DRSC/TRiP Functional Genomics Resources

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Protein Alignment NaCP60E and Scn7a

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:NP_033161.2 Gene:Scn7a / 20272 MGIID:102965 Length:1681 Species:Mus musculus


Alignment Length:2518 Identity:616/2518 - (24%)
Similarity:975/2518 - (38%) Gaps:908/2518 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 VVAYTQRSQVKHENRHI------QLVREYGFHPRTKASVEDGDVLPRKFEPFPEHMYGKPLEEID 77
            :|.:|..|....|| ||      ....|.|..|  ..::|.|..||..:...|.....:|||::|
Mouse    10 LVPFTTESLELIEN-HIAKKCNEDPEEEEGLKP--SRNLEAGKRLPIPYGTLPRGTVSEPLEDVD 71

  Fly    78 TFIY--EETFCVVSKRFRKNYIHRFTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATILFNC 140
            .:.|  ..||.|::   |...|.||..........|.:..||..:....:..|...::.::|.:.
Mouse    72 PYYYVKRNTFMVLN---RSRVIFRFNAVSIFCTLSPLNSLRRAAIKALVHPLFRLLILISVLTDS 133

  Fly   141 IFLAMT---ETVEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATIGM 202
            |.:.|:   |.:...|...|.||:.|:::|:||:|.....:::|.:.||||||.|......|...
Mouse   134 ILMCMSNLPEWILAIENTLLGIYAFEILVKVIARGIWAGSFSFLGDLWNWLDFSVTLFELITRFS 198

  Fly   203 EVGNLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGE 267
            .:.:...|:|.|..|.||.:.:..||::|:..|....::|...:.|.:|.|.||:|..:.::||.
Mouse   199 PLSSFLMLKTIRTFRILKIIPLNHGLQSIVMTLAQCLKKLFGAIALALFFLAVFSLLGMGLFMGN 263

  Fly   268 LRNKCVRQVPTDWTNVSHTDWQIWVNDTDNWLYDEDEL----------PVLCGNLTGARHCPFEY 322
            |::||:|....:.....|       |.|.:..|..:.:          .:||||.|.|..||..|
Mouse   264 LKHKCLRWPEENENETLH-------NRTGSLNYSPERINFYYMEGAKYALLCGNRTDAGQCPEGY 321

  Fly   323 VCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCGPMSVSFFTVVVFFGSFYL 387
            ||:..|.||::|:|:||||.||:|..|:|:|.||.|.:|:.:|...|.:.:.||.::.|:.:|||
Mouse   322 VCVKEGTNPDNGFTSFDNFGWSLLAMFRLMTQDYPELLYHQILYASGKVYMIFFVMISFWFAFYL 386

  Fly   388 INLMLAVVALSYEEEAEITNEERKKDLLDHRDDSTFSFDPSV-LNVKKLNKNNKKKIDSRKGVLL 451
            .:|.|.::.::||:|.:...||            :...||.. ..||:|::.|.           
Mouse   387 TSLFLGILTMTYEKEKQRACEE------------SGGLDPKCQQTVKELDEEND----------- 428

  Fly   452 ASYSKKKTRRKKTKGGKEGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQY 516
                                                                       .|:.:.
Mouse   429 -----------------------------------------------------------AAEMET 434

  Fly   517 QQMEQQHKLAKSGSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSS 581
            .|:|.:.:             :||                                    |.|::
Mouse   435 TQIEMKKR-------------SPT------------------------------------SINTT 450

  Fly   582 GVNRESSQDDSGVVDDHEEQDTTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEF 646
                         :|..|  |||  :||....|.:                              
Mouse   451 -------------LDILE--DTT--LGHREEPETS------------------------------ 468

  Fly   647 SSEVVVIDDLPDRNCDRCVH--------W-CTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNT 702
                       .:.|..|.|        | |:  ..|::......:|:..||.:|.:.:|||||.
Mouse   469 -----------RKKCPICWHKFIKTCFIWKCS--PCWVKLNEFADRVITHPLADLFLVICIVLNI 520

  Fly   703 AFLAMEHHGMSESFRNALDVGNKVFTSIFTFECIVKLMALSK-DFFLCGWNIFDLLIVTASLLDI 766
            .|||:||..|||..|:.|.|||.||..|:|.|.|:|::|:.. .:|...|||||.::|...|.:|
Mouse   521 CFLALEHFPMSEELRSLLHVGNLVFIGIYTIEMILKIIAMHPYGYFQISWNIFDSILVVLELTEI 585

  Fly   767 IFELVDGLSVLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLF 831
            :...|:||:||..:.|: .:||.:.....|.|:.|:.|::.||.:|.|:|.|.:|..||.||:||
Mouse   586 LLADVEGLAVLITVPLI-FIKLGKYGPPFKSLMRILGSSLMALKDLVLLLCIFVYFSAVFGMKLF 649

  Fly   832 SKDYTP----EKFDPDPVPRWNFNDFFHSFMMIFRILCGEWIEPLWDCMRAEEEQGASTCFAIFL 892
            .:.|..    .|.|..| .||:.:||.|::|.:||||||||||.||:||   |..|.:.|...::
Mouse   650 GRSYKDCVCHIKEDCQP-QRWHMSDFLHAYMTVFRILCGEWIETLWECM---EVAGQAWCIPFYM 710

  Fly   893 PTLVMGNFMVLNLFLALLLNSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERK 957
            ..:::||.::|.||:. |::||:..:..|   ||.:|:|                          
Mouse   711 MVILIGNLLILYLFVT-LVSSFSYYDATS---EVNKEAK-------------------------- 745

  Fly   958 FAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIP 1022
                                                         :.|.:|.|            
Mouse   746 ---------------------------------------------NLQLAMAR------------ 753

  Fly  1023 LHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQN 1087
                                                                             
Mouse   754 ----------------------------------------------------------------- 753

  Fly  1088 LTPFVQAERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGD 1152
                          |.||:::.            .::|:....|..|:  |.||.  |       
Mouse   754 --------------IKSGINSM------------LLKLMCTERSVPTE--ATDQI--C------- 781

  Fly  1153 SLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSG 1217
                                         .||.::::                          ||
Mouse   782 -----------------------------DPSVKENI--------------------------SG 791

  Fly  1218 QSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMG 1282
            .:|:.:|..|                       .||:.:::.....|                  
Mouse   792 HTLSELSNTQ-----------------------TFLRYKDQSSSTEK------------------ 815

  Fly  1283 QPENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGA 1347
                 |.|..||..::|                          .||:|.|.       :.|.:|.
Mouse   816 -----TPVTESESQSLI--------------------------ASPSASET-------VPIASGE 842

  Fly  1348 SERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRK 1412
            |               |..:|.:...||:|.:..::.   |:|:.|..:...:|           
Mouse   843 S---------------DIENLDNKETRSKSGNGGSKE---KMKQSSSSECSTVD----------- 878

  Fly  1413 ICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKP 1477
                                                             :::.|..|.|.|.|| 
Mouse   879 -------------------------------------------------IAISEEEEMVYEHEK- 893

  Fly  1478 ISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSI 1542
                         ..||              .|.||.                        ||| 
Mouse   894 -------------SKLH--------------KNGYER------------------------KSS- 906

  Fly  1543 EPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQST 1607
                                                                .||..|       
Mouse   907 ----------------------------------------------------TGQISR------- 912

  Fly  1608 LDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSY 1672
                                                                             
Mouse   913 ----------------------------------------------------------------- 912

  Fly  1673 VDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHW 1737
                                                                     ::::.|.|
Mouse   913 ---------------------------------------------------------ESRNGKIW 920

  Fly  1738 TRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMIL 1802
            ..:|.....:|:...||.|:.::....:.||..|||.:|:.||.|.:|.:.:..|..||::||:|
Mouse   921 KNIRKTCCKIVENSWFECFIGLVTLLCTGTLALEDIYIDQRKTTKILLEYADMIFAYIFILEMLL 985

  Fly  1803 KWLALGFSKYFTSFWTILDFIIVFVSVFSLLIEENENLKVLRSLRTLRALRPLRAISRWQGMRIV 1867
            ||:|.||..:|::.|..|||::|.|...||:.:..|:|..|.|::.|||   ||.:|:::.|::|
Mouse   986 KWVAYGFKAFFSNNWYKLDFMVVIVFCLSLIGKTREDLNPLTSIKFLRA---LRVLSQFERMKVV 1047

  Fly  1868 VNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVN-EMGELLPITEVNDKWDC----I 1927
            :.||:.......:|.||||:.||:||::|||.|.|||::|:: ..||..|:.||.:|..|    .
Mouse  1048 LRALIKTTLPTVSVFLVCLMIWLLFSVIGVQLFAGKFYECIDPTKGERFPVFEVMNKSQCEKLLF 1112

  Fly  1928 EQNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFI 1992
            .::..|.|:|:.||:||.|:|:|||||||.||:.:|..|:|:.||::||..|.|||.|.||:||:
Mouse  1113 NESMPWENAKLNFDNVGNGFLSLLQVATFNGWISIMNSAIDSVGVNMQPSFEYNLYMYSYFIIFV 1177

  Fly  1993 VCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPINHF 2057
            :.|.|..|.:.|||||.|||  |:|.:.|...:|:|..||..|.|:|||.....||...||.|.|
Mouse  1178 IFGLFLPLCMLIGVIIRNFN--KQKIKQGGSNIFITVKQKKQYRALKKLLYADVQKPTPRPRNKF 1240

  Fly  2058 LAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQ-PH---AVFFILEVSNAFFTTVFGLEAIVK 2118
            ....:||...|.|.:.|.:||.....|:.|:..:| |.   |:|::    |:.|..:|.||.|:|
Mouse  1241 QGFLFDLVTHRVFNVIIILLICFQATTIMIQKDEQSPQMETAIFWM----NSIFVMLFTLECILK 1301

  Fly  2119 IVGLRYHYFTVPWNVFDFLLVLASIFGILMEDIMIDLPISPTLLRVVRVFRIGRILRLIKAAKGI 2183
            :...|.||||..|||.||::|:.||.|:|:...:....:.|:|::::.:.|:..|||..|..|..
Mouse  1302 LTAFRCHYFTSAWNVHDFMVVIFSITGLLLPLTIGQYFVPPSLVQLILLSRVIHILRPGKGPKVF 1366

  Fly  2184 RKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKLQGALDDMVNFQTFGRSMQLLFRLM 2248
            ..|:..|:::||||.||..|:.|:.|||||.||..|..||.:..::|:.||:|||.||..||::.
Mouse  1367 HDLMLPLILALPALLNISLLIFLVMFIYAIFGMYNFAYVKKEAGINDVSNFETFGSSMLCLFQVT 1431

  Fly  2249 TSAGWNDVLESLM-IQPPDCDP-FIHGHT--NGNCGHPLLAITYFTSFIIISYMIVINMYIAIIL 2309
            |.:||:.:|:::. .|..|||| .|:..|  .|:||.|.:.|:||.|:|:||::|::||||.:|:
Mouse  1432 TFSGWDGMLDAIFNSQWSDCDPDKINPGTQVKGDCGSPSVGISYFVSYILISWLIIVNMYIVLIM 1496

  Fly  2310 ENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISKPNNVALVS 2374
            |..:...|::...:.|||...|:..|:::||..||:|..|:||||.|:|||||.::|||...||:
Mouse  1497 EFLSIPSQKKSRTLSEDDFRRFFRVWNRFDPDRTQYIDSSKLSDFAAALDPPLFMAKPNKGQLVA 1561

  Fly  2375 FNLPISKGNKIHCLDILHALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWK 2439
            .:||::.|::|||||||.|..|.|:|..|..:   ::..:::..|....|.:...|.:::|...|
Mouse  1562 MDLPMAAGDRIHCLDILLAFTKRVMGKDERVE---KILSEIESGFMLANPFKITYEPITTTLKRK 1623

  Fly  2440 RQEKAAKTIQTGWKEYLRRKREKERSNS---GDSATQTSSPGGWQSKL 2484
            ::..:|..||..:|.|..|:.:|..|::   .|.....:|.|....|:
Mouse  1624 QEAVSATIIQRAYKSYRLRQNDKNVSDTPAIDDRRDDLTSKGAHSGKI 1671

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 77/228 (34%)
Ion_trans 705..902 CDD:278921 83/201 (41%)
Ion_trans 1768..2019 CDD:278921 114/255 (45%)
Na_channel_gate 2009..2063 CDD:240441 21/53 (40%)
Ion_trans 2085..2320 CDD:278921 95/242 (39%)
GPHH 2331..2386 CDD:293510 26/54 (48%)
Scn7aNP_033161.2 Ion_trans 140..405 CDD:278921 89/271 (33%)
Ion_trans 523..739 CDD:278921 90/224 (40%)
Na_trans_assoc 743..927 CDD:284034 66/814 (8%)
Ion_trans 951..1204 CDD:278921 114/257 (44%)
Na_channel_gate 1195..1246 CDD:240441 21/52 (40%)
Ion_trans 1275..1497 CDD:278921 92/225 (41%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100419
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.720

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