Protein Alignment NaCP60E and Scn11a

DIOPT Version :10

• Sequence 1: NP_001261172.1
• Gene: NaCP60E / 37981
• FlyBaseID: FBgn0085434
• Length: 2896
• Species: Drosophila melanogaster
• Sequence 2: XP_017168851.1
• Gene: Scn11a / 24046
• MGIID: 1345149
• Length: 1782
• Species: Mus musculus
• Alignment Length: 2524
• Identity: 748/2524 - (29%)
• Similarity: 1099/2524 - (43%)
• Gaps: 817/2524 - (32%)

  Fly     7 TFNDEKAVAKHQVVAYTQRSQVKHENRHIQLVREYGFHPRTKASVEDGDVLPRKFEPFPEHMYGK 71
            ||:...|:.|...:   |:.:.|.:::.....:     ||.:..::....||:.:...|..:..|
Mouse    37 TFDSLAAIEKRITI---QKEKKKSKDKAATEPQ-----PRPQLDLKASRKLPKLYGDVPPDLIAK 93

  Fly    72 PLEEIDTFIYE-ETFCVVSKRFRKNYIHRFTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMAT 135
            |||::|.|..: :||.|::|   |..|:||:..::||:..|::|.|...:.|:.:..|...::.|
Mouse    94 PLEDLDPFYKDHKTFMVLNK---KRTIYRFSAKRALFILGPFNPIRSFMIRISVHSVFSMFIICT 155

  Fly   136 ILFNCIFLAMTETVEE------AEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVIT 194
            ::.||:|:|...:|:.      .||:|:.||.:|.||||:|:||::::::|||:|||||||:||.
Mouse   156 VIINCMFMANNSSVDSRPSSNIPEYVFIGIYVLEAVIKILARGFIVDEFSYLRDPWNWLDFIVIG 220

  Fly   195 SGYAT--IGMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFA 257
            :..|.  :|.:|.||:.|||||||||||.:|::.|||.|:.|||.|.::|.:||.||:|||.:||
Mouse   221 TAIAPCFLGNKVNNLSTLRTFRVLRALKAISVISGLKVIVGALLRSVKKLVDVMVLTLFCLSIFA 285

  Fly   258 LFALQVYMGELRNKCVRQ--VPTDWTNVSHTDWQIWVNDTDNWLYDEDELPVLCGNLTGARHCPF 320
            |...|::||.|..||::.  .|..::|   .|..:..||::::        ::|||..|.|.||.
Mouse   286 LVGQQLFMGILSQKCIKDDCGPNAFSN---KDCFVKENDSEDF--------IMCGNWLGRRSCPD 339

  Fly   321 EYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCGPMSVSFFTVVVFFGSF 385
            ...|.....||::.|||||:|.||.|..|:::|.|.||.:|..:|.|.|...|.||.||:|.|||
Mouse   340 GSTCNKTTFNPDYNYTNFDSFGWSFLAMFRVMTQDSWEKLYRQILRTSGIYFVFFFVVVIFLGSF 404

  Fly   386 YLINLMLAVVALSYEEE-AEITNEERKKDLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGV 449
            ||:||.||||.::|||: ..:..|...|:.:..........:...|....:::.:...:.:
Mouse   405 YLLNLTLAVVTMAYEEQNRNVAAETEAKEKMFQEAQQLLREEKEALVAMGIDRTSLNSLQA---- 465

  Fly   450 LLASYSKKKTRRKKTKGGK-------EGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSA 507
              :|:|.||   :|..|.|       .|......:.|:.:|:
Mouse   466 --SSFSPKK---RKFFGSKTRKSFFMRGSKTARASASDSEDD----------------------- 502

  Fly   508 LTMQAQKQYQQMEQQHKLAKSGSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQLIAN 572
                |.|..|.:||..:|::      |.|:.
Mouse   503 ----ASKNPQLLEQTKRLSQ------NLPVE---------------------------------- 523

  Fly   573 SGQPSSNSSGVNRESSQDDSGVVDDH-EEQDTTNDMGHVSTVELALSPREVR---LIKCNGNIAR 633
                                 :.|:| :.......:..||.:.:.:..:|..   ...|..|:|
Mouse   524 ---------------------LFDEHVDPLHRQRALSAVSILTITMQEQEKSQEPCFPCGKNLA- 566

  Fly   634 IKNHNVYALHQEFSSEVVVIDDLPDRNCDRCVHWCTDYESWLQFQNCLYKVVRDPLFELAITLCI 698
                          |:.:|.:..|               .||..:..|..::.||..|||||:||
Mouse   567 --------------SKYLVWECSP---------------PWLCIKKVLQTIMTDPFTELAITICI 602

  Fly   699 VLNTAFLAMEHHGMSESFRNALDVGNKVFTSIFTFECIVKLMALSK-DFFLCGWNIFDLLIVTAS 762
            ::||.|||||||.|..|.::.|.:||.|||.||..|..:|::||.. .:|..||||||.::...|
Mouse   603 IVNTVFLAMEHHNMDNSLKDILKIGNWVFTGIFIAEMCLKIIALDPYHYFRHGWNIFDSIVALVS 667

  Fly   763 LLDIIF-ELVDGLSVLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVI 826
            |.|::| :|...||.|..||:|||.|||:||.|:..|:.||..::|||||||::|.||::||:|:
Mouse   668 LADVLFHKLSKNLSFLASLRVLRVFKLAKSWPTLNTLIKIIGHSVGALGNLTVVLTIVVFIFSVV 732

  Fly   827 GMQLFSKDYTPE-KFDPDPVPRWNFNDFFHSFMMIFRILCGEWIEPLWDCMRAEEEQGASTCFAI 890
            ||:||...:... ...|:.:.||:..||:|||:::||||||||||.:|:||  :|.:|:..|..:
Mouse   733 GMRLFGAKFNKTCSTSPESLRRWHMGDFYHSFLVVFRILCGEWIENMWECM--QEMEGSPLCVIV 795

  Fly   891 FLPTLVMGNFMVLNLFLALLLNSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKE 955
            |:..:|:|..:|||||:|||||||::||                                ||
Mouse   796 FVLIMVVGKLVVLNLFIALLLNSFSNEE--------------------------------KD--- 825

  Fly   956 RKFAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQ 1020
                                            |:..|...:||
Mouse   826 --------------------------------GNPEGETRKTK---------------------- 836

  Fly  1021 IPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTC 1085
                                     :||
Mouse   837 -------------------------VQL------------------------------------- 839

  Fly  1086 QNLTPFVQAERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNR 1150
                                                                             
Mouse   840 ----------------------------------------------------------------- 839

  Fly  1151 GDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHS 1215
                                                 :|||.|::
Mouse   840 -------------------------------------ALDRFSRA-------------------- 847

  Fly  1216 SGQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISN--VMRSRRPS 1278
                                              |.|:           .|.:.|  ..|.||.:
Mouse   848 ----------------------------------FYFM-----------ARALQNFCCKRCRRQN 867

  Fly  1279 SQMGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAI 1343
            |.  :|...|           :||..|    .|.|.:|:.:             :.|.....:.:
Mouse   868 SP--KPNEAT-----------ESFAGE----SRDTATLDTR-------------SWKEYDSEMTL 902

  Fly  1344 ITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISN 1408
            .||        :...||.|                               |.|:   ::|.....
Mouse   903 YTG--------QAGAPLAP-------------------------------LAKE---EDDMECCG 925

  Fly  1409 EIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPE 1473
            |    ||               |:..||                                   |.
Mouse   926 E----CD---------------ASPTSQ-----------------------------------PS 936

  Fly  1474 EEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSL 1538
            ||.....|.::::::|....||
Mouse   937 EEAQACDLPLKTKRLPSPDDHG------------------------------------------- 958

  Fly  1539 KSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEH 1603
               :|....::                                                    |.
Mouse   959 ---VEMEVFSE----------------------------------------------------ED 968

  Fly  1604 PQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHC 1668
            |..|:      ||||.:|      ||:|.|:                                .|
Mouse   969 PNLTI------QSARKKS------DAASMLS--------------------------------EC 989

  Fly  1669 LVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQ------KCYDHFYFRCPWFMS 1727
            ....::|:.    ||.|            ......|.||.|||:      .|......:.||.:
Mouse   990 STIDLNDIF----RNLQ------------KTVSPQKQPDRCFPKGLSCIFLCCKTIKKKSPWVL- 1037

  Fly  1728 CMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSF 1792
                     |..:|.....:|....||.|::.:|..||..|.|||:||.....::::|...:..|
Mouse  1038 ---------WWNLRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVNLPSRPQVEKLLKCTDNIF 1093

  Fly  1793 CLIFVVEMILKWLALGFSKYFTSFWTILDFIIVFVSVFSLLIEENENLKVLRSLRTLRALRPLRA 1857
            ..||::||||||:|.||.|||||.|..|||:||.||..||     .||..|:|.|.|||||||||
Mouse  1094 TFIFLLEMILKWVAFGFRKYFTSAWCWLDFLIVVVSGLSL-----TNLPNLKSFRNLRALRPLRA 1153

  Fly  1858 ISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVN--EMGELLPITEV 1920
            :|:::||::||||||.|||:|.|||||||:|||||.|:||.||.|||.:|:|  ::.:....:.|
Mouse  1154 LSQFEGMKVVVNALMSAIPAILNVLLVCLIFWLIFCILGVNFFSGKFGRCINGTDINKYFNASNV 1218

  Fly  1921 NDKWDCIEQNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAY 1985
            .::..|:..||||....:.||:||..|||||||||::||:::|..|||:||.|.||..|||||||
Mouse  1219 PNQSQCLVSNYTWKVPNVNFDNVGNAYLALLQVATYKGWLDIMNAAVDSRGKDEQPAFEANLYAY 1283

  Fly  1986 IYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVI 2050
            :|||:||:.||||||||||||||||||..:||..|  .::|:||.||.||.||||||.|||||.|
Mouse  1284 LYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKISG--QDIFMTEEQKKYYNAMKKLGTKKPQKPI 1346

  Fly  2051 KRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEA 2115
            .||:|...|..:||..|:.|::.|..||..||:.|..|...||:.|..|.::.|..|..:|.:|.
Mouse  1347 PRPLNKCQAFVFDLVTSQVFDVIILGLIVTNMIIMMAESEGQPNEVKKIFDILNIVFVVIFTVEC 1411

  Fly  2116 IVKIVGLRYHYFTVPWNVFDFLLVLASIFGILMEDIMIDLPISPTLLRVVRVFRIGRILRLIKAA 2180
            ::|:..||.||||..||:||.::|:.||...|:..:.......|||.|:||:.||||||||::||
Mouse  1412 LIKVFALRQHYFTNGWNLFDCVVVVLSIISTLVSGLENSNVFPPTLFRIVRLARIGRILRLVRAA 1476

  Fly  2181 KGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKLQGALDDMVNFQTFGRSMQLLF 2245
            :|||.|||||::|||:|||||.||.|:.|||||.||:.|..||....:||:.||.||..||..||
Mouse  1477 RGIRTLLFALMMSLPSLFNIGLLLFLVMFIYAIFGMNWFSKVKRGSGIDDIFNFDTFSGSMLCLF 1541

  Fly  2246 RLMTSAGWNDVLESLMIQPPDCDPFIHGHTNGNCGHPLLAITYFTSFIIISYMIVINMYIAIILE 2310
            ::.|||||:.:|..::.....|    :..:..:|..|.:||.||.|:||||::||:|||||:|||
Mouse  1542 QITTSAGWDALLNPMLESKASC----NSSSQESCQQPQIAIVYFVSYIIISFLIVVNMYIAVILE 1602

  Fly  2311 NFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISKPNNVALVSF 2375
            |||.|.:|.|..:.|||.|:||..|.|:||.|||||.:|.||||..:|..||.::|||....:..
Mouse  1603 NFNTATEESEDPLGEDDFEIFYEIWEKFDPEATQFIQYSSLSDFADALPEPLRVAKPNRFQFLMM 1667

  Fly  2376 NLPISKGNKIHCLDILHALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKR 2440
            :||:..|:::||:|:|.|....|||:....|..|.:.|:   ||.:..|.:|..|.:.:|...|.
Mouse  1668 DLPMVMGDRLHCMDVLFAFTTRVLGNSSGLDTMKAMMEE---KFMEANPFKKLYEPIVTTTKRKE 1729

  Fly  2441 QEKAAKTIQTGWKEYLRRKREKERSNSGDSATQTSSPGGWQSKLSALNFFHLQV 2494
            :|:.|..||..::.::.:..:.:......|:.|....|    .||:|:...::|
Mouse  1730 EEECAAVIQRAYRRHMEKMIKLKLKGRSSSSLQVFCNG----DLSSLDVPKIKV 1779

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	125..371	CDD:459842	107/255 (42%)
		Ion_trans	687..902	CDD:459842	105/217 (48%)
		Ion_trans	1751..2019	CDD:459842	151/269 (56%)
		Na_channel_gate	2009..2063	CDD:240441	30/53 (57%)
		Ion_trans	2067..2320	CDD:459842	120/252 (48%)
		GPHH	2332..2378	CDD:465306	21/45 (47%)
Scn11a	XP_017168851.1	Ion_trans	145..424	CDD:459842	127/289 (44%)
		Ion_trans	591..825	CDD:459842	119/267 (45%)
		Na_trans_assoc	829..1047	CDD:461936	76/762 (10%)
		Ion_trans	1051..1315	CDD:459842	149/268 (56%)
		Na_channel_gate	1307..1359	CDD:240441	30/53 (57%)
		Ion_trans	1363..1612	CDD:459842	120/252 (48%)
		GPHH	1623..1670	CDD:465306	22/46 (48%)