DRSC/TRiP Functional Genomics Resources

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Protein Alignment NaCP60E and Scn10a

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:NP_001192250.1 Gene:Scn10a / 20264 MGIID:108029 Length:1958 Species:Mus musculus


Alignment Length:2646 Identity:824/2646 - (31%)
Similarity:1182/2646 - (44%) Gaps:850/2646 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 EKAVAKHQVVAYTQRSQVKHENRHIQLVREYGFHPRTKASVEDGDVLPRKFEPFPEHMYGKPLEE 75
            ||.:|.|:.   .::.:.|...:     ::....||.:..::..:.|||.:...|..:.|:|||:
Mouse    25 EKQIAAHRA---AKKGRPKQRGQ-----KDKSEKPRPQLDLKACNQLPRFYGELPAELVGEPLED 81

  Fly    76 IDTFI-YEETFCVVSKRFRKNYIHRFTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATILFN 139
            :|.|. ...||.|:.|   ...|.||:.|.:|:||.|::..||..:.::.:.:|...:..|||.|
Mouse    82 LDPFYSTHRTFIVLDK---SRTISRFSATWALWLFSPFNLIRRTAIKVSVHSWFSIFITVTILVN 143

  Fly   140 CIFLAMTETVEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEV 204
            |:.:..|:..|:.||.|..:|:.|.:|||:|:||.||::||||:|||||||.|||..|....:::
Mouse   144 CVCMTRTDLPEKLEYAFTVVYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGAAIDL 208

  Fly   205 GNLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELR 269
            ..::|||||||||||||||::||||.|:.||:||.|:||:|..||:|||.||||..||::.|.|:
Mouse   209 RGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVRKLADVTILTVFCLSVFALVGLQLFKGNLK 273

  Fly   270 NKCVRQ--VPTDWTNVSHT---DWQIWVNDTDNWLYDEDELPVLCGNLTGARHCPFEYVCLCVGE 329
            |||::.  .|....|:|..   |..|....||         |:||||.:.|.|||.:|||....:
Mouse   274 NKCIKNGTDPHKADNLSSEMAGDIFIKPGTTD---------PLLCGNGSDAGHCPNDYVCRKTSD 329

  Fly   330 NPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAV 394
            ||:..||:||:|.|:.|:.|:|:|.|.||.:|...|...|.|.:.||.:|:|.|||||:||:|||
Mouse   330 NPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRASGKMYMVFFVLVIFLGSFYLVNLILAV 394

  Fly   395 VALSYEEE-----AEITNEERK-KDLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLAS 453
            |.::|||:     |||..:|:| |:.|:     ....:..||....::..:   :.|..|..||.
Mouse   395 VTMAYEEQSQATIAEIEAKEKKFKEALE-----VLQKEQEVLAALGIDTTS---LYSHNGSPLAP 451

  Fly   454 YSKKKTRRKKTKGGKEGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQYQQ 518
            .:..:.|.:......||.|         |||:|..:.|                        |.|
Mouse   452 KNANERRPRVKSRMSEGST---------DDNRSLQSDP------------------------YNQ 483

  Fly   519 MEQQHKLAKSGSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGV 583
            .                        |:||    :|:                 :||:..::.|.|
Mouse   484 R------------------------RMSF----LGL-----------------SSGRRRASHSSV 503

  Fly   584 --NRESSQDDS---GVVDD---HEEQDTTND---MGH---------------------------- 609
              .|..|||.|   |::||   |.:|::...   :|.                            
Mouse   504 FHFRAPSQDVSFPDGILDDGVFHGDQESRRSSILLGRGAGQAGPLPRSPLPQSPNPGPRRGEEGQ 568

  Fly   610 --VSTVELALSPREVRLIKCNGNIARIKNH-NVYALHQEFSSE----VV-----VIDDLPDR--N 660
              |.|.|||....|...:...|.    ||. :...|::.|.::    ||     ||::|.:.  .
Mouse   569 RGVPTGELATGAPEGPALDAAGQ----KNFLSADYLNEPFRAQRAMSVVSIMTSVIEELEESKLK 629

  Fly   661 CDRC--------VHW-CTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESF 716
            |..|        :.| |.  ..|.:|:..|:::|.||..||.||||||:||.|:||||:.|:::|
Mouse   630 CPPCLISLAQKYLIWECC--PKWKKFKMVLFELVTDPFAELTITLCIVVNTVFMAMEHYPMTDAF 692

  Fly   717 RNALDVGNKVFTSIFTFECIVKLMALSK-DFFLCGWNIFDLLIVTASLLDIIFELVDGLSVLRGL 780
            ...|..||.|||..||.|...|::|... .:|...|||||.:|||.|||::.......|||||..
Mouse   693 DAMLQAGNIVFTVFFTMEMAFKIIAFDPYYYFQKKWNIFDCVIVTVSLLELSTSKKGSLSVLRTF 757

  Fly   781 RLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTPEKFDPDPV 845
            |||||.|||:||.|:.:|:.||.:::|||||||.||.|:::|||::|.||.|::|...:   |.:
Mouse   758 RLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTFILAIIVFIFALVGKQLLSENYGCRR---DGI 819

  Fly   846 P-------RWNFNDFFHSFMMIFRILCGEWIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVL 903
            .       ||:..||||||:::||||||||||.:|.||...::.   .|..:||..:|:||.:||
Mouse   820 SVWNGERLRWHMCDFFHSFLVVFRILCGEWIENMWVCMEVSQDY---ICLTLFLTVMVLGNLVVL 881

  Fly   904 NLFLALLLNSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLD 968
            |||:|||||||:::.|.:.::: ||.:.|..::.|:                             
Mouse   882 NLFIALLLNSFSADNLTAPEDD-GEVNNLQVALARI----------------------------- 916

  Fly   969 AQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDG 1033
                  |...|:|:                                                   
Mouse   917 ------QVFGHRAS--------------------------------------------------- 924

  Fly  1034 LEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRL 1098
                                                                :.:|.::::..||
Mouse   925 ----------------------------------------------------RAITSYIRSHCRL 937

  Fly  1099 QHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYG 1163
            :                                                                
Mouse   938 R---------------------------------------------------------------- 938

  Fly  1164 SEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQD 1228
                   :.|.:..|..:.|                    |.|.:||  .|          |..|
Mouse   939 -------WPKVETQLGMKPP--------------------LTSCKAE--NH----------IATD 964

  Fly  1229 ELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHS 1293
            .:.:..|||.:..|.                                      |..||     |.
Mouse   965 AVNAAVGNLAKPALG--------------------------------------GPKEN-----HG 986

  Fly  1294 EFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVL 1358
            :|                           :::|:         :...:.|..|.|:....:|   
Mouse   987 DF---------------------------ITDPN---------VWVSVPIAEGESDLDELEE--- 1012

  Fly  1359 PLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVA 1423
                       .|...|||   :.|.:|.|.::..|::.:|.::.                    
Mouse  1013 -----------DVEHASQS---SWQEESPKGQQELLQQVQKCEDH-------------------- 1043

  Fly  1424 MEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKM 1488
               .|..:..:..:..:.:|:|.          :|::|                        |:.
Mouse  1044 ---QAARSPPSGMSSEDLAPYLG----------ERWQR------------------------EES 1071

  Fly  1489 PRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSL 1553
            ||                                       |||                     
Mouse  1072 PR---------------------------------------VPA--------------------- 1076

  Fly  1554 KTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSAR 1618
                                                                             
Mouse  1077 ----------------------------------------------------------------- 1076

  Fly  1619 TESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRN 1683
                 .|..|.||         :|.|....||..:.......|.|:        :|:        
Mouse  1077 -----EGVDDTSS---------SEGSTVDCPDPEEILRKIPELAEE--------LDE-------- 1111

  Fly  1684 SQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKH-WT---RVRTAV 1744
                                  ||||||:.|..    |||    |....::|. |.   :||...
Mouse  1112 ----------------------PDDCFPEGCTR----RCP----CCKVNTSKFPWATGWQVRKTC 1146

  Fly  1745 LTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGF 1809
            ..:|:...||.|::.:|..||..|.|||..|::...:|.||.:.:..|..|||.||:|||:|.||
Mouse  1147 YRIVEHSWFESFIIFMILLSSGALAFEDNYLEEKPRVKSVLEYTDRVFTFIFVFEMLLKWVAYGF 1211

  Fly  1810 SKYFTSFWTILDFIIVFVSVFSLL--IEENENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALM 1872
            .||||:.|..|||:||.:|:.||:  |.|..::..:::||||||||||||:||::|||:||:||:
Mouse  1212 KKYFTNAWCWLDFLIVNISLTSLIAKILEYSDVASIKALRTLRALRPLRALSRFEGMRVVVDALV 1276

  Fly  1873 YAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEMGELLPI---TEVNDKWDCIEQNYT-- 1932
            .|||||.|||||||:||||||||||..|.|||.:||:.......:   |.|.:|.||..||.|  
Mouse  1277 GAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFSRCVDTRSNPFSVVNSTFVTNKSDCYNQNNTGH 1341

  Fly  1933 --WINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCG 1995
              |:|.|:.||:|.||||||||||||:|||::|..|||:|.::.||..|.:||.|:|||:||:.|
Mouse  1342 FFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSRDINSQPNWEESLYMYLYFVVFIIFG 1406

  Fly  1996 SFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPINHFLAM 2060
            .|||||||:||||||||..|||..|  .::|:||.||.||.||||||.|||||.|.||:|.:...
Mouse  1407 GFFTLNLFVGVIIDNFNQQKKKIRG--QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGF 1469

  Fly  2061 FYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRYH 2125
            .:|:...:.|:|.|..||.|||:||.:|..:|......:|...|.||..||..|.::|:..||.:
Mouse  1470 VFDIVTRQAFDIIIMALICLNMITMMVETDNQSEEKTKVLGRINQFFVAVFTGECVMKMFALRQY 1534

  Fly  2126 YFTVPWNVFDFLLVLASIFGILMEDIMIDLP--ISPTLLRVVRVFRIGRILRLIKAAKGIRKLLF 2188
            |||..||||||::|:.||..:|...|:..|.  .|||||||:|:.|||||||||:||||||.|||
Mouse  1535 YFTNGWNVFDFIVVILSISSLLFSAILSSLESYFSPTLLRVIRLARIGRILRLIRAAKGIRTLLF 1599

  Fly  2189 ALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKLQGALDDMVNFQTFGRSMQLLFRLMTSAGW 2253
            ||::|||||||||.||.|:.|||:|.||:.|.||..:..:|||.||:|||.||..||::.|||||
Mouse  1600 ALMMSLPALFNIGLLLFLVMFIYSIFGMASFANVIDEAGIDDMFNFKTFGNSMLCLFQITTSAGW 1664

  Fly  2254 NDVLESLM-IQPPDCD---PFIHGHTNGNCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQ 2314
            :.:|..:: ..||.||   |..:| :.||||.|.:.|.:||::||||::||:|||||:||||||.
Mouse  1665 DGLLSPILNTGPPYCDPNRPNSNG-SKGNCGSPAVGILFFTTYIIISFLIVVNMYIAVILENFNV 1728

  Fly  2315 AHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISKPNNVALVSFNLPI 2379
            |.:|....:.|||.:|||..|.|:||.|||||.||.||||..:|..||.|.|||...|:..:||:
Mouse  1729 ATEESTEPLSEDDFDMFYETWEKFDPEATQFIAFSALSDFADTLSGPLRIPKPNQNILIQMDLPL 1793

  Fly  2380 SKGNKIHCLDILHALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEKA 2444
            ..|:||||||||.|..|:|||...|.|:   |:..|:.||.....::...|.:::|...|:::.:
Mouse  1794 VPGDKIHCLDILFAFTKNVLGESGELDS---LKTNMEEKFMATNLSKASYEPIATTLRCKQEDIS 1855

  Fly  2445 AKTIQTGWKEYLRRK-----------REKE---------------RSNSG-----DSATQTSSPG 2478
            |..||..::.|:.::           |.:|               ..|.|     ::|:.||.|.
Mouse  1856 ATIIQKAYRNYMLQRSLMLSNPLHVPRAEEDGVSLPREGYVTFMANDNGGLPDKSETASATSFPP 1920

  Fly  2479 GWQSKLSALNFFHLQVSRRGTACSSRASSRKSSRASDASDLSELAG 2524
            .:.|....|              |.||:...||...:..:::...|
Mouse  1921 SYDSVTRGL--------------SDRANISTSSSMQNEDEVTAKEG 1952

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 109/223 (49%)
Ion_trans 705..902 CDD:278921 94/204 (46%)
Ion_trans 1768..2019 CDD:278921 148/259 (57%)
Na_channel_gate 2009..2063 CDD:240441 30/53 (57%)
Ion_trans 2085..2320 CDD:278921 128/240 (53%)
GPHH 2331..2386 CDD:293510 29/54 (54%)
Scn10aNP_001192250.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 27..54 5/34 (15%)
I. /evidence=ECO:0000305 116..404 138/296 (47%)
Ion_trans 147..406 CDD:278921 130/267 (49%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 444..483 13/71 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 539..583 6/43 (14%)
II. /evidence=ECO:0000305 646..910 127/272 (47%)
Ion_trans 681..893 CDD:278921 105/217 (48%)
Na_trans_assoc 903..1148 CDD:284034 80/824 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1006..1094 27/300 (9%)
III. /evidence=ECO:0000305 1141..1450 168/310 (54%)
Ion_trans 1170..1428 CDD:278921 146/257 (57%)
Na_channel_gate 1420..1472 CDD:240441 30/53 (57%)
IV. /evidence=ECO:0000305 1459..1758 153/299 (51%)
Ion_trans 1494..1733 CDD:278921 127/239 (53%)
GPHH 1743..1800 CDD:293510 30/56 (54%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1901..1958 14/66 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100419
Panther 1 1.100 - - LDO PTHR10037
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.820

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