DRSC/TRiP Functional Genomics Resources

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Protein Alignment NaCP60E and NALCN

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:XP_024305104.1 Gene:NALCN / 259232 HGNCID:19082 Length:1786 Species:Homo sapiens


Alignment Length:2619 Identity:470/2619 - (17%)
Similarity:803/2619 - (30%) Gaps:1097/2619 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly   106 LFLFYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLAMT-ETVEEAEYI-------FLAIYSI 162
            |::..||           .:.....|.:.:::..|:...|| |.....:|:       .:.:|:.
Human    50 LWINKPW-----------VHSLLRICAIISVISVCMNTPMTFEHYPPLQYVTFTLDTLLMFLYTA 103

  Fly   163 EMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEVGNLAG------------------ 209
            ||:.|:..:|.:....:|:::.|...|..::...:.::.::|..:|.                  
Human   104 EMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVLQVFEIADIVDQMSPWGMLRIPRPLI 168

  Fly   210 -LRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCV 273
             :|.||:....:    :|..: |.|.|..|..|:..|....:|.|:::.:..:|:: |.....||
Human   169 MIRAFRIYFRFE----LPRTR-ITNILKRSGEQIWSVSIFLLFFLLLYGILGVQMF-GTFTYHCV 227

  Fly   274 RQVPTDWTNVSHTDWQIWVNDT--DNWLYDEDELP-VLCG-NLTGARHCPFEYVCLCVGE----N 330
                              ||||  .|..::...:| ..|. .|.....||..:.|:.:.:    .
Human   228 ------------------VNDTKPGNVTWNSLAIPDTHCSPELEEGYQCPPGFKCMDLEDLGLSR 274

  Fly   331 PNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCG-P--MSVSFFTVVVFFGSFYLINLML 392
            ...||:.|:....|:.|.::..:.:.|  |:.|..|... |  .|..:|..::||.::.:.|:.:
Human   275 QELGYSGFNEIGTSIFTVYEAASQEGW--VFLMYRAIDSFPRWRSYFYFITLIFFLAWLVKNVFI 337

  Fly   393 AVVALSYEEEAEITNEERKKDLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKK 457
            ||:   .|..|||                                                    
Human   338 AVI---IETFAEI---------------------------------------------------- 347

  Fly   458 KTRRKKTKGGKEGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQ 522
                                                                   :.|:|||   
Human   348 -------------------------------------------------------RVQFQQM--- 354

  Fly   523 HKLAKSGSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRES 587
                    .||.:....|...::..:|:..|             .||:|                
Human   355 --------WGSRSSTTSTATTQMFHEDAAGG-------------WQLVA---------------- 382

  Fly   588 SQDDSGVVDDHEEQDTTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVV 652
                   ||.::.|              ..:|.                                
Human   383 -------VDVNKPQ--------------GRAPA-------------------------------- 394

  Fly   653 IDDLPDRNCDRCVHWCTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFR 717
                                       ||.|::|..:|.:.| |.:|.....:|..::...|:||
Human   395 ---------------------------CLQKMMRSSVFHMFI-LSMVTVDVIVAASNYYKGENFR 431

  Fly   718 NALD---VGNKVFTSIFTFECIVKLMALS-KDFFLCGWNIFDLLIVTASLLDIIFELVDG-LSVL 777
            ...|   :....||.:|..|.::|:..|. ..:.....:.|:||:|..:.|.:..:|... .:..
Human   432 RQYDEFYLAEVAFTVLFDLEALLKIWCLGFTGYISSSLHKFELLLVIGTTLHVYPDLYHSQFTYF 496

  Fly   778 RGLRLLRVLKLAQSWTTMKVLLSIIISTIG---ALGNLTLILVIVIYIFAVIGMQLFSKDYTPEK 839
            :.||::|::|::.:      |...:....|   .||:|.:....::.:.:.|.:|:|.   ..|:
Human   497 QVLRVVRLIKISPA------LEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFC---FVEE 552

  Fly   840 FDPDPVPRWNFNDFFHSFMMIFRILCGE-WIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVL 903
            .|       .|..|..:||.:|:||..| |::.:...:.|.....|......|:...:....::|
Human   553 LD-------RFTTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAPVVAIYFILYHLFATLILL 610

  Fly   904 NLFLALLLNSFN-SEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKER-----KFAEKF 962
            :||:|::|::.. .|:||..|:                   .|:.:...|.||:     :..|||
Human   611 SLFVAVILDNLELDEDLKKLKQ-------------------LKQSEANADTKEKLPLRLRIFEKF 656

  Fly   963 QQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGL 1027
            .                                             ||                 
Human   657 P---------------------------------------------NR----------------- 659

  Fly  1028 HTIVDGLEYDDTGDLPEQIQLQAHPLPPTSD-SMPPTYESAMMATTGGSFSSVNGNGTCQNLTPF 1091
                           |:.:::...|    || ::|...||.|                       
Human   660 ---------------PQMVKISKLP----SDFTVPKIRESFM----------------------- 682

  Fly  1092 VQAERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQD 1156
                             :|:..|::   .::..||....:|.:....:.:||         :::|
Human   683 -----------------KQFIDRQQ---QDTCCLLRSLPTTSSSSCDHSKRS---------AIED 718

  Fly  1157 NSSRRYGSEE-HDEAFLKYQKSLLTRSPSYRKSLDR--LSQSSGQSQRSLLKSEEAEMRRHSSG- 1217
            |   :|..:: ....|....::||.:..:..|.|.:  |..||..|.|..|....:..  |||| 
Human   719 N---KYIDQKLRKSVFSIRARNLLEKETAVTKILSKRPLPTSSPISIRCCLYLGRSHC--HSSGV 778

  Fly  1218 -----QSLNSMSIE-----QDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVM 1272
                 |.:.|.|.|     :..:||.|.::|               ||...|:.|:..:|||.  
Human   779 RACTRQRMLSGSFEGQPAKERSILSVQHHIR---------------QERRSLRHGSNSQRISR-- 826

  Fly  1273 RSRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAI 1337
                                          .|.||.:.:..::..|..:...|     |...|.|
Human   827 ------------------------------GKSLETLTQDHSNTVRYRNAQRE-----DSEIKMI 856

  Fly  1338 MEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDE 1402
            .|                                                  |:...|.:||:.|
Human   857 QE--------------------------------------------------KKEQAEMKRKVQE 871

  Fly  1403 DFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIER 1467
            :     |:|                                                        
Human   872 E-----ELR-------------------------------------------------------- 875

  Fly  1468 VEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPA 1532
             |..|..:||:             |:.|                                     
Human   876 -ENHPYFDKPL-------------FIVG------------------------------------- 889

  Fly  1533 TPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQ-QHFHATSIQAAPTPAHTHAHSQAHAHSMAG 1596
                                          .||: ::|....::                     
Human   890 ------------------------------REHRFRNFCRVVVR--------------------- 903

  Fly  1597 QRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRL 1661
                           |.|.:::|                                          
Human   904 ---------------ARFNASKT------------------------------------------ 911

  Fly  1662 TEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFM 1726
                                        ||:|    ||.|..|.      .:.||          
Human   912 ----------------------------DPVT----GAVKNTKY------HQLYD---------- 928

  Fly  1727 SCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLY----- 1786
                          ...::|.:|     |.::::...|.|::.||       ...:||::     
Human   929 --------------LLGLVTYLD-----WVMIIVTICSCISMMFE-------SPFRRVMHAPTLQ 967

  Fly  1787 WINFSFCLIFVVEMILKWLALGFSKYFTSFWTILDF---IIVFVSVFSLLI----------EENE 1838
            ...:.|.:...:|:.||.:|.|.  :||....|.||   :.:|:.:.||:.          |...
Human   968 IAEYVFVIFMSIELNLKIMADGL--FFTPTAVIRDFGGVMDIFIYLVSLIFLCWMPQNVPAESGA 1030

  Fly  1839 NLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGK 1903
            .|     |..||.|||||.......||.||..|......||.|.::.|...|:|:..|||.|.||
Human  1031 QL-----LMVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLVSILLLTLMLVFASFGVQLFAGK 1090

  Fly  1904 FFKCVNEMGELLPITEVND-----KWDC---------IEQNY-----------------TWINSK 1937
            ..||             ||     :.||         :.:|.                 .|.|.:
Human  1091 LAKC-------------NDPNIIRREDCNGIFRINVSVSKNLNLKLRPGEKKPGFWVPRVWANPR 1142

  Fly  1938 -ITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLN 2001
             ..||:||...|||.:|.:.:||:||.         |:...|...::. ||..:|:..|....|.
Human  1143 NFNFDNVGNAMLALFEVLSLKGWVEVR---------DVIIHRVGPIHG-IYIHVFVFLGCMIGLT 1197

  Fly  2002 LFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPINH-FLAMFYDLS 2065
            ||:||:|.|||    :.:|..|   ||..|:.:.....:|...:|..:..||.|. |.|..||::
Human  1198 LFVGVVIANFN----ENKGTAL---LTVDQRRWEDLKSRLKIAQPLHLPPRPDNDGFRAKMYDIT 1255

  Fly  2066 NSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGL-------- 2122
            ....|:..|.:|:....:.:.:: :|....|...|...:..||.:|.||..:||:.:        
Human  1256 QHPFFKRTIALLVLAQSVLLSVK-WDVEDPVTVPLATMSVVFTFIFVLEVTMKIIAMSPAGFWQS 1319

  Fly  2123 ---RYHYFT----VPWNVFDFLLVLASIFGILMEDIMIDLPISPTLLRVVRVFRI-GRILRLIKA 2179
               ||....    |.|.|..|.|:.|  :..:|...:|          |.|.|.| |:.:.|   
Human  1320 RRNRYDLLVTSLGVVWVVLHFALLNA--YTYMMGACVI----------VFRFFSICGKHVTL--- 1369

  Fly  2180 AKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKLQGALDDMVNFQTFGRSMQLL 2244
                :.||..:|||:...|.|...:.|:...||..|:.|||.||....::...||.:.|:::.:|
Human  1370 ----KMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYGENINRHANFSSAGKAITVL 1430

  Fly  2245 FRLMTSAGWNDVLESLMIQPPDCDPFIHGHTNGNCGHPLLAITYFTSFIIISYMIVINMYIAIIL 2309
            ||::|...||.::...|:|||.|.|....:...:||:...|:.||.||.:|...|::|:.:|||:
Human  1431 FRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIV 1495

  Fly  2310 ENFNQAHQEEEIGIVE-DDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISKPNNVALV 2373
            |||:..:..||..::. :||..|.|.|:..|                   |...|:..   ...|
Human  1496 ENFSLFYSTEEDQLLSYNDLRHFQIIWNMVD-------------------DKREGVIP---TFRV 1538

  Fly  2374 SFNLPISKGNKIHCLDILHALVKHVLGHVEETDN-----FKQL-----QEQMDVKFKKQFP---T 2425
            .|.|.:.:|.....||....|.||:...:|...|     |..:     ...:|::...|..   .
Human  1539 KFLLRLLRGRLEVDLDKDKLLFKHMCYEMERLHNGGDVTFHDVLSMLSYRSVDIRKSLQLEELLA 1603

  Fly  2426 RKELEIVSSTRIWKRQEKAAKTIQTGWKEYLRRKREKERSNS------------------GDSAT 2472
            |::||...      .:|.|.:||:...|:.|:|.|.|::.:.                  ...:.
Human  1604 REQLEYTI------EEEVAKQTIRMWLKKCLKRIRAKQQQSCSIIHSLRESQQQELSRFLNPPSI 1662

  Fly  2473 QTSSPGGWQSKLSALNFFHLQVSRRGTACSSRASSRKSSR--ASDASDLSELAGPWLNLPLMLVS 2535
            :|:.|....:..|..|....:.|.:....|...|.|..||  |:||.......|.| .||    |
Human  1663 ETTQPSEDTNANSQDNSMQPETSSQQQLLSPTLSDRGGSRQDAADAGKPQRKFGQW-RLP----S 1722

  Fly  2536 GADEVVKDIKQQNDELGKR 2554
            ....:...:...|...|.|
Human  1723 APKPISHSVSSVNLRFGGR 1741

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 48/255 (19%)
Ion_trans 705..902 CDD:278921 43/205 (21%)
Ion_trans 1768..2019 CDD:278921 81/300 (27%)
Na_channel_gate 2009..2063 CDD:240441 15/54 (28%)
Ion_trans 2085..2320 CDD:278921 73/250 (29%)
GPHH 2331..2386 CDD:293510 10/54 (19%)
NALCNXP_024305104.1 Ion_trans 55..350 CDD:306908 66/441 (15%)
Ion_trans 402..622 CDD:306908 52/236 (22%)
Ion_trans 935..1209 CDD:306908 85/319 (27%)
Ion_trans 1257..1506 CDD:306908 76/268 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.840

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