DRSC/TRiP Functional Genomics Resources

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Protein Alignment NaCP60E and unc-2

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:NP_001355464.1 Gene:unc-2 / 180570 WormBaseID:WBGene00006742 Length:2171 Species:Caenorhabditis elegans


Alignment Length:3065 Identity:591/3065 - (19%)
Similarity:988/3065 - (32%) Gaps:1268/3065 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 DDQATFNDEKA-----VAKHQVVAYTQRSQVKHENRHI----QLVREYGFHPRTKASVEDGDVLP 58
            ||:..|:....     |:.|:..|... :::|..:|.:    ||..|   ..|.:...|.|    
 Worm   154 DDERKFSSPHRRRVVDVSDHKTCALLM-TRMKEASRQLPSPSQLAAE---EARREQKAESG---- 210

  Fly    59 RKFEPFPEHMYGKPLEEIDTFIYEETFCVVSKRFRKNYIHRFTGTKSLFLFYPWSPARRVCVYIA 123
                               ||:.:.|       ...|...:..|..|||:|...:..||....|.
 Worm   211 -------------------TFVRKTT-------LSSNAPVKEKGPSSLFIFAEDNIIRRNAKAII 249

  Fly   124 TNQFFDYCVMATILFNCIFL------------AMTETVEEAEYIFLAIYSIEMVIKIIAKGFLLN 176
            ....|:|.::.||:.||:.|            |::|.:|..|..|:.|:.:|.|:|:||.||.|:
 Worm   250 EWGPFEYFILLTIIGNCVVLSMEQHLPKNDKKALSEWLERTEPYFMGIFCLECVLKVIAFGFALH 314

  Fly   177 KYTYLRNPWNWLDFVVITSGYATI-----GMEVGN-------LAGLRTFRVLRALKTVSIMPGLK 229
            |.:|||:.||.:||:|:.||..|:     ..:..|       |..||..||||.||.||.:|.|:
 Worm   315 KGSYLRSGWNIMDFIVVVSGVVTMLPFSPATQTANQPVDSVDLRTLRAVRVLRPLKLVSGIPSLQ 379

  Fly   230 TIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVPTDWTNVSHTDWQIWVND 294
            .::.::|.:...|.::..|.:|.:::||:..|:.|.|...:.|..: ..:..|||          
 Worm   380 VVLKSILCAMAPLLQIGLLVLFAIIIFAIIGLEFYSGAFHSACYNE-RGEIENVS---------- 433

  Fly   295 TDNWLYDEDELPVLCGNLT---GARHCPFE-YVCLCVGENPNHGYTNFDNFMWSMLTTFQLITLD 355
                     |.|:.|.|.|   |..:|..: ..||.....||:|.|:|||..::|:|.||.||::
 Worm   434 ---------ERPMPCTNKTSPMGVYNCDVKGTTCLQKWIGPNYGITSFDNIGFAMITVFQCITME 489

  Fly   356 YWENVYNMVLATCG-PMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNEERKKDLLDHRD 419
            .|..|......:.| ..:.::|..::..|||:::||:|.|::..:.:|.|  ..|.:::.|..|.
 Worm   490 GWTTVMYYTNDSLGSTYNWAYFIPLIVLGSFFMLNLVLGVLSGEFAKERE--RVENRREFLKLRR 552

  Fly   420 DSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGKEGGTNGNGNGSNGDDN 484
            .....        ::||...:..:.:.:.:|                 ||..|            
 Worm   553 QQQIE--------RELNGYLEWILTAEEVIL-----------------KEDRT------------ 580

  Fly   485 KSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQHKLAKSGSGGSNNPMAPTPKGRISFQD 549
                             ||...|..|:|:::                .:|..:.           
 Worm   581 -----------------TEEEKAAIMEARRR----------------AANKKLK----------- 601

  Fly   550 SGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQDDSGVVDDHEEQDTTNDMGHVSTVE 614
                                     |.|...|....|..::|    :|..|::..::.|   |||
 Worm   602 -------------------------QASKQQSTETEEDFEED----EDEMEEEYVDEGG---TVE 634

  Fly   615 LALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDRNCDRCVHWCTDYESWLQFQN 679
                                                   |:..:|....|.|....:...|:.| 
 Worm   635 ---------------------------------------DEFAERKKRGCCHSVGKFIKQLRIQ- 659

  Fly   680 CLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIFTFECIVKLMAL-S 743
             :..:|:..:|..::...:.|||..:|.||:|..:.|.:.|.....||..||..|.::||.|: |
 Worm   660 -IRIMVKTQIFYWSVITLVFLNTCCVASEHYGQPQWFTDFLKYAEFVFLGIFVVEMLLKLFAMGS 723

  Fly   744 KDFFLCGWNIFDLLIVTASLLDIIFELV----DGLSVLRGLRLLRVLKLAQSWTTMKVLLSIIIS 804
            :.:|...:|.||.:::..|..::|:..|    .|:||:|.|||||:.||...|.:::.|:..:::
 Worm   724 RTYFASKFNRFDCVVIVGSAAEVIWAEVYGGSFGISVMRALRLLRIFKLTSYWVSLRNLVRSLMN 788

  Fly   805 TIGALGNLTLILVIVIYIFAVIGMQLFSKDYTPEKFD-PDPVPRWNFNDFFHSFMMIFRILCGE- 867
            ::.::.:|..:|.:.|.|||::|||||.     .:|: |...|..:|:.|..:.:.:|:||.|| 
 Worm   789 SMRSIISLLFLLFLFILIFALLGMQLFG-----GRFNFPTMHPYTHFDTFPVALITVFQILTGED 848

  Fly   868 WIEPLWDCMRAEEEQG----ASTCFAIFLPTLVM-GNFMVLNLFLALLL-NSFNSEELKSKKEEV 926
            |.|.::   .|.|.||    ....::|:...||: ||:.:||:|||:.: |..|::||.:.:|  
 Worm   849 WNEVMY---LAIESQGGIYSGGWPYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAAEE-- 908

  Fly   927 GEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDKP 991
                                    .|.|..:..|:.::  ||.|                     
 Worm   909 ------------------------ADEKANEIEEESEE--LDEQ--------------------- 926

  Fly   992 GVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPPT 1056
                        |||                   |.|..:|                        
 Worm   927 ------------YQE-------------------GDHCTID------------------------ 936

  Fly  1057 SDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEATYTE 1121
                       |...|.|...:|                                          
 Worm   937 -----------MEGKTAGDMCAV------------------------------------------ 948

  Fly  1122 SIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYR 1186
                                                                            .
 Worm   949 ----------------------------------------------------------------A 949

  Fly  1187 KSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQ 1251
            :::|.|.:                                                .|       
 Worm   950 RAMDDLDE------------------------------------------------EC------- 959

  Fly  1252 FLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTSL 1316
               ||||                    |..|.|:                               
 Worm   960 ---EEEE--------------------SPFGGPK------------------------------- 970

  Fly  1317 ERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAA 1381
                                                      |:.||.|.               
 Worm   971 ------------------------------------------PMVPYSSM--------------- 978

  Fly  1382 AQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLR 1446
                                                                          |..
 Worm   979 --------------------------------------------------------------FFL 981

  Fly  1447 RKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNS 1511
            ...:||                                                           
 Worm   982 SPTNPF----------------------------------------------------------- 987

  Fly  1512 YENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQA 1576
                                                                             
 Worm   988 ----------------------------------------------------------------- 987

  Fly  1577 APTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKT 1641
                                                                             
 Worm   988 ----------------------------------------------------------------- 987

  Fly  1642 EQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVP 1706
                                                                             
 Worm   988 ----------------------------------------------------------------- 987

  Fly  1707 DDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFE 1771
                                              |..:.::|.|..||..|:.:|..||::|..|
 Worm   988 ----------------------------------RVLIHSIVCTKYFEMMVMTVICLSSVSLAAE 1018

  Fly  1772 DINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGF----SKYFTSFWTILDFIIVFVSVFSL 1832
            | .:|:.....:||.::::.|..:|..||:||.:..|.    ..|...||.|||.|:|..::|:.
 Worm  1019 D-PVDEENPRNKVLQYMDYCFTGVFACEMLLKLIDQGILLHPGSYCRDFWNILDGIVVTCALFAF 1082

  Fly  1833 LIEENE-----NLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIF 1892
            .....|     ||..::|||.||.||||:.|.|...::.|.:.::.::.::||:|:|..:|..||
 Worm  1083 GFAGTEGSAGKNLNTIKSLRVLRVLRPLKTIKRIPKLKAVFDCVVNSLKNVFNILIVYFLFQFIF 1147

  Fly  1893 SIMGVQFFGGKFFKCVNE--------MGELLPITEVNDKWDCIEQNYTWINSKITFDHVGMGYLA 1949
            :::.||.|.||||.|.::        .|:.......||. ..:||. .|......:|:.....|.
 Worm  1148 AVIAVQLFNGKFFFCTDKNRKFANTCHGQFFVYDNQNDP-PRVEQR-EWRLRPFNYDNTINAMLT 1210

  Fly  1950 LLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNML 2014
            |..|.|.|||..:..:::|....|..|.....:...:::|:|.:...||.:|:|:.:||..|.  
 Worm  1211 LFVVTTGEGWPGIRQNSMDTTFEDQGPSPFFRVEVALFYVMFFIVFPFFFVNIFVALIIITFQ-- 1273

  Fly  2015 KKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKV-IKRPINHFLAMFYDLSNSRRFEIAIFVLI 2078
                |.|..|:...:..|:....:......:|:.: :....|......:.|..|..||..|..:|
 Worm  1274 ----EQGEAELSEGDLDKNQKQCIDFALNARPRSLFMPEDKNSTKYRIWRLVTSPPFEYFIMTMI 1334

  Fly  2079 FLNMLTMGIEHYDQPHAVFF--ILEVSNAFFTTVFGLEAIVKIV--GLRYHYFTVPWNVFDFLLV 2139
            ..|.|.:.:::|:.|  :|:  ||.:.|...|.||.:|:|:||:  |:| :||...||.|||:.|
 Worm  1335 CCNTLILMMKYYNNP--LFYEEILRLFNTALTAVFTVESILKILAFGVR-NYFRDGWNRFDFVTV 1396

  Fly  2140 LASIFGILMEDI---MIDLPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIG 2201
            :.||...|:.:.   .:.|..       :|:||..|::||::....||.||:..|.|..||..:.
 Worm  1397 VGSITDALVTEFGGHFVSLGF-------LRLFRAARLIRLLQQGYTIRILLWTFVQSFKALPYVC 1454

  Fly  2202 ALLGLITFIYAILGMSLFGNVKLQGA--LDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQP 2264
            .|:|::.|||||:||.:|||:.|..|  ::...|||:|..::.||||..|..||.|::.: .:|.
 Worm  1455 LLIGMLFFIYAIVGMQVFGNIWLNAATEINRHNNFQSFFNAVILLFRCATGEGWQDIMMA-AVQG 1518

  Fly  2265 PDCD-------PFIHGHTNGNCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIG 2322
            .||.       .|..|.|   ||.. ::..|||||:.:|..:::|:::|:|::||:...::..| 
 Worm  1519 KDCARAGSAEINFEKGQT---CGSN-VSYAYFTSFVFLSSFLMLNLFVAVIMDNFDYLTRDSSI- 1578

  Fly  2323 IVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISK--PNNVA---LVSFNLPISKG 2382
            :....|:.|...|:.|||.||..||:|::.:.:..:.||:|..|  |..:|   |:..|:|:::.
 Worm  1579 LGPHHLDEFIRVWADYDPAATGRIHYSEMYEMLRIMAPPVGFGKKCPYRLAYKHLIRMNMPVAED 1643

  Fly  2383 NKIHCLDILHALVKHVLG----HVEETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEK 2443
            ..:|....|.||::..|.    .|||.|   :..|::.:..||.:|.:.:..:|... :....|.
 Worm  1644 GTVHFTTTLFALIRESLSIKMRPVEEMD---EADEELRLTLKKIWPLKAKKNMVDLV-VPPNHEL 1704

  Fly  2444 AAKTIQTG--------WKEYLRRKREKERSNSGDSATQTSSPGGWQSKLSALNFFHLQVSRRGTA 2500
            ..:.:..|        .:.|..||          |.|:....|.:...|.:|           .|
 Worm  1705 CFQKLTVGKIYAGLLILENYRARK----------SGTEVGGQGLFGGGLRSL-----------VA 1748

  Fly  2501 CSSRASSRKSSRASDASD-----LSELAGPWLNLPLMLVSGADEVVKDIKQQNDELGKRGSIFVE 2560
            .:..|.|:.||......:     :.:.|..:...|.|...|:       .||.......|     
 Worm  1749 AAKAAESQHSSHTPQPPEETTPIIPQHAQQFSAAPTMSAQGS-------LQQMQGTSSGG----- 1801

  Fly  2561 APRASRRRSFYNFFL-------RHQDAVDDSLTS-PSVHRKTAMNNTTNTTSN--SASTSGTASS 2615
               ..|..|.:|.|:       :..|..|....| ...|.|  ||:|....|:  |....||::.
 Worm  1802 ---GQRPYSLFNSFVDTIKSGKQDGDVTDVQYQSVDQQHEK--MNSTGRRLSDMFSKIRRGTSAD 1861

  Fly  2616 TATAPATGCGPAATS---ASD-----SDRHQAVGGGSAPS---------RKRASSFIRKKPPLER 2663
            .        .|..|.   |.|     |.|::::...|.||         |.|..|     ||..|
 Worm  1862 H--------NPHQTEHLLAQDNRSPSSPRYRSMARASPPSPAERYGHPPRYRTES-----PPSSR 1913

  Fly  2664 GLSAQSALR---VNKNAFVS-----EASAPEVIVTRPSPEQQTHPH------------------- 2701
            . ..|.::|   :.:|.:.:     .:..|:.   ....:||..||                   
 Worm  1914 S-EYQMSIRDPIIRRNRYNTMEHSRSSHDPQY---HQDQQQQQQPHHQQHSQHLQHSHHKTYQNH 1974

  Fly  2702 -SLSLRP---DNATLVHVLVHRESEEYKEEDESSP-SVSGNGNGFGVG-----LDMLSKQP---- 2752
             ..|..|   |::::..  .:|...|::...:|:| .||.:.:.....     |.::|..|    
 Worm  1975 NQYSRSPIYSDDSSVAE--SYRREREFRRYQDSTPQDVSEDDDPMPTAVRARRLPLISTMPTHYE 2037

  Fly  2753 ----PPQIR--------ITTG---SVESSMDTCAMPTVQ------IMVDSPKDPPRGDFS----- 2791
                |....        :.||   ...:|......||.|      :...||...||...|     
 Worm  2038 SAYQPSSYNQHLNDSYGLGTGYQRDYHTSHSHSHHPTSQQQQHQPMYSTSPLISPRSSHSYYTPR 2102

  Fly  2792 SAPIDDVGAP---IDVNVQGDTSQVFYDYNPEKATDDQGNGQDETAQFESLPDRQ-------RXP 2846
            |:...::.:|   |..:.:|..|...|                .|:.....|||:       :..
 Worm  2103 SSQYYEIPSPSPDIYPSYRGSASPRRY----------------PTSTVVVAPDREGSSARVIQAQ 2151

  Fly  2847 PVNTPLRDSE 2856
            |.:.||.|||
 Worm  2152 PGSIPLSDSE 2161

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 75/235 (32%)
Ion_trans 705..902 CDD:278921 67/208 (32%)
Ion_trans 1768..2019 CDD:278921 78/267 (29%)
Na_channel_gate 2009..2063 CDD:240441 7/54 (13%)
Ion_trans 2085..2320 CDD:278921 86/250 (34%)
GPHH 2331..2386 CDD:293510 19/59 (32%)
unc-2NP_001355464.1 Ion_trans 254..536 CDD:366146 93/301 (31%)
Ion_trans 667..904 CDD:366146 79/244 (32%)
Ion_trans 998..1279 CDD:366146 86/289 (30%)
Ion_trans 1323..1577 CDD:366146 93/268 (35%)
GPHH 1586..1639 CDD:374878 18/52 (35%)
Ca_chan_IQ 1650..1726 CDD:370105 16/79 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.940

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