DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NaCP60E and Scn5a

DIOPT Version :9

Sequence 1:	NP_001261172.1	Gene:	NaCP60E / 37981	FlyBaseID:	FBgn0085434	Length:	2896	Species:	Drosophila melanogaster
Sequence 2:	XP_038936827.1	Gene:	Scn5a / 25665	RGDID:	3637	Length:	2020	Species:	Rattus norvegicus

Alignment Length:	2639	Identity:	857/2639 - (32%)
Similarity:	1198/2639 - (45%)	Gaps:	783/2639 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 EKAVAKHQVVAYTQRSQVKHENRHIQLVREYGFHPRTKASVEDGDVLPRKFEPFPEHMYGKPLEE 75
            ||.:|:.|....:..||...|.    |..|..  ||.:..::....||..:...|..:.|:|||:
  Rat    25 EKRMAEKQARGGSATSQESREG----LQEEEA--PRPQLDLQASKKLPDLYGNPPRELIGEPLED 83

  Fly    76 IDTFI-YEETFCVVSKRFRKNYIHRFTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATILFN 139
            :|.|. .::||.|::|   ...|.||:.|.:|::..|:.|.||..|.|..:..|...:|.|||.|
  Rat    84 LDPFYSTQKTFIVLNK---GKTIFRFSATNALYVLSPFHPVRRAAVKILVHSLFSMLIMCTILTN 145

  Fly   140 CIFLAMTET---VEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATIG 201
            |:|:|..:.   .:..||.|.|||:.|.::||:|:||.|:.:|:||:|||||||.||...|.|..
  Rat   146 CVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIVMAYTTEF 210

  Fly   202 MEVGNLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMG 266
            :::||::.||||||||||||:|::.|||||:.||:.|.::||:||.||:|||.||||..||::||
  Rat   211 VDLGNVSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 275

  Fly   267 ELRNKCVRQVPTDWTNVSHTD---------W---QIWVNDTDNWLYDEDELPV-LCGNLTGARHC 318
            .||:||||    ::|.::.|:         |   .:::||..|:|.......| ||||.:.|..|
  Rat   276 NLRHKCVR----NFTELNGTNGSVEADGLVWNSLDVYLNDPANYLLKNGTTDVLLCGNSSDAGTC 336

  Fly   319 PFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCGPMSVSFFTVVVFFG 383
            |..|.||..||||:||||:||:|.|:.|..|:|:|.|.||.:|...|.:.|.:.:.||.:|:|.|
  Rat   337 PEGYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLG 401

  Fly   384 SFYLINLMLAVVALSYEEEAEIT---NEERKKDLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDS 445
            ||||:||:|||||::|||:.:.|   .||::|...:..:  ....:...|.::.::..:...::.
  Rat   402 SFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAME--MLKKEHEALTIRGVDTVSHSSLEM 464

  Fly   446 RKGVLLASYSKKKTRRKKTKGGKEGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTM 510
            .....:.::.:|..|||:...|.|.|         |||.           .|:..:.:.|.||
  Rat   465 SPLAPVTNHERKSKRRKRLSSGTEDG---------GDDR-----------LPKSDSEDGPRAL-- 507

  Fly   511 QAQKQYQQMEQQHKLAKSGSGGSNNPMAP-TPKGRI-SFQDSGMGV-------KNPNMLYPSDYK 566
                  .|:...|.|:::.       |.| :.:|.| :|:....|.       :|........::
  Rat   508 ------NQLSLTHGLSRTS-------MRPRSSRGSIFTFRRRDQGSEADFADDENSTAGESESHR 559

  Fly   567 GQLI--------ANSGQPSSNSSGV------NRESSQDDSGVVD-----DHE------------- 599
            ..|:        :..|||...:|..      .|.|:.|.:|||.     |.|
  Rat   560 TSLLVPWPLRHPSAQGQPGPGASAPGYVLNGKRNSTVDCNGVVSLLGAGDAEATSPGSYLLRPMV 624

  Fly   600 ---EQDTTNDMGHVSTVELALSPREVRLIKCNGNI----ARIKNHNVYALHQEFSSEVVV----I 653
               ..|||.........:: |:|:    ..|....    ||          |...|.|.|    :
  Rat   625 LDRPPDTTTPSEEPGGPQM-LTPQ----APCADGFEEPGAR----------QRALSAVSVLTSAL 674

  Fly   654 DDLPD--RNCDRC--------VHW-CTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAM 707
            ::|.:  |.|..|        :.| |...  |:..:..:..||.||..:|.||:||||||.|:|:
  Rat   675 EELEESHRKCPPCWNRFAQHYLIWECCPL--WMSIKQKVKFVVMDPFADLTITMCIVLNTLFMAL 737

  Fly   708 EHHGMSESFRNALDVGNKVFTSIFTFECIVKLMALSK-DFFLCGWNIFDLLIVTASLLDIIFELV 771
            ||:.|:..|...|.|||.|||.|||.|...|::||.. .:|..||||||.:||..||:::....:
  Rat   738 EHYNMTAEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRM 802

  Fly   772 DGLSVLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYT 836
            ..|||||..|||||.|||:||.|:..|:.||.:::||||||||:|.|:::||||:|||||.|:|:
  Rat   803 GNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYS 867

  Fly   837 PEKF---DPDPVPRWNFNDFFHSFMMIFRILCGEWIEPLWDCMRAEEEQGASTCFAIFLPTLVMG 898
            ..:.   |...:|||:..||||:|::|||||||||||.:||||   |..|.|.|..:||..:|:|
  Rat   868 ELRHRISDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCM---EVSGQSLCLLVFLLVMVIG 929

  Fly   899 NFMVLNLFLALLLNSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQ 963
            |.:||||||||||:||:::.|.:..|: ||.:.|..::.|::..:|             |.::
  Rat   930 NLVVLNLFLALLLSSFSADNLTAPDED-GEMNNLQLALARIQRGLR-------------FVKR-- 978

  Fly   964 QIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLH 1028
                       .|......:...|..||..||                               .|
  Rat   979 -----------TTWDFCCGILRRRPKKPAALA-------------------------------TH 1001

  Fly  1029 TIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQ 1093
            :           .||..|.....|.||..:.:||
  Rat  1002 S-----------QLPSCITAPRSPPPPEVEKVPP------------------------------- 1024

  Fly  1094 AERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNS 1158
                               :|:|..:.|                  |:|.|.|
  Rat  1025 -------------------ARKETRFEE------------------DKRPGQG------------ 1040

  Fly  1159 SRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSM 1223
                                                :.|.|:...:....||
  Rat  1041 ------------------------------------TPGDSEPVCVPIAVAE------------- 1056

  Fly  1224 SIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENET 1288
            |..:|:                        :|:||...||:
  Rat  1057 SDTEDQ------------------------EEDEENSLGTE------------------------ 1073

  Fly  1289 MVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAA 1353
                                                      :|::|  .:...:::|..|
  Rat  1074 ------------------------------------------EESSK--QQESQVVSGGHE---- 1090

  Fly  1354 DEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIH 1418
                    ||..      ||....||.....:
  Rat  1091 --------PYQE------PRAWSQVSETTSSE--------------------------------- 1108

  Fly  1419 APFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRI 1483
                       |..|.|||...|                                |:|
  Rat  1109 -----------AGASTSQADWQQ--------------------------------EQK------- 1123

  Fly  1484 ESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLA 1548
                                                      |.|..|.
  Rat  1124 ------------------------------------------TEPQAPG---------------- 1130

  Fly  1549 QISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAAS 1613
                                       ...||
  Rat  1131 ---------------------------CGETP--------------------------------- 1135

  Fly  1614 FQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTV 1678
                 .:|:|.|:              |....:||.                   |:..:.||
  Rat  1136 -----EDSYSEGS--------------TADMTNTAD-------------------LLEQIPDL-- 1160

  Fly  1679 GGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCM--DTQS-AKHWTRV 1740
                                 .:..|.|:|||.:.|..    |||   .||  .||| .|.|.|:
  Rat  1161 ---------------------GEDVKDPEDCFTEGCVR----RCP---CCMVDTTQSPGKVWWRL 1197

  Fly  1741 RTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWL 1805
            |.....:|:...||.|::.:|..||..|.||||.|::.||:|.:|.:.:..|..:||:||:|||:
  Rat  1198 RKTCYRIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWV 1262

  Fly  1806 ALGFSKYFTSFWTILDFIIVFVSVFSLLIEE--NENLKVLRSLRTLRALRPLRAISRWQGMRIVV 1868
            |.||.||||:.|..|||:||.||:.||:...  ...:..::|||||||||||||:||::|||:||
  Rat  1263 AYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVV 1327

  Fly  1869 NALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEMGELLPI--TEVNDKWDCIEQNY 1931
            |||:.|||||.|||||||:||||||||||..|.|||.:|:|:....||:  |.||:|.:|...|.
  Rat  1328 NALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSECESFNV 1392

  Fly  1932 T----WINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFI 1992
            |    |...|:.||:||.|||||||||||:|||::|..|||:||.:.|||.|.|||.|||||:||
  Rat  1393 TGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEDNLYMYIYFVVFI 1457

  Fly  1993 VCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPINHF 2057
            :.||||||||||||||||||..|||..|  .::|:||.||.||.||||||.|||||.|.||:|.:
  Rat  1458 IFGSFFTLNLFIGVIIDNFNQQKKKLGG--QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKY 1520

  Fly  2058 LAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGL 2122
            ....:|:...:.|::.|..||.|||:||.:|..||......||...|..|..:|..|.|||:..|
  Rat  1521 QGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKVNILAKINLLFVAIFTGECIVKMAAL 1585

  Fly  2123 RYHYFTVPWNVFDFLLVLASIFGILMEDIMIDLPISPTLLRVVRVFRIGRILRLIKAAKGIRKLL 2187
            |::|||..||:|||::|:.||.|.::.||:.....||||.||:|:.|||||||||:.|||||.||
  Rat  1586 RHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLL 1650

  Fly  2188 FALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKLQGALDDMVNFQTFGRSMQLLFRLMTSAG 2252
            |||::|||||||||.||.|:.|||:|.||:.|..||.:..:|||.|||||..||..||::.||||
  Rat  1651 FALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAG 1715

  Fly  2253 WNDVLESLM-IQPPDCDPFI--HGHTNGNCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQ 2314
            |:.:|..:: ..||.|||.:  ...:.||||.|.:.|.:||::||||::||:|||||||||||:.
  Rat  1716 WDGLLSPILNTGPPYCDPNLPNSNGSRGNCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSV 1780

  Fly  2315 AHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISKPNNVALVSFNLPI 2379
            |.:|....:.|||.:|||..|.|:||.|||||.:..||||..:|..||.|:|||.::|::.:||:
  Rat  1781 ATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYLALSDFADALSEPLRIAKPNQISLINMDLPM 1845

  Fly  2380 SKGNKIHCLDILHALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEKA 2444
            ..|::|||:|||.|..|.|||...|.|   .|:.||:.||....|::...|.:::|...|.:|.:
  Rat  1846 VSGDRIHCMDILFAFTKRVLGESGEMD---ALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVS 1907

  Fly  2445 AKTIQTGWKEYLRRKREKERS--------NSGDSATQTSSPGGWQSKLSALNFFHLQVSRRGTAC 2501
            |..||..::.:|.::..|..|        .||.|........|..:.:...||     |||....
  Rat  1908 ATVIQRAFRRHLLQRSVKHASFLFRQQAGGSGLSDEDAPEREGLIAYMMNGNF-----SRRSAPL 1967

  Fly  2502 SSRASSRKS-----------------SRASDASDLSELA 2523
            ||.:.|..|                 .||||.|...:||
  Rat  1968 SSSSISSTSFPPSYDSVTRATSDNLPVRASDYSRSEDLA 2006

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	152..371	CDD:278921	113/231 (49%)
		Ion_trans	705..902	CDD:278921	103/200 (52%)
		Ion_trans	1768..2019	CDD:278921	156/258 (60%)
		Na_channel_gate	2009..2063	CDD:240441	30/53 (57%)
		Ion_trans	2085..2320	CDD:278921	126/237 (53%)
		GPHH	2331..2386	CDD:293510	26/54 (48%)
Scn5a	XP_038936827.1	Ion_trans	131..424	CDD:395416	141/296 (48%)
		Na_trans_cytopl	484..668	CDD:403218	43/233 (18%)
		Ion_trans	717..930	CDD:395416	113/215 (53%)
		Na_trans_assoc	956..1203	CDD:399489	89/823 (11%)
		Ion_trans	1207..1482	CDD:395416	160/274 (58%)
		Na_channel_gate	1474..1526	CDD:240441	30/53 (57%)
		Ion_trans	1531..1785	CDD:395416	133/253 (53%)
		GPHH	1797..1844	CDD:407139	23/46 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D37221at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100419
Panther	1	1.100	-	-	O	PTHR10037
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820