DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NaCP60E and Scn5a

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:XP_006512056.1 Gene:Scn5a / 20271 MGIID:98251 Length:2085 Species:Mus musculus


Alignment Length:2652 Identity:858/2652 - (32%)
Similarity:1200/2652 - (45%) Gaps:809/2652 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 EKAVAKHQVVAYTQRSQVKHENRHIQLVREYGFHPRTKASVEDGDVLPRKFEPFPEHMYGKPLEE 75
            ||.:|:.|    .:.|....|:|. .|..|..  ||.:..::....||..:...|..:.|:|||:
Mouse    90 EKRMAEKQ----ARGSATSQESRE-GLPEEEA--PRPQLDLQASKKLPDLYGNPPRELIGEPLED 147

  Fly    76 IDTFI-YEETFCVVSKRFRKNYIHRFTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATILFN 139
            :|.|. .::||.|::|   ...|.||:.|.:|::..|:.|.||..|.|..:..|...:|.|||.|
Mouse   148 LDPFYSTQKTFIVLNK---GKTIFRFSATNALYVLSPFHPVRRAAVKILVHSLFSMLIMCTILTN 209

  Fly   140 CIFLAMTET---VEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATIG 201
            |:|:|..:.   .:..||.|.|||:.|.::||:|:||.|:.:|:||:|||||||.||...|.|..
Mouse   210 CVFMAQHDPPPWTKYVEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIVMAYTTEF 274

  Fly   202 MEVGNLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMG 266
            :::||::.||||||||||||:|::.|||||:.||:.|.::||:||.||:|||.||||..||::||
Mouse   275 VDLGNVSALRTFRVLRALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMG 339

  Fly   267 ELRNKCVRQVPTDWTNVSHTD---------W---QIWVNDTDNWLYDEDELPV-LCGNLTGARHC 318
            .||:||||    ::|.::.|:         |   .:::||..|:|.......| ||||.:.|..|
Mouse   340 NLRHKCVR----NFTELNGTNGSVEADGIVWNSLDVYLNDPANYLLKNGTTDVLLCGNSSDAGTC 400

  Fly   319 PFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCGPMSVSFFTVVVFFG 383
            |..|.||..||||:||||:||:|.|:.|..|:|:|.|.||.:|...|.:.|.:.:.||.:|:|.|
Mouse   401 PEGYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFLG 465

  Fly   384 SFYLINLMLAVVALSYEEEAEIT---NEERKKDLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDS 445
            ||||:||:|||||::|||:.:.|   .||::|...:..:  ....:...|.::.::..::..::.
Mouse   466 SFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAME--MLKKEHEALTIRGVDTVSRSSLEM 528

  Fly   446 RKGVLLASYSKKKTRRKKTKGGKEGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTM 510
            .....:.::.::..|||:...|.|.|         |||.           .|:..:.:.|.||  
Mouse   529 SPLAPVTNHERRSKRRKRLSSGTEDG---------GDDR-----------LPKSDSEDGPRAL-- 571

  Fly   511 QAQKQYQQMEQQHKLAKSGSGGSNNPMAP-TPKGRI-SFQDSGMGVKNPNMLYPSDYKGQLIANS 573
                  .|:...|.|:::.       |.| :.:|.| :|:....|.:       :|:.....:.:
Mouse   572 ------NQLSLTHGLSRTS-------MRPRSSRGSIFTFRRRDQGSE-------ADFADDENSTA 616

  Fly   574 GQPSSNSSG------VNRESSQDDSGVVDDHEEQDTTNDMGHVSTVELALSPREVRLIKCNGNIA 632
            |:..|:.:.      :.|.|:|...|.        .|:..|||      |:.:....:.|||.::
Mouse   617 GESESHRTSLLVPWPLRRPSTQGQPGF--------GTSAPGHV------LNGKRNSTVDCNGVVS 667

  Fly   633 RIKNHNVYALHQEFSS------EVVVIDDLPD--------------------------------- 658
            .:.     |...|.:|      ..:|:|..||                                 
Mouse   668 LLG-----AGDAEATSPGSHLLRPIVLDRPPDTTTPSEEPGGPQMLTPQAPCADGFEEPGARQRA 727

  Fly   659 ------------------RNCDRC--------VHW-CTDYESWLQFQNCLYKVVRDPLFELAITL 696
                              |.|..|        :.| |...  |:..:..:..||.||..:|.||:
Mouse   728 LSAVSVLTSALEELEESHRKCPPCWNRFAQHYLIWECCPL--WMSIKQKVKFVVMDPFADLTITM 790

  Fly   697 CIVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIFTFECIVKLMALSK-DFFLCGWNIFDLLIVT 760
            ||||||.|:|:||:.|:..|...|.|||.|||.|||.|...|::||.. .:|..||||||.:||.
Mouse   791 CIVLNTLFMALEHYNMTAEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVI 855

  Fly   761 ASLLDIIFELVDGLSVLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAV 825
            .||:::....:..|||||..|||||.|||:||.|:..|:.||.:::||||||||:|.|:::||||
Mouse   856 LSLMELGLSRMGNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAV 920

  Fly   826 IGMQLFSKDYTPEKF---DPDPVPRWNFNDFFHSFMMIFRILCGEWIEPLWDCMRAEEEQGASTC 887
            :|||||.|:|:..:.   |...:|||:..||||:|::|||||||||||.:||||   |..|.|.|
Mouse   921 VGMQLFGKNYSELRHRISDSGLLPRWHMMDFFHAFLIIFRILCGEWIETMWDCM---EVSGQSLC 982

  Fly   888 FAIFLPTLVMGNFMVLNLFLALLLNSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKD 952
            ..:||..:|:||.:||||||||||:||:::.|.:..|: ||.:.|..::.|::..:|..::...|
Mouse   983 LLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDED-GEMNNLQLALARIQRGLRFVKRTTWD 1046

  Fly   953 RKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGL--ERGDKPGVLAETKFHRLSYQESMNRPVSGS 1015
                                        ...||  .|..||..||                    
Mouse  1047 ----------------------------FCCGLLRRRPKKPAALA-------------------- 1063

  Fly  1016 DFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVN 1080
                       .|:           .||..|.....|.||..:..||                  
Mouse  1064 -----------THS-----------QLPSCIAAPRSPPPPEVEKAPP------------------ 1088

  Fly  1081 GNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGC 1145
                                            :|:|..:.|. :..||....||:|.       |
Mouse  1089 --------------------------------ARKETRFEED-KRPGQGTPGDTEPV-------C 1113

  Fly  1146 GSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAE 1210
            ......:|..|:       :|.||.                                        
Mouse  1114 VPIAVAESDTDD-------QEEDEE---------------------------------------- 1131

  Fly  1211 MRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSR 1275
                      ||:..|::|...||                     |.::..|..           
Mouse  1132 ----------NSLGTEEEESSKQQ---------------------ESQVVSGGH----------- 1154

  Fly  1276 RPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEH 1340
                   :|..|                             .|..|.:||               
Mouse  1155 -------EPPQE-----------------------------PRAWSQVSE--------------- 1168

  Fly  1341 IAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFS 1405
                |.:||                                                        
Mouse  1169 ----TTSSE-------------------------------------------------------- 1173

  Fly  1406 ISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEE 1470
                                    |..|.|||...|                             
Mouse  1174 ------------------------AEASTSQADWQQ----------------------------- 1185

  Fly  1471 VPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPP 1535
                         |.|..||                                    .|....|| 
Mouse  1186 -------------EREAEPR------------------------------------APGCGETP- 1200

  Fly  1536 TSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRR 1600
                                                                             
Mouse  1201 ----------------------------------------------------------------- 1200

  Fly  1601 MEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKP 1665
                              .:|:|.|:              |....:||.                
Mouse  1201 ------------------EDSYSEGS--------------TADMTNTAD---------------- 1217

  Fly  1666 WHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCM- 1729
               |:..:.||                       .:..|.|:|||.:.|..    |||   .|| 
Mouse  1218 ---LLEQIPDL-----------------------GEDVKDPEDCFTEGCVR----RCP---CCMV 1249

  Fly  1730 DTQSA--KHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSF 1792
            ||..|  |.|.|:|.....:|:...||.|::.:|..||..|.||||.|::.||:|.:|.:.:..|
Mouse  1250 DTTQAPGKVWWRLRKTCYRIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMF 1314

  Fly  1793 CLIFVVEMILKWLALGFSKYFTSFWTILDFIIVFVSVFSLLIEE--NENLKVLRSLRTLRALRPL 1855
            ..:||:||:|||:|.||.||||:.|..|||:||.||:.||:...  ...:..::|||||||||||
Mouse  1315 TYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLIVDVSLVSLVANTLGFAEMGPIKSLRTLRALRPL 1379

  Fly  1856 RAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEMGELLPI--T 1918
            ||:||::|||:|||||:.|||||.|||||||:||||||||||..|.|||.:|:|:....||:  |
Mouse  1380 RALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFGRCINQTEGDLPLNYT 1444

  Fly  1919 EVNDKWDCIEQNYT----WINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQRE 1979
            .||:|.:|...|.|    |...|:.||:||.|||||||||||:|||::|..|||:||.:.|||.|
Mouse  1445 IVNNKSECESFNVTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWE 1509

  Fly  1980 ANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRK 2044
            .|||.|||||:||:.||||||||||||||||||..|||..|  .::|:||.||.||.||||||.|
Mouse  1510 DNLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGG--QDIFMTEEQKKYYNAMKKLGSK 1572

  Fly  2045 KPQKVIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTT 2109
            ||||.|.||:|.:....:|:...:.|::.|..||.|||:||.:|..||......||...|..|..
Mouse  1573 KPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKVNILAKINLLFVA 1637

  Fly  2110 VFGLEAIVKIVGLRYHYFTVPWNVFDFLLVLASIFGILMEDIMIDLPISPTLLRVVRVFRIGRIL 2174
            :|..|.|||:..||::|||..||:|||::|:.||.|.::.||:.....||||.||:|:.||||||
Mouse  1638 IFTGECIVKMAALRHYYFTNSWNIFDFVVVILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRIL 1702

  Fly  2175 RLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKLQGALDDMVNFQTFGR 2239
            |||:.|||||.|||||::|||||||||.||.|:.|||:|.||:.|..||.:..:|||.|||||..
Mouse  1703 RLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEAGIDDMFNFQTFAN 1767

  Fly  2240 SMQLLFRLMTSAGWNDVLESLM-IQPPDCDPFI--HGHTNGNCGHPLLAITYFTSFIIISYMIVI 2301
            ||..||::.|||||:.:|..:: ..||.|||.:  ...:.||||.|.:.|.:||::||||::||:
Mouse  1768 SMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGSRGNCGSPAVGILFFTTYIIISFLIVV 1832

  Fly  2302 NMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISK 2366
            |||||||||||:.|.:|....:.|||.:|||..|.|:||.|||||.:..||||..:|..||.|:|
Mouse  1833 NMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYLALSDFADALSEPLRIAK 1897

  Fly  2367 PNNVALVSFNLPISKGNKIHCLDILHALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPTRKELEI 2431
            ||.::|::.:||:..|::|||:|||.|..|.|||...|.|   .|:.||:.||....|::...|.
Mouse  1898 PNQISLINMDLPMVSGDRIHCMDILFAFTKRVLGESGEMD---ALKIQMEEKFMAANPSKISYEP 1959

  Fly  2432 VSSTRIWKRQEKAAKTIQTGWKEYLRRKREKERS--------NSGDSATQTSSPGGWQSKLSALN 2488
            :::|...|.:|.:|..||..::.:|.::..|..|        :||.|........|..:.:...|
Mouse  1960 ITTTLRRKHEEVSATVIQRAFRRHLLQRSVKHASFLFRQQAGSSGLSDEDAPEREGLIAYMMNEN 2024

  Fly  2489 FFHLQVSRR-GTACSSRASS-----------RKSS-----RASDASDLSELA 2523
            |     ||| |...||..||           |.:|     ||||.|...:||
Mouse  2025 F-----SRRSGPLSSSSISSTSFPPSYDSVTRATSDNLPVRASDYSRSEDLA 2071

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 113/231 (49%)
Ion_trans 705..902 CDD:278921 103/200 (52%)
Ion_trans 1768..2019 CDD:278921 156/258 (60%)
Na_channel_gate 2009..2063 CDD:240441 30/53 (57%)
Ion_trans 2085..2320 CDD:278921 126/237 (53%)
GPHH 2331..2386 CDD:293510 26/54 (48%)
Scn5aXP_006512056.1 Ion_trans 195..488 CDD:366146 141/296 (48%)
Na_trans_cytopl 550..732 CDD:371806 41/242 (17%)
Ion_trans 781..994 CDD:366146 113/215 (53%)
Na_trans_assoc 1020..1268 CDD:368948 93/825 (11%)
Ion_trans 1272..1547 CDD:366146 160/274 (58%)
Na_channel_gate 1539..1591 CDD:240441 30/53 (57%)
Ion_trans 1596..1850 CDD:366146 133/253 (53%)
GPHH 1862..1909 CDD:374878 23/46 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100419
Panther 1 1.100 - - O PTHR10037
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
65.820

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