DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NaCP60E and Scn4a

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:NP_037310.2 Gene:Scn4a / 25722 RGDID:3636 Length:1840 Species:Rattus norvegicus


Alignment Length:2594 Identity:806/2594 - (31%)
Similarity:1131/2594 - (43%) Gaps:902/2594 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 DEKAVAKHQVVAYTQRSQVKHENRHIQLVREYGFHPRTKASVEDGDVLPRKFEPFPEHMYGKPLE 74
            :::||.:...:...::.:::...|            :.::.:|.|..||..:...|..:.|.|||
  Rat    29 EQRAVEEEARLQRNKQMEIEEPER------------KPRSDLEAGKNLPLIYGDPPPEVIGIPLE 81

  Fly    75 EIDTFIYE-ETFCVVSKRFRKNYIHRFTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATILF 138
            ::|.:..: :||.|::|   ...|.||:.|.:|:|..|:|..|||.:.:..:..|...:|.|||.
  Rat    82 DLDPYYSDKKTFIVLNK---GKAIFRFSATPALYLLSPFSIVRRVAIKVLIHALFSMFIMITILT 143

  Fly   139 NCIFLAMTET---VEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATI 200
            ||:|:.|:..   .:..||.|..||:.|.:||::|:||.::.:|:||:|||||||.|||..|.|.
  Rat   144 NCVFMTMSNPPSWSKHVEYTFTGIYTFESLIKMLARGFCIDDFTFLRDPWNWLDFSVITMAYVTE 208

  Fly   201 GMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYM 265
            .:::||::.||||||||||||::::||||||:.||:.|.::|::||.||:|||.||||..||::|
  Rat   209 FVDLGNISALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFM 273

  Fly   266 GELRNKCVRQVP------------------------------------TDWTNVSHTDWQIWVND 294
            |.||.||||..|                                    ..|...|..||:.::||
  Rat   274 GNLRQKCVRWPPPMNDTNTTWYGNDTWYSNDTWYGNDTWYINDTWNSQESWAGNSTFDWEAYIND 338

  Fly   295 TDNWLYDE---DELPVLCGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDY 356
            ..|:.:.|   |.|  ||||.:.|.|||..|.|:..|.|||:|||::|.|.|:.|..|:|:|.||
  Rat   339 EGNFYFLEGSNDAL--LCGNSSDAGHCPEGYECIKAGRNPNYGYTSYDTFSWAFLALFRLMTQDY 401

  Fly   357 WENVYNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNEERKKDLLDHRDDS 421
            |||::.:.|...|...:.||.|::|.||||||||:|||||::|.|:.|.|..|      |...:.
  Rat   402 WENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAMAYAEQNEATLAE------DQEKEE 460

  Fly   422 TFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGK--EGGTNGNGNGSNGDDN 484
            .|.                        .:|..|.|.:...:|.|..:  |.|...:|:       
  Rat   461 EFQ------------------------QMLEKYKKHQEEVEKAKAAQALESGEEADGD------- 494

  Fly   485 KSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQHKLAKSGSGGSNNPMAPTPKGRISFQD 549
                        |.|:                                                 
  Rat   495 ------------PTHN------------------------------------------------- 498

  Fly   550 SGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQDDSGVVDDHEEQDTTNDMGHVSTVE 614
                         .|..|.|.|      |...|..|.|...||.:.|..||.:..          
  Rat   499 -------------KDCNGSLDA------SGEKGPPRPSCSADSAISDAMEELEEA---------- 534

  Fly   615 LALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDRNCD----RCVH----W--CT 669
                                        ||:               |.    :|.|    |  |.
  Rat   535 ----------------------------HQK---------------CPPWWYKCAHKVLIWNCCA 556

  Fly   670 DYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIFTFE 734
               .|::|::.:|.:|.||..:|.||:||||||.|:||||:.|:|.|.|.|.|||.|||.|||.|
  Rat   557 ---PWVKFKHIIYLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLSVGNLVFTGIFTAE 618

  Fly   735 CIVKLMALSK-DFFLCGWNIFDLLIVTASLLDIIFELVDGLSVLRGLRLLRVLKLAQSWTTMKVL 798
            .::||:|:.. ::|..||||||..|||.||:::....|.||||||..|||||.|||:||.|:.:|
  Rat   619 MVLKLIAMDPYEYFQQGWNIFDSFIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNML 683

  Fly   799 LSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTP--EKFDPD-PVPRWNFNDFFHSFMMI 860
            :.||.:::||||||||:|.|:::||||:|||||.|.|..  .|...| .:|||:.|||||||:::
  Rat   684 IKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIASDCNLPRWHMNDFFHSFLIV 748

  Fly   861 FRILCGEWIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLFLALLLNSFNSEELKSKKEE 925
            ||||||||||.:||||   |..|.:.|..:||..:|:||.:||||||||||:||:::.|.:..|:
  Rat   749 FRILCGEWIETMWDCM---EVAGQAMCLTVFLMVMVIGNLVVLNLFLALLLSSFSADSLAASDED 810

  Fly   926 VGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDK 990
             ||.:.|..:|.|::..|             .||:.|                   .:||.||. 
  Rat   811 -GEMNNLQIAIGRIKWGI-------------GFAKTF-------------------LLGLLRGK- 841

  Fly   991 PGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPP 1055
              :|:                                               |::|.|       
  Rat   842 --ILS-----------------------------------------------PKEIIL------- 850

  Fly  1056 TSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEATYT 1120
                               |.....|.|                            ::.||:|  
  Rat   851 -------------------SLGEPGGAG----------------------------ENAEEST-- 866

  Fly  1121 ESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSY 1185
                                                                             
  Rat   867 ----------------------------------------------------------------- 866

  Fly  1186 RKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELF 1250
                                                                             
  Rat   867 ----------------------------------------------------------------- 866

  Fly  1251 QFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTS 1315
                                      |..:..:|..|               :|||::       
  Rat   867 --------------------------PEDEKKEPPPE---------------DKELKD------- 883

  Fly  1316 LERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSA 1380
                               ..|:.|:.:..|.......|.:....|||.:               
  Rat   884 -------------------NHILNHVGLTDGPRSSIELDHLNFINNPYLT--------------- 914

  Fly  1381 AAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFL 1445
                                                ||.|..:.|:..                 
  Rat   915 ------------------------------------IHVPIASEESDL----------------- 926

  Fly  1446 RRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTN 1510
                                    |:|.||:..:....|..|.|.:.|:..:.      |:.||.
  Rat   927 ------------------------EMPTEEETDAFSEPEDIKKPLQPLYDGNS------SVCSTA 961

  Fly  1511 SYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQ 1575
            .|                              :||.                             
  Rat   962 DY------------------------------KPPE----------------------------- 967

  Fly  1576 AAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQK 1640
                                      |.|:                                   
  Rat   968 --------------------------EDPE----------------------------------- 971

  Fly  1641 TEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKV 1705
             ||::.. |:..|                                                    
  Rat   972 -EQAEEN-PEGEQ---------------------------------------------------- 982

  Fly  1706 PDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCF 1770
            |::||.:.|..    |||.....:.....|.|..:|.|...:|:...||.|::.:|..||..|.|
  Rat   983 PEECFTEACVK----RCPCLYVDISQGRGKMWWTLRRACFKIVEHNWFETFIVFMILLSSGALAF 1043

  Fly  1771 EDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGFSKYFTSFWTILDFIIVFVSVFSLLIE 1835
            |||.:::.:.::.:|.:.:..|..||::||:|||:|.||..|||:.|..|||:||.||:.||:..
  Rat  1044 EDIYIEQRRVIRTILEYADKVFTYIFILEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSIISLVAN 1108

  Fly  1836 --ENENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQ 1898
              ....|..::|||||||||||||:||::|||:|||||:.|||||.|||||||:||||||||||.
  Rat  1109 WLGYSELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVN 1173

  Fly  1899 FFGGKFFKCVN-EMGELLPITEVNDKWDCIEQNYT----WINSKITFDHVGMGYLALLQVATFEG 1958
            .|.|||:.||| ...|...|:.||:|.:|....||    |:|.|:.:|:||:|||:|||||||:|
  Rat  1174 LFAGKFYYCVNTTTSERFDISVVNNKSECESLMYTGQVRWMNVKVNYDNVGLGYLSLLQVATFKG 1238

  Fly  1959 WMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVL 2023
            ||::|..|||:|..:.||..|.|||.|:||||||:.||||||||||||||||||..|||:.|  .
  Rat  1239 WMDIMYAAVDSREKEEQPDYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGG--K 1301

  Fly  2024 EMFLTESQKHYYTAMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIE 2088
            ::|:||.||.||.||||||.|||||.|.||.|....|.||....:.|:|:|.:||.|||:||.:|
  Rat  1302 DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDFVTKQVFDISIMILICLNMVTMMVE 1366

  Fly  2089 HYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRYHYFTVPWNVFDFLLVLASIFGILMEDIMI 2153
            ..||......||...|..|..:|..|.::|:..||::|||:.||:|||::|:.||.|:.:.|::.
  Rat  1367 TDDQSQLKVDILYNINMVFIIIFTGECVLKMFALRHYYFTIGWNIFDFVVVILSIVGLALSDLIQ 1431

  Fly  2154 DLPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSL 2218
            ...:||||.||:|:.||||:||||:.|||||.|||||::|||||||||.||.|:.|||:|.|||.
  Rat  1432 KYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSN 1496

  Fly  2219 FGNVKLQGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQ-PPDCDPFIHG---HTNGNC 2279
            |..||.:..:|||.||:|||.|:..||.:.|||||:.:|..::.. ||||||.:..   :..|:|
  Rat  1497 FAYVKKESGIDDMFNFETFGNSIICLFEITTSAGWDGLLNPILNSGPPDCDPTLENPGTNVRGDC 1561

  Fly  2280 GHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQ 2344
            |:|.:.|.:|.|:||||::||:||||||||||||.|.:|....:.|||.||||..|.|:||.|||
  Rat  1562 GNPSIGICFFCSYIIISFLIVVNMYIAIILENFNVATEESSEPLSEDDFEMFYETWEKFDPDATQ 1626

  Fly  2345 FIHFSQLSDFIASLDPPLGISKPNNVALVSFNLPISKGNKIHCLDILHALVKHVLGHVEETDNFK 2409
            ||.:|:||||:.:|..||.|:|||.:.|::.:||:..|:||||||||.||.|.|||...|.|..|
  Rat  1627 FIDYSRLSDFVDTLQEPLKIAKPNKIKLITLDLPMVPGDKIHCLDILFALTKEVLGDSGEMDALK 1691

  Fly  2410 QLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEKAAKTIQTGWKEYLRRKREKERS--------N 2466
            |..|:   ||....|::...|.:::|...|::|..|..||..::.:|.::..|:.|        .
  Rat  1692 QTMEE---KFMAANPSKVSYEPITTTLKRKQEEVCAIKIQRAYRRHLLQRSVKQASYMYRHSQDG 1753

  Fly  2467 SGDSATQTSSPGGWQSKLSALNFFHLQVSRRGTACSSRASSRKSSRASDASDLSELAGP 2525
            :||.|.:..   |..:......:.|   .:.|....|:....|:|        :|.|||
  Rat  1754 NGDGAPEKE---GLLANTMNKMYGH---EKEGDGVQSQGEEEKAS--------TEDAGP 1798

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 113/257 (44%)
Ion_trans 705..902 CDD:278921 110/200 (55%)
Ion_trans 1768..2019 CDD:278921 149/257 (58%)
Na_channel_gate 2009..2063 CDD:240441 31/53 (58%)
Ion_trans 2085..2320 CDD:278921 123/238 (52%)
GPHH 2331..2386 CDD:293510 28/54 (52%)
Scn4aNP_037310.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 36..63 3/38 (8%)
I. /evidence=ECO:0000305 113..448 147/336 (44%)
Ion_trans 130..451 CDD:395416 142/322 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 481..522 13/127 (10%)
II. /evidence=ECO:0000305 554..826 146/278 (53%)
Ion_trans 571..784 CDD:395416 120/215 (56%)
Na_trans_assoc 810..1019 CDD:399489 71/820 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 854..884 11/256 (4%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 925..983 20/278 (7%)
III. /evidence=ECO:0000305 1006..1319 171/314 (54%)
Ion_trans 1023..1297 CDD:395416 153/273 (56%)
Na_channel_gate 1289..1341 CDD:240441 31/53 (58%)
Important for rapid channel inactivation. /evidence=ECO:0000269|PubMed:28012039 1303..1305 0/1 (0%)
IV. /evidence=ECO:0000305 1328..1626 151/297 (51%)
Ion_trans 1346..1602 CDD:395416 132/255 (52%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1775..1840 9/35 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100419
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.720

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