DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NaCP60E and Scn9a

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:NP_001277603.1 Gene:Scn9a / 20274 MGIID:107636 Length:1984 Species:Mus musculus


Alignment Length:2596 Identity:815/2596 - (31%)
Similarity:1166/2596 - (44%) Gaps:864/2596 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 PRTKASVEDGDVLPRKFEPFPEHMYGKPLEEIDTFIYE-ETFCVVSKRFRKNYIHRFTGTKSLFL 108
            |:..:.:|.|..||..:...|..|..:|||::|.:..: :||.|::|   ...|.||..|.:|::
Mouse    47 PKPSSDLEAGKQLPFIYGDIPPGMVSEPLEDLDPYYADKKTFIVLNK---GKAIFRFNATPALYM 108

  Fly   109 FYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLAMT---ETVEEAEYIFLAIYSIEMVIKIIA 170
            ..|:||.||:.:.|..:..|...:|.|||.||||:.|:   :..:..||.|..||:.|.:|||:|
Mouse   109 LSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTMSNPPDWTKNVEYTFTGIYTFESLIKILA 173

  Fly   171 KGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINAL 235
            :||.:.::|:||:||||||||||...|.|..:.:||::.||||||||||||:|::||||||:.||
Mouse   174 RGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGAL 238

  Fly   236 LHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVPTDWTNVSHTDWQIWVNDTDNWLY 300
            :.|.::|::||.||:|||.||||..||::||.|::||.|:             .:..|:|...:.
Mouse   239 IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRK-------------DLEQNETLESIM 290

  Fly   301 ----DEDEL------------PVLCGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFMWSMLTTF 349
                .|:||            .:|||..|.:..||..|.|:..|.||::|||:||.|.|:.|..|
Mouse   291 STAESEEELKRYFYYLEGSKDALLCGFSTDSGQCPEGYECVTAGRNPDYGYTSFDTFGWAFLALF 355

  Fly   350 QLITLDYWENVYNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNEERKKDL 414
            :|:|.|||||:|...|...|...:.||.||:|.||||||||:|||||::|||:.:...||.|:  
Mouse   356 RLMTQDYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQ-- 418

  Fly   415 LDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGKEGGTNGNGNGS 479
                         ..|..:::....||:.:..:.:..|:.......|.:..|..|         |
Mouse   419 -------------KELEFQQMLDRLKKEQEEAEAIAAAAAEYTSLGRSRIMGLSE---------S 461

  Fly   480 NGDDNKSHSATPSPGPSPRHSATERPSALTMQAQK--QYQQMEQQHKLAKSGSGGSNNPMAPTPK 542
            :.:.::..|          .||.||.:....:.||  ..::.....||:||||..|         
Mouse   462 SSETSRLSS----------KSAKERRNRRKKKKQKLSSGEEKGDDEKLSKSGSEES--------- 507

  Fly   543 GRISFQDSGMGVK-----------NPNMLYPSDYKGQLIANSGQPSSNSS-----------GVNR 585
              |..:...:||:           .||. .|...:|.|.  |.:.||.:|           |...
Mouse   508 --IRKKSFHLGVEGHHRAREKRLSTPNQ-SPLSIRGSLF--SARRSSRTSLFSFKGRGRDLGSET 567

  Fly   586 ESSQDDSGVVDDHEEQDTTNDMGHVSTVELALSPREVR----------------------LIKCN 628
            |.:.|:..:..|:|.:..:..:.|        .|||.|                      .:.||
Mouse   568 EFADDEHSIFGDNESRRGSLFVPH--------RPRERRSSNISQASRSPPVLPVNGKMHSAVDCN 624

  Fly   629 GNIARIKNHNVYAL-HQEFSSEVVV---------------------------------------- 652
            |.::.:...:...| :.:...||::                                        
Mouse   625 GVVSLVDGPSALMLPNGQLLPEVIIDKATSDDSGTTNQMRKKRLSSSYFLSEDMLNDPHLRQRAM 689

  Fly   653 ---------IDDLPDRNCDRCVHW------------CTDYESWLQFQNCLYKVVRDPLFELAITL 696
                     :::| :.:..:|..|            |:.|  |::|:..:|.:|.||..:||||:
Mouse   690 SRASILTNTVEEL-EESRQKCPPWWYRFAHTFLIWNCSPY--WIKFKKFIYFIVMDPFVDLAITI 751

  Fly   697 CIVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIFTFECIVKLMALSK-DFFLCGWNIFDLLIVT 760
            ||||||.|:|||||.|::.|:|.|.|||.|||.||..|.::||:|:.. ::|..||||||.||||
Mouse   752 CIVLNTLFMAMEHHPMTDEFKNVLAVGNLVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVT 816

  Fly   761 ASLLDIIFELVDGLSVLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAV 825
            .||:::....|:||||||..|||||.|||:||.|:.:|:.||.:::||||||||:|.|:::||||
Mouse   817 LSLVELFLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV 881

  Fly   826 IGMQLFSKDYTP--EKFDPD-PVPRWNFNDFFHSFMMIFRILCGEWIEPLWDCMRAEEEQGASTC 887
            :|||||.|.|..  .|.:.: .:|||:.|||||||:::||:|||||||.:||||   |..|.:.|
Mouse   882 VGMQLFGKSYKECVCKINENCKLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCM---EVAGQTMC 943

  Fly   888 FAIFLPTLVMGNFMVLNLFLALLLNSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKD 952
            ..:::..:|:||.:||||||||||:||:|:.|.:.:|                            
Mouse   944 LIVYMMVMVIGNLVVLNLFLALLLSSFSSDNLTAIEE---------------------------- 980

  Fly   953 RKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDF 1017
                                                                             
Mouse   981 ----------------------------------------------------------------- 980

  Fly  1018 GFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGN 1082
                                                                             
Mouse   981 ----------------------------------------------------------------- 980

  Fly  1083 GTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGS 1147
                                                              |||  ||:.:.....
Mouse   981 --------------------------------------------------DTD--ANNLQIAVAR 993

  Fly  1148 FNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMR 1212
            ..||                    :.|.|.                                   
Mouse   994 IKRG--------------------INYVKQ----------------------------------- 1003

  Fly  1213 RHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRP 1277
                                   .|||.:|....|:           .||:|     :..|:..|
Mouse  1004 -----------------------TLREFILKSFSKK-----------PKGSK-----DTKRTADP 1029

  Fly  1278 SSQM-GQPENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHI 1341
            :::. ....|.|:.|.|:..|    |.||.::|...::||                         
Mouse  1030 NNKRENYISNRTLAEISKDHN----FLKEKDKISGFSSSL------------------------- 1065

  Fly  1342 AIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSI 1406
                   ::|..||     |.|.|                                         
Mouse  1066 -------DKSFMDE-----NDYQS----------------------------------------- 1077

  Fly  1407 SNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEV 1471
                                                                             
Mouse  1078 ----------------------------------------------------------------- 1077

  Fly  1472 PEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPT 1536
                                |:|.|                                        
Mouse  1078 --------------------FIHNP---------------------------------------- 1082

  Fly  1537 SLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRM 1601
                           ||..|.|:|                                  .|:    
Mouse  1083 ---------------SLTVTVPIA----------------------------------PGE---- 1094

  Fly  1602 EHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPW 1666
                      :..::..||..||   |:.|..:     |..:::|::.:.               
Mouse  1095 ----------SDLENMNTEELSS---DSDSDYS-----KERRNRSSSSEC--------------- 1126

  Fly  1667 HCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDT 1731
                |.||:...|    .:.|..:|:.         |..|:.||...|...|    |.....:|:
Mouse  1127 ----STVDNPLPG----EEEAEAEPIN---------ADEPEACFTDGCVRRF----PCCQVNIDS 1170

  Fly  1732 QSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIF 1796
            ...|.|..:|.....:|:...||.|::::|..||..|.||||.::|.||:|.:|.:.:..|..||
Mouse  1171 GKGKVWWTIRKTCYRIVEHSWFESFIVLMILLSSGALAFEDIYIEKKKTIKIILEYADKIFTYIF 1235

  Fly  1797 VVEMILKWLALGFSKYFTSFWTILDFIIVFVSVFSLLIEE--NENLKVLRSLRTLRALRPLRAIS 1859
            ::||:|||:|.|:..|||:.|..|||:||.||:.:|:...  ..:|..::|||||||||||||:|
Mouse  1236 ILEMLLKWVAYGYKTYFTNAWCWLDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALS 1300

  Fly  1860 RWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEM-GELLPITEVNDK 1923
            |::|||:|||||:.|||||.|||||||:||||||||||..|.|||::|||.. |....:::|.::
Mouse  1301 RFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECVNTTDGSRFSVSQVANR 1365

  Fly  1924 WDC-----IEQNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLY 1983
            .:|     :..|..|.|.|:.||:||:|||:|||||||:|||::|..|||:..|:.||..|.|||
Mouse  1366 SECFALMNVSGNVRWKNLKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVDSVNVNAQPIYEYNLY 1430

  Fly  1984 AYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQK 2048
            .||||||||:.||||||||||||||||||..|||..|  .::|:||.||.||.||||||.|||||
Mouse  1431 MYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGG--QDIFMTEEQKKYYNAMKKLGSKKPQK 1493

  Fly  2049 VIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGL 2113
            .|.||.|.|....:||..::.|:|.|.|||.|||:||.:|...|...:.|:|...|..|..:|..
Mouse  1494 PIPRPGNKFQGCIFDLVTNQAFDITIMVLICLNMVTMMVEKEGQTDYMSFVLYWINVVFIILFTG 1558

  Fly  2114 EAIVKIVGLRYHYFTVPWNVFDFLLVLASIFGILMEDIMIDLPISPTLLRVVRVFRIGRILRLIK 2178
            |.::|::.||::||||.||:|||::|:.||.|:.:.:::....:||||.||:|:.||||||||||
Mouse  1559 ECVLKLISLRHYYFTVGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLARIGRILRLIK 1623

  Fly  2179 AAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKLQGALDDMVNFQTFGRSMQL 2243
            .|||||.|||||::|||||||||.||.|:.|||||.|||.|..||.:..::||.||:|||.||..
Mouse  1624 GAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEAGINDMFNFETFGNSMIC 1688

  Fly  2244 LFRLMTSAGWNDVLESLM-IQPPDCDP-FIH--GHTNGNCGHPLLAITYFTSFIIISYMIVINMY 2304
            ||::.|||||:.:|..:: ..|||||| .:|  ....|:||:|.:.|.||.|:||||:::|:|||
Mouse  1689 LFQITTSAGWDGLLAPILNSAPPDCDPKKVHPGSSVEGDCGNPSVGIFYFVSYIIISFLVVVNMY 1753

  Fly  2305 IAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISKPNN 2369
            ||:|||||:.|.:|....:.|||.||||..|.|:||.|||||.|.:||||.|:|||||.|:|||.
Mouse  1754 IAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQFIEFCKLSDFAAALDPPLLIAKPNK 1818

  Fly  2370 VALVSFNLPISKGNKIHCLDILHALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPTRKELEIVSS 2434
            |.|::.:||:..|::|||||||.|..|.|||...|.|:   |:.||:.:|....|::...|.:::
Mouse  1819 VQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDS---LRSQMEERFMSANPSKVSYEPITT 1880

  Fly  2435 TRIWKRQEKAAKTIQTGWKEYLRRKREKERSN----SG--------------DSATQTSSP 2477
            |...|:::.:|..||..::.|..|:..|..|:    .|              |:..:.|||
Mouse  1881 TLKRKQEDVSATIIQRAYRRYRLRQNVKNISSIYIKDGDRDDDLPNKEDIVFDNVNENSSP 1941

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 106/234 (45%)
Ion_trans 705..902 CDD:278921 106/200 (53%)
Ion_trans 1768..2019 CDD:278921 149/258 (58%)
Na_channel_gate 2009..2063 CDD:240441 31/53 (58%)
Ion_trans 2085..2320 CDD:278921 124/238 (52%)
GPHH 2331..2386 CDD:293510 31/54 (57%)
Scn9aNP_001277603.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 26..55 1/7 (14%)
I. /evidence=ECO:0000305 112..410 142/310 (46%)
Ion_trans 147..410 CDD:278921 127/275 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 458..540 22/112 (20%)
Na_trans_cytopl 487..606 CDD:288761 29/140 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 574..609 7/42 (17%)
II. /evidence=ECO:0000305 725..988 145/477 (30%)
Ion_trans 760..955 CDD:278921 104/197 (53%)
Na_trans_assoc 981..1185 CDD:284034 70/613 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1015..1039 6/39 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1089..1145 17/134 (13%)
III. /evidence=ECO:0000305 1178..1486 168/309 (54%)
Ion_trans 1224..1464 CDD:278921 138/239 (58%)
Na_channel_gate 1456..1508 CDD:240441 31/53 (58%)
IV. /evidence=ECO:0000305 1495..1793 153/297 (52%)
Ion_trans 1530..1768 CDD:278921 123/237 (52%)
GPHH 1780..1835 CDD:293510 31/54 (57%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1933..1984 4/9 (44%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100419
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.710

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