Protein Alignment NaCP60E and cch1

DIOPT Version :10

• Sequence 1: NP_001261172.1
• Gene: NaCP60E / 37981
• FlyBaseID: FBgn0085434
• Length: 2896
• Species: Drosophila melanogaster
• Sequence 2: NP_593894.1
• Gene: cch1 / 2542812
• PomBaseID: SPAC6F6.01
• Length: 1854
• Species: Schizosaccharomyces pombe
• Alignment Length: 2573
• Identity: 426/2573 - (16%)
• Similarity: 739/2573 - (28%)
• Gaps: 1171/2573 - (45%)

  Fly    60 KFEPFPEHMYGKPLEEIDTFIYEETFCVVSKRFRKNYIHRFTGTKSLFLFYPWSPARRVCVYIAT 124
            |..|:..|.:.:        ||.....||... |.|.    |..::|    |:||..|   .|..
pombe   139 KLSPYFTHFFSE--------IYAAVLRVVGPP-RANE----TPGRNL----PFSPILR---QIYN 183

  Fly   125 NQFFDYCVMATILFNCIFLAM--------TETVEEAEYIFLAIYSIEMVIKIIAKGFL------- 174
            :..::..:...|:.:.:.|.:        ::|::....:...:|::||::||...|||
pombe   184 HPLYNIFIFVVIVLHAVLLMIRSDDPHDKSQTIDYLIIVIGILYTLEMLLKIYLFGFLYDGSSSF 248

  Fly   175 ---LNKYT--------YLRNPWNWLDFVVITSGY-ATIGMEVGNLAGLRTFRV---LRALKTVSI 224
               :|.||        |||:.||.:|||.|.:.: :.||.:...:  .|.|.:   ||..:.::|
pombe   249 YDFINSYTKKTPRTMSYLRHSWNRVDFVAIVALWISVIGKKQQGI--FRLFSMIACLRLTRLLNI 311

  Fly   225 MPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCV-------RQVPTDWTN 282
            ....:||:.:|..|...|.:|::...|..::.|:..:|.:...|..:||       :.:||....
pombe   312 TRKTETILKSLKESSTPLVQVVSFNAFFGVMIAILGVQFFKASLNRQCVWLGDYGDQYLPTGQFC 376

  Fly   283 VSHTDWQIWVNDTDNWLYDEDELPVLCGNLTGARHCPFEYVC----LC-VGENPNHGYTNFDNFM 342
            ..|     |.|.......|::..|   .|:.     |..::|    :| |.|||.....:||||.
pombe   377 GGH-----WENGIKRAYLDKNGFP---SNVN-----PRGFICAEKSVCRVVENPYSNTVSFDNFF 428

  Fly   343 WSMLTTFQLITLDYWENVYNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITN 407
            .|:...|.:::.:.:.::...::.....:|...|.:..:|.:.:|::|::|||..|:.:
pombe   429 NSLELIFVIMSSNGFTDIMYDIMDAEYFVSCLLFIISAYFLTLWLMSLVIAVVTSSFID------ 487

  Fly   408 EERKKDLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGKEGGT 472
                   |.|
pombe   488 -------LQH------------------------------------------------------- 490

  Fly   473 NGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQHKLAKSGSGGSNNPM 537
                :|.|..:.||
pombe   491 ----SGKNQKEQKS--------------------------------------------------- 500

  Fly   538 APTPKGRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQDDSGVVDDHEEQD 602
                                                                     ||.|
pombe   501 ---------------------------------------------------------VDKH---- 504

  Fly   603 TTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDRNCDRCVHW 667
                                        :.|.|....|..:..|
pombe   505 ----------------------------LIRNKLCEKYLFYSNF--------------------- 520

  Fly   668 CTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNK--VFTSI 730
                 .|:.|           :....:|||               ::::.......|:  :|.:.
pombe   521 -----IWISF-----------IVAQFVTLC---------------TQTYDQTSSTANRYLIFYAC 554

  Fly   731 FTF----ECIVKLMALSKD---FFLCGWNIFDLLIVTASLLDIIFEL------VDGLSVLRGLRL 782
            ..|    |.|::..|...|   ||....|:.|:::...:|:.::..:      ...||:....|:
pombe   555 VDFLLAAEVILRFFAYLPDYRLFFRRYTNLVDIVLAVLNLVTLLPSIRKNPVAFGWLSIFAIARI 619

  Fly   783 LRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTPEKFDPDPVPR 847
            .|.:.|..  .|.|: ..::.|....|.||.|.||||::|.::..::||.........|.|.:
pombe   620 YRCILLIP--YTRKI-AKLLFSNFKQLLNLMLFLVIVLFIASLCAVRLFQDLPNDGDSDDDAI-- 679

  Fly   848 WNFNDFFHSFMMIFRILCGE-WIEPLWDCMRAEEEQGASTCF-----AIFLPTLVMGNFMVLNLF 906
             :|...:.||:.:::||..| |.    |.|.|.:.:.|....     |.|....:..|.:||::|
pombe   680 -SFATTYESFLYMYQILTSENWT----DVMFAIQARLAHLHLSWIPGAFFTLWFLFSNNVVLSMF 739

  Fly   907 LALLLNSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQ 971
            :|::..:|...|...|.|::  :..|||
pombe   740 IAVIQVNFAPSESDLKMEQL--KMYLAR------------------------------------- 765

  Fly   972 AHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEY 1036
                                                                             
pombe   766 ----------------------------------------------------------------- 765

  Fly  1037 DDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQ 1101
                                                                             
pombe   766 ----------------------------------------------------------------- 765

  Fly  1102 ISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEE 1166
                                   ||..||
pombe   766 -----------------------LLRNYN------------------------------------ 771

  Fly  1167 HDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELL 1231
                  .:|.||                                        :||::
pombe   772 ------PFQASL----------------------------------------TLNAL-------- 782

  Fly  1232 SQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFD 1296
                                                      .:|..|:.|:..:|:..|....|
pombe   783 ------------------------------------------IKRNGSRKGKTVDESHYEWLYED 805

  Fly  1297 NIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLN 1361
            |||:.|               .:::|:    |..:                           ||.
pombe   806 NIIKGF---------------LRVTNI----PPKE---------------------------PLK 824

  Fly  1362 PYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEA 1426
            |  |.|.|.                 :|.:.||.|         :||..::
pombe   825 P--SLDTSP-----------------ELSKYSLAK---------LSNNFKR-------------- 847

  Fly  1427 MAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRK 1491
                             |:.|. |||:..:  |||:                  :.|..||
pombe   848 -----------------FVMRD-DPFSQAY--FKRV------------------IGIRWEK---- 870

  Fly  1492 FLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTT 1556
                       .::||
pombe   871 -----------DMNLK------------------------------------------------- 875

  Fly  1557 PPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTES 1621
                                                                             
pombe   876 ----------------------------------------------------------------- 875

  Fly  1622 HSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQG 1686
              :.|.|..:|.|....::||                 .|...|     .|.|...|....|...
pombe   876 --TAAKDMQAAKAFVRIKQTE-----------------FLKNHP-----KYNDVFWVIKPSNRIR 916

  Fly  1687 AYNDPMTFPS----YGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTAV-LT 1746
            .:...:..|.    ||..:..:     :..:....|.:.|                 :.||| :.
pombe   917 RFCQRLVMPGVNERYGGVEPYQ-----WVYRVIQVFIYAC-----------------ILTAVIIE 959

  Fly  1747 VVDTPAFE-----------WFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEM 1800
            .:.||.:|           |||                             |...:|..||.:|.
pombe   960 CIATPIYERDHLLNDKQHAWFV-----------------------------WTEVAFATIFTIEA 995

  Fly  1801 ILKWLALGF----SKYFTSFWTILDFII---VFVSVFSLLIEENENLKVLRSLRTLRALRPLRAI 1858
            .:|.:|.||    :.|..|.|..:||.:   ::::::::|   ..:..:.|:.|..:|||.||.|
pombe   996 AIKIIADGFCITPNAYLRSTWNCIDFFVLVTLWINLYAVL---TSHALLSRAFRAFKALRVLRLI 1057

  Fly  1859 SRWQ-GMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEMGEL------LP 1916
            :..| ..|:..:||:.....||:..:|.....:.|::.....|||..:.| |:...|      |.
pombe  1058 NLTQTSQRMFHDALISGFFKIFSAAVVSATLLIPFALWAKNVFGGLLYSC-NDDNVLSASQCVLE 1121

  Fly  1917 ITEVNDKWDCIEQNYTWIN-SKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREA 1980
            .....:.|: :.....|.| ....||......|||.::|:.|||:::|...:|..|.:.|||..|
pombe  1122 YASTPNNWE-VWAPRVWSNPPDYDFDRFPHALLALFEIASIEGWVDIMRSVMDITGFNNQPQTNA 1185

  Fly  1981 NLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKK 2045
            :....::||:|.:....:.|.|||.:||.|       |.......|.|..|:.:....:|:...:
pombe  1186 SSGNAMFFVLFNLVSMIYILTLFIAIIISN-------YAERTGSAFFTAEQRAWLELRRKIKSMR 1243

  Fly  2046 PQK-VIKRPINHFLAMFYDLSNS-----RRFEIAIFVLIFLNMLTMGIEHYDQP-------HAVF 2097
            |.| ...||:. ...:.||.:..     ||....::::..|.:||:   .|..|       :::|
pombe  1244 PSKRPAIRPLG-LRGLCYDFAVQKHGIWRRTFTGLYIVHLLFLLTI---FYPCPIAYTYVRNSIF 1304

  Fly  2098 FILEVSNAFFTTVFGLEAIVKIVGLRYHYFTVP-WNVFDFLLVLASI---FGIL--MEDIMIDLP 2156
            .||.:       .:.:...||:.||.::||... ||:||.::.|.|:   ..||  .|:..:.|
pombe  1305 LILSI-------CYTINICVKVYGLSFYYFFHSFWNMFDVVVTLGSLTCNIAILAKFENRSLTL- 1361

  Fly  2157 ISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGN 2221
            :..|||.:|.|       .||.......:|...:|.|||::|::.|...::...:||....:||.
pombe  1362 LQTTLLVLVTV-------HLIPKFDNFDQLSKTVVASLPSIFSLIATWIVLYITFAIAFNQIFGL 1419

  Fly  2222 VKLQGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQPPDC---DPFIHGHTNGNCGHPL 2283
            .||........||::...::.|||.:....|||||:....|..|:|   |.|.    |.:||:..
pombe  1420 TKLGLNGGPNKNFRSIRNALVLLFTMTFGEGWNDVMHDYTISYPNCVNGDDFY----NSDCGNKP 1480

  Fly  2284 LAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEE--IGIVEDDLEMFYIRWSKYDPHATQFI 2346
            .|...|.::.|||..|.:||:|.::.:||:..|.:..  ..:..:|...|...|:.:||..|.:|
pombe  1481 WAYGLFIAWNIISMYIFVNMFITVVFDNFSYIHTKSSSFTNLQRNDFRQFKDSWAPFDPMVTGYI 1545

  Fly  2347 HFSQLSDFIAS----------------------------------LDPPLGISKPNNVAL----- 2372
            .......|:.|                                  |:.||..|:.|..||
pombe  1546 PKRNAVKFVLSLRGVYDFRIYRDEHTLRSIISKVQSKTGQQSVPMLENPLMGSEINLEALDQIID 1610

  Fly  2373 -VSFNLPISKGNKIHCLDILHALVKHVL---GHVEETDNFKQLQE-QMDVKFKKQFPTR---KEL 2429
             :..|:...:.|      :|::|...::   |:|....|...|.. ...|..::.||..   :..
pombe  1611 TIDVNVVKERRN------VLNSLCTEIMTLPGNVISFSNILMLVVLHKIVDHREAFPISDYIRRA 1669

  Fly  2430 EIVSSTRIWKRQEKAAKTIQTG--WKEYLRRKREKERS 2465
            .::|......|.||....::|.  .|.:|:...||:::
pombe  1670 YVLSELEKSIRMEKLLGLVETSIIRKTFLQHMEEKKKA 1707

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	125..371	CDD:459842	63/287 (22%)
		Ion_trans	687..902	CDD:459842	50/235 (21%)
		Ion_trans	1751..2019	CDD:459842	72/293 (25%)
		Na_channel_gate	2009..2063	CDD:240441	10/54 (19%)
		Ion_trans	2067..2320	CDD:459842	76/273 (28%)
		GPHH	2332..2378	CDD:465306	15/85 (18%)
cch1	NP_593894.1	Ion_trans	184..485	CDD:459842	71/315 (23%)
		Ion_trans	514..748	CDD:459842	58/295 (20%)
		Ion_trans	941..1220	CDD:459842	79/336 (24%)
		Ion_trans	1267..1517	CDD:459842	76/271 (28%)