DRSC/TRiP Functional Genomics Resources

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Protein Alignment NaCP60E and unc-77

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:NP_001293824.1 Gene:unc-77 / 177379 WormBaseID:WBGene00006809 Length:1867 Species:Caenorhabditis elegans


Alignment Length:2767 Identity:501/2767 - (18%)
Similarity:837/2767 - (30%) Gaps:1185/2767 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly   118 VCVY----IATNQFFDYCVMATILFNCIFLAMTETVEEAEYIFLAIYSIEMVIKIIAKGFLLNKY 178
            ||::    |...|..:|.::|                 |::|.::|:.::.|::|..:|......
 Worm   101 VCIHTPRTIELFQPLNYIILA-----------------ADFISVSIFMLDSVLRIHYEGIFRCDS 148

  Fly   179 TYLRNPW----------NWLDFV-----VITSGYATIGME----VGNLAGLRTFRVLRALKTVSI 224
            :||.|.|          :.|.|:     :|.:.:..:.:.    .|.:..:|.|.::|.:..|..
 Worm   149 SYLSNRWSQFSVFISIIHLLSFLLHCYQLIDNFFPFLHLNYRAWYGAIRSIRPFIIIRLIPLVVK 213

  Fly   225 MPGLKTIINALL-HSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVPTDWTNVSHTDW 288
            ....|..|..|| .|.:|:..|....:|.:.::|:|.:|:: |.:...|| |..||..||:..| 
 Worm   214 FKLPKNRIEQLLKRSSQQVKNVTLFFVFFMTLYAIFGIQLF-GRMDYHCV-QPKTDPNNVTIMD- 275

  Fly   289 QIWVNDTDNWLYDEDELPVLCG-NLTGARHCPFEYVCLCVGEN-PNHG-YTNFDNFMWSMLTTFQ 350
             :.:.||            :|. ...|...||...||:.:..| ...| |..|::|..|:.|.:.
 Worm   276 -LAIPDT------------MCAPEGIGGYECPAPMVCMQLNLNAKGEGFYGMFNDFGASVFTVYL 327

  Fly   351 LITLDYWENVYNMVLATC-----GPMSVSFFTVVVFFGSFYLINLMLAVVALSYEE-EAEITNEE 409
            ..:.:.|  ||  ||..|     ..::..:|..::||.::.:.|:.:||:..::.| ..:.:...
 Worm   328 AASEEGW--VY--VLYDCMDSLPSYLAFLYFCTLIFFLAWLVKNVFIAVITETFAEIRVQFSEMW 388

  Fly   410 RKKDLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGKEGGTNG 474
            :||::                   .|::..:||::                  ||          
 Worm   389 QKKEV-------------------TLDEGFRKKLE------------------KT---------- 406

  Fly   475 NGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQHKLAKSGSGGSNNPMAP 539
                                                                             
 Worm   407 ----------------------------------------------------------------- 406

  Fly   540 TPKGRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQDDSGVVDDHEEQDTT 604
                     |.|.                                                    
 Worm   407 ---------DDGW---------------------------------------------------- 410

  Fly   605 NDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDRNCDRCVHWCT 669
                              |||:.:|.:.                        |:....: :.|  
 Worm   411 ------------------RLIRLDGEVE------------------------PEGPKQK-LQW-- 430

  Fly   670 DYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAM--EHHGMSESFRN----ALDVGNKVFT 728
                          ::|...|:..:.:.:|:|....||  ..|..::..|.    ..:||   ||
 Worm   431 --------------MLRSMYFQCFVIIFVVINAIGNAMFVYRHDETDKPRKYNFYLFEVG---FT 478

  Fly   729 SIFTFECIVKLMALS-KDFFLCGWNIFDLLIVTASLLDII--FELVDGLSVLRGLRLLRVLKLAQ 790
            .:|..|||:|::... ::|...|...|:|::...|.|:.:  |...:..:..:..||||::|.: 
 Worm   479 ILFNVECIIKILCYGFRNFIRRGIFKFELILCLGSSLNCVKFFYERNYFTYFQTFRLLRLIKAS- 542

  Fly   791 SWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTPEKFDPDPVPR-WNFNDFF 854
              ..::..:..|.|....||.|.:..:..|..::.|.:|||   |:        ||. .:|..|.
 Worm   543 --PILEDFVWKIFSPGKKLGGLVIFTIAFICCYSAISLQLF---YS--------VPNLHHFRTFP 594

  Fly   855 HSFMMIFRILCGE-WIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLFLALLLNSFN-SE 917
            .:||.:|:|:..| |.:.:.:.:||.::.........|:...:....:||:||:|::|::.. .|
 Worm   595 QAFMSMFQIITQEGWTDFVVEVLRATDDNLVPLVALYFVAYHLFVTLIVLSLFVAVILDNLEMDE 659

  Fly   918 ELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAA 982
            |||..|:            .|.|:.....|.....|. |.| |||.                   
 Worm   660 ELKKVKQ------------LRAREATTSMRSTLPWRL-RVF-EKFP------------------- 691

  Fly   983 VGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQ 1047
                  .:|.:.|..|              :.|||                              
 Worm   692 ------TRPQMAAMRK--------------ADSDF------------------------------ 706

  Fly  1048 LQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYD 1112
                |:|...                |||:                      ||.:         
 Worm   707 ----PMPKVR----------------GSFT----------------------HQFA--------- 720

  Fly  1113 SREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKS 1177
                  ...|:|        .||...:|       |.....:..::.:|           |..||
 Worm   721 ------VDHSLE--------TTDVIESD-------FEFPKRIMKSAGKR-----------KISKS 753

  Fly  1178 LLT----RSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNL- 1237
            .||    .|.|.|.||:.|.:.|.::::||                .||:|. ........|:| 
 Worm   754 GLTFRQIGSTSLRCSLNNLLEMSDRTRQSL----------------SNSLSF-LPHFTRSSGSLY 801

  Fly  1238 -REELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQS 1301
             |::.|...:....:|||                                 |.|.:.:|:...::
 Worm   802 PRKDALPKSRSMTGKFLQ---------------------------------TAVRNKQFNMYSEN 833

  Fly  1302 FEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSY 1366
                               .:||.||   |.|.|             :.:...|:          
 Worm   834 -------------------GDLSRPS---DSAPK-------------KNAKQGEI---------- 853

  Fly  1367 DLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAA 1431
            |:.::.::         ||..::.|      .:|:||.                           
 Worm   854 DIRALQQK---------RQLAEITR------NRIEEDM--------------------------- 876

  Fly  1432 TSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGP 1496
                           |:..||   |||  .|.|:.|.          |.||...:||        
 Worm   877 ---------------RENHPF---FDR--PLFLVGRA----------SQLREFCKKM-------- 903

  Fly  1497 DQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAA 1561
                                                                             
 Worm   904 ----------------------------------------------------------------- 903

  Fly  1562 LTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGA 1626
                               .|:...||                                      
 Worm   904 -------------------VHSKYDSQ-------------------------------------- 911

  Fly  1627 ADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDP 1691
                                                           ||.|.||.:         
 Worm   912 -----------------------------------------------DDGTNGGAK--------- 920

  Fly  1692 MTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWF 1756
                    ||                                 |.:..:| |::.::  |..:|.
 Worm   921 --------TK---------------------------------KRFKEIR-ALIGIM--PYIDWA 941

  Fly  1757 VLVLIFASSITLCFED------INLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGFSKYFT- 1814
            :..:...|.|::.||.      .||..|....::   .::.|.|....|:.:|.:|.|.  :|| 
 Worm   942 MATVTIVSCISMLFESPWPTTGENLVMNNGYLQI---SDYFFVLSMTFELCVKIIANGL--FFTP 1001

  Fly  1815 -----SFWTILDFIIVFVSVFSLL-----IEENENLKVLRSLRTLRALRPLRAISRWQGMRIVVN 1869
                 ....:::..|.|.||..|.     :|.|   .:.:.|...||:||||..:....:|.||.
 Worm  1002 KAVVRDVGGVMNLFIYFTSVIFLAWMPKHVEIN---SLAQFLMICRAMRPLRIYTLVPHIRRVVL 1063

  Fly  1870 ALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEMGELLPITEVNDKWDCIEQNYT-- 1932
            ........|..|.::.:|...||:..|||..|||...|             ||......:|.|  
 Worm  1064 EFFRGFKEILLVTILMIVVMFIFASFGVQIVGGKLAAC-------------NDPTVSSRENCTGV 1115

  Fly  1933 -----------------------------WINSK-ITFDHVGMGYLALLQVATFEGWMEVMADAV 1967
                                         |.|.: ..|||||...|||.:..:|:|| .|:.|.:
 Worm  1116 FWQKLFVTRLEVYGKDTEAMHPKIMVPRVWTNPRNFNFDHVGNAMLALFETLSFKGW-NVIRDIL 1179

  Fly  1968 DARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQK 2032
            .:|         ...:|.::..|::..|....|.||:||:|.|:.    :..|..|   ||..|:
 Worm  1180 WSR---------HGPWAVVFIHIYVFIGCMIGLTLFVGVVIANYT----QNRGTAL---LTVDQR 1228

  Fly  2033 HYYTAMKKLGRKKPQKVIKRPIN--HFLAMFYDLSNSRRFEIAIFVLIFLNMLTM----GIEHYD 2091
            .::....:|...:|..|..:|..  ......|||:.||.|..|..:|:.||..|:    .:|..:
 Worm  1229 RWHDLKARLKMAQPLHVPPKPSESARLRTKLYDLTMSRWFNQAFALLVVLNSFTLVIPWNVEEEE 1293

  Fly  2092 QPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRYHYFTVPW----NVFDFLLVLASIFGIL----- 2147
            |.....|.:....||...:|.:|.|:|::...:..|   |    |..|.|:   ::||::     
 Worm  1294 QRATYVFTVTALAAFMNMLFVIEIILKVIAYTFSGF---WQSRRNRVDLLI---TVFGVIWIFLH 1352

  Fly  2148 ----MEDIMIDLPISPTLLRVVRVFR----IGRILRLIKAAKGIRKLLFALVVSLPALFNIGALL 2204
                :....||:.:...|.:....|.    |.|...:......::.|:..:::|:...|.|...|
 Worm  1353 FFVALPSSKIDVDVQVELKKFTYTFGYLVVILRFFTIASRNSTLKMLMLTVIMSMFRSFFIITAL 1417

  Fly  2205 GLITFIYAILGMSLFGNVKLQGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQPPDC-- 2267
            .|:...||..|:.||..||...|:...|||:|...::.:|||.:|...|||::...|...|.|  
 Worm  1418 FLLVLFYAYTGVILFPMVKYGMAVSKHVNFRTASEALVVLFRCLTGEDWNDIMHDCMRSAPFCYW 1482

  Fly  2268 -DPFIHGHTNGNCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVE-DDLEM 2330
             :...:..|  :||:...||.||.||.:|...||.|:.:|:|:|||:..:..||..::. .|:..
 Worm  1483 NEGMNYWET--DCGNFYGAIIYFCSFYLIITYIVRNLLVAVIMENFSLFYSSEEDALLSYADIRN 1545

  Fly  2331 FYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISKPNNVALVSFNLPISKGNKIHCLDI----L 2391
            |...|:..|....:.|                      .|..|.|.|.:.||.    |::    .
 Worm  1546 FQYVWNMVDQEQKRTI----------------------PVERVKFLLRLLKGR----LEVDPEKD 1584

  Fly  2392 HALVKHVLGHVEETDNFKQLQ----------EQMDVKFKKQFP---TRKELEIVSSTRIWKRQEK 2443
            ..|.||:...:|...|.:::.          ..:|::...|..   .|:|||.:.      .:|.
 Worm  1585 RILFKHMCYEMERLHNGEEVSFHDVLYMLSYRSVDIRKSLQLEELLQREELEFII------EEEV 1643

  Fly  2444 AAKTIQTGWKEYLRRKREKERSNSGDSATQTSSPGGWQSKLSALNFFHLQVSRRGTACSSRASSR 2508
            |.:||:| |.|...||                                           .|..|:
 Worm  1644 AKQTIRT-WLEGCLRK-------------------------------------------MRNPSQ 1664

  Fly  2509 KSSRASDASDLSELAGPWLNLPLMLVSGADEVVKDIKQQNDELGKRGSIFVEAPRASRRRSFYNF 2573
            |     ||..:....|   ..|::..||                 ..||..|...|.|.| |.|.
 Worm  1665 K-----DAEGVLPFGG---GHPVIHSSG-----------------HSSISHEETVAQRLR-FENI 1703

  Fly  2574 FLRHQDAVD-------DSLTSPSVHRKTAMNNTTNTTSNSASTSGTASSTATAPATGCGPAATSA 2631
               ..|:||       :..|.|.:.:|.|:.|...:..:..|.:|.....|.....|        
 Worm  1704 ---RGDSVDTEETESSEEETPPPIRKKAAVKNRRGSIPDVLSRTGLFQEAARKFMVG-------- 1757

  Fly  2632 SDSDRHQAVGGGSAPSR-----KRASSFIRK----------------KPPL-ERGLSAQSALRVN 2674
            |.|::.|.  ...:|..     |||:|.|||                .|.: |||..:..:.:..
 Worm  1758 SSSEKKQV--KSRSPETVQLLPKRANSEIRKGSGQPKNFHLQLNVYDLPDVEERGEDSPFSPKNL 1820

  Fly  2675 KNAFVSEASAPEVIVTRPSPEQQTHPHSLSLRPDNAT 2711
            .:.|..|.|  .:::|...|...||.....|.|...|
 Worm  1821 SDDFNGEHS--PLVITPSLPVPPTHGSPRPLMPCETT 1855

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 59/246 (24%)
Ion_trans 705..902 CDD:278921 49/207 (24%)
Ion_trans 1768..2019 CDD:278921 72/299 (24%)
Na_channel_gate 2009..2063 CDD:240441 10/55 (18%)
Ion_trans 2085..2320 CDD:278921 68/258 (26%)
GPHH 2331..2386 CDD:293510 10/54 (19%)
unc-77NP_001293824.1 Ion_trans 107..383 CDD:278921 70/312 (22%)
Ion_trans 455..660 CDD:278921 53/221 (24%)
Ion_trans 973..1214 CDD:278921 66/271 (24%)
Ion_trans 1310..1534 CDD:278921 63/231 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.940

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