DRSC/TRiP Functional Genomics Resources

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Protein Alignment NaCP60E and Ca-alpha1T

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:NP_001259267.1 Gene:Ca-alpha1T / 31550 FlyBaseID:FBgn0264386 Length:3218 Species:Drosophila melanogaster


Alignment Length:3365 Identity:703/3365 - (20%)
Similarity:1198/3365 - (35%) Gaps:1069/3365 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   110 YPWSP------------ARRVCVYIATNQFFDYCVMATILFNCIFLAMTE-TVEEA--------- 152
            ||..|            .|..|:.:.||.:|:...:..||.|||.|.|.: .|::|         
  Fly   273 YPGFPEISIRALTQYTRPRNWCLMLITNPWFERVSILVILLNCITLGMYQPCVDDACVTNRCKIL 337

  Fly   153 ---EYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEVG--NLAGLRT 212
               :.|..|.:::||.||::|.| :..|.|||.:.||.|||.::.:|.....|.|.  ||..:||
  Fly   338 QIFDDIIFAFFALEMTIKMVAMG-ICGKNTYLADSWNRLDFFIVLAGLLEYVMHVENLNLTAIRT 401

  Fly   213 FRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVP 277
            .||||.|:.::.:|.::.::..||.:...|..|:.|..|...:|.:..:|::.|.||.:|     
  Fly   402 IRVLRPLRAINRIPSMRILVMLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWEGILRQRC----- 461

  Fly   278 TDWTNVSHTDWQIW-------------VNDTDNWL-YDEDELPV----------LCGNL----TG 314
                ::..|:..::             ||....:. :.:|:..:          ||||.    .|
  Fly   462 ----SLMRTEGMVYPLTVPEVYRVRVRVNSLSQYYEFSKDQDYICSTPNDSGMHLCGNFPPYRIG 522

  Fly   315 ARHCP-----FEY----------------VCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWE 358
            :..|.     |::                .|...||||..|..:|||...:.:..|.:|:|:.|.
  Fly   523 SLVCNEEAKLFDFNEPTNTSCVNWNQYYTTCKQSGENPFQGTISFDNIGMAWVAIFLVISLEGWT 587

  Fly   359 NVYNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEE--------------------- 402
            ::...|..........:|.:::..|||::|||.|.|:|..:.|.                     
  Fly   588 DIMYYVQDAHSFWDWIYFVLLIVIGSFFMINLCLVVIATQFSETKKREMERMRQERARYTSTSTL 652

  Fly   403 -------------AEIT------------------------NEERKKDLLDHRDDSTFSFDPSVL 430
                         |||.                        .::||:.||.:.|:.|||  ||.:
  Fly   653 ASSTNNSEPATCYAEIVKYIAHLWRRFKRRMLKKYRLYKYQRQQRKEGLLPNADNLTFS--PSRI 715

  Fly   431 NV--KKLNKNNKKKIDSRKGVLLA-----SYSKKKTRRKKTKGGKEGGTNGNGN------GSNGD 482
            ..  .|..|.:.:|..|.:..::.     :.:.................||:||      |:|.:
  Fly   716 KCHHPKCPKYSNRKPSSIQDQMITVMVPLNSASNNINNNNNNNSNSSNHNGSGNHTAAGGGNNNN 780

  Fly   483 DNKSHSATP------------SPGPSPRHSATERPSALTMQAQKQYQ-QMEQQHKLAKSGSGGSN 534
            :|.:::|..            |.......||..:...|....|:|:| |.:||.:...|.|..:.
  Fly   781 NNNNNNAASCTTVALVNGINGSAASVTMSSAHHQQHQLLQHQQQQHQNQQQQQQQQQHSSSDNTE 845

  Fly   535 NPMAP------------------TPKGRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQ------ 575
            ..:||                  .|:|..:.|.:.: :|.|..:..|:   |||...|.      
  Fly   846 QSLAPDGLPRSSSLKKSTAHHQLKPEGSAAEQKTIL-LKFPQQMIDSE---QLILQLGNLGKSHP 906

  Fly   576 --------PSSNS---------------------------------------------------- 580
                    |:|.|                                                    
  Fly   907 CTSGFLSPPTSASRRPSVMFNEYVLLHTPPALNADPATAGTTTTVAPTVATVAGTAAAAAAAAAT 971

  Fly   581 ---SGVNRESSQDDSGVV----------------------------------------------- 595
               ||.|...:...||..                                               
  Fly   972 GSGSGNNNHQNGGASGGAGTGGTTEKSNIFSTEKMTQAGDGSIWQVNLPQTIGTIANPYADCSEL 1036

  Fly   596 ---------------------------------------DDHEE---------------QDTTND 606
                                                   |.|..               |:.|..
  Fly  1037 GIHDAMTCQELLAFSVAFSAALPTGQSTLESFYTSLARCDPHTAEALRAHHKPRSVPTGQNQTTP 1101

  Fly   607 MGHVSTVELA---------LSPREVRLIKCNGNI-ARIKNHNVYALHQE---------------- 645
            ....:||.:|         |.|..|..: ..|.| :...||.....||:                
  Fly  1102 GAEGATVMVASTAGDTGQTLQPSTVSAV-VGGTIDSHAANHRRKEHHQQSHHHHNNNNTTSHSRN 1165

  Fly   646 --------------------------------FSSEVVVIDDLPDRN--CDRC---VHWCTDYE- 672
                                            :.:.:..:|:.|.:.  ..||   |:.|.... 
  Fly  1166 YRSRQGQGNSRMREPRAPTGNYMEDYACCYDLYQNALSPLDERPRQRSPTTRCLISVYRCMSRVC 1230

  Fly   673 SWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIFTFECIV 737
            ||:  :..:.::|....|:..|.|.|::||..:.:|:|.........::..|.||:.||..|.::
  Fly  1231 SWI--RRYIRRLVEHKYFQQGILLAILINTLSMGIEYHNQPPELTAIVETSNVVFSGIFAVEMLL 1293

  Fly   738 KLMALSKDFFLC-GWNIFDLLIVTASLLDIIFELV--------DGLSVLRGLRLLRVLKLAQSWT 793
            |::|.....::. |:|:||.:||..|.::|....:        .||||||..||||:|||.:...
  Fly  1294 KVVAEGPFRYIANGFNVFDGIIVILSAIEICQTFMGNGTGGGGSGLSVLRTFRLLRILKLVRFMP 1358

  Fly   794 TMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDY--------------TPEKFDPDP 844
            .::..|.:::.|:..:.....:||:.|:||:::||.||...:              .||.....|
  Fly  1359 NLRRQLFVMLRTMDNVAVFFSLLVLFIFIFSILGMYLFGGKFCKFLDESGLERECTCPEIISRHP 1423

  Fly   845 ---VPRWNFNDFFHSFMMIFRILCGE-WIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNL 905
               ..|.:||:...:.:.:|:||..| |...|::.|    |:.:......|:..:..||:::.||
  Fly  1424 QCECDRKHFNNILWATVTVFQILTQEDWNVVLFNGM----EKTSHWAALYFVALMTFGNYVLFNL 1484

  Fly   906 FLALLLNSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQ 970
            .:|:|:..|:||                             |.||::|::|:..:|.::      
  Fly  1485 LVAILVEGFSSE-----------------------------RNERREREQRELVKKLRE------ 1514

  Fly   971 QAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLE 1035
                :||:...:.|:.  |:....|::.....||.|..||..|..|..   .|.|.:..|::.  
  Fly  1515 ----ETLAENYSDGMY--DESRSEADSSTTNDSYYEVRNRWRSAEDVR---KLQDSVELIIEA-- 1568

  Fly  1036 YDDTGDLPEQIQLQAHPLPPTSD----SMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAER 1096
               ..::..|..||     ||.|    .:|.:  ||..:.:|.|.:|..|:           .||
  Fly  1569 ---KSNMHRQRLLQ-----PTHDYQINELPAS--SAAPSASGTSGASAPGD-----------RER 1612

  Fly  1097 RLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRR 1161
                       .:..|...|             ...|.| ...|:.:|.|....|   ..::..|
  Fly  1613 -----------DRDRDRDRE-------------RDRDRD-RERDREAGGGGKEEG---AQHAKPR 1649

  Fly  1162 YGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIE 1226
            .|        ||...|:..|    |....|||:........::.:..|      :.|...|.::|
  Fly  1650 GG--------LKKTYSIKER----RSEAPRLSKIRLARDPPIITTTAA------TPQDSPSTTLE 1696

  Fly  1227 QDELLSQQGNLR------------EELLNCDQKELFQFLQEEEELQKGTKL-RRISNVMRSRRPS 1278
            ......|.|::.            ..:....|:.|.:.:...:.:.....| .:..|::.:.:..
  Fly  1697 PGMSFRQWGDMEPPSPPSPSLLRPPNIFTGGQRSLDEGIPSIDLIPPSPVLSHKPLNILNASQLG 1761

  Fly  1279 SQMGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTSL--------------------ERKLSNL 1323
            ..||.....|....|...::|      :::|.:|::|.                    ...|:::
  Fly  1762 VGMGGGVPSTAGSSSSMHSVI------IDDISKSSSSTAAATPIYVPTISSTADAQSQSHSLNDV 1820

  Fly  1324 SEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNP---YDSYDL-----SSVPRRSQSVSA 1380
            |..|....|.....|...| .||||...::....|||.|   ..|:..     ||..||:.:::.
  Fly  1821 SVGSSPGGEIPATGMSRNA-NTGASTSGSSSSERLPLAPPPQQGSFKQRLRRGSSKKRRASALAL 1884

  Fly  1381 AAQRQSVKLKRRSLEKQRKIDED-------------------------------------FSISN 1408
            |......   ||:|:.|.:..:|                                     .|..|
  Fly  1885 ATDDNPA---RRTLDNQARRTQDEEEEQQQLNNGGDNSCLLRNSNAVVSGSSSGTKETNRLSPQN 1946

  Fly  1409 EIRKICDQI---HAPFVAMEAMAVAATSASQAQPNQSPFLR-----RKVDPFTVQFDRFKRLSLI 1465
            .||::.:.:   ..|..:..|.|....|......||.|.||     |::....:.|.:...|:| 
  Fly  1947 SIRRLSNTLSIGSGPVGSRRASACIFNSQVYQNLNQPPKLRPGSGQRRMSSIELAFSKTSHLNL- 2010

  Fly  1466 ERVEEVPEEEKPIS--TLRIESEKMPRKF--LHGPDQLRLDSLSL--KSTNSYENLLIQKQKLGM 1524
               ..:....|.:|  ..:::.:|..:.:  |:.||.:....:..  |..||..:.         
  Fly  2011 ---HNLEANRKSLSYTNSKMDLDKWNKSYGNLNEPDNMLQQYMEARDKRKNSISHY--------- 2063

  Fly  1525 ATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQA 1589
                        :||..:|...|.|:..|           |||..               ...:.
  Fly  2064 ------------NLKKRLEEKELQQLQQL-----------HQQQL---------------LQQRQ 2090

  Fly  1590 HAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQK 1654
            .:.|...|:::.:..|..|.|.....:.:..|...|..:..|.|.:.:.|.|             
  Fly  2091 DSFSSTTQQQQQQLQQHRLSKDQQQLAMQPHSMVPGGGERYSKLKMLIEQLT------------- 2142

  Fly  1655 PSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFY 1719
            |..||  ||:..:.|..:.:|                                        :.|.
  Fly  2143 PKHFT--TEREDYSLYIFPED----------------------------------------NRFR 2165

  Fly  1720 FRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRV 1784
            ..|.||::       :.|               |:..||:.|..:.|||..|..|:..:.|.:..
  Fly  2166 QICTWFVN-------QKW---------------FDNVVLLFIALNCITLAMERPNIPPSSTERLF 2208

  Fly  1785 LYWINFSFCLIFVVEMILKWLALGF----SKYFTSFWTILDFIIVFVSVFSL---LIEENEN--L 1840
            |...|:.|.::|.|||.:|.:|.|.    ..||||.|.|:|..:|.:|:..|   ||.|:..  .
  Fly  2209 LATANYVFTVVFTVEMFIKVVATGMFYGHDAYFTSGWNIMDGSLVTISIIDLLMSLISESSPRIF 2273

  Fly  1841 KVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFF 1905
            .:||..|.||:|||||.|:|..|:::||..|:.::..|.|::|:|..|::||.|:|||.|.|.|:
  Fly  2274 GILRVFRLLRSLRPLRVINRAPGLKLVVQTLLSSLRPIGNIVLICCTFFIIFGILGVQLFKGTFY 2338

  Fly  1906 KCVNEMGELLPITEVNDKWDC--IEQNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVD 1968
            .|..|     .|..|.:..:|  |..| .|.|.|..||.:|...::|..:::.:||:.:|...:|
  Fly  2339 YCEGE-----NIKGVRNADECRRIPGN-VWTNRKYNFDDLGKALMSLFVLSSRDGWVNIMYTGLD 2397

  Fly  1969 ARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKH 2033
            |.|||.||....|.:..:||:.||:...||.||:|:||:::||:..:::.|         :.:|.
  Fly  2398 AVGVDQQPIVNYNEWRLLYFIAFILLVGFFVLNMFVGVVVENFHRCREEQE---------KEEKI 2453

  Fly  2034 YYTAMKKLGRKKPQKVIKRP---INHF-LAMF-YDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQP 2093
            ...|.:.|..:|.::.:..|   .|:. ..|| :::..|:.|::||..:|.||::||.:|:|..|
  Fly  2454 RRAAKRALQMEKKRRRMHEPPYYTNYSPTRMFVHNVVTSKYFDLAIAAVIGLNVVTMAMEYYKMP 2518

  Fly  2094 HAVFFILEVSNAFFTTVFGLEAIVKIVGLRYH-YFTVPWNVFDFLLVLASIFGILMEDIMID--- 2154
            ..:.:.|::.|.|||.||.|||.:|:|.|.:. |....||..|..:||.||.||::|::..:   
  Fly  2519 SGLKYALKIFNYFFTAVFILEANMKLVALGWKLYLKDRWNQLDVGIVLLSIVGIVLEELETNTHQ 2583

  Fly  2155 -LPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSL 2218
             :||:||::||:||.||.|:|:|:|.|.|||.||..::.:||.:.|:|.|..|:.||:|.||:.|
  Fly  2584 IIPINPTIIRVMRVLRIARVLKLLKMANGIRALLDTVMQALPQVGNLGLLFFLLFFIFAALGVEL 2648

  Fly  2219 FG------NVKLQGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQPPDCDPFIHGHTNG 2277
            ||      .:..|| |.:..:|..||.:...|||:.|...||.:::..:  ..:||.......| 
  Fly  2649 FGRLECSDEIPCQG-LGEHAHFANFGMAFLTLFRVATGDNWNGIMKDTL--RDNCDDAADCVRN- 2709

  Fly  2278 NCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHA 2342
            .|...::|..:|..|::::..:::|:.:|:::::..::|::     :||:|:| .:...:.....
  Fly  2710 CCVSSVIAPIFFVIFVLMAQFVLVNVVVAVLMKHLEESHKQ-----MEDELDM-EVELERELVRE 2768

  Fly  2343 TQFIHFSQLSDFIASLD-----PPLGISKPNNVALVSFNLPISKGNKIHCLDILHALVKHVLGHV 2402
            .:|....:|...:|...     ||..::|..       :||                        
  Fly  2769 QEFAQEQKLCQQLAEAQSKAAAPPRPLAKVK-------SLP------------------------ 2802

  Fly  2403 EETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEKAAKTIQTGWKEYLRRKREKERSNS 2467
               .||......:|    |:||.      ||..........||..:           .:...:.|
  Fly  2803 ---KNFIYSTPSLD----KKFPA------VSGVNNPSLTSSAATNL-----------NQVATAGS 2843

  Fly  2468 GDSATQTSSPGGW---------------QSKLSALNFFHLQVSRRGTACSSRASSRKSSRASDAS 2517
            |.:|......|..               ||.|..|:...:..:....|..:|..........:.|
  Fly  2844 GGAAPGAVPAGSGAGPRRQTVQYFQQPPQSMLGGLSLAEMGGTLTPQALGARLGEPFGGGGGNKS 2908

  Fly  2518 DLSELAGP-----WLNLPLMLVSGADEVVKDIKQQNDELGKRGSIFVEA---PRASRRRSFYNFF 2574
                  ||     |                    |.:.:.|||.:..|.   .:|.|||:     
  Fly  2909 ------GPRRQSYW--------------------QINPIRKRGVLSKERSLDEQAIRRRN----- 2942

  Fly  2575 LRHQDAVDDSLTSPSVHRKTAMNNTTNTTSNSASTSGTASSTATAPATGCGPAATSASDSDRHQA 2639
            |..:....|||....    .|::....|...|..:.|.......:...|.|              
  Fly  2943 LEAKRTSCDSLPWGG----DALDCRRGTIFESLESDGGGVGGGGSGGGGGG-------------- 2989

  Fly  2640 VGGGSAPSRK--RASSFIRKKPPLERGLSAQSALRVNKNA---------FVSEASAPEVI-VTRP 2692
            :|||.:...:  |::.....:...:..||..|||..:...         .|:..|.|..: :..|
  Fly  2990 LGGGVSYDLRSVRSADVGHSEMDGDVSLSVVSALVPSVTTPLPPPLSLPIVTPTSTPTPLQLPMP 3054

  Fly  2693 SPEQQTH--------------------------PHSLSLRPDNATLVHVLVHRESEEYKEEDESS 2731
            .|....|                          |.|:..|..:.:...:...:..:|..:.||:|
  Fly  3055 MPMPMAHPPPRRPFGWSQSVDQGCLRSNLLLSVPRSMPPRSRSGSTKQLFKQQALDEDADMDENS 3119

  Fly  2732 ---PSVSGNGNGFGVGLDMLSKQPPPQIRITTGSVESSMDTCAMPTVQIMVDSPKDPPRGDFSSA 2793
               |:.:|.|:|.|                               :|.::..|..|.|....||.
  Fly  3120 LLLPTAAGGGSGPG-------------------------------SVAVIASSSLDLPDQSGSSK 3153

  Fly  2794 PI-DDVGAPIDVNVQGDTSQVFYDYNPEKATDDQGNGQDETAQFESLPDR 2842
            .| .|:...:.   :.|:|.:....:..:..|.:...:.|..|.....||
  Fly  3154 QILPDIALGVS---KSDSSDILRIISERRRMDQREQREPEQDQDNEAEDR 3200

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 68/281 (24%)
Ion_trans 705..902 CDD:278921 59/223 (26%)
Ion_trans 1768..2019 CDD:278921 95/261 (36%)
Na_channel_gate 2009..2063 CDD:240441 11/58 (19%)
Ion_trans 2085..2320 CDD:278921 84/245 (34%)
GPHH 2331..2386 CDD:293510 8/59 (14%)
Ca-alpha1TNP_001259267.1 Ion_trans 332..636 CDD:278921 78/313 (25%)
Ion_trans 1261..1495 CDD:278921 64/237 (27%)
Ion_trans 2192..2448 CDD:278921 95/261 (36%)
Ion_trans 2510..2728 CDD:278921 81/221 (37%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45439097
Domainoid 1 1.000 73 1.000 Domainoid score I3264
eggNOG 1 0.900 - - E1_KOG2301
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 311 1.000 Inparanoid score I473
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - P PTHR10037
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
65.890

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