DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NaCP60E and Catsper2

DIOPT Version :9

Sequence 1:	NP_001261172.1	Gene:	NaCP60E / 37981	FlyBaseID:	FBgn0085434	Length:	2896	Species:	Drosophila melanogaster
Sequence 2:	NP_694715.2	Gene:	Catsper2 / 212670	MGIID:	2387404	Length:	588	Species:	Mus musculus

Alignment Length:	323	Identity:	80/323 - (24%)
Similarity:	152/323 - (47%)	Gaps:	69/323 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly  1747 VVDTPAFEWFVLVLIFASSITLCFEDINLDKNKT----LKRVLYWINFSFCLIFVVEMILKWLAL 1807
            |:|:..|..|::.|||.::..|..|...::...|    :|..|...::...|.|:||::|.|||
Mouse   102 VLDSSVFSKFIISLIFLNTFVLMVEIELMESTNTALWPVKLALEVADWFILLSFIVEILLMWLA- 165

  Fly  1808 GFSKYFTSFWTILDFIIVFVSVFSLLIEENENLKV------LRSLRTLRALRPLRAISRWQGMRI 1866
            .||.::...|.:.||   ||::.|||.|....|.|      |:.||..|.||.|:..:|::.:::
Mouse   166 SFSLFWKDAWNVFDF---FVTLLSLLPELVVLLGVPAHSVWLQLLRVCRVLRSLKLFARFRQIKV 227

  Fly  1867 VVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEMGELLPITEVNDKWDCIEQNY 1931
            ::.||:.|:.|:..:|::.|:|:.||::.||.|| .::.:...|               .:|.|.
Mouse   228 ILLALVRALKSMTFLLMLLLIFFYIFAVTGVYFF-REYSRSTIE---------------GLEYNM 276

  Fly  1932 TW---INSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIV 1993
            .:   :||.:|          :..:.|.:.|..|:.|.       .:....:.:::.||.:::::
Mouse   277 FFSDLLNSLVT----------VFILFTLDHWYAVLQDI-------WKVPESSRVFSSIYVILWLL 324

  Fly  1994 CGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKH----YYTAMKKLGRKKPQKVIKR 2052
            .||....|:.:.:::.||..::.:         |:|...|    |...|.|      |::|:|
Mouse   325 LGSIIFRNIIVAMMVTNFQNIRSE---------LSEEMSHLEVQYKADMFK------QQIIQR 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	152..371	CDD:278921
		Ion_trans	705..902	CDD:278921
		Ion_trans	1768..2019	CDD:278921	64/263 (24%)
		Na_channel_gate	2009..2063	CDD:240441	11/48 (23%)
		Ion_trans	2085..2320	CDD:278921
		GPHH	2331..2386	CDD:293510
Catsper2	NP_694715.2	Ion_trans	105..350	CDD:366146	69/290 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810