DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NaCP60E and Catsper4

DIOPT Version :9

Sequence 1:	NP_001261172.1	Gene:	NaCP60E / 37981	FlyBaseID:	FBgn0085434	Length:	2896	Species:	Drosophila melanogaster
Sequence 2:	NP_808534.1	Gene:	Catsper4 / 329954	MGIID:	3043288	Length:	442	Species:	Mus musculus

Alignment Length:	326	Identity:	83/326 - (25%)
Similarity:	136/326 - (41%)	Gaps:	79/326 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1751 PAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFS-----FCLIFVVEMILKWLALGFS 1810
            |||:..:..|:.:::||     |.|..|..|.:..|.: ||     ...|.:.|::|.||. ||.
Mouse    68 PAFQLLLAFLLLSNAIT-----IALRTNSYLGQKHYEL-FSTIDDIVLTILICEVLLGWLN-GFW 125

  Fly  1811 KYFTSFWTILDFIIVFVSVFSLLIEENENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAI 1875
            .::...|.||:|.|||:......|::.:.:.:...||.||.:....|:   :.:..::..::.::
Mouse   126 IFWKDGWNILNFAIVFILFMGFFIKQLDMVAITYPLRVLRLVHVCMAV---EPLARIIKVILQSM 187

  Fly  1876 PSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEMGELLPITEVNDKWDCIEQNYTWINSKITF 1940
            |.:.||:.:.|.|.|:||:.||..||....|                                .|
Mouse   188 PDLANVMALILFFMLVFSVFGVTLFGAFVPK--------------------------------HF 220

  Fly  1941 DHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAY-----IYFVIFIVCGSFFTL 2000
            .::|:....|....|.:||:::..|.          |.:...||.     |||.:||..|:|..|
Mouse   221 QNMGVALYTLFICITQDGWLDIYTDF----------QMDEREYAMEVGGAIYFAVFITLGAFIGL 275

  Fly  2001 NLFIGVIIDNF-NMLKKKYEGGVLEMFLTESQK-----------HYYTAMKKLGRKKPQKVIKRP 2053
            |||:.|:..|. .|:|...|.|.|.:..||:::           |...|     ||....|.|.|
Mouse   276 NLFVVVVTTNLEQMMKTGEEEGHLNIKFTETEEDEDWTDELPLVHCTEA-----RKDTSTVPKEP 335

  Fly  2054 I 2054
            :
Mouse   336 L 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	152..371	CDD:278921
		Ion_trans	705..902	CDD:278921
		Ion_trans	1768..2019	CDD:278921	65/261 (25%)
		Na_channel_gate	2009..2063	CDD:240441	15/58 (26%)
		Ion_trans	2085..2320	CDD:278921
		GPHH	2331..2386	CDD:293510
Catsper4	NP_808534.1	Ion_trans	91..289	CDD:278921	60/244 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810