DRSC/TRiP Functional Genomics Resources

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Protein Alignment NaCP60E and Scn11a

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:NP_062138.1 Gene:Scn11a / 29701 RGDID:3630 Length:1765 Species:Rattus norvegicus


Alignment Length:2517 Identity:724/2517 - (28%)
Similarity:1080/2517 - (42%) Gaps:841/2517 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 FNDE---KAVAKHQVVAYTQRSQVKHENRHIQLVREYGFHPRTKASVEDGDVLPRKFEPFPEHMY 69
            |.||   :......:.|..:|..::.|.:..:........||.:..::....||:.:...|..:.
  Rat    10 FPDERNFRPFTSDSLAAIEKRIAIQKERKKSKDKAAAEPQPRPQLDLKASRKLPKLYGDIPPELV 74

  Fly    70 GKPLEEIDTFIYE-ETFCVVSKRFRKNYIHRFTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVM 133
            .||||::|.|..: :||.|::|   |..|:||:..::||:..|::|.|.:.:.|:.:..|...::
  Rat    75 AKPLEDLDPFYKDHKTFMVLNK---KRTIYRFSAKRALFILGPFNPLRSLMIRISVHSVFSMFII 136

  Fly   134 ATILFNCIFLAMTETVEEA------EYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVV 192
            .|::.||:|:|  .::|.:      ||:|:.||.:|.||||:|:||:::::::||:|||||||:|
  Rat   137 CTVIINCMFMA--NSMERSFDNDIPEYVFIGIYILEAVIKILARGFIVDEFSFLRDPWNWLDFIV 199

  Fly   193 ITSGYATI--GMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMV 255
            |.:..||.  |.:| ||:.||||||.||||.:|::.|||.|:.|||.|.::|.:||.||:|||.:
  Rat   200 IGTAIATCFPGSQV-NLSALRTFRVFRALKAISVISGLKVIVGALLRSVKKLVDVMVLTLFCLSI 263

  Fly   256 FALFALQVYMGELRNKCVRQ--VPTDWTNVSHTDWQIWVNDTDNWLYDEDELPVLCGNLTGARHC 318
            |||...|::||.|..||::.  .|...:|....:.:   .|::::        ::||...|:|.|
  Rat   264 FALVGQQLFMGILNQKCIKHNCGPNPASNKDCFEKE---KDSEDF--------IMCGTWLGSRPC 317

  Fly   319 PFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCGPMSVSFFTVVVFFG 383
            |....|.....||::.||.||||.||.|..|:::|.|.||.:|..:|.|.|...|.||.||:|.|
  Rat   318 PNGSTCDKTTLNPDNNYTKFDNFGWSFLAMFRVMTQDSWERLYRQILRTSGIYFVFFFVVVIFLG 382

  Fly   384 SFYLINLMLAVVALSYEEE-AEITNEERKKDLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRK 447
            ||||:||.||||.::|||: ..:..|...|:.:..........:...|....:::::...:.:  
  Rat   383 SFYLLNLTLAVVTMAYEEQNRNVAAETEAKEKMFQEAQQLLREEKEALVAMGIDRSSLNSLQA-- 445

  Fly   448 GVLLASYSKKKTRRKKTKGGK-------EGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATERP 505
                :|:|.||   :|..|.|       .|......:.|:.:|:                     
  Rat   446 ----SSFSPKK---RKFFGSKTRKSFFMRGSKTAQASASDSEDD--------------------- 482

  Fly   506 SALTMQAQKQYQQMEQQHKLAKSGSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQLI 570
                  |.|..|.:||..:|:::                                .|.|      
  Rat   483 ------ASKNPQLLEQTKRLSQN--------------------------------LPVD------ 503

  Fly   571 ANSGQPSSNSSGVNRESSQDDSGVVDDH-EEQDTTNDMGHVSTVELALSPRE---VRLIKCNGNI 631
                                   :.|:| :.......:..||.:.:.:..:|   .....|..|:
  Rat   504 -----------------------LFDEHVDPLHRQRALSAVSILTITMQEQEKFQEPCFPCGKNL 545

  Fly   632 ARIKNHNVYALHQEFSSEVVVIDDLPDRNCDRCVHWCTDYESWLQFQNCLYKVVRDPLFELAITL 696
            |               |:.:|.|..|               .||..:..|..::.||..|||||:
  Rat   546 A---------------SKYLVWDCSP---------------QWLCIKKVLRTIMTDPFTELAITI 580

  Fly   697 CIVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIFTFECIVKLMALSK-DFFLCGWNIFDLLIVT 760
            ||::||.|||:|||.|.::.:..|.:||.|||.||..|..:|::||.. .:|..|||:||.::..
  Rat   581 CIIINTVFLAVEHHNMDDNLKTILKIGNWVFTGIFIAEMCLKIIALDPYHYFRHGWNVFDSIVAL 645

  Fly   761 ASLLDIIFELV--DGLSVLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIF 823
            .||.|:::..:  :..|.|..||:|||.|||:||.|:..|:.||..::|||||||::|.||::||
  Rat   646 LSLADVLYNTLSDNNRSFLASLRVLRVFKLAKSWPTLNTLIKIIGHSVGALGNLTVVLTIVVFIF 710

  Fly   824 AVIGMQLFSKDYTPEKFDPDPVP--RWNFNDFFHSFMMIFRILCGEWIEPLWDCMRAEEEQGAST 886
            :|:||:||...:....:.....|  ||:.::|:|||:::||||||||||.:|.||  ::..|:..
  Rat   711 SVVGMRLFGTKFNKTAYATQERPRRRWHMDNFYHSFLVVFRILCGEWIENMWGCM--QDMDGSPL 773

  Fly   887 CFAIFLPTLVMGNFMVLNLFLALLLNSFNSEELKSKKEEVGEESKLARSIERVR----------- 940
            |..:|:..:|:|..:|||||:|||||||::||.....|....::|:..:::|.|           
  Rat   774 CIIVFVLIMVIGKLVVLNLFIALLLNSFSNEEKDGSLEGETRKTKVQLALDRFRRAFSFMLHALQ 838

  Fly   941 DLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQ 1005
            ....||.:.:...|.::..|.|                                           
  Rat   839 SFCCKKCRRKNSPKPKETTESF------------------------------------------- 860

  Fly  1006 ESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMP-PTYESAMM 1069
                                             .|:..:.|      ||   |:.| ..|::.|.
  Rat   861 ---------------------------------AGENKDSI------LP---DARPWKEYDTDMA 883

  Fly  1070 ATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDT 1134
            ..||.:.:.         |.|..:.|                         :.:|..|:..:..|
  Rat   884 LYTGQAGAP---------LAPLAEVE-------------------------DDVEYCGEGGALPT 914

  Fly  1135 DPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQS 1199
            .                                                                
  Rat   915 S---------------------------------------------------------------- 915

  Fly  1200 QRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTK 1264
                         :||:|              .|.|:|..|                        
  Rat   916 -------------QHSAG--------------VQAGDLPPE------------------------ 929

  Fly  1265 LRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPA 1329
                         :.|:..|:::. ||...|.      |::|                       
  Rat   930 -------------TKQLTSPDDQG-VEMEVFS------EEDL----------------------- 951

  Fly  1330 ADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSL 1394
                      |::|                         .|..::|.:||..::..::.|.    
  Rat   952 ----------HLSI-------------------------QSPRKKSDAVSMLSECSTIDLN---- 977

  Fly  1395 EKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRF 1459
                                                                          |.|
  Rat   978 --------------------------------------------------------------DIF 980

  Fly  1460 KRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGM 1524
            :.|.                                                             
  Rat   981 RNLQ------------------------------------------------------------- 984

  Fly  1525 ATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQA 1589
                                         ||..|                               
  Rat   985 -----------------------------KTVSP------------------------------- 989

  Fly  1590 HAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQK 1654
                                                                             
  Rat   990 ----------------------------------------------------------------- 989

  Fly  1655 PSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFY 1719
                                                            .|.||.|||:....||.
  Rat   990 ------------------------------------------------KKQPDRCFPKGLSCHFL 1006

  Fly  1720 F------RCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKN 1778
            .      :.||.:          |..:|.....:|....||.|::.:|..||..|.|||:||...
  Rat  1007 CHKTDKRKSPWVL----------WWNIRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVNLPSR 1061

  Fly  1779 KTLKRVLYWINFSFCLIFVVEMILKWLALGFSKYFTSFWTILDFIIVFVSVFSLLIEENENLKVL 1843
            ..::::|...:..|..||::||||||:|.||.:||||.|..|||:||.|||.||:     ||..|
  Rat  1062 PQVEKLLRCTDNIFTFIFLLEMILKWVAFGFRRYFTSAWCWLDFLIVVVSVLSLM-----NLPSL 1121

  Fly  1844 RSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCV 1908
            :|.|||||||||||:|:::||::||.||:.|||:|.|||||||:|||:|.|:||..|.|||.:|:
  Rat  1122 KSFRTLRALRPLRALSQFEGMKVVVYALISAIPAILNVLLVCLIFWLVFCILGVNLFSGKFGRCI 1186

  Fly  1909 N--EMGELLPITEVNDKWDCIEQNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARG 1971
            |  ::...|..|||.::..|...||:|...::.||:||..|||||||||::||:|:|..|||:|.
  Rat  1187 NGTDINMYLDFTEVPNRSQCNISNYSWKVPQVNFDNVGNAYLALLQVATYKGWLEIMNAAVDSRE 1251

  Fly  1972 VDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYT 2036
            .|.||..|||||||:|||:||:.||||||||||||||||||..:||..|  .::|:||.||.||.
  Rat  1252 KDEQPDFEANLYAYLYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGG--QDIFMTEEQKKYYN 1314

  Fly  2037 AMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILE 2101
            ||||||.|||||.|.||:|...|..:||..|:.|::.|..||.|||:.|..|..|||..|....:
  Rat  1315 AMKKLGTKKPQKPIPRPLNKCQAFVFDLVTSQVFDVIILGLIVLNMIIMMAESADQPKDVKKTFD 1379

  Fly  2102 VSNAFFTTVFGLEAIVKIVGLRYHYFTVPWNVFDFLLVLASIFGIL---MEDIMIDLPISPTLLR 2163
            :.|..|..:|.:|.::|:..||.||||..||:||.::|:.||...|   :||..|..|  |||.|
  Rat  1380 ILNIAFVVIFTIECLIKVFALRQHYFTNGWNLFDCVVVVLSIISTLVSRLEDSDISFP--PTLFR 1442

  Fly  2164 VVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKLQGAL 2228
            |||:.||||||||::||:|||.|||||::|||:|||||.||.|:.|||||.|||.|..||....:
  Rat  1443 VVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLVMFIYAIFGMSWFSKVKKGSGI 1507

  Fly  2229 DDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQPPDCDPFIHGHTNGNCGHPLLAITYFTSFI 2293
            ||:.||:||..||..||::.|||||:.:|..::.....|    :..:..:|..|.:|:.||.|:|
  Rat  1508 DDIFNFETFTGSMLCLFQITTSAGWDTLLNPMLEAKEHC----NSSSQDSCQQPQIAVVYFVSYI 1568

  Fly  2294 IISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASL 2358
            |||::||:|||||:||||||.|.:|.|..:.|||.|:||..|.|:||.|:|||.:|.||||..:|
  Rat  1569 IISFLIVVNMYIAVILENFNTATEESEDPLGEDDFEIFYEVWEKFDPEASQFIQYSALSDFADAL 1633

  Fly  2359 DPPLGISKPNNVALVSFNLPISKGNKIHCLDILHALVKHVLGHVEETDNFKQLQEQMDVKFKKQF 2423
            ..||.::|||....:..:||:..|:::||:|:|.|....|||.....|..|.:.|:   ||.:..
  Rat  1634 PEPLRVAKPNKFQFLVMDLPMVMGDRLHCMDVLFAFTTRVLGDSSGLDTMKTMMEE---KFMEAN 1695

  Fly  2424 PTRKELEIVSSTRIWKRQEKAAKTIQTGWKEYLRRK---REKERSNS 2467
            |.:|..|.:.:|...|.:|:.|..||..:::::.:.   |.|:||:|
  Rat  1696 PFKKLYEPIVTTTKRKEEEQGAAVIQRAYRKHMEKMVKLRLKDRSSS 1742

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 96/228 (42%)
Ion_trans 705..902 CDD:278921 85/201 (42%)
Ion_trans 1768..2019 CDD:278921 144/252 (57%)
Na_channel_gate 2009..2063 CDD:240441 30/53 (57%)
Ion_trans 2085..2320 CDD:278921 118/237 (50%)
GPHH 2331..2386 CDD:293510 24/54 (44%)
Scn11aNP_062138.1 I. /evidence=ECO:0000305 115..403 126/301 (42%)
Ion_trans 160..404 CDD:278921 116/255 (45%)
II. /evidence=ECO:0000305 554..820 117/282 (41%)
Ion_trans 589..807 CDD:278921 99/219 (45%)
Na_trans_assoc 812..1029 CDD:284034 63/838 (8%)
III. /evidence=ECO:0000305 1022..1319 163/303 (54%)
Ion_trans 1051..1297 CDD:278921 142/250 (57%)
Na_channel_gate 1289..1341 CDD:240441 30/53 (57%)
IV. /evidence=ECO:0000305 1328..1619 145/296 (49%)
Ion_trans 1363..1595 CDD:278921 118/237 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100419
Panther 1 1.100 - - O PTHR10037
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
65.820

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