DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NaCP60E and para

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster


Alignment Length:2856 Identity:852/2856 - (29%)
Similarity:1239/2856 - (43%) Gaps:910/2856 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSDDQATFNDE-----KAVAKHQVVAYTQRSQVKHENRHIQLVR--------EYGFH-------- 44
            |::|..:.::|     :...:..:|...||...:||.:. :|.|        :||..        
  Fly     1 MTEDSDSISEEERSLFRPFTRESLVQIEQRIAAEHEKQK-ELERKRAEGEVPQYGRKKKQKEIRY 64

  Fly    45 --------PRTKASVEDGDVLPRKFE-PFPEHMYGKPLEEIDTFIYEE--TFCVVSKRFRKNYIH 98
                    |:...::|.|..:|.:.: .||..:...|||:||.: |..  ||.||||   ...|.
  Fly    65 DDEDEDEGPQPDPTLEQGVPIPVRLQGSFPPELASTPLEDIDPY-YSNVLTFVVVSK---GKDIF 125

  Fly    99 RFTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLAM--TETVEEAEYIFLAIYS 161
            ||:.:|::::..|::|.|||.:||..:..|...::.|||.|||.:.|  |.|||..|.||..||:
  Fly   126 RFSASKAMWMLDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMIMPTTPTVESTEVIFTGIYT 190

  Fly   162 IEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEVGNLAGLRTFRVLRALKTVSIMP 226
            .|..:|::|:||:|..:||||:.|||||||||...|.|:|:::||||.|||||||||||||:|:|
  Fly   191 FESAVKVMARGFILCPFTYLRDAWNWLDFVVIALAYVTMGIDLGNLAALRTFRVLRALKTVAIVP 255

  Fly   227 GLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVPTD--WTNVSHTDWQ 289
            |||||:.|::.|.:.|.:|:.||:|.|.||||..||:|||.|..||:::.|.|  |.|::..:|.
  Fly   256 GLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKCIKKFPLDGSWGNLTDENWD 320

  Fly   290 IWVNDTDNWLYDEDE---LPVLCGNLTGARHCPFEYVCL-CVGENPNHGYTNFDNFMWSMLTTFQ 350
            ....::.|| |.|||   .| ||||::||..|..:|||| ..|.|||:|||:||:|.|:.|:.|:
  Fly   321 YHNRNSSNW-YSEDEGISFP-LCGNISGAGQCDDDYVCLQGFGPNPNYGYTSFDSFGWAFLSAFR 383

  Fly   351 LITLDYWENVYNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYE------EEAEITNEE 409
            |:|.|:||::|.:||...||..:.||.|::|.|||||:||:||:||:||:      ||.|...||
  Fly   384 LMTQDFWEDLYQLVLRAAGPWHMLFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEE 448

  Fly   410 ----------RKKDLLDHRDD---------------------------STFSFDPSVLNVKKLNK 437
                      .|...|:.|.:                           |..|::..|...|..:.
  Fly   449 AIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAALHPEMAKSPTYSCISYELFVGGEKGNDD 513

  Fly   438 NNKKK-------IDSRKGVLLASYSKKKTRRKKTKGGKEGGTNGNGNGS----NGDDNKSHSATP 491
            |||:|       ::|....::.......|..:.||..|...|:.:..||    ......||..|.
  Fly   514 NNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKVSTTSLSLPGSPFNIRRGSRSSHKYTI 578

  Fly   492 SPGPS----PRHSATERPSALTMQAQKQYQQMEQQHKLAKS--------------------GSGG 532
            ..|..    |  .:..:|..|:     .||..:|....|..                    |:.|
  Fly   579 RNGRGRFGIP--GSDRKPLVLS-----TYQDAQQHLPYADDSNAVTPMSEENGAIIVPVYYGNLG 636

  Fly   533 SNNPMAPTPKGRISFQDSG--MGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQDDSGVV 595
            |.:....:.:.|||:...|  :|             |..:......:..|...||.:.....|..
  Fly   637 SRHSSYTSHQSRISYTSHGDLLG-------------GMAVMGVSTMTKESKLRNRNTRNQSVGAT 688

  Fly   596 DDHEE-QDTTNDMGHVSTVELALSPREVRL-IKCNGNIARIKNHN------VYALHQEFSSEVVV 652
            :.... .||.:.:.|          |:..: ::|.....:||:|:      |.........:|:|
  Fly   689 NGGTTCLDTNHKLDH----------RDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMV 743

  Fly   653 IDDLPD-------RNCDR----------------------------------CVHWCTDYESWLQ 676
            ::|:.:       |..||                                  ||..|.  ..||:
  Fly   744 LNDIIEQAAGRHSRASDRGVSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCC--WVWLK 806

  Fly   677 FQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIFTFECIVKLMA 741
            ||..:..:|.||..||.||||||:||.|:||:||.|::.....|..||..||:.|..|..:||||
  Fly   807 FQEWVSLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMA 871

  Fly   742 LS-KDFFLCGWNIFDLLIVTASLLDIIFELVDGLSVLRGLRLLRVLKLAQSWTTMKVLLSIIIST 805
            :| |.:|..||||||.:||..|||::..|.|.||||||..|||||.|||:||.|:.:|:||:..|
  Fly   872 MSPKYYFQEGWNIFDFIIVALSLLELGLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMGRT 936

  Fly   806 IGALGNLTLILVIVIYIFAVIGMQLFSKDYTPEK--FDPDPVPRWNFNDFFHSFMMIFRILCGEW 868
            :|||||||.:|.|:|:||||:|||||.|:|...|  |....:|||||.||.||||::||:|||||
  Fly   937 MGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKDRFPDGDLPRWNFTDFMHSFMIVFRVLCGEW 1001

  Fly   869 IEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLFLALLLNSFNSEELKSKKEEVGEESKLA 933
            ||.:||||..    |..:|...||.|:|:||.:||||||||||::|.|..|.:...: .:.:|:|
  Fly  1002 IESMWDCMYV----GDVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTAD-NDTNKIA 1061

  Fly   934 RSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETK 998
            .:..|:...        |...:|..|:.|:.|        ...|::|.:      |:|       
  Fly  1062 EAFNRIGRF--------KSWVKRNIADCFKLI--------RNKLTNQIS------DQP------- 1097

  Fly   999 FHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPT 1063
                                                    :|:...||                 
  Fly  1098 ----------------------------------------SGERTNQI----------------- 1105

  Fly  1064 YESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEATYTESIELLGQ 1128
                       |:....|.|.|:                                          
  Fly  1106 -----------SWIWSEGKGVCR------------------------------------------ 1117

  Fly  1129 YNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLS 1193
                            |.|...||                                         
  Fly  1118 ----------------CISAEHGD----------------------------------------- 1125

  Fly  1194 QSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEE 1258
                                       |.:.:..||:|:                          
  Fly  1126 ---------------------------NELELGHDEILA-------------------------- 1137

  Fly  1259 LQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNL 1323
                                                 |.:|:...||       .|.||      
  Fly  1138 -------------------------------------DGLIKKGIKE-------QTQLE------ 1152

  Fly  1324 SEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVK 1388
                             :||..|.                                         
  Fly  1153 -----------------VAIGDGM----------------------------------------- 1159

  Fly  1389 LKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFT 1453
                          :|:|..:::                        ..:|.:|.:|....|.  
  Fly  1160 --------------EFTIHGDMK------------------------NNKPKKSKYLNNATDD-- 1184

  Fly  1454 VQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQ 1518
                                                            |:.|:.|..|::|    
  Fly  1185 ------------------------------------------------DTASINSYGSHKN---- 1197

  Fly  1519 KQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHT 1583
                                                                        .|...
  Fly  1198 ------------------------------------------------------------RPFKD 1202

  Fly  1584 HAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTA 1648
            .:| :..|.:|.|:.:|                                                
  Fly  1203 ESH-KGSAETMEGEEKR------------------------------------------------ 1218

  Fly  1649 PDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQK 1713
             ||:::........::...|               .:|..:..:...::......:.|.||    
  Fly  1219 -DASKEDLGLDEELDEEGEC---------------EEGPLDGDIIIHAHDEDILDEYPADC---- 1263

  Fly  1714 CYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKN 1778
            |.|.:|.:.|......|:...:.|..:|.....:::...||..|:.:|..||:.|..||::|.:.
  Fly  1264 CPDSYYKKFPILAGDDDSPFWQGWGNLRLKTFQLIENKYFETAVITMILMSSLALALEDVHLPQR 1328

  Fly  1779 KTLKRVLYWINFSFCLIFVVEMILKWLALGFSKYFTSFWTILDFIIVFVSVFSLL--IEENENLK 1841
            ..|:.:||:::..|.:||.:||::|||||||..|||:.|..|||:||.||:.:.:  :.....::
  Fly  1329 PILQDILYYMDRIFTVIFFLEMLIKWLALGFKVYFTNAWCWLDFVIVMVSLINFVASLVGAGGIQ 1393

  Fly  1842 VLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFK 1906
            ..:::|||||||||||:||.||||:|||||:.|||||||||||||:|||||:|||||.|.||:||
  Fly  1394 AFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLLVCLIFWLIFAIMGVQLFAGKYFK 1458

  Fly  1907 CVNEMGELLPITEVNDKWDCIEQNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARG 1971
            |.:..|..|....:.::..|..:||||:||.:.|||||..||.|.|||||:||:::|.||:|:|.
  Fly  1459 CEDMNGTKLSHEIIPNRNACESENYTWVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSRE 1523

  Fly  1972 VDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYT 2036
            ||.||.||.|:|.|:|||.||:.||||||||||||||||||..||| .||.||||:||.||.||.
  Fly  1524 VDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIIDNFNEQKKK-AGGSLEMFMTEDQKKYYN 1587

  Fly  2037 AMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILE 2101
            ||||:|.|||.|.|.||.....|:.:::...::|:|.|.:.|.|||.||.::.||.......:|:
  Fly  1588 AMKKMGSKKPLKAIPRPRWRPQAIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLD 1652

  Fly  2102 VSNAFFTTVFGLEAIVKIVGLRYHYFTVPWNVFDFLLVLASIFGILMEDIMIDLPISPTLLRVVR 2166
            ..||.|..:|..|.::||..||||||..|||:||.::|:.||.|:::.||:....:|||||||||
  Fly  1653 YLNAIFVVIFSSECLLKIFALRYHYFIEPWNLFDVVVVILSILGLVLSDIIEKYFVSPTLLRVVR 1717

  Fly  2167 VFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKLQGALDDM 2231
            |.::||:|||:|.|||||.|||||.:||||||||..||.|:.||:||.|||.|.:||.:..::|:
  Fly  1718 VAKVGRVLRLVKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKEKSGINDV 1782

  Fly  2232 VNFQTFGRSMQLLFRLMTSAGWNDVLESLM----IQPPDCDPFIHGHTNGNCGHPLLAITYFTSF 2292
            .||:|||:||.|||::.|||||:.||::::    ..|||.|   .|:. ||||...:.||:..|:
  Fly  1783 YNFKTFGQSMILLFQMSTSAGWDGVLDAIINEEACDPPDND---KGYP-GNCGSATVGITFLLSY 1843

  Fly  2293 IIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIAS 2357
            ::||::||||||||:||||::||.::.:.|:.:||.:|:|..|.::||..||:|.:.|||:|:..
  Fly  1844 LVISFLIVINMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDV 1908

  Fly  2358 LDPPLGISKPNNVALVSFNLPISKGNKIHCLDILHALVKHVLGH----VEETDNFKQLQEQMDVK 2418
            |:|||.|.|||...::|.::||.:|:.::|:|||.||.|.....    :|||....::..:    
  Fly  1909 LEPPLQIHKPNKYKIISMDIPICRGDLMYCVDILDALTKDFFARKGNPIEETGEIGEIAAR---- 1969

  Fly  2419 FKKQFPTRKELEIVSSTRIWK-RQEKAAKTIQTGWKEYLRRKREKERSNSGDSATQTSSPGGWQS 2482
                 |..:..|.|||| :|: |:|..|:.||..|:::      |.|...|.|....:..|    
  Fly  1970 -----PDTEGYEPVSST-LWRQREEYCARLIQHAWRKH------KARGEGGGSFEPDTDHG---- 2018

  Fly  2483 KLSALNFFHLQVSRRGTACSSRASSRKSSRASDASDLSELAGPWLNLPLMLVSGADEVVKDIKQQ 2547
                                            |..|               ....|....:....
  Fly  2019 --------------------------------DGGD---------------PDAGDPAPDEATDG 2036

  Fly  2548 NDELGKRGSIFVEAPRASRRRSFYNFFLRHQDAVDDSLTSPSVHRKTAMNNTTNTTSNSASTSGT 2612
            :...|..||:...|..|:             ||.:.::.||......|.         :|:.:..
  Fly  2037 DAPAGGDGSVNGTAEGAA-------------DADESNVNSPGEDAAAAA---------AAAAAAA 2079

  Fly  2613 ASSTATAPATGCGPAATSAS---DSD------RHQAVGGGSAPS--RKRASSFIRKKPPLE 2662
            |:.|.||.:.|.|.|....:   :||      .|:.|....:||  .:.|.. .|.:|||:
  Fly  2080 AAGTTTAGSPGAGSAGRQTAVLVESDGFVTKNGHKVVIHSRSPSITSRTADVXARPRPPLQ 2140

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 116/224 (52%)
Ion_trans 705..902 CDD:278921 108/199 (54%)
Ion_trans 1768..2019 CDD:278921 145/252 (58%)
Na_channel_gate 2009..2063 CDD:240441 32/53 (60%)
Ion_trans 2085..2320 CDD:278921 121/238 (51%)
GPHH 2331..2386 CDD:293510 23/54 (43%)
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 142/272 (52%)
Na_trans_cytopl 515..648 CDD:288761 25/139 (18%)
Ion_trans 835..1028 CDD:278921 106/196 (54%)
Na_trans_assoc 1054..1296 CDD:284034 68/820 (8%)
Ion_trans 1318..1571 CDD:278921 145/253 (57%)
Na_channel_gate 1561..1613 CDD:240441 32/52 (62%)
Ion_trans 1636..1871 CDD:278921 121/238 (51%)
GPHH 1880..1930 CDD:293510 21/49 (43%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45439098
Domainoid 1 1.000 73 1.000 Domainoid score I3264
eggNOG 1 0.900 - - E1_KOG2301
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 311 1.000 Inparanoid score I473
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D14342at50557
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100419
Panther 1 1.100 - - P PTHR10037
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
98.830

Return to query results.
Submit another query.