Protein Alignment NaCP60E and Nalcn

DIOPT Version :10

• Sequence 1: NP_001261172.1
• Gene: NaCP60E / 37981
• FlyBaseID: FBgn0085434
• Length: 2896
• Species: Drosophila melanogaster
• Sequence 2: NP_001380622.1
• Gene: Nalcn / 266760
• RGDID: 628710
• Length: 1770
• Species: Rattus norvegicus
• Alignment Length: 2630
• Identity: 469/2630 - (17%)
• Similarity: 798/2630 - (30%)
• Gaps: 1139/2630 - (43%)

  Fly   106 LFLFYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLAMT-ETVEEAEYI-------FLAIYSI 162
            |::..||           .:.....|.:.:::..|:...|| |.....:|:       .:.:|:.
  Rat    31 LWINKPW-----------VHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTA 84

  Fly   163 EMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEVGNLAG----------LRTFRVLR 217
            ||:.|:..:|.:....:|:::.|...|..::...:.::.::|..:|.          ||..|.|.
  Rat    85 EMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLI 149

  Fly   218 ALKTVSI-----MPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVP 277
            .::...|     :|..: |.|.|..|..|:..|....:|.|:::.:..:|:: |.....||
  Rat   150 MIRAFRIYFRFELPRTR-ITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMF-GTFTYHCV---- 208

  Fly   278 TDWTNVSHTDWQIWVNDT--DNWLYDEDELP-VLCG-NLTGARHCPFEYVCLCVGE----NPNHG 334
                          ||||  .|..::...:| ..|. .|.....||..:.|:.:.:    ....|
  Rat   209 --------------VNDTKPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSRQELG 259

  Fly   335 YTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCG-P--MSVSFFTVVVFFGSFYLINLMLAVVA 396
            |:.|:....|:.|.::..:.:.|  |:.|..|... |  .|..:|..::||.::.:.|:.:||:
  Rat   260 YSGFNEIGTSIFTVYEASSQEGW--VFLMYRAIDSFPRWRSYFYFITLIFFLAWLVKNVFIAVI- 321

  Fly   397 LSYEEEAEITNEERKKDLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRR 461
              .|..|||
  Rat   322 --IETFAEI-------------------------------------------------------- 328

  Fly   462 KKTKGGKEGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQHKLA 526
                                                               :.|:|||
  Rat   329 ---------------------------------------------------RVQFQQM------- 335

  Fly   527 KSGSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQDD 591
                .|:.:....|...::..:|:..|             .||:|
  Rat   336 ----WGTRSSTTSTATTQMFHEDAAGG-------------WQLVA-------------------- 363

  Fly   592 SGVVDDHEEQDTTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDL 656
               ||.::.|              ..:|.
  Rat   364 ---VDVNKPQ--------------GRAPA------------------------------------ 375

  Fly   657 PDRNCDRCVHWCTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALD 721
                                   ||.|::|..:|.:.| |.:|.....:|..::...|:||...|
  Rat   376 -----------------------CLQKMMRSSVFHMFI-LSMVTVDVIVAASNYYKGENFRRQYD 416

  Fly   722 ---VGNKVFTSIFTFECIVKLMALS-KDFFLCGWNIFDLLIVTASLLDIIFELVDG-LSVLRGLR 781
               :....||.:|..|.::|:..|. ..:.....:.|:||:|..:.|.:..:|... .:..:.||
  Rat   417 EFYLAEVAFTVLFDLEALLKIWCLGFTGYISSSLHKFELLLVIGTTLHVYPDLYHSQFTYFQVLR 481

  Fly   782 LLRVLKLAQSWTTMKVLLSIIISTIG---ALGNLTLILVIVIYIFAVIGMQLFSKDYTPEKFDPD 843
            ::|::|::.:      |...:....|   .||:|.:....::.:.:.|.:|:|.   ..|:.|
  Rat   482 VVRLIKISPA------LEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFC---FVEELD-- 535

  Fly   844 PVPRWNFNDFFHSFMMIFRILCGE-WIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLFL 907
                 .|..|..:||.:|:||..| |::.:...:.|.....|......|:...:....::|:||:
  Rat   536 -----RFTTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAPLVAIYFILYHLFATLILLSLFV 595

  Fly   908 ALLLNSFN-SEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKER-----KFAEKFQQIV 966
            |::|::.. .|:||..|:                   .|:.:...|.||:     :..|||.
  Rat   596 AVILDNLELDEDLKKLKQ-------------------LKQSEANADTKEKLPLRLRIFEKFP--- 638

  Fly   967 LDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIV 1031
                                                      ||
  Rat   639 ------------------------------------------NR--------------------- 640

  Fly  1032 DGLEYDDTGDLPEQIQLQAHPLPPTSD-SMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAE 1095
                       |:.:::...|    || ::|...||.|
  Rat   641 -----------PQMVKISKLP----SDFTVPKIRESFM--------------------------- 663

  Fly  1096 RRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSR 1160
                         :|:..|::........:|...:|:..|   |.:|         .:::||
  Rat   664 -------------KQFIDRQQQDTCCLFRILPSTSSSSCD---NPKR---------PTVEDN--- 700

  Fly  1161 RYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEA--EMRRHSSGQSLNSM 1223
                        ||....|      |||:..:      ..|:||:.|.|  ::.|..:.|.:.|.
  Rat   701 ------------KYIDQKL------RKSVFSI------RARNLLEKETAVTKILRACTRQRMLSG 741

  Fly  1224 SIE-----QDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQ 1283
            |.|     :..:||.|.::|               ||...|:.|:..:|||.
  Rat   742 SFEGQPAKERSILSVQHHIR---------------QERRSLRHGSNSQRISR------------- 778

  Fly  1284 PENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGAS 1348
                               .|.||.:.:..::..|..:...|     |...|.|.|
  Rat   779 -------------------GKSLETLTQDHSNTVRYRNAQRE-----DSEIKMIQE--------- 810

  Fly  1349 ERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKI 1413
                                                     |:...|.:||:.|:     |:|
  Rat   811 -----------------------------------------KKEQAEMKRKVQEE-----ELR-- 827

  Fly  1414 CDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPI 1478
                                                                   |..|..:||:
  Rat   828 -------------------------------------------------------ENHPYFDKPL 837

  Fly  1479 STLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIE 1543
                         |:.|
  Rat   838 -------------FIVG------------------------------------------------ 841

  Fly  1544 PPTLAQISSLKTTPPLAALTEHQ-QHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQST 1607
                               .||: ::|....::
  Rat   842 -------------------REHRFRNFCRVVVR-------------------------------- 855

  Fly  1608 LDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSY 1672
                |.|.:::|
  Rat   856 ----ARFNASKT----------------------------------------------------- 863

  Fly  1673 VDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHW 1737
                             ||:|    ||.|..|.      .:.||
  Rat   864 -----------------DPVT----GAVKNTKY------HQLYD--------------------- 880

  Fly  1738 TRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLY-----WINFSFCLIFV 1797
               ...::|.:|     |.::.:...|.|::.||       ...:||::     ...:.|.:...
  Rat   881 ---LLGLVTYLD-----WVMITVTICSCISMMFE-------SPFRRVMHAPTLQIAEYVFVIFMS 930

  Fly  1798 VEMILKWLALGFSKYFTSFWTILDF---IIVFVSVFSLLI----------EENENLKVLRSLRTL 1849
            :|:.||.:|.|.  :||....|.||   :.:|:.:.||:.          |....|     |..|
  Rat   931 IELNLKIMADGL--FFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGAQL-----LMVL 988

  Fly  1850 RALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEMGEL 1914
            |.|||||.......||.||..|......||.|.::.|...|:|:..|||.|.||..||
  Rat   989 RCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGKLAKC------- 1046

  Fly  1915 LPITEVND-----KWDC---------IEQNY-----------------TWINSK-ITFDHVGMGY 1947
                  ||     :.||         :.:|.                 .|.|.: ..||:||...
  Rat  1047 ------NDPNIIRREDCNGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAM 1105

  Fly  1948 LALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFN 2012
            |||.:|.:.:||:||.         |:...|...::. ||..:|:..|....|.||:||:|.|||
  Rat  1106 LALFEVLSLKGWVEVR---------DVIIHRVGPIHG-IYIHVFVFLGCMIGLTLFVGVVIANFN 1160

  Fly  2013 MLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPINH-FLAMFYDLSNSRRFEIAIFV 2076
                :.:|..|   ||..|:.:.....:|...:|..:..||.|. |.|..||::....|:..|.:
  Rat  1161 ----ENKGTAL---LTVDQRRWEDLKSRLKIAQPLHLPPRPDNDGFRAKMYDITQHPFFKRTIAL 1218

  Fly  2077 LIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGL-----------RYHYFT-- 2128
            |:....:.:.:: :|....|...|...:..||.:|.||..:||:.:           ||....
  Rat  1219 LVLAQSVLLSVK-WDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMSPAGFWQSRRNRYDLLVTS 1282

  Fly  2129 --VPWNVFDFLLVLASIFGILMEDIMIDLPISPTLLRVVRVFRI-GRILRLIKAAKGIRKLLFAL 2190
              |.|.|..|.|:.|  :..:|...:|          |.|.|.| |:.:.|       :.||..:
  Rat  1283 LGVVWVVLHFALLNA--YTYMMGACVI----------VFRFFSICGKHVTL-------KMLLLTV 1328

  Fly  2191 VVSLPALFNIGALLGLITFIYAILGMSLFGNVKLQGALDDMVNFQTFGRSMQLLFRLMTSAGWND 2255
            |||:...|.|...:.|:...||..|:.|||.||....::...||.:.|:::.:|||::|...||.
  Rat  1329 VVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYGENINRHANFSSAGKAITVLFRIVTGEDWNK 1393

  Fly  2256 VLESLMIQPPDCDPFIHGHTNGNCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEE 2320
            ::...|:|||.|.|....:...:||:...|:.||.||.:|...|::|:.:|||:|||:..:..||
  Rat  1394 IMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFSLFYSTEE 1458

  Fly  2321 IGIVE-DDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISKPNNVALVSFNLPISKGNK 2384
            ..::. :||..|.|.|:..|                   |...|:..   ...|.|.|.:.:|..
  Rat  1459 DQLLSYNDLRHFQIIWNMVD-------------------DKREGVIP---TFRVKFLLRLLRGRL 1501

  Fly  2385 IHCLDILHALVKHVLGHVEETDN-----FKQL-----QEQMDVKFKKQFP---TRKELEIVSSTR 2436
            ...||....|.||:...:|...|     |..:     ...:|::...|..   .|::||...
  Rat  1502 EVDLDKDKLLFKHMCYEMERLHNGGDVTFHDVLSMLSYRSVDIRKSLQLEELLAREQLEYTI--- 1563

  Fly  2437 IWKRQEKAAKTIQTGWKEYLRRKREKER------------------------------------S 2465
               .:|.|.:||:...|:.|:|.|.|::                                    :
  Rat  1564 ---EEEVAKQTIRMWLKKCLKRIRAKQQQSCSIIHSLRESQQQELSRFLNPPSIETTQPSEDTNA 1625

  Fly  2466 NSGDSATQTSSPGGWQSKLSALNFFHLQVSRRGTACSSRASSRKSSRASDASDLSELAGPWLNLP 2530
            ||.|..||..| ...|..||             ...|.|..||:.  |:|........|.| .||
  Rat  1626 NSQDHNTQPES-SSQQQLLS-------------PTLSDRGGSRQD--AADTGKPQRKIGQW-RLP 1673

  Fly  2531 LMLVSGADEVV-------KDIKQQNDELGK 2553
            ...::.....|       :|.:::.:|:.|
  Rat  1674 SAAIAEKTAPVNKMSSYSQDPEREEEEVSK 1703

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	125..371	CDD:459842	55/279 (20%)
		Ion_trans	687..902	CDD:459842	47/223 (21%)
		Ion_trans	1751..2019	CDD:459842	84/317 (26%)
		Na_channel_gate	2009..2063	CDD:240441	15/54 (28%)
		Ion_trans	2067..2320	CDD:459842	76/268 (28%)
		GPHH	2332..2378	CDD:465306	7/45 (16%)
Nalcn	NP_001380622.1	Ion_trans	36..331	CDD:459842	68/437 (16%)
		Ion_trans	383..603	CDD:459842	52/236 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	762..789		10/58 (17%)
		Ion_trans	887..1161	CDD:459842	85/319 (27%)
		Ion_trans	1209..1458	CDD:459842	76/268 (28%)