DRSC/TRiP Functional Genomics Resources

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Protein Alignment NaCP60E and Cacna1a

DIOPT Version :10

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:XP_063133859.1 Gene:Cacna1a / 25398 RGDID:2244 Length:2457 Species:Rattus norvegicus


Alignment Length:2957 Identity:645/2957 - (21%)
Similarity:1077/2957 - (36%) Gaps:950/2957 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    93 RKNYIHRFTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLA------------M 145
            |:|.:   |..:|||||...:..|:....|.....|:|.::|||:.|||.||            |
  Rat   159 RQNCL---TVNRSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPM 220

  Fly   146 TETVEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSG-YATIGMEVGNLAG 209
            :|.:::.|..|:.|:..|..|||:|.||..:|.:||||.||.:||||:.:| .||:|.|. :|..
  Rat   221 SERLDDTEPYFIGIFCFEAGIKIVALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEF-DLRT 284

  Fly   210 LRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVR 274
            ||..||||.||.||.:|.|:.::.:::.:...|.::..|..|.:::||:..|:.|||:....|..
  Rat   285 LRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFE 349

  Fly   275 QVPTDWTNVSHTDWQIWVNDTDNWLYDEDELPVLCGNLTGARHCPFEYVCLCVGENPNHGYTNFD 339
            :                  .||:   .:.|.|..||....||.||....|....|.||:|.|.||
  Rat   350 E------------------GTDD---IQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFD 393

  Fly   340 NFMWSMLTTFQLITLDYWEN-VYNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEA 403
            |.::::||.||.||::.|.: :||...|:....:..:|..::..|||:::||:|.|::..:.:|.
  Rat   394 NILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKER 458

  Fly   404 EITNEERKKDLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGK 468
            |  ..|.::..|..|......        ::|| ...:.|...:.|:||.               
  Rat   459 E--RVENRRAFLKLRRQQQIE--------RELN-GYMEWISKAEEVILAE--------------- 497

  Fly   469 EGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQHKLAKSGSGGS 533
                         |:.......|..|...|  ||                      |.||     
  Rat   498 -------------DETDVEQRHPFDGALRR--AT----------------------LKKS----- 520

  Fly   534 NNPMAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQL--IANSGQPSSNSSGVNRESSQDDSGVVD 596
                                  ..::|.|.:.:.||  ||:.|.|.:.:|               
  Rat   521 ----------------------KTDLLNPEEAEDQLADIASVGSPFARAS--------------- 548

  Fly   597 DHEEQDTTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDRNC 661
                                        ||.    |:::|...:  |::                
  Rat   549 ----------------------------IKS----AKLENSTFF--HKK---------------- 563

  Fly   662 DRCVHWCTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKV 726
                      |..::|.  :.::|:...|...:...:.|||..:|:.|:...|...:.|.....:
  Rat   564 ----------ERRMRFY--IRRMVKTQAFYWTVLSLVALNTLCVAIVHYNQPEWLSDFLYYAEFI 616

  Fly   727 FTSIFTFECIVKLMAL-SKDFFLCGWNIFDLLIVTASLLDIIFELVD-----GLSVLRGLRLLRV 785
            |..:|..|..:|:..| ::.:|...:|.||..::..|:.::|:.::.     |:||||.|||||:
  Rat   617 FLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRI 681

  Fly   786 LKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTPEKFDPDPVPRWNF 850
            .|:.:.|.:::.|:..:::::.::.:|..:|.:.|.:||::|||||...:   .|| :..|..||
  Rat   682 FKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF---NFD-EGTPPTNF 742

  Fly   851 NDFFHSFMMIFRILCGE-WIEPLWDCMRAEEEQGASTCFAIFLPTLVM-GNFMVLNLFLALLL-N 912
            :.|..:.|.:|:||.|| |.|.::|.::::........|:|:...|.: ||:.:||:|||:.: |
  Rat   743 DTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDN 807

  Fly   913 SFNSEELKSKKEEVGEESKLARSIERVRDL--------------IRKKRQERKDRK---ERKFAE 960
            ..|::||...::|..|.:....::::.:::              ::::::.:|..|   |::.:|
  Rat   808 LANAQELTKDEQEEEEAANQKLALQKAKEVAEVSPLSAANMSIAVKEQQKNQKPAKSVWEQRTSE 872

  Fly   961 KFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHD 1025
            ..:|.:|.:::|.....:.:......|..:|.|    |.|       ::||:             
  Rat   873 MRKQNLLASREALYGDAAERWPTTYARPLRPDV----KTH-------LDRPL------------- 913

  Fly  1026 GLHTIVDGLEYDDTGD----LPEQIQLQAHPLP-----------PTSDSMPPTYESAMMATTGGS 1075
                :||..|..:...    .||.::..|.|..           |:|....|..|.         
  Rat   914 ----VVDPQENRNNNTNKSRAPEALRQTARPRESARDPDARRAWPSSPERAPGREG--------- 965

  Fly  1076 FSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYAND 1140
                          |:.:.....|              ||.|...|.:       ..|.||    
  Rat   966 --------------PYGRESEPQQ--------------REHAPPREHV-------PWDADP---- 991

  Fly  1141 QRSGCGSFNR---------GDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSS 1196
            :|:..|...|         |:..:..:.||.|.|..|..         .|.|..|.:......:.
  Rat   992 ERAKAGDAPRRHTHRPVAEGEPRRHRARRRPGDEPDDRP---------ERRPRPRDATRPARAAD 1047

  Fly  1197 GQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQK 1261
            |:.      .:....|||..|...:                       |.:|             
  Rat  1048 GEG------DDGERKRRHRHGPPAH-----------------------DDRE------------- 1070

  Fly  1262 GTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEP 1326
                ||    .|.|:.|...|.|.:...:..:   ..||      :::.|....|...|.|:...
  Rat  1071 ----RR----HRRRKESQGSGVPMSGPNLSTT---RPIQ------QDLGRQDLPLAEDLDNMKNN 1118

  Fly  1327 SPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKR 1391
            ..|..|                          |.:|:||...|.:|.....:..:..        
  Rat  1119 KLATGE--------------------------PASPHDSLGHSGLPPSPAKIGNSTN-------- 1149

  Fly  1392 RSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQF 1456
                                        |..|:      ||:...|...::|             
  Rat  1150 ----------------------------PGPAL------ATNPQNAASRRTP------------- 1167

  Fly  1457 DRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQK 1521
                                                 :.|                         
  Rat  1168 -------------------------------------NNP------------------------- 1170

  Fly  1522 LGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAH 1586
             |..:.|..|.||..||  .:..|:..|.:|.||    |...||.    |..|..|..|      
  Rat  1171 -GNPSNPGPPKTPENSL--IVTNPSSTQPNSAKT----ARKPEHM----AVEIPPACPP------ 1218

  Fly  1587 SQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDA 1651
                          :.|....::|.|:                ...|.....:|.|:.::...:.
  Rat  1219 --------------LNHTVVQVNKNAN----------------PDPLPKKEEEKKEEEEADPGED 1253

  Fly  1652 TQKP-----SAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFP 1711
            ..||     |.|...|..|...|..|:.:|..                                 
  Rat  1254 GPKPMPPYSSMFILSTTNPLRRLCHYILNLRY--------------------------------- 1285

  Fly  1712 QKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLD 1776
                                                     ||..:|::|..|||.|..|| .:.
  Rat  1286 -----------------------------------------FEMCILMVIAMSSIALAAED-PVQ 1308

  Fly  1777 KNKTLKRVLYWINFSFCLIFVVEMILKWLALGF----SKYFTSFWTILDFIIVFVSVFSLLIEEN 1837
            .|.....||.:.::.|..:|..||::|.:.||.    ..||...|.|||||:|..::.:.....|
  Rat  1309 PNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGN 1373

  Fly  1838 ---ENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQF 1899
               :::..::|||.||.||||:.|.|...::.|.:.::.::.::||:|:|.::|..||:::.||.
  Rat  1374 SKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQL 1438

  Fly  1900 FGGKFFKCVNEMGELLPITEVNDKWDCIEQNYT------WINSKITFDHVGMGYLALLQVATFEG 1958
            |.||||.|.:|..|.  ..:...|:...|:|..      |......:|:|....|.|..|:|.||
  Rat  1439 FKGKFFHCTDESKEF--ERDCRGKYLLYEKNEVKARDREWKKYDFHYDNVLWALLTLFTVSTGEG 1501

  Fly  1959 WMEVMADAVDARGVDLQP----QREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYE 2019
            |.:|:..:|||...:..|    :.|.:::..:|||:|    .||.:|:|:.:||..|.....|  
  Rat  1502 WPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVF----PFFFVNIFVALIIITFQEQGDK-- 1560

  Fly  2020 GGVLEMFLTESQKH----YYTAMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRFEIAIFVLIFL 2080
              ::|.:..|..:.    :..:.|.|.|..||.  |:...:.:..|.   .|..||..|..:|.|
  Rat  1561 --MMEEYSLEKNERACIDFAISAKPLTRHMPQN--KQSFQYRMWQFV---VSPPFEYTIMAMIAL 1618

  Fly  2081 NMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLR-YHYFTVPWNVFDFLLVLASIF 2144
            |.:.:.::.|....|....|.|.|..||::|.||.::|::... .:||...||:|||:.||.||.
  Rat  1619 NTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSIT 1683

  Fly  2145 GILMEDI---MIDLPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGL 2206
            .||:.:.   .|:|..       :|:||..|:::|::....||.||:..|.|..||..:..|:.:
  Rat  1684 DILVTEFGNNFINLSF-------LRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAM 1741

  Fly  2207 ITFIYAILGMSLFGNVKLQGALDDM----------VNFQTFGRSMQLLFRLMTSAGWNDVLESLM 2261
            :.|||||:||.:|||:.:.|..:|.          .||:||.:::.||||..|...|::::.|.:
  Rat  1742 LFFIYAIIGMQVFGNIGIDGEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCL 1806

  Fly  2262 IQPPDCDPFIHGHTNGNCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVED 2326
            ...| ||. ..|.....||:. .|..||.|||.:...:::|:::|:|::||....::..| :...
  Rat  1807 SGKP-CDK-NSGIQKPECGNE-FAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSI-LGPH 1867

  Fly  2327 DLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISK--PNNVA---LVSFNLPISKGNKIH 2386
            .|:.:...|::|||.|...||:..:...:..:.||||:.|  |:.||   |:..:||::..|.:|
  Rat  1868 HLDEYVRVWAEYDPAACGRIHYKDMYSLLRVISPPLGLGKKCPHRVACKRLLRMDLPVADDNTVH 1932

  Fly  2387 CLDILHALVKHVL------GHVEETDNFKQLQEQMDVKFKKQ----FP--TRKELEIV----SST 2435
            ....|.||::..|      |..:        ::|||.:.:|:    :|  ::|.|:::    .||
  Rat  1933 FNSTLMALIRTALDIKIAKGGAD--------KQQMDAELRKEMMAIWPNLSQKTLDLLVTPHKST 1989

  Fly  2436 RIWKRQEKAAKTIQTGWKEYLRRKREK------ERSN---------SGDSATQTSSPGGWQSKLS 2485
            .:...:..||..|.    ||.|:.:.|      |..|         ...|.||...|.  |:.|.
  Rat  1990 DLTVGKIYAAMMIM----EYYRQSKAKKLQAMREEQNRTPLMFQRMEPPSPTQEGGPS--QNALP 2048

  Fly  2486 ALNFFHLQVSRRGTACSSRASSRKSSR--ASDASDLSELAGPWLNLPLMLVSGADEVVKDIKQQN 2548
            :     .|:...|...:..:|.::|..  ...|.::.:..|.|                     :
  Rat  2049 S-----TQLDPGGGLMAQESSMKESPSWVTQRAQEMFQKTGTW---------------------S 2087

  Fly  2549 DELGKRGSIFVEAPRASRRRSFYNFFLRHQDAVDDSLTSPSVHRKTAMNNTTNTTSNSASTSGTA 2613
            .|.|                                   |.:....:..|:.:.......|.|.:
  Rat  2088 PERG-----------------------------------PPIDMPNSQPNSQSVEMREMGTDGYS 2117

  Fly  2614 SSTATAPATGCGPAATSASDSDRHQAVGGGSAPSRKRAS--SFIRKKPPLERGLS--AQSALRVN 2674
            .|....|..|...||:.......:|...|     |.|.:  |.|....|::|..|  ...|.|::
  Rat  2118 DSEHYLPMEGQTRAASMPRLPAENQRRRG-----RPRGNNLSTISDTSPMKRSASVLGPKARRLD 2177

  Fly  2675 KNAFVSEASAPEVIVTRPSPEQQTHPHSLSLRPDNATLVHVLVHRESE----EYKEEDESSPSVS 2735
                       :..:.|..||:....|  ..|.|..       ||.||    .|.:.|       
  Rat  2178 -----------DYSLERVPPEENQRYH--QRRRDRG-------HRTSERSLGRYTDVD------- 2215

  Fly  2736 GNGNGFGVGLDMLSKQPPPQIRITTGSVESSMDTCAMPTVQIMVDSPKDPPRGDFSSAPID-DVG 2799
               .|.|..|.|           ||.|                         ||..|...| |.|
  Rat  2216 ---TGLGTDLSM-----------TTQS-------------------------GDLPSKDRDQDRG 2241

  Fly  2800 APIDVNVQGDTSQVFYDYNPEKATDDQGNGQDETAQFESLPDRQRXPPVNTPLRDSEKRSSRGSR 2864
            .|.|...:.......:.::|                  ..|||:| .........:..|..|.||
  Rat  2242 RPKDRKHRPHHHHHHHHHHP------------------PAPDRERYAQERPDTGRARAREQRWSR 2288

  Fly  2865 SSSSSTSSIRSCSSSSSSSAASAAAPSARRTS 2896
            |.|....  .:.....|||.:.:.|||...||
  Rat  2289 SPSEGRE--HATHRQGSSSVSGSPAPSTSGTS 2318

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 125..371 CDD:459842 90/259 (35%)
Ion_trans 687..902 CDD:459842 62/222 (28%)
Ion_trans 1751..2019 CDD:459842 90/284 (32%)
Na_channel_gate 2009..2063 CDD:240441 11/57 (19%)
Ion_trans 2067..2320 CDD:459842 87/266 (33%)
GPHH 2332..2378 CDD:465306 16/50 (32%)
Cacna1aXP_063133859.1 None

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