Protein Alignment NaCP60E and egl-19

DIOPT Version :10

• Sequence 1: NP_001261172.1
• Gene: NaCP60E / 37981
• FlyBaseID: FBgn0085434
• Length: 2896
• Species: Drosophila melanogaster
• Sequence 2: NP_001023079.1
• Gene: egl-19 / 177513
• WormBaseID: WBGene00001187
• Length: 1877
• Species: Caenorhabditis elegans
• Alignment Length: 2814
• Identity: 547/2814 - (19%)
• Similarity: 898/2814 - (31%)
• Gaps: 1246/2814 - (44%)

  Fly    95 NYIHRFTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLAMTE------------ 147
            |.:.|  ..:||......:|.|::|:.|...:.|::.::..|..|||.||:.:
 Worm    59 NVVER--SERSLLCLSLNNPIRKLCISIVEWKPFEFLILFMICANCIALAIYQPYPAQDSDYKNT 121

  Fly   148 TVEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEVGNLAG--- 209
            .:|..||:|:.:::||.|:||:|.||:.:...||||.||.|||:::..|..:..:...::.|
 Worm   122 LLETIEYVFIVVFTIECVLKIVAMGFMFHPSAYLRNAWNILDFIIVVIGLVSTILSKMSIQGFDV 186

  Fly   210 --LRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKC 272
              ||.|||||.|:.||.:|.|:.::||:|.:...|..:..|.:|.::::|:..|:::.|:|.:.|
 Worm   187 KALRAFRVLRPLRLVSGVPSLQVVLNAILRAMIPLLHIALLVLFVILIYAIIGLELFCGKLHSTC 251

  Fly   273 VRQVPTDWTNVSHTDWQIWVNDTDNWLYDEDELPVLCGNLT----------------GARHCPFE 321
                               ::.....|..:|..|  ||..|                |.|   :|
 Worm   252 -------------------IDPATGQLAQKDPTP--CGTDTEGSAFKCQPSDSLTNMGVR---WE 292

  Fly   322 YVCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCG---PMSVSFFTVVVFFG 383
            .........||:|.||||||..:|||.||.::|:.|.:|...|....|   |.  .:|..:|..|
 Worm   293 CSSNTTWPGPNNGITNFDNFGLAMLTVFQCVSLEGWTDVMYWVNDAVGREWPW--IYFVTLVILG 355

  Fly   384 SFYLINLMLAVVALSYEEEAEITNEERKKDLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKG 448
            ||:::||:|                                                       |
 Worm   356 SFFVLNLVL-------------------------------------------------------G 365

  Fly   449 VLLASYSKKKTRRKKTKGGKEGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQAQ 513
            ||...:||:: .:.:.:|                                          ..|..
 Worm   366 VLSGEFSKER-EKARARG------------------------------------------LFQKF 387

  Fly   514 KQYQQMEQQHKLAKSGSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQL----IANSG 574
            ::.||:|:                                          |.||.|    .|...
 Worm   388 REKQQLEE------------------------------------------DLKGYLDWITQAEDI 410

  Fly   575 QPSSNSSGVNRESSQDDS------GVVDDHEEQDTTNDMGHVSTVELALSPREVRLIKCNGNIAR 633
            :|      ||.:..:|:.      |...|.|.::...|               ||..|....:.|
 Worm   411 EP------VNEDEQEDEPVAQTVVGEEADEEGEERVED---------------VRPSKWAARMKR 454

  Fly   634 IKNHNVYALHQEFSSEVVVIDDLPDRNCDRCVHWCTDYESWLQFQNCLYKVVRDPLFELAITLCI 698
            ::..|                    |.|.|...                ::|:...|...:.|.:
 Worm   455 LEKLN--------------------RRCRRACR----------------RLVKSQTFYWLVILLV 483

  Fly   699 VLNTAFLAMEHHGMSESFRNALDVGNKVFTSIFTFECIVKLMALS-KDFFLCGWNIFDLLIVTAS 762
            :|||..|..||:|.||...:...:.|..|..:|:.|.::|:.:|. ..:....:|.||..:|.:|
 Worm   484 LLNTLVLTSEHYGQSEWLDHFQTMANLFFVILFSMEMLLKMYSLGFTTYTTSQFNRFDCFVVISS 548

  Fly   763 LLDII---FELVD--GLSVLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYI 822
            :|:.:   |:|:.  |:||||..||||:.|:.:.||:::.|:|.:::::.::.:|.|:|.:.|.|
 Worm   549 ILEFVLVYFDLMKPLGVSVLRSARLLRIFKVTKYWTSLRNLVSSLLNSLRSIISLLLLLFLFIVI 613

  Fly   823 FAVIGMQLFSKDYTPEKFDP-DPVPRWNFNDFFHSFMMIFRILCGE-WIEPLWDCMRAEEEQGAS 885
            ||::|||:|...:   .|:| .|.||.||:.|..:.:.:|:||.|| |...::..:  |...|..
 Worm   614 FALLGMQVFGGKF---NFNPQQPKPRANFDTFVQALLTVFQILTGEDWNTVMYHGI--ESFGGVG 673

  Fly   886 TCFAI----FLPTLVMGNFMVLNLFLALLLNSFNSEELKSKKEEVGEESKLARSIERVRDLIRKK 946
            |...|    ::...:.||:::||:|||:.::
 Worm   674 TLGVIVCIYYIVLFICGNYILLNVFLAIAVD---------------------------------- 704

  Fly   947 RQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRP 1011
                                                                             
 Worm   705 ----------------------------------------------------------------- 704

  Fly  1012 VSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSF 1076
                                                                             
 Worm   705 ----------------------------------------------------------------- 704

  Fly  1077 SSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQ 1141
                                                                 |..|.|
 Worm   705 -----------------------------------------------------NLADAD------ 710

  Fly  1142 RSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKS 1206
                                                                        ||..:
 Worm   711 ------------------------------------------------------------SLTNA 715

  Fly  1207 EEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNV 1271
            |:.|               ||.|:   :|                   |:||.::
 Worm   716 EKEE---------------EQQEI---EG-------------------EDEEFEE---------- 733

  Fly  1272 MRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKA 1336
                      |:.|.|   ||                             .:.||.
 Worm   734 ----------GEDEGE---EH-----------------------------GMDEPE--------- 747

  Fly  1337 IMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKID 1401
                     |..|.::|.                 |||...|.||:
 Worm   748 ---------GDEEMTSAR-----------------PRRMSEVPAAS------------------- 767

  Fly  1402 EDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIE 1466
                                                                             
 Worm   768 ----------------------------------------------------------------- 767

  Fly  1467 RVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYE---NLLIQKQKLGMATPP 1528
            .|:.:|:    .|:|.|                      |..|||:.   |:::
 Worm   768 TVKPIPK----ASSLFI----------------------LSHTNSFRVFCNMVV----------- 795

  Fly  1529 AVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHS 1593
                                                                             
 Worm   796 ----------------------------------------------------------------- 795

  Fly  1594 MAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAF 1658
                                                                             
 Worm   796 ----------------------------------------------------------------- 795

  Fly  1659 TRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCP 1723
                                                                     :|.||
 Worm   796 ---------------------------------------------------------NHSYF--- 800

  Fly  1724 WFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWI 1788
                                      |.|    ||..|..||..|..|| .|..|.|...:|.:.
 Worm   801 --------------------------TNA----VLFCILVSSAMLAAED-PLQANSTRNMILNYF 834

  Fly  1789 NFSFCLIFVVEMILKWLALGFSKYFTSF----WTILDFIIVFVSVFSLLIEENENLKVLRSLRTL 1849
            ::.|..:|.||:.||.:..|...:..||    :.:||.::|.||:.|.:: ..:.:.|::.||.|
 Worm   835 DYFFTSVFTVEITLKVIVFGLVFHKGSFCRNAFNLLDILVVAVSLTSFVL-RTDAMSVVKILRVL 898

  Fly  1850 RALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEMGEL 1914
            |.|||||||:|.:|::.||..::.|:.:|.|::||..:...:|:|:|||.|.|.||.| |::.::
 Worm   899 RVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIMLVTFMLQFMFAIIGVQLFKGTFFLC-NDLSKM 962

  Fly  1915 LPIT--------EVNDKWDCIEQNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARG 1971
            ....        |..|....:.:...|.|:...||:||...::|..|:|||||.:::..|:|:..
 Worm   963 TEAECRGEYIHYEDGDPTKPVSKKRVWSNNDFNFDNVGDAMISLFVVSTFEGWPQLLYVAIDSNE 1027

  Fly  1972 VDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNF-NMLKKKYEGGVLEMFLTESQKHYY 2035
            .|..|...:.....::|:.||:..:||.:|:|:|.:|..| |..:::||...|:   ...:|...
 Worm  1028 EDKGPIHNSRQAVALFFIAFIIVIAFFMMNIFVGFVIVTFQNEGEREYENCELD---KNQRKCIE 1089

  Fly  2036 TAMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFIL 2100
            .|:|   .|..::.|  |.|......:....||.||..||::|.:|.:::..:||.........|
 Worm  1090 FALK---AKPHRRYI--PRNRLQYRVWWFVTSRAFEYVIFLIIVMNTVSLACKHYPSSRGFEDFL 1149

  Fly  2101 EVSNAFFTTVFGLEAIVKIVGLR-YHYFTVPWNVFDFLLVLASIFGILMEDIMIDLPISPTLLRV 2164
            :|.|..||.||..||::|||.|. .:|.:..|||||.|:|:.|...|....:.   |....|:.:
 Worm  1150 DVFNLIFTGVFAFEAVLKIVALNPKNYISDRWNVFDLLVVVGSFIDITYGKLN---PGGTNLISI 1211

  Fly  2165 --VRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKLQGA 2227
              .|:||:.|:::|:...:|||.||:..:.|..||..:..|:.|:.||||::||..||.|    |
 Worm  1212 NFFRLFRVMRLVKLLSRGEGIRTLLWTFMKSFQALPYVALLIVLLFFIYAVIGMQFFGKV----A 1272

  Fly  2228 LDDMV------NFQTFGRSMQLLFRLMTSAGWNDVLESLMIQPPD-----CDPFIHGHTNG---- 2277
            |||..      ||.:|..::.:|||..|...|.|:    |:...|     |||....:..|
 Worm  1273 LDDSTSIHRNNNFHSFPAAILVLFRSATGEAWQDI----MLSCSDREDVRCDPMSDDYHKGGLNE 1333

  Fly  2278 -NCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPH 2341
             .||:. .|..||.||.::...:|||:::|:|::||:...::..| :....||.|...||:|||.
 Worm  1334 SRCGNN-FAYPYFISFFMLCSFLVINLFVAVIMDNFDYLTRDWSI-LGPHHLEEFVRLWSEYDPD 1396

  Fly  2342 ATQFIHFSQLSDFIASLDPPLGISK--PNNVA---LVSFNLPISKGNKIHCLDILHALVK----- 2396
            |...|....:...:..:.||||..|  |:.:|   |||.|:|::....:.....|.|||:
 Worm  1397 AKGRIKHLDVVTLLRKISPPLGFGKLCPHRLACKRLVSMNMPLNSDGTVCFNATLFALVRTNLKI 1461

  Fly  2397 HVLGHVEETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEK------------------ 2443
            :..|:::|.:      ||:....|               |||||..|
 Worm  1462 YTEGNIDEAN------EQLRSAIK---------------RIWKRTHKDLLDEVVPPAGKEDDVTV 1505

  Fly  2444 ----AAKTIQTGWKEYLRR-KREKERSNSGDSATQTSSPGGWQSKLSALNFFHLQVSRRGTACSS 2503
                |...||    :|.|| |:.||....|....||......|:.|..|:....::.|   |.|.
 Worm  1506 GKFYATFLIQ----DYFRRFKKRKEMEAKGVLPAQTPQAMALQAGLRTLHEIGPELKR---AISG 1563

  Fly  2504 RASS------------RKSSRASDASDLSELAGPWLNLPLMLVSGADEVVKDIKQQNDELGKRGS 2556
            ...:            |..|..::.  :..|:|.....|               .:::.:.|..:
 Worm  1564 NLETDFNFDEPEPQHRRPHSLFNNL--VHRLSGAGSKSP---------------TEHERIEKGST 1611

  Fly  2557 IFVEAPRASRRRSFYNFFLRHQDAVDDSLTSPS-VHRKTAMNNTTNTTSNSASTSGTASSTATAP 2620
            :....||        :|...|..|..:....|| :||...:|.:.|.    ...:|:|......|
 Worm  1612 LLPFQPR--------SFSPTHSLAGAEGSPVPSQMHRGAPINQSINL----PPVNGSARRLPALP 1664

  Fly  2621 --------ATGCGPAATSASD------------SDRHQAV----------GGGSAPSRKRASSFI 2655
                    .|..||......|            ::|:..|          .||.:....|.:..:
 Worm  1665 PYANHIHDETDDGPRYRDTGDRAGYDQSSRMVVANRNLPVDPDEEEQWMRSGGPSNRSDRRNPHL 1729

  Fly  2656 RKKPPLERGLSAQSALRVNKNAF------VSEASAPEV-IVTRP--SPEQQTHP------HSLSL 2705
            |:...:.|| :|.:...::..|:      |.|..:..: ..:||  .|.:.:.|      .||.|
 Worm  1730 REPMLVARG-AALALAGMSSEAYEGTYRPVGEGKSVRLPFSSRPVLRPAEDSRPVDRLIGQSLGL 1793

  Fly  2706 -RPDNATLVHVLVHRESEE 2723
             |..:|.:|.. ..||.||
 Worm  1794 GRYADARIVGA-ARREIEE 1811

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	125..371	CDD:459842	81/281 (29%)
		Ion_trans	687..902	CDD:459842	70/226 (31%)
		Ion_trans	1751..2019	CDD:459842	90/280 (32%)
		Na_channel_gate	2009..2063	CDD:240441	12/54 (22%)
		Ion_trans	2067..2320	CDD:459842	92/271 (34%)
		GPHH	2332..2378	CDD:465306	18/50 (36%)
egl-19	NP_001023079.1	Ion_trans	87..379	CDD:459842	95/373 (25%)
		Ion_trans	493..714	CDD:459842	74/508 (15%)
		Ion_trans	797..1074	CDD:459842	94/312 (30%)
		Ion_trans	1116..1376	CDD:459842	92/271 (34%)
		GPHH	1385..1438	CDD:465306	19/52 (37%)
		Ca_chan_IQ	1448..1523	CDD:462591	21/99 (21%)
		CAC1F_C	1545..1827	CDD:465298	55/301 (18%)