DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NaCP60E and egl-19

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:NP_001023079.1 Gene:egl-19 / 177513 WormBaseID:WBGene00001187 Length:1877 Species:Caenorhabditis elegans


Alignment Length:2813 Identity:546/2813 - (19%)
Similarity:897/2813 - (31%) Gaps:1244/2813 - (44%)


- Green bases have known domain annotations that are detailed below.


  Fly    95 NYIHRFTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLAMTE------------ 147
            |.:.|  ..:||......:|.|::|:.|...:.|::.::..|..|||.||:.:            
 Worm    59 NVVER--SERSLLCLSLNNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNT 121

  Fly   148 TVEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEVGNLAG--- 209
            .:|..||:|:.:::||.|:||:|.||:.:...||||.||.|||:::..|..:..:...::.|   
 Worm   122 LLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDV 186

  Fly   210 --LRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKC 272
              ||.|||||.|:.||.:|.|:.::||:|.:...|..:..|.:|.::::|:..|:::.|:|.:.|
 Worm   187 KALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTC 251

  Fly   273 VRQVPTDWTNVSHTDWQIWVNDTDNWLYDEDELPVLCGNLT--GARHCP-----------FEYVC 324
                               ::.....|..:|..|  ||..|  .|..|.           :|...
 Worm   252 -------------------IDPATGQLAQKDPTP--CGTDTEGSAFKCQPSDSLTNMGVRWECSS 295

  Fly   325 LCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCG---PMSVSFFTVVVFFGSFY 386
            ......||:|.||||||..:|||.||.::|:.|.:|...|....|   |.  .:|..:|..|||:
 Worm   296 NTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPW--IYFVTLVILGSFF 358

  Fly   387 LINLMLAVVALSYEEEAEITNEERKKDLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLL 451
            ::||:|                                                       |||.
 Worm   359 VLNLVL-------------------------------------------------------GVLS 368

  Fly   452 ASYSKKKTRRKKTKGGKEGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQY 516
            ..:||:: .:.:.:|                                          ..|..::.
 Worm   369 GEFSKER-EKARARG------------------------------------------LFQKFREK 390

  Fly   517 QQMEQQHKLAKSGSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQL----IANSGQPS 577
            ||:|:                                          |.||.|    .|...:| 
 Worm   391 QQLEE------------------------------------------DLKGYLDWITQAEDIEP- 412

  Fly   578 SNSSGVNRESSQDDS------GVVDDHEEQDTTNDMGHVSTVELALSPREVRLIKCNGNIARIKN 636
                 ||.:..:|:.      |...|.|.::...|               ||..|....:.|::.
 Worm   413 -----VNEDEQEDEPVAQTVVGEEADEEGEERVED---------------VRPSKWAARMKRLEK 457

  Fly   637 HNVYALHQEFSSEVVVIDDLPDRNCDRCVHWCTDYESWLQFQNCLYKVVRDPLFELAITLCIVLN 701
            .|                    |.|.|...                ::|:...|...:.|.::||
 Worm   458 LN--------------------RRCRRACR----------------RLVKSQTFYWLVILLVLLN 486

  Fly   702 TAFLAMEHHGMSESFRNALDVGNKVFTSIFTFECIVKLMALS-KDFFLCGWNIFDLLIVTASLLD 765
            |..|..||:|.||...:...:.|..|..:|:.|.::|:.:|. ..:....:|.||..:|.:|:|:
 Worm   487 TLVLTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISSILE 551

  Fly   766 II---FELVD--GLSVLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAV 825
            .:   |:|:.  |:||||..||||:.|:.:.||:::.|:|.:::::.::.:|.|:|.:.|.|||:
 Worm   552 FVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTSLRNLVSSLLNSLRSIISLLLLLFLFIVIFAL 616

  Fly   826 IGMQLFSKDYTPEKFDP-DPVPRWNFNDFFHSFMMIFRILCGE-WIEPLWDCMRAEEEQGASTCF 888
            :|||:|...:   .|:| .|.||.||:.|..:.:.:|:||.|| |...::..:  |...|..|..
 Worm   617 LGMQVFGGKF---NFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGI--ESFGGVGTLG 676

  Fly   889 AI----FLPTLVMGNFMVLNLFLALLLNSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQE 949
            .|    ::...:.||:::||:|||:.::                                     
 Worm   677 VIVCIYYIVLFICGNYILLNVFLAIAVD------------------------------------- 704

  Fly   950 RKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSG 1014
                                                                             
 Worm   705 ----------------------------------------------------------------- 704

  Fly  1015 SDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSV 1079
                                                                             
 Worm   705 ----------------------------------------------------------------- 704

  Fly  1080 NGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSG 1144
                                                              |..|.|         
 Worm   705 --------------------------------------------------NLADAD--------- 710

  Fly  1145 CGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEA 1209
                                                                     ||..:|:.
 Worm   711 ---------------------------------------------------------SLTNAEKE 718

  Fly  1210 EMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRS 1274
            |               ||.|:   :|                   |:||.::             
 Worm   719 E---------------EQQEI---EG-------------------EDEEFEE------------- 733

  Fly  1275 RRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIME 1339
                   |:.|.|   ||                             .:.||.            
 Worm   734 -------GEDEGE---EH-----------------------------GMDEPE------------ 747

  Fly  1340 HIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDF 1404
                  |..|.::|.                 |||...|.||:                      
 Worm   748 ------GDEEMTSAR-----------------PRRMSEVPAAS---------------------- 767

  Fly  1405 SISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVE 1469
                                                                          .|:
 Worm   768 --------------------------------------------------------------TVK 770

  Fly  1470 EVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYE---NLLIQKQKLGMATPPAVP 1531
            .:|:    .|:|.|                      |..|||:.   |:::              
 Worm   771 PIPK----ASSLFI----------------------LSHTNSFRVFCNMVV-------------- 795

  Fly  1532 ATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAG 1596
                                                                             
 Worm   796 ----------------------------------------------------------------- 795

  Fly  1597 QRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRL 1661
                                                                             
 Worm   796 ----------------------------------------------------------------- 795

  Fly  1662 TEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFM 1726
                                                                  :|.||      
 Worm   796 ------------------------------------------------------NHSYF------ 800

  Fly  1727 SCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFS 1791
                                   |.|    ||..|..||..|..|| .|..|.|...:|.:.::.
 Worm   801 -----------------------TNA----VLFCILVSSAMLAAED-PLQANSTRNMILNYFDYF 837

  Fly  1792 FCLIFVVEMILKWLALGFSKYFTSF----WTILDFIIVFVSVFSLLIEENENLKVLRSLRTLRAL 1852
            |..:|.||:.||.:..|...:..||    :.:||.::|.||:.|.:: ..:.:.|::.||.||.|
 Worm   838 FTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL-RTDAMSVVKILRVLRVL 901

  Fly  1853 RPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEMGELLPI 1917
            ||||||:|.:|::.||..::.|:.:|.|::||..:...:|:|:|||.|.|.||.| |::.::...
 Worm   902 RPLRAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLC-NDLSKMTEA 965

  Fly  1918 T--------EVNDKWDCIEQNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDL 1974
            .        |..|....:.:...|.|:...||:||...::|..|:|||||.:::..|:|:...|.
 Worm   966 ECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNEEDK 1030

  Fly  1975 QPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNF-NMLKKKYEGGVLEMFLTESQKHYYTAM 2038
            .|...:.....::|:.||:..:||.:|:|:|.:|..| |..:::||.       .|..|:....:
 Worm  1031 GPIHNSRQAVALFFIAFIIVIAFFMMNIFVGFVIVTFQNEGEREYEN-------CELDKNQRKCI 1088

  Fly  2039 KKLGRKKPQKVIKR--PINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILE 2101
            :...:.||.   :|  |.|......:....||.||..||::|.:|.:::..:||.........|:
 Worm  1089 EFALKAKPH---RRYIPRNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFLD 1150

  Fly  2102 VSNAFFTTVFGLEAIVKIVGLR-YHYFTVPWNVFDFLLVLASIFGILMEDIMIDLPISPTLLRV- 2164
            |.|..||.||..||::|||.|. .:|.:..|||||.|:|:.|...|....:.   |....|:.: 
 Worm  1151 VFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLN---PGGTNLISIN 1212

  Fly  2165 -VRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKLQGAL 2228
             .|:||:.|:::|:...:|||.||:..:.|..||..:..|:.|:.||||::||..||.|    ||
 Worm  1213 FFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKV----AL 1273

  Fly  2229 DDMV------NFQTFGRSMQLLFRLMTSAGWNDVLESLMIQPPD-----CDPFIHGHTNG----- 2277
            ||..      ||.:|..::.:|||..|...|.|:    |:...|     |||....:..|     
 Worm  1274 DDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDI----MLSCSDREDVRCDPMSDDYHKGGLNES 1334

  Fly  2278 NCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHA 2342
            .||:. .|..||.||.::...:|||:::|:|::||:...::..| :....||.|...||:|||.|
 Worm  1335 RCGNN-FAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSI-LGPHHLEEFVRLWSEYDPDA 1397

  Fly  2343 TQFIHFSQLSDFIASLDPPLGISK--PNNVA---LVSFNLPISKGNKIHCLDILHALVK-----H 2397
            ...|....:...:..:.||||..|  |:.:|   |||.|:|::....:.....|.|||:     :
 Worm  1398 KGRIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKIY 1462

  Fly  2398 VLGHVEETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEK------------------- 2443
            ..|:::|.:      ||:....|               |||||..|                   
 Worm  1463 TEGNIDEAN------EQLRSAIK---------------RIWKRTHKDLLDEVVPPAGKEDDVTVG 1506

  Fly  2444 ---AAKTIQTGWKEYLRR-KREKERSNSGDSATQTSSPGGWQSKLSALNFFHLQVSRRGTACSSR 2504
               |...||    :|.|| |:.||....|....||......|:.|..|:....::.|   |.|..
 Worm  1507 KFYATFLIQ----DYFRRFKKRKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKR---AISGN 1564

  Fly  2505 ASS------------RKSSRASDASDLSELAGPWLNLPLMLVSGADEVVKDIKQQNDELGKRGSI 2557
            ..:            |..|..::.  :..|:|.....|               .:::.:.|..::
 Worm  1565 LETDFNFDEPEPQHRRPHSLFNNL--VHRLSGAGSKSP---------------TEHERIEKGSTL 1612

  Fly  2558 FVEAPRASRRRSFYNFFLRHQDAVDDSLTSPS-VHRKTAMNNTTNTTSNSASTSGTASSTATAP- 2620
            ....||        :|...|..|..:....|| :||...:|.:.|.    ...:|:|......| 
 Worm  1613 LPFQPR--------SFSPTHSLAGAEGSPVPSQMHRGAPINQSINL----PPVNGSARRLPALPP 1665

  Fly  2621 -------ATGCGPAATSASD------------SDRHQAV----------GGGSAPSRKRASSFIR 2656
                   .|..||......|            ::|:..|          .||.:....|.:..:|
 Worm  1666 YANHIHDETDDGPRYRDTGDRAGYDQSSRMVVANRNLPVDPDEEEQWMRSGGPSNRSDRRNPHLR 1730

  Fly  2657 KKPPLERGLSAQSALRVNKNAF------VSEASAPEV-IVTRP--SPEQQTHP------HSLSL- 2705
            :...:.|| :|.:...::..|:      |.|..:..: ..:||  .|.:.:.|      .||.| 
 Worm  1731 EPMLVARG-AALALAGMSSEAYEGTYRPVGEGKSVRLPFSSRPVLRPAEDSRPVDRLIGQSLGLG 1794

  Fly  2706 RPDNATLVHVLVHRESEE 2723
            |..:|.:|.. ..||.||
 Worm  1795 RYADARIVGA-ARREIEE 1811

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 73/239 (31%)
Ion_trans 705..902 CDD:278921 65/208 (31%)
Ion_trans 1768..2019 CDD:278921 84/263 (32%)
Na_channel_gate 2009..2063 CDD:240441 11/56 (20%)
Ion_trans 2085..2320 CDD:278921 84/253 (33%)
GPHH 2331..2386 CDD:293510 20/59 (34%)
egl-19NP_001023079.1 Ion_trans 105..379 CDD:278921 90/352 (26%)
Ion_trans 493..714 CDD:278921 74/508 (15%)
Ion_trans 815..1074 CDD:278921 84/261 (32%)
Ion_trans 1134..1376 CDD:278921 84/253 (33%)
GPHH 1384..1447 CDD:293510 21/62 (34%)
Ca_chan_IQ 1449..1521 CDD:285917 20/96 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.940

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