back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NaCP60E and Scn2a

DIOPT Version :9

Sequence 1:	NP_001261172.1	Gene:	NaCP60E / 37981	FlyBaseID:	FBgn0085434	Length:	2896	Species:	Drosophila melanogaster
Sequence 2:	NP_036779.2	Gene:	Scn2a / 24766	RGDID:	3632	Length:	2005	Species:	Rattus norvegicus

Alignment Length:	2640	Identity:	831/2640 - (31%)
Similarity:	1202/2640 - (45%)	Gaps:	866/2640 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FNDEKAVAKHQVVAYTQRSQVKHENRHIQLVREYGFHPRTKASVEDGDVLPRKFEPFPEHMYGKP 72
            |..|...|..|.:|..:..:.|.|.:...  .|.|  |:..:.:|.|..||..:...|..|..:|
  Rat    17 FTRESLAAIEQRIAEEKAKRPKQERKDED--DENG--PKPNSDLEAGKSLPFIYGDIPPEMVSEP 77

  Fly    73 LEEIDT-FIYEETFCVVSKRFRKNYIHRFTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATI 136
            ||::|. :|.::||.|::|   ...|.||:.|.:|::..|::|.|::.:.|..:..|:..:|.||
  Rat    78 LEDLDPYYINKKTFIVLNK---GKAISRFSATSALYILTPFNPIRKLAIKILVHSLFNVLIMCTI 139

  Fly   137 LFNCIFLAMT---ETVEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYA 198
            |.||:|:.|:   :..:..||.|..||:.|.:|||:|:||.|..:|:||:|||||||.|||..|.
  Rat   140 LTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYV 204

  Fly   199 TIGMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQV 263
            |..:.:||::.||||||||||||:|::||||||:.||:.|.::|::||.||:|||.||||..||:
  Rat   205 TEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQL 269

  Fly   264 YMGELRNKCVRQVP----------------TDWT------NVSHTDWQIWVNDTDNWLYDEDEL- 305
            :||.|||||::..|                .||.      .|:..:|..::.|..::.:.|.:.
  Rat   270 FMGNLRNKCLQWPPDNSTFEINITSFFNNSLDWNGTAFNRTVNMFNWDEYIEDKSHFYFLEGQND 334

  Fly   306 PVLCGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCGP 370
            .:||||.:.|..||..|:|:..|.|||:|||:||.|.|:.|:.|:|:|.|:|||:|.:.|...|.
  Rat   335 ALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGK 399

  Fly   371 MSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNEERK------KDLLDH------------ 417
            ..:.||.:|:|.||||||||:|||||::|||:.:.|.||.:      :.:|:.
  Rat   400 TYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAA 464

  Fly   418 -------RDDS------TFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGKE 469
                   ||.|      .||...||  ..||:..::|::              |.||||.|..::
  Rat   465 AAASAESRDFSGAGGIGVFSESSSV--ASKLSSKSEKEL--------------KNRRKKKKQKEQ 513

  Fly   470 GGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATE------------RPSALTMQAQKQYQQMEQQ 522
            .          |::.|..:.        |.||:|            ..|.||.:     ::....
  Rat   514 A----------GEEEKEDAV--------RKSASEDSIRKKGFRFSLEGSRLTYE-----KRFSSP 555

  Fly   523 HKLAKSGSGGSNNPMAPTP------KGRI---------------SFQDSGMGVKNPNMLYPSDYK 566
            |:...|..|...:|...:.      |||:               :|:|:..  :..::..|..:.
  Rat   556 HQSLLSIRGSLFSPRRNSRASLFSFKGRVKDIGSENDFADDEHSTFEDNDS--RRDSLFVPHRHG 618

  Fly   567 GQLIANSGQPSSNSSGV-------NRESSQDDSGVVD----------------------DHEEQD 602
            .:..:|..|.|..|.|:       ...|:.|.:|||.                      :.|.:.
  Rat   619 ERRPSNVSQASRASRGIPTLPMNGKMHSAVDCNGVVSLVGGPSALTSPVGQLLPEGTTTETEIRK 683

  Fly   603 TTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDRNC------ 661
            ..:...||| ::|...|...|.:    ::|.|..:.:..|.:.            .:.|
  Rat   684 RRSSSYHVS-MDLLEDPSRQRAM----SMASILTNTMEELEES------------RQKCPPCWYK 731

  Fly   662 --DRCVHW-CTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVG 723
              :.|:.| |.  :.||:.::.:..||.||..:||||:||||||.|:||||:.|:|.|.:.|.||
  Rat   732 FANMCLIWDCC--KPWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVG 794

  Fly   724 NKVFTSIFTFECIVKLMALSK-DFFLCGWNIFDLLIVTASLLDIIFELVDGLSVLRGLRLLRVLK 787
            |.|||.|||.|..:|::|:.. .:|..||||||..||:.||:::....|:||||||..|||||.|
  Rat   795 NLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRVFK 859

  Fly   788 LAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTP--EKFDPD-PVPRWN 849
            ||:||.|:.:|:.||.:::||||||||:|.|:::||||:|||||.|.|..  .|...| .:|||:
  Rat   860 LAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWH 924

  Fly   850 FNDFFHSFMMIFRILCGEWIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLFLALLLNSF 914
            .:||||||:::||:|||||||.:||||   |..|.:.|..:|:..:|:||.:||||||||||:||
  Rat   925 MHDFFHSFLIVFRVLCGEWIETMWDCM---EVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLSSF 986

  Fly   915 NSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSH 979
            :|:.|.:..:: .|.:.|..::.|:        |:..|..:||..|..|:..:..|:|
  Rat   987 SSDNLAATDDD-NEMNNLQIAVGRM--------QKGIDFVKRKIREFIQKAFVRKQKA------- 1035

  Fly   980 QAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPE 1044
                          |.|.|                       ||.|
  Rat  1036 --------------LDEIK-----------------------PLED------------------- 1044

  Fly  1045 QIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQ 1109

  Rat  1045 ----------------------------------------------------------------- 1044

  Fly  1110 QYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKY 1174
                                        .|:::..|
  Rat  1045 ----------------------------LNNKKDSC----------------------------- 1052

  Fly  1175 QKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSS---GQSLNSMSIEQDELLSQQGN 1236
                                                :..|::   |:.||.:         :.||
  Rat  1053 ------------------------------------ISNHTTIEIGKDLNYL---------KDGN 1072

  Fly  1237 LREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQS 1301
                                     ||              :|.:|....:.:|:.|::
  Rat  1073 -------------------------GT--------------TSGIGSSVEKYVVDESDY------ 1092

  Fly  1302 FEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSY 1366
                              :|.::.||              ..:|          |.:.|...|..
  Rat  1093 ------------------MSFINNPS--------------LTVT----------VPIALGESDFE 1115

  Fly  1367 DLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAA 1431
            :|::                               |:||..:::
  Rat  1116 NLNT-------------------------------EEFSSESDM--------------------- 1128

  Fly  1432 TSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGP 1496
                                                     ||.|         ||
  Rat  1129 -----------------------------------------EESK---------EK--------- 1134

  Fly  1497 DQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAA 1561
                     |.:|:|.|.
  Rat  1135 ---------LNATSSSEG----------------------------------------------- 1143

  Fly  1562 LTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGA 1626
                                                        ||:|..|..:..:.|:
  Rat  1144 --------------------------------------------STVDIGAPAEGEQPEA----- 1159

  Fly  1627 ADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDP 1691
                           |..:|..|:|
  Rat  1160 ---------------EPEESLEPEA---------------------------------------- 1169

  Fly  1692 MTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSC---MDTQSAKHWTRVRTAVLTVVDTPAF 1753
                             ||.:.|...  |:|     |   ::....|.|..:|.....:|:...|
  Rat  1170 -----------------CFTEDCVRK--FKC-----CQISIEEGKGKLWWNLRKTCYKIVEHNWF 1210

  Fly  1754 EWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGFSKYFTSFWT 1818
            |.|::.:|..||..|.||||.:::.||:|.:|.:.:..|..||::||:|||:|.||..|||:.|.
  Rat  1211 ETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQMYFTNAWC 1275

  Fly  1819 ILDFIIVFVSVFSLLIEE--NENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNV 1881
            .|||:||.||:.||....  ...|..::|||||||||||||:||::|||:|||||:.|||||.||
  Rat  1276 WLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNV 1340

  Fly  1882 LLVCLVFWLIFSIMGVQFFGGKFFKCVN-EMGELLPITEVNDKWDC---IEQNYT--WINSKITF 1940
            |||||:||||||||||..|.|||:.|:| ..||:..::.||:..:|   ||.|.|  |.|.|:.|
  Rat  1341 LLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSECQALIESNQTARWKNVKVNF 1405

  Fly  1941 DHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIG 2005
            |:||:|||:|||||||:|||::|..|||:|.|:|||:.|.|||.|:||||||:.|||||||||||
  Rat  1406 DNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIG 1470

  Fly  2006 VIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRF 2070
            |||||||..|||:.|  .::|:||.||.||.||||||.|||||.|.||.|.|..|.:|....:.|
  Rat  1471 VIIDNFNQQKKKFGG--QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVF 1533

  Fly  2071 EIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRYHYFTVPWNVFD 2135
            :|:|.:||.|||:||.:|..||...:..||...|..|..:|..|.::|::.||::|||:.||:||
  Rat  1534 DISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRHYYFTIGWNIFD 1598

  Fly  2136 FLLVLASIFGILMEDIMIDLPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNI 2200
            |::|:.||.|:.:.:::....:||||.||:|:.||||||||||.|||||.|||||::||||||||
  Rat  1599 FVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNI 1663

  Fly  2201 GALLGLITFIYAILGMSLFGNVKLQGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQ-P 2264
            |.||.|:.|||||.|||.|..||.:..:|||.||:|||.||..||::.|||||:.:|..::.. |
  Rat  1664 GLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGP 1728

  Fly  2265 PDCDP---FIHGHTNGNCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVED 2326
            |||||   .......|:||:|.:.|.:|.|:||||:::|:|||||:|||||:.|.:|....:.||
  Rat  1729 PDCDPEKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSED 1793

  Fly  2327 DLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISKPNNVALVSFNLPISKGNKIHCLDIL 2391
            |.||||..|.|:||.|||||.|.:||||.|:|||||.|:|||.|.|::.:||:..|::|||||||
  Rat  1794 DFEMFYEVWEKFDPDATQFIEFCKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDIL 1858

  Fly  2392 HALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEKAAKTIQTGWKEYL 2456
            .|..|.|||...|.|   .|:.||:.:|....|::...|.:::|...|::|.:|..||..::.||
  Rat  1859 FAFTKRVLGESGEMD---ALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIVIQRAYRRYL 1920

  Fly  2457 RR----------KREKERSNSG---------DSATQTSSP 2477
            .:          |::|.:.:.|         |...:.|:|
  Rat  1921 LKQKVKKVSSIYKKDKGKEDEGTPIKEDIITDKLNENSTP 1960

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.