|
Fly 45 PRTKASVEDGDVLPRKFEPFPEHMYGKPLEEIDT-FIYEETFCVVSKRFRKNYIHRFTGTKSLFL 108
|:..:.:|.|..||..:...|..|..:|||::|. :|.::||.|::| ...|.||:.|.:|::
Mouse 49 PKPNSDLEAGKNLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNK---GKAIFRFSATSALYI 110
Fly 109 FYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLAMT---ETVEEAEYIFLAIYSIEMVIKIIA 170
..|::|.|::.:.|..:..|...:|.|||.||:|:.|: :..:..||.|..||:.|.:|||||
Mouse 111 LTPFNPLRKIAIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIA 175
Fly 171 KGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINAL 235
:||.|..:|:||:|||||||.|||..|.|..:::||::.||||||||||||:|::||||||:.||
Mouse 176 RGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGAL 240
Fly 236 LHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVPTDWTNVSHT-------------- 286
:.|.::|::||.||:|||.||||..||::||.||||||:..||:.:...|:
Mouse 241 IQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVQWPPTNASLEEHSIEKNITMDYNGTLV 305
Fly 287 -------DWQIWVNDTDNWLYDEDEL-PVLCGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFMW 343
||:.::.|:....:.|..| .:||||.:.|..||..|:|:..|.|||:|||:||.|.|
Mouse 306 NETVFEFDWKSYIQDSRYHYFLEGVLDALLCGNSSDAGQCPEGYMCVKAGRNPNYGYTSFDTFSW 370
Fly 344 SMLTTFQLITLDYWENVYNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNE 408
:.|:.|:|:|.|:|||:|.:.|...|...:.||.:|:|.||||||||:|||||::|||:.:.|.|
Mouse 371 AFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLE 435
Fly 409 ERKK---------DLLDHRDD----------STFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASY 454
|.:: :.|..:.: |..|.:||.......:.:...|:.|: |.
Mouse 436 EAEQKEAEFQQMLEQLKKQQEAAQQAAATTASEHSREPSAAGRLSDSSSEASKLSSK------SA 494
Fly 455 SKKKTRRKKTKGGKEGGTNGNGNGSNGDDNKSHSAT-------------------------PSPG 494
.:::.||||.|..::.| |...||::.|.:. .||.
Mouse 495 KERRNRRKKRKQKEQSG------GEEKDDDEFHKSESEDSIRRKGFRFSIEGNRLTYEKRYSSPH 553
Fly 495 P----------SPRHSATERPSALTMQAQ-----KQYQQMEQQHKLAKSGSGGSNNPMAPTPKGR 544
. |||.:: |.|..:.:.: .:....:.:|...:......::...|...|.
Mouse 554 QSLLSIRGSLFSPRRNS--RTSLFSFRGRAKDVGSENDFADDEHSTFEDNESRRDSLFVPRRHGE 616
Fly 545 ISFQDSGMGVKNPNML--YPSDYK-------GQLIANSGQPSSNSSGVNR--------ESSQDDS 592
....:.....::..|| :|::.| ..:::..|.||..:|.|.: :.:.||:
Mouse 617 RRNSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVGGPSVPTSPVGQLLPEVIIDKPATDDN 681
Fly 593 GVVDDHEEQDTTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLP 657
|...:.|.:...:...|||...|....:..|.: :||.|..:.|..|.:.
Mouse 682 GTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAM----SIASILTNTVEELEES------------ 730
Fly 658 DRNCDRCVH--------W-CTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMS 713
.:.|..|.: | |:.| ||:.::.:..||.||..:||||:||||||.|:||||:.|:
Mouse 731 RQKCPPCWYKFSNIFLIWDCSPY--WLKVKHIVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMT 793
Fly 714 ESFRNALDVGNKVFTSIFTFECIVKLMALSK-DFFLCGWNIFDLLIVTASLLDIIFELVDGLSVL 777
|.|.:.|.|||.|||.|||.|..:|::|:.. .:|..||||||..|||.||:::....|:|||||
Mouse 794 EHFNHVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEGLSVL 858
Fly 778 RGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTP--EKF 840
|..|||||.|||:||.|:.:|:.||.:::||||||||:|.|:::||||:|||||.|.|.. .|.
Mouse 859 RSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKI 923
Fly 841 DPD-PVPRWNFNDFFHSFMMIFRILCGEWIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLN 904
..| .:|||:.|||||||:::||:|||||||.:|||| |..|.:.|..:|:..:|:||.:|||
Mouse 924 ATDCKLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCM---EVAGQAMCLTVFMMVMVIGNLVVLN 985
Fly 905 LFLALLLNSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDA 969
|||||||:||:::.|.:..:: .|.:.|..:::|:...|...: ||..|..||..:..
Mouse 986 LFLALLLSSFSADNLAATDDD-NEMNNLQIAVDRMHKGIAYVK--------RKIYEFIQQSFVKK 1041
Fly 970 QQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGL 1034
|: :|.|.| ||.|
Mouse 1042 QK---------------------ILDEIK-----------------------PLDD--------- 1053
Fly 1035 EYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQ 1099
:|
Mouse 1054 --------------------------------------------LN------------------- 1055
Fly 1100 HQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGS 1164
||.|:...|.:...|
Mouse 1056 -------------------------------------------------NRKDNCISNHTTEIG- 1070
Fly 1165 EEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDE 1229
|.||.|...:|.:... .:|.|:....|::.:
Mouse 1071 ----------------------KDLDCLKDVNGTTSGI------------GTGSSVEKYIIDESD 1101
Fly 1230 LLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSE 1294
.:|...| ||..:..| ..|..|:
Mouse 1102 YMSFINN----------------------------------------PSLTVTVP---IAVGESD 1123
Fly 1295 FDNI-IQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVL 1358
|:|: .:.|..| :.||.....|:|.|.:::.:|..| ||
Mouse 1124 FENLNTEDFSSE--------SDLEESKEKLNESSSSSEGSTVDI--------GA----------- 1161
Fly 1359 PLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVA 1423
Mouse 1162 ----------------------------------------------------------------- 1161
Fly 1424 MEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKM 1488
|.||:|:
Mouse 1162 ------------------------------------------------PAEEQPV---------- 1168
Fly 1489 PRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSL 1553
||
Mouse 1169 -----------------------------------------------------IE---------- 1170
Fly 1554 KTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSAR 1618
|:.||:
Mouse 1171 --------------------------------------------------PEETLE--------- 1176
Fly 1619 TESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRN 1683
Mouse 1177 ----------------------------------------------------------------- 1176
Fly 1684 SQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSC---MDTQSAKHWTRVRTAVL 1745
|:.||.:.|... |:| | ::....|.|..:|....
Mouse 1177 ----------------------PEACFTEGCVQR--FKC-----CQISVEEGRGKQWWNLRRTCF 1212
Fly 1746 TVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGFS 1810
.:|:...||.|::.:|..||..|.||||.:|:.||:|.:|.:.:..|..||::||:|||:|.|:.
Mouse 1213 RIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGYQ 1277
Fly 1811 KYFTSFWTILDFIIVFVSVFSLLIEE--NENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMY 1873
.|||:.|..|||:||.||:.||.... ...|..::|||||||||||||:||::|||:|||||:.
Mouse 1278 TYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLG 1342
Fly 1874 AIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVN-EMGELLPITEVNDKWDC---IEQNYT-- 1932
|||||.|||||||:||||||||||..|.|||:.||| ..|::..|:|||:..|| ||:|.|
Mouse 1343 AIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNTTTGDIFEISEVNNHSDCLKLIERNETAR 1407
Fly 1933 WINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSF 1997
|.|.|:.||:||.|||:|||||||:|||::|..|||:|.|:|||:.|.:||.|:||||||:.|||
Mouse 1408 WKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSF 1472
Fly 1998 FTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPINHFLAMFY 2062
|||||||||||||||..|||:.| .::|:||.||.||.||||||.|||||.|.||.|.|..|.:
Mouse 1473 FTLNLFIGVIIDNFNQQKKKFGG--QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVF 1535
Fly 2063 DLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRYHYF 2127
|....:.|:|:|.:||.|||:||.:|..||...|..||...|..|..:|..|.::|::.||::||
Mouse 1536 DFVTRQVFDISIMILICLNMVTMMVETDDQSDYVTSILSRINLVFIVLFTGECVLKLISLRHYYF 1600
Fly 2128 TVPWNVFDFLLVLASIFGILMEDIMIDLPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVV 2192
|:.||:|||::|:.||.|:.:.:::....:||||.||:|:.||||||||||.|||||.|||||::
Mouse 1601 TIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMM 1665
Fly 2193 SLPALFNIGALLGLITFIYAILGMSLFGNVKLQGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVL 2257
|||||||||.||.|:.|||||.|||.|..||.:..:|||.||:|||.||..||::.|||||:.:|
Mouse 1666 SLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLL 1730
Fly 2258 ESLM-IQPPDCDPFIHGHTN------GNCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQA 2315
..:: .:|||||| ...| |:||:|.:.|.:|.|:||||:::|:|||||:|||||:.|
Mouse 1731 APILNSKPPDCDP---NKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVA 1792
Fly 2316 HQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISKPNNVALVSFNLPIS 2380
.:|....:.|||.||||..|.|:||.||||:.|.:||.|.|:|:|||.:.:||.:.|::.:||:.
Mouse 1793 TEESAEPLSEDDFEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMV 1857
Fly 2381 KGNKIHCLDILHALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEKAA 2445
.|::|||||||.|..|.|||...|.| .|:.||:.:|....|::...:.:::|...|::|.:|
Mouse 1858 SGDRIHCLDILFAFTKRVLGESGEMD---ALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSA 1919
Fly 2446 KTIQTGWKEYLRRKREKERS 2465
..||..::.:|.::..|:.|
Mouse 1920 VIIQRAYRRHLLKRTVKQAS 1939
| 
