DRSC/TRiP Functional Genomics Resources

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Protein Alignment NaCP60E and Scn10a

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:NP_058943.2 Gene:Scn10a / 29571 RGDID:3629 Length:1956 Species:Rattus norvegicus


Alignment Length:2624 Identity:830/2624 - (31%)
Similarity:1180/2624 - (44%) Gaps:808/2624 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 EKAVAKHQVVAYTQRSQVKHENRHIQLVREYGFHPRTKASVEDGDVLPRKFEPFPEHMYGKPLEE 75
            ||.:|.|:.   .::::.||..:     .:.|..||.:..::..:.||:.:...|..:.|:|||:
  Rat    25 EKQIAAHRA---AKKARTKHRGQ-----EDKGEKPRPQLDLKACNQLPKFYGELPAELVGEPLED 81

  Fly    76 IDTFI-YEETFCVVSKRFRKNYIHRFTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATILFN 139
            :|.|. ...||.|::|   ...|.||:.|.:|:||.|::..||..:.::.:.:|...:..|||.|
  Rat    82 LDPFYSTHRTFMVLNK---SRTISRFSATWALWLFSPFNLIRRTAIKVSVHSWFSIFITITILVN 143

  Fly   140 CIFLAMTETVEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEV 204
            |:.:..|:..|:.||:|..||:.|.:|||:|:||.||::||||:|||||||.|||..|....:::
  Rat   144 CVCMTRTDLPEKVEYVFTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGAAIDL 208

  Fly   205 GNLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELR 269
            ..::|||||||||||||||::||||.|:.||:||.|:||:|..||:|||.||||..||::.|.|:
  Rat   209 RGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVRKLADVTILTVFCLSVFALVGLQLFKGNLK 273

  Fly   270 NKCVRQVPTDWTNVSHTDWQIWVNDTDNWLYDEDEL----------------PVLCGNLTGARHC 318
            |||:|                  |.||.  :..|.|                |:||||.:.|.||
  Rat   274 NKCIR------------------NGTDP--HKADNLSSEMAEYIFIKPGTTDPLLCGNGSDAGHC 318

  Fly   319 PFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCGPMSVSFFTVVVFFG 383
            |..||||...:||:..||:||:|.|:.|:.|:|:|.|.||.:|...|...|.|.:.||.:|:|.|
  Rat   319 PGGYVCLKTPDNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRASGKMYMVFFVLVIFLG 383

  Fly   384 SFYLINLMLAVVALSYEEE-----AEITNEERK-KDLLDHRDDSTFSFDPSVLNVKKLNKNNKKK 442
            ||||:||:||||.::|||:     |||..:|:| ::.|:     ....:..||....::..:   
  Rat   384 SFYLVNLILAVVTMAYEEQSQATIAEIEAKEKKFQEALE-----VLQKEQEVLAALGIDTTS--- 440

  Fly   443 IDSRKGVLLASYSKKKTRRKKTKGGKEGGTNGNGNGSNGDDNKSHSATP-----------SPGPS 496
            :.|..|..|||.:..:.|.:......||.|         |||:|..:.|           |.|  
  Rat   441 LQSHSGSPLASKNANERRPRVKSRVSEGST---------DDNRSPQSDPYNQRRMSFLGLSSG-- 494

  Fly   497 PRHSATER--------------PSALTMQAQKQYQQMEQQHKLAKSGSGGSNNPM--APTPK--- 542
             |..|:..              |..:|........|..::..:......|...|:  :|.|:   
  Rat   495 -RRRASHGSVFHFRAPSQDISFPDGITDDGVFHGDQESRRGSILLGRGAGQTGPLPRSPLPQSPN 558

  Fly   543 -GRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQDDSGVVDDHEEQDTTND 606
             ||...::..:||....:...:. :|..:..:||.|..|:|...|..:             ....
  Rat   559 PGRRHGEEGQLGVPTGELTAGAP-EGPALDTTGQKSFLSAGYLNEPFR-------------AQRA 609

  Fly   607 MGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDRNCDRCVHWCTDY 671
            |..||.:...:...|...:||...:.            .|:.:.::.:..|              
  Rat   610 MSVVSIMTSVIEELEESKLKCPPCLI------------SFAQKYLIWECCP-------------- 648

  Fly   672 ESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIFTFECI 736
             .|.:|:..|:::|.||..||.||||||:||.|:||||:.|:::|...|..||.|||..||.|..
  Rat   649 -KWRKFKMALFELVTDPFAELTITLCIVVNTVFMAMEHYPMTDAFDAMLQAGNIVFTVFFTMEMA 712

  Fly   737 VKLMALSK-DFFLCGWNIFDLLIVTASLLDIIFELVDGLSVLRGLRLLRVLKLAQSWTTMKVLLS 800
            .|::|... .:|...|||||.:|||.|||::.......|||||..|||||.|||:||.|:..|:.
  Rat   713 FKIIAFDPYYYFQKKWNIFDCVIVTVSLLELSASKKGSLSVLRTFRLLRVFKLAKSWPTLNTLIK 777

  Fly   801 IIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTPEKFDPDPVP-------RWNFNDFFHSFM 858
            ||.:::|||||||.||.|:::|||::|.||.|:||...|   |.|.       ||:..||||||:
  Rat   778 IIGNSVGALGNLTFILAIIVFIFALVGKQLLSEDYGCRK---DGVSVWNGEKLRWHMCDFFHSFL 839

  Fly   859 MIFRILCGEWIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLFLALLLNSFNSEELKSKK 923
            ::||||||||||.:|.||...::   |.|..:||..:|:||.:|||||:|||||||:::.|.:.:
  Rat   840 VVFRILCGEWIENMWVCMEVSQK---SICLILFLTVMVLGNLVVLNLFIALLLNSFSADNLTAPE 901

  Fly   924 EEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLERG 988
            :: ||.:.|..::.|:                                   |.|.|:|:..:   
  Rat   902 DD-GEVNNLQLALARI-----------------------------------QVLGHRASRAI--- 927

  Fly   989 DKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPL 1053
                         .||..|..|        |:.|                      :::.|....
  Rat   928 -------------ASYISSHCR--------FRWP----------------------KVETQLGMK 949

  Fly  1054 PPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEAT 1118
            ||.:.|                                                           
  Rat   950 PPLTSS----------------------------------------------------------- 955

  Fly  1119 YTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSP 1183
                                                                             
  Rat   956 ----------------------------------------------------------------- 955

  Fly  1184 SYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKE 1248
                                      |.:.|          |..|.:.:..|||.:..|:..:  
  Rat   956 --------------------------EAKNH----------IATDAVSAAVGNLTKPALSSPK-- 982

  Fly  1249 LFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRST 1313
                                                ||     |.:|                  
  Rat   983 ------------------------------------EN-----HGDF------------------ 988

  Fly  1314 TSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSV 1378
                     :::|:         :...:.|..|.|:   .||                       
  Rat   989 ---------ITDPN---------VWVSVPIAEGESD---LDE----------------------- 1009

  Fly  1379 SAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSP 1443
                                 ::||                    ||            |.:||.
  Rat  1010 ---------------------LEED--------------------ME------------QASQSS 1021

  Fly  1444 FLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKS 1508
            :                            :||.|    :.:.|::|:                  
  Rat  1022 W----------------------------QEEDP----KGQQEQLPQ------------------ 1036

  Fly  1509 TNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIE-PPTLAQISSLKTTPPLAALTEHQQHFHAT 1572
                    :||.:...|      |..|.|:.||.: .|.|.:....|.:|.:.|           
  Rat  1037 --------VQKCENHQA------ARSPASMMSSEDLAPYLGESWKRKDSPQVPA----------- 1076

  Fly  1573 SIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAM 1637
                                                               .|..|.||      
  Rat  1077 ---------------------------------------------------EGVDDTSS------ 1084

  Fly  1638 AQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKA 1702
               :|.|....||    |....|.       :....|||                          
  Rat  1085 ---SEGSTVDCPD----PEEILRK-------IPELADDL-------------------------- 1109

  Fly  1703 AKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKH-WT---RVRTAVLTVVDTPAFEWFVLVLIFA 1763
             ..|||||.:.|..    |||    |.:..::|. |.   :||.....:|:...||.|::.:|..
  Rat  1110 -DEPDDCFTEGCTR----RCP----CCNVNTSKSPWATGWQVRKTCYRIVEHSWFESFIIFMILL 1165

  Fly  1764 SSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGFSKYFTSFWTILDFIIVFVS 1828
            ||..|.|||..|::...:|.||.:.:..|..|||.||:|||:|.||.||||:.|..|||:||.:|
  Rat  1166 SSGALAFEDNYLEEKPRVKSVLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNIS 1230

  Fly  1829 VFSLL--IEENENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLI 1891
            :.||:  |.|..::..:::||||||||||||:||::|||:||:||:.|||||.|||||||:||||
  Rat  1231 LTSLIAKILEYSDVASIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLI 1295

  Fly  1892 FSIMGVQFFGGKFFKCV---NEMGELLPITEVNDKWDCIEQNYT----WINSKITFDHVGMGYLA 1949
            ||||||..|.|||.|||   |.....:..|.||:|.:|..||.|    |:|.|:.||:|.|||||
  Rat  1296 FSIMGVNLFAGKFSKCVDTRNNPFSNVNSTMVNNKSECHNQNSTGHFFWVNVKVNFDNVAMGYLA 1360

  Fly  1950 LLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNML 2014
            |||||||:|||::|..|||:..::.||..|.|||.|:|||:||:.|.|||||||:||||||||..
  Rat  1361 LLQVATFKGWMDIMYAAVDSGEINSQPNWENNLYMYLYFVVFIIFGGFFTLNLFVGVIIDNFNQQ 1425

  Fly  2015 KKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRFEIAIFVLIF 2079
            |||..|  .::|:||.||.||.||||||.|||||.|.||:|.:....:|:...:.|:|.|.|||.
  Rat  1426 KKKLGG--QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFVFDIVTRQAFDIIIMVLIC 1488

  Fly  2080 LNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRYHYFTVPWNVFDFLLVLASIF 2144
            |||:||.:|..:|......:|...|.||..||..|.::|:..||.:|||..||||||::|:.||.
  Rat  1489 LNMITMMVETDEQGEEKTKVLGRINQFFVAVFTGECVMKMFALRQYYFTNGWNVFDFIVVILSIG 1553

  Fly  2145 GILMEDIMIDLP--ISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLI 2207
            .:|...|:..|.  .||||.||:|:.|||||||||:||||||.|||||::|||||||||.||.|:
  Rat  1554 SLLFSAILKSLENYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLV 1618

  Fly  2208 TFIYAILGMSLFGNVKLQGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLM-IQPPDCDPFI 2271
            .|||:|.||:.|.||..:..:|||.||:|||.||..||::.|||||:.:|..:: ..||.|||.:
  Rat  1619 MFIYSIFGMASFANVVDEAGIDDMFNFKTFGNSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNL 1683

  Fly  2272 --HGHTNGNCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIR 2334
              ...:.||||.|.:.|.:||::||||::||:|||||:||||||.|.:|....:.|||.:|||..
  Rat  1684 PNSNGSRGNCGSPAVGIIFFTTYIIISFLIVVNMYIAVILENFNVATEESTEPLSEDDFDMFYET 1748

  Fly  2335 WSKYDPHATQFIHFSQLSDFIASLDPPLGISKPNNVALVSFNLPISKGNKIHCLDILHALVKHVL 2399
            |.|:||.|||||.||.||||..:|..||.|.|||...|:..:||:..|:||||||||.|..|:||
  Rat  1749 WEKFDPEATQFIAFSALSDFADTLSGPLRIPKPNQNILIQMDLPLVPGDKIHCLDILFAFTKNVL 1813

  Fly  2400 GHVEETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEKAAKTIQTGWKEYLRRK----- 2459
            |...|.|:   |:..|:.||.....::...|.:::|..||:::.:|..||..::.|:..:     
  Rat  1814 GESGELDS---LKTNMEEKFMATNLSKASYEPIATTLRWKQEDLSATVIQKAYRSYMLHRSLTLS 1875

  Fly  2460 ------REKE-------------RSNSG-----DSATQTSSPGGWQSKLSALNFFHLQVSRRGTA 2500
                  |.:|             .:|||     ::|:.||.|..:.|....|             
  Rat  1876 NTLHVPRAEEDGVSLPGEGYVTFMANSGLPDKSETASATSFPPSYDSVTRGL------------- 1927

  Fly  2501 CSSRASSRKSSRASDASDLSELAG 2524
             |.||:...||...:..:::...|
  Rat  1928 -SDRANINPSSSMQNEDEVAAKEG 1950

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 110/234 (47%)
Ion_trans 705..902 CDD:278921 98/204 (48%)
Ion_trans 1768..2019 CDD:278921 150/259 (58%)
Na_channel_gate 2009..2063 CDD:240441 30/53 (57%)
Ion_trans 2085..2320 CDD:278921 126/239 (53%)
GPHH 2331..2386 CDD:293510 29/54 (54%)
Scn10aNP_058943.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 31..54 6/30 (20%)
I. /evidence=ECO:0000305 116..404 139/307 (45%)
Ion_trans 129..406 CDD:395416 137/296 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 441..484 14/51 (27%)
Na_trans_cytopl <482..614 CDD:403218 23/148 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 537..581 8/43 (19%)
II. /evidence=ECO:0000305 646..910 131/285 (46%)
Ion_trans 663..893 CDD:395416 122/235 (52%)
Na_trans_assoc 903..1148 CDD:399489 88/825 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1008..1094 33/296 (11%)
III. /evidence=ECO:0000305 1141..1450 170/310 (55%)
Ion_trans 1152..1428 CDD:395416 154/275 (56%)
Na_channel_gate 1420..1472 CDD:240441 30/53 (57%)
IV. /evidence=ECO:0000305 1459..1758 152/298 (51%)
Ion_trans 1476..1733 CDD:395416 135/256 (53%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1906..1956 12/59 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100419
Panther 1 1.100 - - LDO PTHR10037
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
65.820

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