Protein Alignment NaCP60E and Scn10a

DIOPT Version :10

• Sequence 1: NP_001261172.1
• Gene: NaCP60E / 37981
• FlyBaseID: FBgn0085434
• Length: 2896
• Species: Drosophila melanogaster
• Sequence 2: NP_058943.2
• Gene: Scn10a / 29571
• RGDID: 3629
• Length: 1956
• Species: Rattus norvegicus
• Alignment Length: 2624
• Identity: 830/2624 - (31%)
• Similarity: 1180/2624 - (44%)
• Gaps: 808/2624 - (30%)

  Fly    11 EKAVAKHQVVAYTQRSQVKHENRHIQLVREYGFHPRTKASVEDGDVLPRKFEPFPEHMYGKPLEE 75
            ||.:|.|:.   .::::.||..:     .:.|..||.:..::..:.||:.:...|..:.|:|||:
  Rat    25 EKQIAAHRA---AKKARTKHRGQ-----EDKGEKPRPQLDLKACNQLPKFYGELPAELVGEPLED 81

  Fly    76 IDTFI-YEETFCVVSKRFRKNYIHRFTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATILFN 139
            :|.|. ...||.|::|   ...|.||:.|.:|:||.|::..||..:.::.:.:|...:..|||.|
  Rat    82 LDPFYSTHRTFMVLNK---SRTISRFSATWALWLFSPFNLIRRTAIKVSVHSWFSIFITITILVN 143

  Fly   140 CIFLAMTETVEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEV 204
            |:.:..|:..|:.||:|..||:.|.:|||:|:||.||::||||:|||||||.|||..|....:::
  Rat   144 CVCMTRTDLPEKVEYVFTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGAAIDL 208

  Fly   205 GNLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELR 269
            ..::|||||||||||||||::||||.|:.||:||.|:||:|..||:|||.||||..||::.|.|:
  Rat   209 RGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVRKLADVTILTVFCLSVFALVGLQLFKGNLK 273

  Fly   270 NKCVRQVPTDWTNVSHTDWQIWVNDTDNWLYDEDEL----------------PVLCGNLTGARHC 318
            |||:|                  |.||.  :..|.|                |:||||.:.|.||
  Rat   274 NKCIR------------------NGTDP--HKADNLSSEMAEYIFIKPGTTDPLLCGNGSDAGHC 318

  Fly   319 PFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCGPMSVSFFTVVVFFG 383
            |..||||...:||:..||:||:|.|:.|:.|:|:|.|.||.:|...|...|.|.:.||.:|:|.|
  Rat   319 PGGYVCLKTPDNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRASGKMYMVFFVLVIFLG 383

  Fly   384 SFYLINLMLAVVALSYEEE-----AEITNEERK-KDLLDHRDDSTFSFDPSVLNVKKLNKNNKKK 442
            ||||:||:||||.::|||:     |||..:|:| ::.|:     ....:..||....::..:
  Rat   384 SFYLVNLILAVVTMAYEEQSQATIAEIEAKEKKFQEALE-----VLQKEQEVLAALGIDTTS--- 440

  Fly   443 IDSRKGVLLASYSKKKTRRKKTKGGKEGGTNGNGNGSNGDDNKSHSATP-----------SPGPS 496
            :.|..|..|||.:..:.|.:......||.|         |||:|..:.|           |.|
  Rat   441 LQSHSGSPLASKNANERRPRVKSRVSEGST---------DDNRSPQSDPYNQRRMSFLGLSSG-- 494

  Fly   497 PRHSATER--------------PSALTMQAQKQYQQMEQQHKLAKSGSGGSNNPM--APTPK--- 542
             |..|:..              |..:|........|..::..:......|...|:  :|.|:
  Rat   495 -RRRASHGSVFHFRAPSQDISFPDGITDDGVFHGDQESRRGSILLGRGAGQTGPLPRSPLPQSPN 558

  Fly   543 -GRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQDDSGVVDDHEEQDTTND 606
             ||...::..:||....:...:. :|..:..:||.|..|:|...|..:             ....
  Rat   559 PGRRHGEEGQLGVPTGELTAGAP-EGPALDTTGQKSFLSAGYLNEPFR-------------AQRA 609

  Fly   607 MGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDRNCDRCVHWCTDY 671
            |..||.:...:...|...:||...:.            .|:.:.::.:..|
  Rat   610 MSVVSIMTSVIEELEESKLKCPPCLI------------SFAQKYLIWECCP-------------- 648

  Fly   672 ESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIFTFECI 736
             .|.:|:..|:::|.||..||.||||||:||.|:||||:.|:::|...|..||.|||..||.|..
  Rat   649 -KWRKFKMALFELVTDPFAELTITLCIVVNTVFMAMEHYPMTDAFDAMLQAGNIVFTVFFTMEMA 712

  Fly   737 VKLMALSK-DFFLCGWNIFDLLIVTASLLDIIFELVDGLSVLRGLRLLRVLKLAQSWTTMKVLLS 800
            .|::|... .:|...|||||.:|||.|||::.......|||||..|||||.|||:||.|:..|:.
  Rat   713 FKIIAFDPYYYFQKKWNIFDCVIVTVSLLELSASKKGSLSVLRTFRLLRVFKLAKSWPTLNTLIK 777

  Fly   801 IIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTPEKFDPDPVP-------RWNFNDFFHSFM 858
            ||.:::|||||||.||.|:::|||::|.||.|:||...|   |.|.       ||:..||||||:
  Rat   778 IIGNSVGALGNLTFILAIIVFIFALVGKQLLSEDYGCRK---DGVSVWNGEKLRWHMCDFFHSFL 839

  Fly   859 MIFRILCGEWIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLFLALLLNSFNSEELKSKK 923
            ::||||||||||.:|.||...::   |.|..:||..:|:||.:|||||:|||||||:::.|.:.:
  Rat   840 VVFRILCGEWIENMWVCMEVSQK---SICLILFLTVMVLGNLVVLNLFIALLLNSFSADNLTAPE 901

  Fly   924 EEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLERG 988
            :: ||.:.|..::.|:                                   |.|.|:|:..:
  Rat   902 DD-GEVNNLQLALARI-----------------------------------QVLGHRASRAI--- 927

  Fly   989 DKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPL 1053
                         .||..|..|        |:.|                      :::.|....
  Rat   928 -------------ASYISSHCR--------FRWP----------------------KVETQLGMK 949

  Fly  1054 PPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEAT 1118
            ||.:.|
  Rat   950 PPLTSS----------------------------------------------------------- 955

  Fly  1119 YTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSP 1183
                                                                             
  Rat   956 ----------------------------------------------------------------- 955

  Fly  1184 SYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKE 1248
                                      |.:.|          |..|.:.:..|||.:..|:..:
  Rat   956 --------------------------EAKNH----------IATDAVSAAVGNLTKPALSSPK-- 982

  Fly  1249 LFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRST 1313
                                                ||     |.:|
  Rat   983 ------------------------------------EN-----HGDF------------------ 988

  Fly  1314 TSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSV 1378
                     :::|:         :...:.|..|.|:   .||
  Rat   989 ---------ITDPN---------VWVSVPIAEGESD---LDE----------------------- 1009

  Fly  1379 SAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSP 1443
                                 ::||                    ||            |.:||.
  Rat  1010 ---------------------LEED--------------------ME------------QASQSS 1021

  Fly  1444 FLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKS 1508
            :                            :||.|    :.:.|::|:
  Rat  1022 W----------------------------QEEDP----KGQQEQLPQ------------------ 1036

  Fly  1509 TNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIE-PPTLAQISSLKTTPPLAALTEHQQHFHAT 1572
                    :||.:...|      |..|.|:.||.: .|.|.:....|.:|.:.|
  Rat  1037 --------VQKCENHQA------ARSPASMMSSEDLAPYLGESWKRKDSPQVPA----------- 1076

  Fly  1573 SIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAM 1637
                                                               .|..|.||
  Rat  1077 ---------------------------------------------------EGVDDTSS------ 1084

  Fly  1638 AQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKA 1702
               :|.|....||    |....|.       :....|||
  Rat  1085 ---SEGSTVDCPD----PEEILRK-------IPELADDL-------------------------- 1109

  Fly  1703 AKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKH-WT---RVRTAVLTVVDTPAFEWFVLVLIFA 1763
             ..|||||.:.|..    |||    |.:..::|. |.   :||.....:|:...||.|::.:|..
  Rat  1110 -DEPDDCFTEGCTR----RCP----CCNVNTSKSPWATGWQVRKTCYRIVEHSWFESFIIFMILL 1165

  Fly  1764 SSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGFSKYFTSFWTILDFIIVFVS 1828
            ||..|.|||..|::...:|.||.:.:..|..|||.||:|||:|.||.||||:.|..|||:||.:|
  Rat  1166 SSGALAFEDNYLEEKPRVKSVLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNIS 1230

  Fly  1829 VFSLL--IEENENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLI 1891
            :.||:  |.|..::..:::||||||||||||:||::|||:||:||:.|||||.|||||||:||||
  Rat  1231 LTSLIAKILEYSDVASIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLI 1295

  Fly  1892 FSIMGVQFFGGKFFKCV---NEMGELLPITEVNDKWDCIEQNYT----WINSKITFDHVGMGYLA 1949
            ||||||..|.|||.|||   |.....:..|.||:|.:|..||.|    |:|.|:.||:|.|||||
  Rat  1296 FSIMGVNLFAGKFSKCVDTRNNPFSNVNSTMVNNKSECHNQNSTGHFFWVNVKVNFDNVAMGYLA 1360

  Fly  1950 LLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNML 2014
            |||||||:|||::|..|||:..::.||..|.|||.|:|||:||:.|.|||||||:||||||||..
  Rat  1361 LLQVATFKGWMDIMYAAVDSGEINSQPNWENNLYMYLYFVVFIIFGGFFTLNLFVGVIIDNFNQQ 1425

  Fly  2015 KKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRFEIAIFVLIF 2079
            |||..|  .::|:||.||.||.||||||.|||||.|.||:|.:....:|:...:.|:|.|.|||.
  Rat  1426 KKKLGG--QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFVFDIVTRQAFDIIIMVLIC 1488

  Fly  2080 LNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRYHYFTVPWNVFDFLLVLASIF 2144
            |||:||.:|..:|......:|...|.||..||..|.::|:..||.:|||..||||||::|:.||.
  Rat  1489 LNMITMMVETDEQGEEKTKVLGRINQFFVAVFTGECVMKMFALRQYYFTNGWNVFDFIVVILSIG 1553

  Fly  2145 GILMEDIMIDLP--ISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLI 2207
            .:|...|:..|.  .||||.||:|:.|||||||||:||||||.|||||::|||||||||.||.|:
  Rat  1554 SLLFSAILKSLENYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLV 1618

  Fly  2208 TFIYAILGMSLFGNVKLQGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLM-IQPPDCDPFI 2271
            .|||:|.||:.|.||..:..:|||.||:|||.||..||::.|||||:.:|..:: ..||.|||.:
  Rat  1619 MFIYSIFGMASFANVVDEAGIDDMFNFKTFGNSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNL 1683

  Fly  2272 --HGHTNGNCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIR 2334
              ...:.||||.|.:.|.:||::||||::||:|||||:||||||.|.:|....:.|||.:|||..
  Rat  1684 PNSNGSRGNCGSPAVGIIFFTTYIIISFLIVVNMYIAVILENFNVATEESTEPLSEDDFDMFYET 1748

  Fly  2335 WSKYDPHATQFIHFSQLSDFIASLDPPLGISKPNNVALVSFNLPISKGNKIHCLDILHALVKHVL 2399
            |.|:||.|||||.||.||||..:|..||.|.|||...|:..:||:..|:||||||||.|..|:||
  Rat  1749 WEKFDPEATQFIAFSALSDFADTLSGPLRIPKPNQNILIQMDLPLVPGDKIHCLDILFAFTKNVL 1813

  Fly  2400 GHVEETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEKAAKTIQTGWKEYLRRK----- 2459
            |...|.|:   |:..|:.||.....::...|.:::|..||:::.:|..||..::.|:..:
  Rat  1814 GESGELDS---LKTNMEEKFMATNLSKASYEPIATTLRWKQEDLSATVIQKAYRSYMLHRSLTLS 1875

  Fly  2460 ------REKE-------------RSNSG-----DSATQTSSPGGWQSKLSALNFFHLQVSRRGTA 2500
                  |.:|             .:|||     ::|:.||.|..:.|....|
  Rat  1876 NTLHVPRAEEDGVSLPGEGYVTFMANSGLPDKSETASATSFPPSYDSVTRGL------------- 1927

  Fly  2501 CSSRASSRKSSRASDASDLSELAG 2524
             |.||:...||...:..:::...|
  Rat  1928 -SDRANINPSSSMQNEDEVAAKEG 1950

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	125..371	CDD:459842	118/261 (45%)
		Ion_trans	687..902	CDD:459842	111/222 (50%)
		Ion_trans	1751..2019	CDD:459842	156/276 (57%)
		Na_channel_gate	2009..2063	CDD:240441	30/53 (57%)
		Ion_trans	2067..2320	CDD:459842	136/257 (53%)
		GPHH	2332..2378	CDD:465306	24/45 (53%)
Scn10a	NP_058943.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	31..54		6/30 (20%)
		I. /evidence=ECO:0000305	116..404		139/307 (45%)
		Ion_trans	129..406	CDD:459842	137/296 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	441..484		14/51 (27%)
		Na_trans_cytopl	487..614	CDD:463401	23/143 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	537..581		8/43 (19%)
		II. /evidence=ECO:0000305	646..910		131/285 (46%)
		Ion_trans	663..893	CDD:459842	122/235 (52%)
		Na_trans_assoc	903..1148	CDD:461936	88/825 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1008..1094		33/296 (11%)
		III. /evidence=ECO:0000305	1141..1450		170/310 (55%)
		Ion_trans	1152..1428	CDD:459842	154/275 (56%)
		Na_channel_gate	1420..1472	CDD:240441	30/53 (57%)
		IV. /evidence=ECO:0000305	1459..1758		152/298 (51%)
		Ion_trans	1476..1733	CDD:459842	135/256 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1906..1956		12/59 (20%)