DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NaCP60E and Nalcn

DIOPT Version :9

Sequence 1:	NP_001261172.1	Gene:	NaCP60E / 37981	FlyBaseID:	FBgn0085434	Length:	2896	Species:	Drosophila melanogaster
Sequence 2:	XP_036014574.1	Gene:	Nalcn / 338370	MGIID:	2444306	Length:	1787	Species:	Mus musculus

Alignment Length:	2617	Identity:	466/2617 - (17%)
Similarity:	801/2617 - (30%)	Gaps:	1112/2617 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 LFLFYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLAMT-ETVEEAEYI-------FLAIYSI 162
            |::..||           .:.....|.:.:::..|:...|| |.....:|:       .:.:|:.
Mouse    47 LWINKPW-----------VHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTA 100

  Fly   163 EMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEVGNLAG----------LRTFRVLR 217
            ||:.|:..:|.:....:|:::.|...|..::...:.::.::|..:|.          ||..|.|.
Mouse   101 EMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLI 165

  Fly   218 ALKTVSI-----MPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVP 277
            .::...|     :|..: |.|.|..|..|:..|....:|.|:::.:..:|:: |.....||
Mouse   166 MIRAFRIYFRFELPRTR-ITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMF-GTFTYHCV---- 224

  Fly   278 TDWTNVSHTDWQIWVNDT--DNWLYDEDELP-VLCG-NLTGARHCPFEYVCLCVGE----NPNHG 334
                          ||||  .|..::...:| ..|. .|.....||..:.|:.:.:    ....|
Mouse   225 --------------VNDTKPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELG 275

  Fly   335 YTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCG-P--MSVSFFTVVVFFGSFYLINLMLAVVA 396
            |:.|:....|:.|.::..:.:.|  |:.|..|... |  .|..:|..::||.::.:.|:.:||:
Mouse   276 YSGFNEIGTSIFTVYEASSQEGW--VFLMYRAIDSFPRWRSYFYFITLIFFLAWLVKNVFIAVI- 337

  Fly   397 LSYEEEAEITNEERKKDLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRR 461
              .|..|||
Mouse   338 --IETFAEI-------------------------------------------------------- 344

  Fly   462 KKTKGGKEGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQHKLA 526
                                                               :.|:|||
Mouse   345 ---------------------------------------------------RVQFQQM------- 351

  Fly   527 KSGSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQDD 591
                .|:.:....|...::..:|:..|             .||:|
Mouse   352 ----WGTRSSTTSTATTQMFHEDAAGG-------------WQLVA-------------------- 379

  Fly   592 SGVVDDHEEQDTTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDL 656
               ||.::.|              ..:|.
Mouse   380 ---VDVNKPQ--------------GRAPA------------------------------------ 391

  Fly   657 PDRNCDRCVHWCTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALD 721
                                   ||.|::|..:|.:.| |.:|.....:|..::...|:||...|
Mouse   392 -----------------------CLQKMMRSSVFHMFI-LSMVTVDVIVAASNYYKGENFRRQYD 432

  Fly   722 ---VGNKVFTSIFTFECIVKLMALS-KDFFLCGWNIFDLLIVTASLLDIIFELVDG-LSVLRGLR 781
               :....||.:|..|.::|:..|. ..:.....:.|:||:|..:.|.:..:|... .:..:.||
Mouse   433 EFYLAEVAFTVLFDLEALLKIWCLGFTGYISSSLHKFELLLVIGTTLHVYPDLYHSQFTYFQVLR 497

  Fly   782 LLRVLKLAQSWTTMKVLLSIIISTIG---ALGNLTLILVIVIYIFAVIGMQLFSKDYTPEKFDPD 843
            ::|::|::.:      |...:....|   .||:|.:....::.:.:.|.:|:|.   ..|:.|
Mouse   498 VVRLIKISPA------LEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFC---FVEELD-- 551

  Fly   844 PVPRWNFNDFFHSFMMIFRILCGE-WIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLFL 907
                 .|..|..:||.:|:||..| |::.:...:.|.....|......|:...:....::|:||:
Mouse   552 -----RFTTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAPLVAIYFILYHLFATLILLSLFV 611

  Fly   908 ALLLNSFN-SEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKER-----KFAEKFQQIV 966
            |::|::.. .|:||..|:                   .|:.:...|.||:     :..|||.
Mouse   612 AVILDNLELDEDLKKLKQ-------------------LKQSEANADTKEKLPLRLRIFEKFP--- 654

  Fly   967 LDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIV 1031
                                                      ||
Mouse   655 ------------------------------------------NR--------------------- 656

  Fly  1032 DGLEYDDTGDLPEQIQLQAHPLPPTSD-SMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAE 1095
                       |:.:::...|    || ::|...||.|
Mouse   657 -----------PQMVKISKLP----SDFTVPKIRESFM--------------------------- 679

  Fly  1096 RRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSR 1160
                         :|:..|::........:|...:|:..|   |.::         .:.:||
Mouse   680 -------------KQFIDRQQQDTCCLFRILPSTSSSSCD---NPKK---------PTAEDN--- 716

  Fly  1161 RYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEA--EMRRHSSGQSLNSM 1223
                        ||....|      |||:..:      ..|:||:.|.|  ::.|..:.|.:.|.
Mouse   717 ------------KYIDQKL------RKSVFSI------RARNLLEKETAVTKILRACTRQRMLSG 757

  Fly  1224 SIE-----QDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQ 1283
            |.|     :..:||.|.::|               ||...|:.|:..:|||.
Mouse   758 SFEGQPAKERSILSVQHHIR---------------QERRSLRHGSNSQRISR------------- 794

  Fly  1284 PENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGAS 1348
                               .|.||.:.:..::..|..:...|     |...|.|.|
Mouse   795 -------------------GKSLETLTQDHSNTVRYRNAQRE-----DSEIKMIQE--------- 826

  Fly  1349 ERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKI 1413
                                                     |:...|.:||:.|:     |:|
Mouse   827 -----------------------------------------KKEQAEMKRKVQEE-----ELR-- 843

  Fly  1414 CDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPI 1478
                                                                   |..|..:||:
Mouse   844 -------------------------------------------------------ENHPYFDKPL 853

  Fly  1479 STLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIE 1543
                         |:.|
Mouse   854 -------------FIVG------------------------------------------------ 857

  Fly  1544 PPTLAQISSLKTTPPLAALTEHQ-QHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQST 1607
                               .||: ::|....::
Mouse   858 -------------------REHRFRNFCRVVVR-------------------------------- 871

  Fly  1608 LDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSY 1672
                |.|.:::|
Mouse   872 ----ARFNASKT----------------------------------------------------- 879

  Fly  1673 VDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHW 1737
                             ||:|    ||.|..|.      .:.||
Mouse   880 -----------------DPVT----GAVKNTKY------HQLYD--------------------- 896

  Fly  1738 TRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLY-----WINFSFCLIFV 1797
               ...::|.:|     |.::.:...|.|::.||       ...:||::     ...:.|.:...
Mouse   897 ---LLGLVTYLD-----WVMITVTICSCISMMFE-------SPFRRVMHAPTLQIAEYVFVIFMS 946

  Fly  1798 VEMILKWLALGFSKYFTSFWTILDF---IIVFVSVFSLLI----------EENENLKVLRSLRTL 1849
            :|:.||.:|.|.  :||....|.||   :.:|:.:.||:.          |....|     |..|
Mouse   947 IELNLKIMADGL--FFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQL-----LMVL 1004

  Fly  1850 RALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEMGEL 1914
            |.|||||.......||.||..|......||.|.::.|...|:|:..|||.|.||..||
Mouse  1005 RCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKC------- 1062

  Fly  1915 LPITEVND-----KWDC---------IEQNY-----------------TWINSK-ITFDHVGMGY 1947
                  ||     :.||         :.:|.                 .|.|.: ..||:||...
Mouse  1063 ------NDPNIIRREDCNGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAM 1121

  Fly  1948 LALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFN 2012
            |||.:|.:.:||:||.         |:...|...::. ||..:|:..|....|.||:||:|.|||
Mouse  1122 LALFEVLSLKGWVEVR---------DVIIHRVGPIHG-IYIHVFVFLGCMIGLTLFVGVVIANFN 1176

  Fly  2013 MLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPINH-FLAMFYDLSNSRRFEIAIFV 2076
                :.:|..|   ||..|:.:.....:|...:|..:..||.|. |.|..||::....|:..|.:
Mouse  1177 ----ENKGTAL---LTVDQRRWEDLKSRLKIAQPLHLPPRPDNDGFRAKMYDITQHPFFKRTIAL 1234

  Fly  2077 LIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGL-----------RYHYFT-- 2128
            |:....:.:.:: :|....|...|...:..||.:|.||..:||:.:           ||....
Mouse  1235 LVLAQSVLLSVK-WDVDDPVTVPLATMSVVFTFIFVLEVTMKIIAMSPAGFWQSRRNRYDLLVTS 1298

  Fly  2129 --VPWNVFDFLLVLASIFGILMEDIMIDLPISPTLLRVVRVFRI-GRILRLIKAAKGIRKLLFAL 2190
              |.|.|..|.|:.|  :..:|...:|          |.|.|.| |:.:.|       :.||..:
Mouse  1299 LGVVWVVLHFALLNA--YTYMMGACVI----------VFRFFSICGKHVTL-------KMLLLTV 1344

  Fly  2191 VVSLPALFNIGALLGLITFIYAILGMSLFGNVKLQGALDDMVNFQTFGRSMQLLFRLMTSAGWND 2255
            |||:...|.|...:.|:...||..|:.|||.||....::...||.:.|:::.:|||::|...||.
Mouse  1345 VVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYGENINRHANFSSAGKAITVLFRIVTGEDWNK 1409

  Fly  2256 VLESLMIQPPDCDPFIHGHTNGNCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEE 2320
            ::...|:|||.|.|....:...:||:...|:.||.||.:|...|::|:.:|||:|||:..:..||
Mouse  1410 IMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFSLFYSTEE 1474

  Fly  2321 IGIVE-DDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISKPNNVALVSFNLPISKGNK 2384
            ..::. :||..|.|.|:..|                   |...|:..   ...|.|.|.:.:|..
Mouse  1475 DQLLSYNDLRHFQIIWNMVD-------------------DKREGVIP---TFRVKFLLRLLRGRL 1517

  Fly  2385 IHCLDILHALVKHVLGHVEETDN--------------------FKQLQEQMDVKFKKQFPTRKEL 2429
            ...||....|.||:...:|...|                    .|.||.: ::..::|.....|.
Mouse  1518 EVDLDKDKLLFKHMCYEMERLHNGGDVTFHDVLSMLSYRSVDIRKSLQLE-ELLAREQLEYTIEE 1581

  Fly  2430 EIVSST-RIW---------KRQEKAAKTIQTGWKEYLRRKREKERSN--SGDSATQTSSPGGWQS 2482
            |:...| |:|         .:|:::...|.:     ||..:|:|||.  ....:.:|:.|....:
Mouse  1582 EVAKQTIRMWLKKCLKRIRAKQQQSCSIIHS-----LRESQEQERSRLFLNPPSIETTQPSEDSN 1641

  Fly  2483 KLSALNFFHLQVSRRGTACSSRASSRKSSR--ASDASDLSELAGPW---------LNLPLMLVSG 2536
            ..|..:....:.|.:....|...|.|..||  |:|........|.|         ...|:..:||
Mouse  1642 ANSQDHSMQPETSSQQQLLSPTLSDRGGSRQDAADTGKPQRKIGQWRLPSAAIAEKTAPVNKMSG 1706

  Fly  2537 ADEVVKDIKQQNDELGK 2553
            ..:   |.:::.:|:.|
Mouse  1707 YSQ---DPEREEEEVSK 1720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	152..371	CDD:278921	50/251 (20%)
		Ion_trans	705..902	CDD:278921	43/205 (21%)
		Ion_trans	1768..2019	CDD:278921	81/300 (27%)
		Na_channel_gate	2009..2063	CDD:240441	15/54 (28%)
		Ion_trans	2085..2320	CDD:278921	73/250 (29%)
		GPHH	2331..2386	CDD:293510	10/54 (19%)
Nalcn	XP_036014574.1	Ion_trans	52..347	CDD:395416	68/437 (16%)
		Ion_trans	399..619	CDD:395416	52/236 (22%)
		Ion_trans	903..1177	CDD:395416	85/319 (27%)
		Ion_trans	1225..1474	CDD:395416	76/268 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R175
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.840