		Ion_trans	687..902	CDD:459842	68/228 (30%)
		Ion_trans	1751..2019	CDD:459842	95/317 (30%)
		Na_channel_gate	2009..2063	CDD:240441	10/57 (18%)
		Ion_trans	2067..2320	CDD:459842	93/277 (34%)
		GPHH	2332..2378	CDD:465306	18/50 (36%)
Ca-alpha1D	NP_723952.2	Ion_trans	767..1042	CDD:459842	97/354 (27%)
		Ion_trans	1137..1379	CDD:459842	76/305 (25%)
		Ion_trans	1496..1809	CDD:459842	95/316 (30%)
		Ion_trans	1851..2126	CDD:459842	93/277 (34%)
		GPHH	2135..2188	CDD:465306	19/52 (37%)
		Ca_chan_IQ	2198..2273	CDD:462591	12/74 (16%)