DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NaCP60E and Scn3a

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:NP_001342095.1 Gene:Scn3a / 20269 MGIID:98249 Length:1996 Species:Mus musculus


Alignment Length:2607 Identity:820/2607 - (31%)
Similarity:1187/2607 - (45%) Gaps:845/2607 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 EKAVAKHQVVAYTQRSQVKHENRHIQLVREYGFHPRTKASVEDGDVLPRKFEPFPEHMYGKPLEE 75
            ||..|:.:.....:...:..||:           |:..:.:|.|..||..:...|..|..:|||:
Mouse    26 EKRAAEEKAKKPKKEQDIDDENK-----------PKPNSDLEAGKNLPFIYGDIPPEMVSEPLED 79

  Fly    76 IDT-FIYEETFCVVSKRFRKNYIHRFTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATILFN 139
            :|. ::.::||.|::|   ...|.||:.|.:|::..|.:|.|::.:.|..:..|...:|.|||.|
Mouse    80 LDPYYVSKKTFVVLNK---GKAIFRFSATSALYILTPLNPVRKIAIKILVHSLFSMLIMCTILTN 141

  Fly   140 CIFLAMT---ETVEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATIG 201
            |:|:.::   :..:..||.|..||:.|.:|||:|:||.|..:|:||:|||||||.||...|.|..
Mouse   142 CVFMTLSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEF 206

  Fly   202 MEVGNLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMG 266
            :::||::.||||||||||||:|::||||||:.||:.|.::|::||.||:|||.||||..||::||
Mouse   207 VDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMG 271

  Fly   267 ELRNKCVRQVPTD--------------------WTNV--SHTDWQIWV-NDTDNWLYDEDELPVL 308
            .|||||::..|:|                    :.||  |..:|:.:: :|:..::.|..:.|:|
Mouse   272 NLRNKCLQWPPSDSAFEINTTSYFNGTMDSNGTFVNVTMSTFNWKDYIADDSHFYVLDGQKDPLL 336

  Fly   309 CGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCGPMSV 373
            |||.:.|..||..|:|:..|.|||:|||:||.|.|:.|:.|:|:|.|||||:|.:.|...|...:
Mouse   337 CGNGSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYM 401

  Fly   374 SFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNEERKKDLLDHRDDSTFSFDPSVLNVKKLNKN 438
            .||.:|:|.|||||:||:|||||::|||:.:.|.||.:      :.::.|         :::.:.
Mouse   402 IFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEEAE------QKEAEF---------QQMLEQ 451

  Fly   439 NKKKIDSRKGVLLASYSKKKTRRKKTKGGKEGGTNGNGNGSNGDDNKSHS-ATPSPGPSPRHSAT 502
            .||:.:..:.|..||.:.:               :.:|.|..|:..:|.| |:.....|.:....
Mouse   452 LKKQQEEAQAVAAASAASR---------------DFSGIGGLGELLESSSEASKLSSKSAKEWRN 501

  Fly   503 ERPSALTMQAQKQYQQMEQQHKLAKSGSGGSNNPMAPTPKG-RISFQDSGMGVKNPNMLYPSD-- 564
            .|      :.::|.:.:|..|:                |:| |....:|...||..:.|:..|  
Mouse   502 RR------KKRRQREHLEGNHR----------------PEGDRFPKSESEDSVKRRSFLFSLDGN 544

  Fly   565 -----------------YKGQLIANSGQPSSNSS-------------GVNRESSQDDSGVVDDHE 599
                             .:|.|.:    |..||.             |...:.:.|:....:|.|
Mouse   545 PLSGDKKLCSPHQSLLSIRGSLFS----PRRNSKTSIFSFRGRAKDVGSENDFADDEHSTFEDSE 605

  Fly   600 EQDTTNDMGH-------VSTVELALSPREV----------RLIKCNGNIA--------------- 632
            .:..:..:.|       .:..:.::|.|.|          ..:.|||.::               
Mouse   606 SRRDSLFVPHRPGERRNSNVSQASMSSRMVPGLPANGKMHSTVDCNGVVSLVGGPSALTSPTGQL 670

  Fly   633 -----------RIKNHNVYALHQEFSSE--------------VVVIDDLPD--RNCDRCVH---- 666
                       |.:..:.|.:..|...:              ...:::|.:  :.|..|.:    
Mouse   671 PPEGTTTETEVRKRRLSSYQISMEMLEDSSGRQRAMSIASILTNTMEELEESRQKCPPCWYRFAN 735

  Fly   667 ----W-CTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKV 726
                | |.|  |||:.::.:..:|.||..:||||:||||||.|:||||:.|:|.|.:.|.|||.|
Mouse   736 VFLIWDCCD--SWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLV 798

  Fly   727 FTSIFTFECIVKLMALSK-DFFLCGWNIFDLLIVTASLLDIIFELVDGLSVLRGLRLLRVLKLAQ 790
            ||.|||.|.::|::|:.. .:|..||||||.:||:.||:::....|:||||||..|||||.|||:
Mouse   799 FTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAK 863

  Fly   791 SWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTP--EKFDPD-PVPRWNFND 852
            ||.|:.:|:.||.:::||||||||:|.|:::||||:|||||.|.|..  .|.:.| .:|||:.||
Mouse   864 SWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINEDCKLPRWHMND 928

  Fly   853 FFHSFMMIFRILCGEWIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLFLALLLNSFNSE 917
            |||||:::||:|||||||.:||||   |..|.:.|..:|:..:|:||.:||||||||||:||:|:
Mouse   929 FFHSFLIVFRVLCGEWIETMWDCM---EVAGQTMCLIVFMLVMVIGNLVVLNLFLALLLSSFSSD 990

  Fly   918 ELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAA 982
            .|.:..:: .|.:.|..::.|:        |:..|..:.|..|.|::...               
Mouse   991 NLAATDDD-NEMNNLQIAVGRM--------QKGIDYVKNKIRECFRKAFF--------------- 1031

  Fly   983 VGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQ 1047
                  .||.|                           |.:|:|  ..:|....::||.:  :|.
Mouse  1032 ------RKPKV---------------------------IEIHEG--NKIDSCMSNNTGVV--EIS 1059

  Fly  1048 LQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYD 1112
            .:.:.|.                         :||||                  :|||.|    
Mouse  1060 KELNYLK-------------------------DGNGT------------------TSGVGT---- 1077

  Fly  1113 SREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKS 1177
                                                                             
Mouse  1078 ----------------------------------------------------------------- 1077

  Fly  1178 LLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELL 1242
                                                   |.|:....|::::.:|...|      
Mouse  1078 ---------------------------------------GSSVEKYVIDENDYMSFINN------ 1097

  Fly  1243 NCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQ---SFEK 1304
                                              ||..:..|   ..|..|:|:|:..   |.|.
Mouse  1098 ----------------------------------PSLTVTVP---IAVGESDFENLNTEEFSSES 1125

  Fly  1305 ELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLS 1369
            ||||.|....:                             |.:||.|..|  |.|          
Mouse  1126 ELEESKEKLNA-----------------------------TSSSEGSTVD--VAP---------- 1149

  Fly  1370 SVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSA 1434
              ||..                                                           
Mouse  1150 --PREG----------------------------------------------------------- 1153

  Fly  1435 SQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQL 1499
                                           |:.|..|||:                        
Mouse  1154 -------------------------------EQAEIEPEED------------------------ 1163

  Fly  1500 RLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTE 1564
                                                                 ||          
Mouse  1164 -----------------------------------------------------LK---------- 1165

  Fly  1565 HQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADA 1629
                                                                             
Mouse  1166 ----------------------------------------------------------------- 1165

  Fly  1630 SSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTF 1694
                                                                             
Mouse  1166 ----------------------------------------------------------------- 1165

  Fly  1695 PSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLV 1759
                       |:.||.:.|...|    |:.....:....|.|..:|....::|:...||.|::.
Mouse  1166 -----------PEACFTEGCIKKF----PFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFIVF 1215

  Fly  1760 LIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGFSKYFTSFWTILDFII 1824
            :|..||..|.||||.:::.||:|.:|.:.:..|..||::||:|||:|.||..|||:.|..|||:|
Mouse  1216 MILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLI 1280

  Fly  1825 VFVSVFSLLIEE--NENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLV 1887
            |.||:.||:...  ...|..::|||||||||||||:||::|||:|||||:.|||||.|||||||:
Mouse  1281 VDVSLVSLVANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLI 1345

  Fly  1888 FWLIFSIMGVQFFGGKFFKCVN-EMGELLPITEVNDKWDC--IEQNYTWINSKITFDHVGMGYLA 1949
            ||||||||||..|.|||:.||| ..|.:..::|||:..||  :.:...|.|.|:.||:||.||||
Mouse  1346 FWLIFSIMGVNLFAGKFYHCVNMTTGSMFDMSEVNNFSDCQALGKQARWKNVKVNFDNVGAGYLA 1410

  Fly  1950 LLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNML 2014
            |||||||:|||::|..|||:|.|.|||..|.|||.|:||||||:.||||||||||||||||||..
Mouse  1411 LLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQ 1475

  Fly  2015 KKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRFEIAIFVLIF 2079
            |||:.|  .::|:||.||.||.||||||.|||||.|.||.|.|..|.:|....:.|:|:|.:||.
Mouse  1476 KKKFGG--QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILIC 1538

  Fly  2080 LNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRYHYFTVPWNVFDFLLVLASIF 2144
            |||:||.:|..||...:..:|...|..|..:|..|.::|::.|||:|||:.||:|||::|:.||.
Mouse  1539 LNMVTMMVETDDQSKYMTLVLSRINLVFIVLFTGEFLLKLISLRYYYFTIGWNIFDFVVVILSIV 1603

  Fly  2145 GILMEDIMIDLPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITF 2209
            |:.:.:::....:||||.||:|:.||||||||||.|||||.|||||::|||||||||.||.|:.|
Mouse  1604 GMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMF 1668

  Fly  2210 IYAILGMSLFGNVKLQGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLM-IQPPDCDP-FIH 2272
            ||||.|||.|..||.:..:|||.||:|||.||..||::.|||||:.:|..:: ..|||||| .||
Mouse  1669 IYAIFGMSNFAYVKKEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDAIH 1733

  Fly  2273 --GHTNGNCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRW 2335
              ....|:||:|.:.|.:|.|:||||:::|:|||||:|||||:.|.:|....:.|||.||||..|
Mouse  1734 PGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVW 1798

  Fly  2336 SKYDPHATQFIHFSQLSDFIASLDPPLGISKPNNVALVSFNLPISKGNKIHCLDILHALVKHVLG 2400
            .|:||.|||||.|.:||||.|:|||||.|:|||.|.|::.:||:..|::|||||||.|..|.|||
Mouse  1799 EKFDPDATQFIEFCKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLG 1863

  Fly  2401 HVEETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEKAAKTIQTGWKEYLRRKREKERS 2465
            ...|.|   .|:.||:.:|....|::...|.:::|...|::|.:|..||..::.||.::|.|..|
Mouse  1864 ESGEMD---ALRIQMEDRFMASNPSKVSYEPITTTLKRKQEEVSAAIIQRNYRCYLLKQRLKNIS 1925

  Fly  2466 NSGDSAT 2472
            |:.|..|
Mouse  1926 NTYDKET 1932

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 113/241 (47%)
Ion_trans 705..902 CDD:278921 105/200 (53%)
Ion_trans 1768..2019 CDD:278921 154/255 (60%)
Na_channel_gate 2009..2063 CDD:240441 32/53 (60%)
Ion_trans 2085..2320 CDD:278921 125/238 (53%)
GPHH 2331..2386 CDD:293510 31/54 (57%)
Scn3aNP_001342095.1 Ion_trans 127..434 CDD:306908 140/306 (46%)
Na_trans_cytopl 510..697 CDD:314757 29/206 (14%)
Ion_trans 759..972 CDD:306908 116/215 (54%)
Na_trans_assoc 998..1201 CDD:310839 71/822 (9%)
Ion_trans 1206..1478 CDD:306908 158/271 (58%)
Na_channel_gate 1470..1522 CDD:240441 32/53 (60%)
Ion_trans 1526..1782 CDD:306908 133/255 (52%)
GPHH 1786..1849 CDD:318993 36/62 (58%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100419
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.720

Return to query results.
Submit another query.