DRSC/TRiP Functional Genomics Resources

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Protein Alignment NaCP60E and Scn8a

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:XP_017172001.1 Gene:Scn8a / 20273 MGIID:103169 Length:1988 Species:Mus musculus


Alignment Length:2676 Identity:821/2676 - (30%)
Similarity:1170/2676 - (43%) Gaps:899/2676 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 PRTKASVEDGDVLPRKFEPFPEHMYGKPLEEIDT-FIYEETFCVVSKRFRKNYIHRFTGTKSLFL 108
            |:..:.:|.|..||..:...|:.:...|||:.|. ::.::||.|::   |...:.||:.|.:|::
Mouse    53 PKPNSDLEAGKSLPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLN---RGKTLFRFSATPALYI 114

  Fly   109 FYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLAMT---ETVEEAEYIFLAIYSIEMVIKIIA 170
            ..|::..||:.:.|..:..|...:|.|||.||:|:..:   |..:..||.|..||:.|.::||||
Mouse   115 LSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPEWSKNVEYTFTGIYTFESLVKIIA 179

  Fly   171 KGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINAL 235
            :||.::.:|:||:|||||||.||...|.|..:::||::.||||||||||||:|::||||||:.||
Mouse   180 RGFCIDGFTFLRDPWNWLDFSVIMMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGAL 244

  Fly   236 LHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVPTDWT---NVSHT-------DWQI 290
            :.|.::|::||.||:|||.||||..||::||.||||||     .|.   |.|:.       ||:.
Mouse   245 IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCV-----VWPINFNESYLENGTRGFDWEE 304

  Fly   291 WVNDTDNWLYDEDEL-PVLCGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITL 354
            ::|:..|:......| |:||||.:.|..||..:.|:..|.|||:|||:||.|.|:.|..|:|:|.
Mouse   305 YINNKTNFYMVPGMLEPLLCGNSSDAGQCPEGFQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQ 369

  Fly   355 DYWENVYNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNEERKKDLLDHRD 419
            |||||:|.:.|...|...:.||.:|:|.|||||:||:|||||::|||:.:.|.||.:      :.
Mouse   370 DYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATLEEAE------QK 428

  Fly   420 DSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGG-------KEGGTNGNGN 477
            ::.|         |.:.:..||:.:..:...:|           |..|       :|.|.:|.|:
Mouse   429 EAEF---------KAMLEQLKKQQEEAQAAAMA-----------TSAGTVSEDAIEEEGEDGVGS 473

  Fly   478 GSNGDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQ---HKLAKSGS-GGSNNPMA 538
            ..:..:....|:         .||.||.:....:.||:..:.|::   .|:.||.| .|......
Mouse   474 PRSSSELSKLSS---------KSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKAF 529

  Fly   539 PTPKGRIS-----FQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQDDSGVVDDH 598
            ..|..||.     ...|.:.:.....|...:.|..:.:..|.......|...|.:.|:...|::.
Mouse   530 RLPDNRIGRKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEES 594

  Fly   599 EEQDTTNDMGHVSTVELALSPREVR------------------------------LIKCNGNIAR 633
            |        |...::.:.:..||.|                              .:.|||.::.
Mouse   595 E--------GRRDSLFIPIRARERRSSYSGYSGYSQCSRSSRIFPSLRRSVKRNSTVDCNGVVSL 651

  Fly   634 I-KNHNVYALHQEF----------SSEV-----------------------------------VV 652
            | ...::..|..|.          ::||                                   .:
Mouse   652 IGPGSHIGRLLPEVKIDKAATDSATTEVEIKKKGPGSLLVSMEQLASYGRKDRINSIMSVVTNTL 716

  Fly   653 IDDLPD--RNCDRCVH--------W-CTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLA 706
            :::|.:  |.|..|.:        | |..|  |::.:..:..:|.||..:||||:||||||.|:|
Mouse   717 VEELEESQRKCPPCWYKFANTFLIWECHPY--WIKLKEIVNLIVMDPFVDLAITICIVLNTLFMA 779

  Fly   707 MEHHGMSESFRNALDVGNKVFTSIFTFECIVKLMALSK-DFFLCGWNIFDLLIVTASLLDIIFEL 770
            ||||.|:..|.:.|.|||.|||.|||.|..:||:|:.. .:|..||||||..||:.||:::....
Mouse   780 MEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELGLAD 844

  Fly   771 VDGLSVLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDY 835
            |:||||||..|||||.|||:||.|:.:|:.||.:::||||||||:|.|:::||||:|||||.|.|
Mouse   845 VEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY 909

  Fly   836 TP--EKFDPD-PVPRWNFNDFFHSFMMIFRILCGEWIEPLWDCMRAEEEQGASTCFAIFLPTLVM 897
            ..  .|...: .:|||:.|||||||:::||:|||||||.:||||   |..|.:.|..:|:..:|:
Mouse   910 KECVCKISQECKLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCM---EVAGQAMCLIVFMMVMVI 971

  Fly   898 GNFMVLNLFLALLLNSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKF 962
            ||.:||||||||||:||:::.|.:..:: ||.:.|..|:.|:                       
Mouse   972 GNLVVLNLFLALLLSSFSADNLAATDDD-GEMNNLQISVIRI----------------------- 1012

  Fly   963 QQIVLDAQQAHAQTLSHQAAVGLERGDKPGVL-AETKFHRLSYQESMNRPVSGSDFGFQIPLHDG 1026
                                       |.||. |:.|.|..                        
Mouse  1013 ---------------------------KKGVAWAKVKVHAF------------------------ 1026

  Fly  1027 LHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPP---TYE---SAMMATTG------GSFSSV 1079
                                 :|||.....:|.:.|   .||   :.:...||      |.|.. 
Mouse  1027 ---------------------MQAHFKQREADEVKPLDELYEKKANCIANHTGVDIHRNGDFQK- 1069

  Fly  1080 NGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSG 1144
            |||||                                                         .||
Mouse  1070 NGNGT---------------------------------------------------------TSG 1077

  Fly  1145 CGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEA 1209
            .||          |..:|..:|...:|:. ..:|..|.|                          
Mouse  1078 IGS----------SVEKYIIDEDHMSFIN-NPNLTVRVP-------------------------- 1105

  Fly  1210 EMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRS 1274
                                                                             
Mouse  1106 ----------------------------------------------------------------- 1105

  Fly  1275 RRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIME 1339
                         ..|..|:|:|:      ..|::           |:.|:|..:.|        
Mouse  1106 -------------IAVGESDFENL------NTEDV-----------SSESDPEGSKD-------- 1132

  Fly  1340 HIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDF 1404
                                                                       |:|:  
Mouse  1133 -----------------------------------------------------------KLDD-- 1136

  Fly  1405 SISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVE 1469
                                       ||:|:.                      ..:.:...||
Mouse  1137 ---------------------------TSSSEG----------------------STIDIKPEVE 1152

  Fly  1470 EVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATP 1534
            |||                                                              
Mouse  1153 EVP-------------------------------------------------------------- 1155

  Fly  1535 PTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRR 1599
                                                                             
Mouse  1156 ----------------------------------------------------------------- 1155

  Fly  1600 RMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEK 1664
             :|.|:..||                                                       
Mouse  1156 -VEQPEEYLD------------------------------------------------------- 1164

  Fly  1665 PWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSC- 1728
                                                     ||.||.:.|...  |:|     | 
Mouse  1165 -----------------------------------------PDACFTEGCVQR--FKC-----CQ 1181

  Fly  1729 --MDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFS 1791
              ::....|.|..:|.....:|:...||.|::.:|..||..|.||||.:::.||::.:|.:.:..
Mouse  1182 VNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKV 1246

  Fly  1792 FCLIFVVEMILKWLALGFSKYFTSFWTILDFIIVFVSVFSLLIEE--NENLKVLRSLRTLRALRP 1854
            |..||::||:|||.|.||.|:||:.|..|||:||.||:.||:...  ...|..::||||||||||
Mouse  1247 FTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRP 1311

  Fly  1855 LRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEMGEL-LPIT 1918
            |||:||::|||:|||||:.|||||.|||||||:||||||||||..|.||:..|.||..|: ..|.
Mouse  1312 LRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNETSEIRFEID 1376

  Fly  1919 EVNDKWDC---IEQNYT---WINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQ 1977
            |||:|.||   :|.|.|   |.|.||.||:||.|||||||||||:|||::|..|||:|..|.||.
Mouse  1377 EVNNKTDCEKLMEGNNTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPD 1441

  Fly  1978 REANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLG 2042
            .|.|:|.||||||||:.||||||||||||||||||..|||:.|  .::|:||.||.||.||||||
Mouse  1442 YEGNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGG--QDIFMTEEQKKYYNAMKKLG 1504

  Fly  2043 RKKPQKVIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFF 2107
            .|||||.|.||:|....:.:|....:.|:|.|.:||.|||:||.:|...|...:..||...|..|
Mouse  1505 SKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVF 1569

  Fly  2108 TTVFGLEAIVKIVGLRYHYFTVPWNVFDFLLVLASIFGILMEDIMIDLPISPTLLRVVRVFRIGR 2172
            ...|..|.::|:..||::|||:.||:|||::|:.||.|:.:.||:....:||||.||:|:.||||
Mouse  1570 VIFFTCECVLKMFALRHYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARIGR 1634

  Fly  2173 ILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKLQGALDDMVNFQTF 2237
            ||||||.|||||.|||||::|||||||||.||.|:.||::|.|||.|..||.:..:|||.||:||
Mouse  1635 ILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFNFETF 1699

  Fly  2238 GRSMQLLFRLMTSAGWNDVLESLMIQPPDC--DPFIHGH-TNGNCGHPLLAITYFTSFIIISYMI 2299
            |.||..||::.|||||:.:|..::.:||||  |....|. ..|:||:|.:.|.:|.|:||||::|
Mouse  1700 GNSMICLFQITTSAGWDGLLLPILNRPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLI 1764

  Fly  2300 VINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGI 2364
            |:|||||||||||:.|.:|....:.|||.|.||..|.|:||.|||||.:.:|:||..:|:.||.:
Mouse  1765 VVNMYIAIILENFSVATEESADPLSEDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRV 1829

  Fly  2365 SKPNNVALVSFNLPISKGNKIHCLDILHALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPTRKEL 2429
            .|||.:.|::.:||:..|::|||||||.|..|.|||...|.|   .|::||:.:|....|::...
Mouse  1830 PKPNTIELIAMDLPMVSGDRIHCLDILFAFTKRVLGDSGELD---ILRQQMEERFVASNPSKVSY 1891

  Fly  2430 EIVSSTRIWKRQEKAAKTIQTGWKEYLRRKREKERSNSGDSATQTSSPGGWQSKLSALNFFHLQV 2494
            |.:::|...|::|.:|..:|..::.:|                                      
Mouse  1892 EPITTTLRRKQEEVSAVVLQRAYRGHL-------------------------------------- 1918

  Fly  2495 SRRGTACSSRASSRKSSRASDASDLSELAGPWLNLPLMLVSGADEVVK--DIKQQNDELGKRGSI 2557
            :|||..| .:.:|.|........:..|......:||     ..|.|.|  ..|||..|.|:|   
Mouse  1919 ARRGFIC-RKITSNKLENGGTHREKKESTPSTASLP-----SYDSVTKPDKEKQQRAEEGRR--- 1974

  Fly  2558 FVEAPRASRRR 2568
                .||.|::
Mouse  1975 ----ERAKRQK 1981

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 112/229 (49%)
Ion_trans 705..902 CDD:278921 105/200 (53%)
Ion_trans 1768..2019 CDD:278921 157/259 (61%)
Na_channel_gate 2009..2063 CDD:240441 30/53 (57%)
Ion_trans 2085..2320 CDD:278921 124/237 (52%)
GPHH 2331..2386 CDD:293510 24/54 (44%)
Scn8aXP_017172001.1 Ion_trans 131..421 CDD:366146 140/294 (48%)
Na_trans_cytopl 504..710 CDD:371806 30/213 (14%)
Ion_trans 760..973 CDD:366146 116/215 (54%)
Na_trans_assoc 999..1200 CDD:368948 72/835 (9%)
Ion_trans 1205..1481 CDD:366146 161/275 (59%)
Na_channel_gate 1473..1525 CDD:240441 30/53 (57%)
Ion_trans 1530..1784 CDD:366146 132/253 (52%)
GPHH 1796..1843 CDD:374878 21/46 (46%)
IQ 1902..1923 CDD:197470 6/58 (10%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100419
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.750

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