DRSC/TRiP Functional Genomics Resources

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Protein Alignment NaCP60E and Cacna1b

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:XP_006233631.1 Gene:Cacna1b / 257648 RGDID:628852 Length:2359 Species:Rattus norvegicus


Alignment Length:3057 Identity:664/3057 - (21%)
Similarity:1099/3057 - (35%) Gaps:1014/3057 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    80 IYEETFCVVSKRFRKNYIHR--------FTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATI 136
            :|:::   :::|.|...::.        ||..:|||:|...:..|:....|.....|:|.::|||
  Rat    44 LYKQS---IAQRARTMALYNPIPVKQNCFTVNRSLFVFSEDNVVRKYAKRITEWPPFEYMILATI 105

  Fly   137 LFNCIFLA------------MTETVEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLD 189
            :.|||.||            |:|.:::.|..|:.|:..|..|||||.||:.:|.:||||.||.:|
  Rat   106 IANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMD 170

  Fly   190 FVVITSG-YATIGMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCL 253
            |||:.:| .||.|.:. :|..||..||||.||.||.:|.|:.::.:::.:...|.::..|..|.:
  Rat   171 FVVVLTGILATAGTDF-DLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAI 234

  Fly   254 MVFALFALQVYMGELRNKCVRQVPTDWTNVSHTDWQIWVNDTDNWLYDEDELPVLCGNLTGARHC 318
            ::||:..|:.|||:....|                  :.|.||  .....:.|  ||....||.|
  Rat   235 LMFAIIGLEFYMGKFHKAC------------------FPNSTD--AEPVGDFP--CGKEAPARLC 277

  Fly   319 PFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENV-YNMVLATCGPMSVSFFTVVVFF 382
            ..:..|......||.|.|||||.::::||.||.||::.|.:: ||...|.....:..:|..::..
  Rat   278 DSDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIII 342

  Fly   383 GSFYLINLMLAVVALSYEEEAEITNEERKKDLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRK 447
            |||:::||:|.|::..:.:|.|  ..|.::..|..|......        ::|| ...:.|...:
  Rat   343 GSFFMLNLVLGVLSGEFAKERE--RVENRRAFLKLRRQQQIE--------RELN-GYLEWIFKAE 396

  Fly   448 GVLLASYSKKKTRRKKTKGGKEGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQA 512
            .|:||.                            :|..:...:|......| :||::        
  Rat   397 EVMLAE----------------------------EDKNAEEKSPLDAVLKR-AATKK-------- 424

  Fly   513 QKQYQQMEQQHKLAKSGSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQP- 576
                                |.|.:....:|...|.|                    :..:|.| 
  Rat   425 --------------------SRNDLIHAEEGEDRFVD--------------------LCAAGSPF 449

  Fly   577 --SSNSSGVNRESSQDDSGVVDDHEEQDTTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNV 639
              :|..||....||                                                   
  Rat   450 ARASLKSGKTESSS--------------------------------------------------- 463

  Fly   640 YALHQEFSSEVVVIDDLPDRNCDRCVHWCTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAF 704
            |...:|                             ..|:..:.::|:...|...:...:.|||..
  Rat   464 YFRRKE-----------------------------KMFRFLIRRMVKAQSFYWVVLCVVALNTLC 499

  Fly   705 LAMEHHGMSESFRNALDVGNKVFTSIFTFECIVKLMALS-KDFFLCGWNIFDLLIVTASLLDIIF 768
            :||.|:...:....||.....||..:|..|..:|:..|. :.:|...:|.||..::..|:.::::
  Rat   500 VAMVHYNQPQRLTTALYFAEFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSIFEVVW 564

  Fly   769 ELVD-----GLSVLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGM 828
            ..:.     |:||||.|||||:.|:.:.|.:::.|:..:::::.::.:|..:|.:.|.:||::||
  Rat   565 AAIKPGTSFGISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGM 629

  Fly   829 QLFSKDYTPEKFDPDPVPRWNFNDFFHSFMMIFRILCGE-WIEPLWDCMRAE--EEQGASTCFAI 890
            |||...:..:    |..|..||:.|..:.:.:|:||.|| |...::..:.::  ..:|..:.|..
  Rat   630 QLFGGQFNFQ----DETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKGMFSSFYF 690

  Fly   891 FLPTLVMGNFMVLNLFLALLL-NSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRK 954
            .:.|| .||:.:||:|||:.: |..|::||...:||:.|.:....::::.::             
  Rat   691 IVLTL-FGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAANQKLALQKAKE------------- 741

  Fly   955 ERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGF 1019
                       |.:.....|..:|..|.|...||                      .||.|    
  Rat   742 -----------VAEVSPMSAANISIAAFVKQTRG----------------------TVSRS---- 769

  Fly  1020 QIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGT 1084
                                                                  .|.||||    
  Rat   770 ------------------------------------------------------SSVSSVN---- 776

  Fly  1085 CQNLTPFVQ---AERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCG 1146
                :|..|   ..|.:..|.:|.:..|...:..||.|:|            .||   ::|    
  Rat   777 ----SPRQQNSAKARSVWEQRASQLRLQNLRASCEALYSE------------MDP---EER---- 818

  Fly  1147 SFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEM 1211
                         .||.|..|..             |..:..:||                    
  Rat   819 -------------LRYASTRHVR-------------PDMKTHMDR-------------------- 837

  Fly  1212 RRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRR 1276
                             .|:.:.|  |:.|                                 |.
  Rat   838 -----------------PLVVEPG--RDGL---------------------------------RG 850

  Fly  1277 PSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEAT---KAIM 1338
            |:....:||.....|.:             :..:|.....:|..::.|.|:....:.|   ||..
  Rat   851 PAGNKSKPEGTEATEGA-------------DPPRRHHRHRDRDKTSASTPAGGEQDRTDCPKAES 902

  Fly  1339 EHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDED 1403
            ..    |||.|..|.                  ||||.|..|......|:.:|.....:|...|:
  Rat   903 TE----TGAREERAR------------------PRRSHSKEAPGADTQVRCERSRRHHRRGSPEE 945

  Fly  1404 FSISNEIRKICDQIHAPFVAMEAMAVAA-----------------TSASQAQPNQSPFLR----R 1447
             :...|.|:.....||...:.|.....|                 |...:.:.::.|..|    .
  Rat   946 -ATEREPRRHRAHRHAQDSSKEGKEGTAPVLVPKGERRARHRGPRTGPRETENSEEPTRRHRAKH 1009

  Fly  1448 KVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLR--LDSLSLKSTN 1510
            ||.|         .|...||  ||.|:|..:    :|.:|..|.  |.|.:.|  |:::::....
  Rat  1010 KVPP---------TLEPPER--EVAEKESNV----VEGDKETRN--HQPKEPRCDLEAIAVTGVG 1057

  Fly  1511 SYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQ 1575
            |...|                  |.|.|:...|.|..|               ::|:  :.|.:.
  Rat  1058 SLHML------------------PSTCLQKVDEQPEDA---------------DNQR--NVTRMG 1087

  Fly  1576 AAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQK 1640
            :.|:...|..|...                 ||                                
  Rat  1088 SQPSDPSTTVHVPV-----------------TL-------------------------------- 1103

  Fly  1641 TEQSQSTAP--DATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAA 1703
                  |.|  :||..|||.|.|..:......:..||:...|          |.....|.:    
  Rat  1104 ------TGPPGEATVVPSANTDLEGQAEGKKEAEADDVLRRG----------PRPIVPYSS---- 1148

  Fly  1704 KVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITL 1768
                                  |.|:...:.     :|.....:|....||..:||:|..|||.|
  Rat  1149 ----------------------MFCLSPTNL-----LRRFCHYIVTMRYFEMVILVVIALSSIAL 1186

  Fly  1769 CFED-INLD--KNKTLKRVLYWINFSFCLIFVVEMILKWLALGF----SKYFTSFWTILDFIIV- 1825
            ..|| :..|  :|..||    ::::.|..:|..||::|.:.||.    ..||...|.|||||:| 
  Rat  1187 AAEDPVRTDSFRNNALK----YMDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVS 1247

  Fly  1826 ---FVSVFSLLI--EENENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVC 1885
               ....||..:  .:.:::..::|||.||.||||:.|.|...::.|.:.::.::.::.|:|:|.
  Rat  1248 GALVAFAFSSFMGGSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVY 1312

  Fly  1886 LVFWLIFSIMGVQFFGGKFFKCVNEMGELLPITEVNDKWDC-----------IE-QNYTWINSKI 1938
            ::|..||:::.||.|.||||.|.:|..||        :.||           :| |...|.....
  Rat  1313 MLFMFIFAVIAVQLFKGKFFYCTDESKEL--------ERDCRGQYLDYEKEEVEAQPRQWKKYDF 1369

  Fly  1939 TFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQP----QREANLYAYIYFVIFIVCGSFFT 1999
            .:|:|....|.|..|:|.|||..|:..:|||...:..|    :.|.:::..:|||:|    .||.
  Rat  1370 HYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGFRMELSIFYVVYFVVF----PFFF 1430

  Fly  2000 LNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQK---HYYTAMKKLGRKKPQKVIKRPINHFLAMF 2061
            :|:|:.:||..|   :::.:..:.|..|.::::   .:..:.|.|.|..||..     ..|....
  Rat  1431 VNIFVALIIITF---QEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNK-----QSFQYKT 1487

  Fly  2062 YDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLR-YH 2125
            :....|..||..|..:|.||.:.:.::.||.|:....:|:..|..||::|.||.|:||:... .:
  Rat  1488 WTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSLECILKIIAFGVLN 1552

  Fly  2126 YFTVPWNVFDFLLVLASIFGILMEDI-----MIDLPISPTLLRVVRVFRIGRILRLIKAAKGIRK 2185
            ||...||||||:.||.||..||:.:|     .|:|..       :|:||..|:::|::....||.
  Rat  1553 YFRDAWNVFDFVTVLGSITDILVTEIAETNNFINLSF-------LRLFRAARLIKLLRQGYTIRI 1610

  Fly  2186 LLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKLQGALDDMV------NFQTFGRSMQLL 2244
            ||:..|.|..||..:..|:.::.|||||:||.:|||:    ||||..      ||:||.:::.||
  Rat  1611 LLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNI----ALDDGTSINRHNNFRTFLQALMLL 1671

  Fly  2245 FRLMTSAGWNDVLESLMIQPPDCDPFIHGHTNGN-CGHPLLAITYFTSFIIISYMIVINMYIAII 2308
            ||..|...|::::.|.:.... |||    |.|.: ||.. .|..||.|||.:...:::|:::|:|
  Rat  1672 FRSATGEAWHEIMLSCLGNRA-CDP----HANASECGSD-FAYFYFVSFIFLCSFLMLNLFVAVI 1730

  Fly  2309 LENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISK--PNNVA 2371
            ::||....::..| :....|:.|...|::|||.|...|.::.:.:.:..:.||||:.|  |..||
  Rat  1731 MDNFEYLTRDSSI-LGPHHLDEFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVA 1794

  Fly  2372 ---LVSFNLPISKGN-KIHCLDILHALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPT------R 2426
               ||..|:|||..: .:|....|.||::..|.........|  |.|.|.:.:|:..:      :
  Rat  1795 YKRLVRMNMPISNEDMTVHFTSTLMALIRTALEIKLAPAGTK--QHQCDAELRKEISSVWANLPQ 1857

  Fly  2427 KELEIVSSTRIWKRQEKAAKTIQTG---WKEYLRRKREKERSNSGDSATQTSSPGGWQSKLSALN 2488
            |.|:::....  |..|.....:...   :..|.:.|..:::::        .:||| .|::..::
  Rat  1858 KTLDLLVPPH--KPDEMTVGKVYAALMIFDFYKQNKTTRDQTH--------QAPGG-LSQMGPVS 1911

  Fly  2489 FFH-LQVSRRGTACSSRASSRKSSRASDASDLSELAGPWLNLPLMLVSGADEVVKDIKQQNDE-- 2550
            .|| |:.:...|..:....:|...|...|:.||.  |..:...   .||..|.:....|:..:  
  Rat  1912 LFHPLKATLEQTQPAVLRGARVFLRQKSATSLSN--GGAIQTQ---ESGIKESLSWGTQRTQDVL 1971

  Fly  2551 ----------------LGKRGSIFVEAPRASRRRSFYNFFLRHQDAVDDSLTSPSVHRKTAMNNT 2599
                            :|:.|::.|:.       ...|..||..|..    ..|.:         
  Rat  1972 YEARAPLERGHSAEIPVGQPGALAVDV-------QMQNMTLRGPDGE----PQPGL--------- 2016

  Fly  2600 TNTTSNSASTSGTASSTATAPATGCGPAATSASDSDRHQAVGGGSAPSRKRASSFIRKKPPLERG 2664
             .:...:||....|:.|..||                       :|...||:.|.:..:|     
  Rat  2017 -ESQGRAASMPRLAAETQPAP-----------------------NASPMKRSISTLAPRP----- 2052

  Fly  2665 LSAQSALRVNKNAFVSEASAPEVIVTRPSPEQQTHPHSLSLRPDNATLVHVLVHRESEEYKEEDE 2729
                           ........::.||.|.|.:|.|            |...||..::.:...|
  Rat  2053 ---------------HGTQLCNTVLDRPPPSQVSHHH------------HHRCHRRRDKKQRSLE 2090

  Fly  2730 SSPSVS-----------GNGNGFGVG---------------------------------LDMLSK 2750
            ..||:|           |:|...|.|                                 .|....
  Rat  2091 KGPSLSVDTEGAPSTAAGSGLPHGEGSTGCRRERKQERGRSQERRQPSSSSSEKQRFYSCDRFGS 2155

  Fly  2751 QPPPQIRIT--------------------TGSVESS--MDTCAMPTVQIMVDSPKDPPRGDFSSA 2793
            :.|||.:.:                    :|||..|  |.|....|          |.||.....
  Rat  2156 REPPQPKPSLSSHPISPTAALEPGPHPQGSGSVNGSPLMSTSGAST----------PGRGGRRQL 2210

  Fly  2794 PIDDVGAPIDVNVQ-GDTSQVFYDYNPEKATDDQGNGQDETAQFESLPDR-----------QRXP 2846
            |...:.....:..: .::|.|.:           ..||.....|.  |.|           .: .
  Rat  2211 PQTPLTPRPSITYKTANSSPVHF-----------AEGQSGLPAFS--PGRLSRGLSEHNALLQKE 2262

  Fly  2847 PVNTPLRDSEKRSS---RGSRSSSS-----------------STSSIRSCSSSSSSSAASAAAPS 2891
            |::.||....:..|   .|.|..|.                 :|:|.||..:|..||..|.:.|.
  Rat  2263 PLSQPLASGSRIGSDPYLGQRLDSEASAHNLPEDTLTFEEAVATNSGRSSRTSYVSSLTSQSHPL 2327

  Fly  2892 AR 2893
            .|
  Rat  2328 RR 2329

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 77/220 (35%)
Ion_trans 705..902 CDD:278921 56/205 (27%)
Ion_trans 1768..2019 CDD:278921 85/279 (30%)
Na_channel_gate 2009..2063 CDD:240441 9/56 (16%)
Ion_trans 2085..2320 CDD:278921 87/247 (35%)
GPHH 2331..2386 CDD:293510 21/60 (35%)
Cacna1bXP_006233631.1 Ion_trans 112..367 CDD:278921 91/279 (33%)
Ion_trans 500..721 CDD:278921 65/225 (29%)
Ion_trans 1186..1448 CDD:278921 85/280 (30%)
Ion_trans 1511..1742 CDD:278921 87/247 (35%)
GPHH 1750..1814 CDD:293510 21/63 (33%)
Ca_chan_IQ 1816..1890 CDD:285917 14/77 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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