DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NaCP60E and Cacna1i

DIOPT Version :9

Sequence 1:	NP_001261172.1	Gene:	NaCP60E / 37981	FlyBaseID:	FBgn0085434	Length:	2896	Species:	Drosophila melanogaster
Sequence 2:	XP_006521012.1	Gene:	Cacna1i / 239556	MGIID:	2178051	Length:	2226	Species:	Mus musculus

Alignment Length:	3022	Identity:	649/3022 - (21%)
Similarity:	1033/3022 - (34%)	Gaps:	1136/3022 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 SPARRVCVYIATNQFFDYCVMATILFNCIFLAMTETVEEAE--------------YIFLAIYSIE 163
            || |..|:.:..|.:|:...|..||.||:.|.|.:..::.|              :||: .:::|
Mouse    65 SP-RNWCIKMVCNPWFECVSMLVILLNCVTLGMYQPCDDMECLSDRCKILQVFDDFIFI-FFAME 127

  Fly   164 MVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEVG--NLAGLRTFRVLRALKTVSIMP 226
            ||:|::|.| :..|..||.:.||.|||.::.:|.....:::.  ||:.:||.||||.||.::.:|
Mouse   128 MVLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLDLQNINLSAIRTVRVLRPLKAINRVP 191

  Fly   227 GLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVPTDWTNVSHTDWQIW 291
            .::.::|.||.:...|..|:.|..|...:|.:..:|::.|.|||:|..:
Mouse   192 SMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLLRNRCFLE---------------- 240

  Fly   292 VNDTDNWLY-------------DEDELPVLCGNLTG----------------ARHC--------- 318
                :|:..             ::||:|.:| :|:|                .|.|
Mouse   241 ----ENFTIQGDVALPPYYQPEEDDEMPFIC-SLSGDNGIMGCHEIPPLKEQGRECCLSKDDMYD 300

  Fly   319 ------------------PFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVL 365
                              .:..||.....||:.|..||||..::.:..||:|||:.|..:...|:
Mouse   301 FGAGRQDLNASGLCVNWNRYYNVCRTGNANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYYVM 365

  Fly   366 ATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNEERKKDLLDHR----DDSTFS-- 424
            ......:..:|.:::..|||::|||.|.|:|..:.|    |.:...:.:|:.|    ..||.:
Mouse   366 DAHSFYNFIYFILLIIVGSFFMINLCLVVIATQFSE----TKQREHRLMLEQRQRYLSSSTVASY 426

  Fly   425 ------FDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGKEGGTNGNGNGSNGD- 482
                  ::.....|..:.:..|::       .|..|...:.||:.|..|.........:.....
Mouse   427 AEPGDCYEEIFQYVCHILRKAKRR-------ALGLYQALQNRRQATGPGTPAPAKPGPHAKEPSH 484

  Fly   483 ----------DNKSH----------SATPSPGPSPRHSATERPSAL--TMQAQKQYQQMEQQHKL 525
                      |...|          ::.||..|..:|.|..|||.|  |...|:
Mouse   485 CKLCPRHSPLDTTPHTLVQPISAILASDPSSCPRCQHEAGRRPSGLGSTDSGQE----------- 538

  Fly   526 AKSGSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQD 590
             .||||||                                 .:..||...|.|:..||:
Mouse   539 -GSGSGGS---------------------------------AEAEANGDGPQSSEDGVS------ 563

  Fly   591 DSGVVDDHEEQDTTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDD 655
             ||:..:.|::|                           ..||:
Mouse   564 -SGLGKEEEQED---------------------------GAARL--------------------- 579

  Fly   656 LPDRNCDRCVHWCTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNAL 720
                        |.|.  |.:.:..|..:|....|...|.:.|::||..:.:|||...|...|.|
Mouse   580 ------------CGDV--WRETRAKLRGIVDSKYFNRGIMMAILVNTVSMGIEHHEQPEELTNIL 630

  Fly   721 DVGNKVFTSIFTFECIVKLMALSK-DFFLCGWNIFDLLIVTASLLDIIFELVDGLSVLRGLRLLR 784
            ::.|.||||:|..|.|:||.|... |:....:||||.:||..|:.:|:.:...||||||..||||
Mouse   631 EICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIVGQADGGLSVLRTFRLLR 695

  Fly   785 VLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTPEKFDPDPVP-RW 848
            ||||.:....::..|.:::.|:..:....::|::.|:||:::||.:|...::......|.|| |.
Mouse   696 VLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRK 760

  Fly   849 NFNDFFHSFMMIFRILCGE-WIEPLWDCMRAEEEQGAST---CFAIFLPTLVMGNFMVLNLFLAL 909
            ||:....:.:.:|:||..| |...|::.|       |||   ....|:..:..||:::.||.:|:
Mouse   761 NFDSLLWAIVTVFQILTQEDWNVVLYNGM-------ASTTPWASLYFVALMTFGNYVLFNLLVAI 818

  Fly   910 LLNSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHA 974
            |:..|.:|.                                                 ||.::::
Mouse   819 LVEGFQAEG-------------------------------------------------DANRSYS 834

  Fly   975 QTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDT 1039
            .  ..|::..||..||                                |.:||         |.:
Mouse   835 D--EDQSSSNLEELDK--------------------------------LPEGL---------DSS 856

  Fly  1040 GDLPEQIQLQAHPLPPTSD-----SMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQ 1099
            .|      |:..|:|.|.:     |:|          .||........|....|
Mouse   857 RD------LKLCPIPMTPNGHLDPSLP----------LGGHLGPAGAMGAAPRL----------- 894

  Fly  1100 HQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGS 1164
                                           |...||
Mouse   895 -------------------------------SLQPDP---------------------------- 900

  Fly  1165 EEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDE 1229
                                                  :|.:.|:   |.||..||..||.:|..
Mouse   901 --------------------------------------VLVALES---RKSSVMSLGRMSYDQRS 924

  Fly  1230 LLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSE 1294
            |.|.:                                           ||..| |..
Mouse   925 LSSSR-------------------------------------------SSYYG-PWG-------- 937

  Fly  1295 FDNIIQSFEKELEEIKRSTTSLERKLS--NLSEPSPAADEATKAIMEHIAIITGASERSAADEVV 1357
                            ||.|...|:.|  :|....|:|        ||.::::|  ||..
Mouse   938 ----------------RSGTWASRRSSWNSLKHKPPSA--------EHESLLSG--ERGG----- 971

  Fly  1358 LPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFV 1422
                       |.|                    |:.|..|   ||
Mouse   972 -----------SCV--------------------RACEGAR---ED------------------- 983

  Fly  1423 AMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEK 1487
                          |.|..:|
Mouse   984 --------------APPRAAP-------------------------------------------- 990

  Fly  1488 MPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISS 1552
                 ||.|
Mouse   991 -----LHAP-------------------------------------------------------- 994

  Fly  1553 LKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSA 1617
                        |..|.|     ..|..||.|.|          .||.:     :||...|...|
Mouse   995 ------------HTHHAH-----HGPHLAHRHRH----------HRRTL-----SLDTRDSVDLA 1027

  Fly  1618 R----TESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTV 1678
            .    ..:||..|..|:     ..|...|......|:..:  ..||::            ||
Mouse  1028 ELVPVVGAHSRAAWRAA-----GQAPGHEDCNGRMPNIAK--DVFTKM------------DD--- 1070

  Fly  1679 GGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTA 1743
               |..:|...:.:.:..  ..:..|:.|...|..|    ..|..|.:.....::     :.|..
Mouse  1071 ---RRDRGEDEEEIDYTL--CFRVRKMIDVYKPDWC----EVREDWSVYLFSPEN-----KFRIL 1121

  Fly  1744 VLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALG 1808
            ..|::....|::.||..||.:.||:..|...::...|.:..|...|:.|..|||.||.||.::||
Mouse  1122 CQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLG 1186

  Fly  1809 F----SKYFTSFWTILDFIIVFVSVFSLLIE-----ENENLKVLRSLRTLRALRPLRAISRWQGM 1864
            .    ..|..|.|.:||..:||||:..:::.     ..:.|.|||.||.||.|||||.|||..|:
Mouse  1187 LYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSVASAGGAKILGVLRVLRLLRTLRPLRVISRAPGL 1251

  Fly  1865 RIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEMGELLPITEVNDKWDCIEQ 1929
            ::||..|:.::..|.|::|:|..|::||.|:|||.|.|||:.|:.     :....:.::.||:..
Mouse  1252 KLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLG-----VDTRNITNRSDCVAA 1311

  Fly  1930 NYTWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVC 1994
            ||.|::.|..||::|...::|..:|:.:||:.:|.:.:||..||.||....|.:..:||:.|::.
Mouse  1312 NYRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLI 1376

  Fly  1995 GSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPINHFLA 2059
            .|||.||:|:||:::||:..::..|.       .|:::.....:::| .||.:|..:.|   :.|
Mouse  1377 VSFFVLNMFVGVVVENFHKCRQHQEA-------EEARRREEKRLRRL-EKKRRKAQRLP---YYA 1430

  Fly  2060 -------MFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIV 2117
                   :.:.:..|...:|.|..:|.||::||.:|||:||.::...|:..|..|||||.|||::
Mouse  1431 TYCPTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVL 1495

  Fly  2118 KIV--GLRYHYFTVPWNVFDFLLVLASIFGILMEDIMID--LPISPTLLRVVRVFRIGRILRLIK 2178
            |:|  ||| .:|...||..|..:||.|:.||.:|:|.|:  |||:||::|::||.||.|:|:|:|
Mouse  1496 KLVAFGLR-RFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLK 1559

  Fly  2179 AAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKLQG-----ALDDMVNFQTFG 2238
            .|.|:|.||..:|.:||.:.|:|.|..|:.||||.||:.|||.:....     .:.....|:.||
Mouse  1560 MATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEGMSRHATFENFG 1624

  Fly  2239 RSMQLLFRLMTSAGWNDVLESLMIQPPDCDPFIHGHTNGNCGHPLLAIT--YFTSFIIISYMIVI 2301
            .:...||::.|...||.:::..:   .||.     |...:|...|..::  ||.||::.:..::|
Mouse  1625 MAFLTLFQVSTGDNWNGIMKDTL---RDCT-----HDERSCLSSLQFVSPLYFVSFVLTAQFVLI 1681

  Fly  2302 NMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLD------- 2359
            |:.:|:::::.:.:::|     .::|.||                      |....|:
Mouse  1682 NVVVAVLMKHLDDSNKE-----AQEDAEM----------------------DAEIELEMAHGLGP 1719

  Fly  2360 -------------------PPLGISKPNNVALVSFNLPISKGNKIHCLDILHALVKHVLGHVEET 2405
                               |.:..|.|......|....:....:.|       |.:|.....:||
Mouse  1720 GPGPCPCPCPCPCPCPCPGPRMPTSSPGAPGRGSGGAGVGGDTESH-------LCRHCYSPAQET 1777

  Fly  2406 DNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEKAAKTIQTGWKEYLRRKREKERSNSGDS 2470
                                   |.:.|.:.|.|...:...||..              :.||..
Mouse  1778 -----------------------LWLDSVSLIIKDSLEGELTIID--------------NLSGSI 1805

  Fly  2471 ATQTSSPGGW-----------------------------------QSKLSALNFFHLQVSRRG-- 2498
            ....|||.|.                                   |.:|:....|.|...|..
Mouse  1806 FHHYSSPAGCDKCHHDKQEGPVAQRSRPRLPHPSPRVTRGHHLPPQVQLAETEAFSLNSDRSSSV 1870

  Fly  2499 -----------TACSSRASSRKSS----RASDASDLSELAGPWLNLP-------LMLVSGA---D 2538
                       |||.......|..    ....|.||.|...|:...|       |:...||   :
Mouse  1871 LLGDDLSLEDPTACPQGPKESKGELEPPEPMQAGDLDECFFPFAGEPVSAGPESLLCEMGAIPFN 1935

  Fly  2539 EVVKDIKQQNDE--------------LGKRGSIFVEAPRASRR--------RSFYNFFLRHQDAV 2581
            .|...:|.::::              |......|..|..||::        .:.....|:...|
Mouse  1936 PVQSWLKHESNQAPPSPFSPDGSSPLLQMPAEFFHPAVSASQKGQEPGMSSGTLPKIALQGSWA- 1999

  Fly  2582 DDSLTSPSVHRKTAMNNTTNTTSNSASTSGTASSTATAPATGCGPAATSASDSDRHQAVGGGSAP 2646
              ||.||||:.......|.:.||..||.|.:|.|..|....     :.:.|||.| :|:|.....
Mouse  2000 --SLRSPSVNCTLLRQATVSDTSLDASPSSSAGSLQTTLED-----SLTLSDSPR-RALGPPVQV 2056

  Fly  2647 SRKRA--SSFIRKKPPLE-RGLSAQSALRVNKNAFVSEASAPEVIVTRPSPEQQTHPHSLSLRPD 2708
            ...||  |...|::..|. |||.:...||.::.:..|..|      |.|.   .|:..|:
Mouse  2057 PGPRASLSPATRRRLSLRGRGLFSLRGLRAHQRSHSSGGS------TSPG---CTYHDSM----- 2107

  Fly  2709 NATLVHVLVHRESEEYKEEDESSPSVSGNGNGFGVGLDMLSKQPPPQIRITTGSVESSMDTCAMP 2773
                               |.|.....|...|.|.|.:...         |..|:..:...|..|
Mouse  2108 -------------------DPSDEEGRGGAGGGGAGSEHSE---------TLSSLSLTSLFCLPP 2144

  Fly  2774 TVQIMVDSPKDPPRG-----DFSS------APIDDVGAP-IDVNVQGDTSQVFYDYNPEKATDDQ 2826
            |:         ||.|     .|||      .|    |.| ..|:|:|.....  .:..:::.|..
Mouse  2145 TL---------PPPGLTPARKFSSTSSLAAGP----GRPGATVSVRGLARSP--SWAADRSKDPP 2194

  Fly  2827 GNGQDETAQFESLPDRQRXPPVNTPLRDSEKR 2858
            |..|..:....|.|:.|. |..:|......||
Mouse  2195 GQAQLASGFGSSAPEPQPPPGESTDAASKRKR 2226

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	152..371	CDD:278921	68/290 (23%)
		Ion_trans	705..902	CDD:278921	68/202 (34%)
		Ion_trans	1768..2019	CDD:278921	93/259 (36%)
		Na_channel_gate	2009..2063	CDD:240441	10/60 (17%)
		Ion_trans	2085..2320	CDD:278921	89/245 (36%)
		GPHH	2331..2386	CDD:293510	6/80 (8%)
Cacna1i	XP_006521012.1	Ion_trans	76..407	CDD:366146	89/357 (25%)
		Ion_trans	597..824	CDD:366146	77/233 (33%)
		Ion_trans	1128..1400	CDD:366146	100/276 (36%)
		Ion_trans	1445..1700	CDD:366146	96/268 (36%)
		PHA03307	1867..>2226	CDD:223039	90/424 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810