DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NaCP60E and cacna1c

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:XP_021330579.1 Gene:cacna1c / 170581 ZFINID:ZDB-GENE-020129-1 Length:2202 Species:Danio rerio


Alignment Length:3044 Identity:604/3044 - (19%)
Similarity:995/3044 - (32%) Gaps:1293/3044 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly   113 SPARRVCVYIATNQFFDYCVMATILFNCIFLAM------------TETVEEAEYIFLAIYSIEMV 165
            :|.||.|:.|...:.|:..::.||..||:.||:            ...:|..||:||.|:::|..
Zfish   144 NPIRRACINIVEWKPFEIIILMTIFANCVALAVYIPFPEDDSNATNSNLERVEYLFLIIFTVEAF 208

  Fly   166 IKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEV-----------GNLAG-----LRTFR 214
            :|:||.|.|.:...||||.||.|||:::..|..:..:|.           |..||     ||.||
Zfish   209 LKVIAYGLLCHPNAYLRNGWNLLDFIIVVVGLFSAILEQATKGDGGTSMGGKAAGFDVKALRAFR 273

  Fly   215 VLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVPTD 279
            |||.|:.||.:|.|:.::|:::.:...|..:..|.:|.::::|:..|:::||::...|       
Zfish   274 VLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHRTC------- 331

  Fly   280 WTNVSHTDWQIWVNDTDNWLYDE-------DELPVLCG-NLTGARHC--PFEYVCLCVGENPNHG 334
                              :.|.:       :|.|..|. :....|||  |....|:...|.||.|
Zfish   332 ------------------FFYKDGHKGHIAEEKPAPCAPSSAHGRHCSPPNITQCMMGWEGPNDG 378

  Fly   335 YTNFDNFMWSMLTTFQLITLDYWENV-YNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALS 398
            .||||||.::|||.||.||::.|.:| |.|..|....:...:|..:|.||||:::||:|      
Zfish   379 ITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVL------ 437

  Fly   399 YEEEAEITNEERKKDLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKK 463
                                                             |||...:||::.:.| 
Zfish   438 -------------------------------------------------GVLSGEFSKEREKAK- 452

  Fly   464 TKGGKEGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQHK---- 524
                           :.||                           .|..::.||:|:..|    
Zfish   453 ---------------ARGD---------------------------FQKLREKQQLEEDLKGYLD 475

  Fly   525 -LAKSGSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESS 588
             :.::......|            .|.|:....|.             |...|:|.:..||    
Zfish   476 WITQAEDIDPEN------------DDEGLDDDKPR-------------NLSMPASENESVN---- 511

  Fly   589 QDDSGVVDDHEEQDTTNDMGHVSTVELA-LSPREVRLI--KCNGNIARIKNHNVYALHQEFSSEV 650
            .|::...|...|...|.....:|..:.: .|.|..||.  ||.   |.:|::..|          
Zfish   512 TDNAPAGDMEGETCCTRMANRISKSKFSRYSRRWNRLCRRKCR---AAVKSNVFY---------- 563

  Fly   651 VVIDDLPDRNCDRCVHWCTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSES 715
                                   ||                  :...:.|||..:|.|||...|.
Zfish   564 -----------------------WL------------------VIFLVFLNTLTIASEHHQQPEW 587

  Fly   716 FRNALDVGNKVFTSIFTFECIVKLMALS-KDFFLCGWNIFDLLIVTASLLDIIFELVD------- 772
            ..|..|:.|||..::||.|.::|:.:|. :.:|:..:|.||..:|...:|:.|  ||:       
Zfish   588 LTNVQDIANKVLLALFTGEMLLKMYSLGLQAYFVSLFNRFDSFVVCGGILETI--LVETKIMSPL 650

  Fly   773 GLSVLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTP 837
            |:||||.:||||:.|:.:.|.::..|::.:::::.::.:|.|:|.:.|.||:::|||||.     
Zfish   651 GISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFG----- 710

  Fly   838 EKFDPDPVPRWNFNDFFHSFMMIFRILCGE-WIEPLWDCMRA---EEEQGASTCFAIFLPTLVMG 898
            .||:.|...|..|::|..|.:.:|:||.|| |...::|.:.|   ....|...|. .|:...:.|
Zfish   711 GKFNFDETRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCI-YFIILFICG 774

  Fly   899 NFMVLNLFLALLL-NSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKF 962
            |:::||:|||:.: |..::|.|.|                     .:|:.:|.|:||:.      
Zfish   775 NYILLNVFLAIAVDNLADAESLTS---------------------AQKEEEEEKERKKL------ 812

  Fly   963 QQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGL 1027
                       |:|.|.:..   :..:||.:..|.|                             
Zfish   813 -----------ARTASPEKR---QNSEKPPLEDEKK----------------------------- 834

  Fly  1028 HTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFV 1092
                           .|:|:|::    .|||...||                             
Zfish   835 ---------------EEKIELKS----ITSDGETPT----------------------------- 851

  Fly  1093 QAERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPY-ANDQRSGCGSFNRGDSLQD 1156
                                    ||.....|..|:.|. :.:|| .||..:|            
Zfish   852 ------------------------ATKINIDEYTGEDNE-EKNPYPVNDFPAG------------ 879

  Fly  1157 NSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLN 1221
                                                                             
Zfish   880 ----------------------------------------------------------------- 879

  Fly  1222 SMSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPEN 1286
                |.||                         ||.|:..|.:.|.:|::               
Zfish   880 ----EDDE-------------------------EEPEMPVGPRPRPLSDI--------------- 900

  Fly  1287 ETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERS 1351
                                            :|...:.|.|.|    ||..             
Zfish   901 --------------------------------QLKEKAVPMPQA----KAFF------------- 916

  Fly  1352 AADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQ 1416
                                                               .||.||:.|.:|.:
Zfish   917 ---------------------------------------------------IFSPSNKFRVLCHK 930

  Fly  1417 IHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTL 1481
            |                                                                
Zfish   931 I---------------------------------------------------------------- 931

  Fly  1482 RIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPT 1546
                                                                             
Zfish   932 ----------------------------------------------------------------- 931

  Fly  1547 LAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKA 1611
                                                                  :.|        
Zfish   932 ------------------------------------------------------VNH-------- 934

  Fly  1612 ASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDL 1676
                                                        :.||.|               
Zfish   935 --------------------------------------------NIFTNL--------------- 940

  Fly  1677 TVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVR 1741
                                                                             
Zfish   941 ----------------------------------------------------------------- 940

  Fly  1742 TAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLK-RVLYWINFSFCLIFVVEMILKWL 1805
                           :|..|..|||:|..||  ..||.:.: ::|.:.::.|..||.:|:|||..
Zfish   941 ---------------ILFFILLSSISLAAED--PVKNDSFRNQILGYADYVFTGIFTIEIILKMT 988

  Fly  1806 ALGF----SKYFTSFWTILDFIIVFVSVFSLLIEENENLKVLRSLRTLRALRPLRAISRWQGMRI 1866
            |.|.    ..:..:::.|||.::|.||:.|..|:.:. :.|::.||.||.|||||||:|.:|::.
Zfish   989 AYGAFLHKGSFCRNYFNILDLVVVSVSLISSGIQSSA-INVVKILRVLRVLRPLRAINRAKGLKH 1052

  Fly  1867 VVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEMGELLPITEVNDKWDC----- 1926
            ||..:..||.:|.|:::|..:...:|:.:|||.|.||||.|.:        |....:.:|     
Zfish  1053 VVQCVFVAIRTIGNIVIVTSLLQFMFACIGVQLFKGKFFYCTD--------TSKQTQAECRGAYI 1109

  Fly  1927 ----------IEQNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREAN 1981
                      .:...:|.||...||.|..|.:||..|:|||||..::..|:|:...|:.|.....
Zfish  1110 LYKDGNVGKPEKAQRSWENSDFNFDDVLQGMMALFAVSTFEGWPGLLYRAIDSHAEDVGPIYNYR 1174

  Fly  1982 LYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKP 2046
            :...|:|:|:|:..:||.:|:|:|.:|..|.      |.|..|....|..|:....::...:.:|
Zfish  1175 VVISIFFIIYIIIIAFFMMNIFVGFVIVTFQ------EQGEQEYKNCELDKNQRQCVEYALKARP 1233

  Fly  2047 QKVIKR--PINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTT 2109
               ::|  |.|.:....:.:.||..||..:|.||.||.:.:.::|:.|..:....:.:.|..||.
Zfish  1234 ---LRRYIPKNPYQYKVWYVVNSTYFEYLMFTLILLNTICLAMQHHGQSQSFNKAMNILNMLFTG 1295

  Fly  2110 VFGLEAIVKIVGLRYH-YFTVPWNVFDFLLVLASIFGILMEDIMIDLPISPTLLRVV-------- 2165
            :|.:|.|:|::..:.. ||:.||||||||:|:.||..:::.:|....|.|.....||        
Zfish  1296 LFTVEMILKLIAFKPRGYFSDPWNVFDFLIVIGSIIDVILSEINPADPSSSPPSSVVRPMGLQNT 1360

  Fly  2166 -----------RVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLF 2219
                       |:||:.|:::|:...:|||.||:..:.|..||..:..|:.::.||||::||.:|
Zfish  1361 EDNARISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMF 1425

  Fly  2220 GNVKLQ--GALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQPPDCDPFIH-GHTNGNCG- 2280
            |.:.|:  ..::...|||||.:::.||||..|...|.:::.:.....| |:.... .|::.:|| 
Zfish  1426 GKIALRDNSQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACSPNRP-CEKGSEINHSSEDCGS 1489

  Fly  2281 HPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQF 2345
            |  .||.||.||.::...::||:::|:|::||:...::..| :....|:.|...|::|||.|...
Zfish  1490 H--FAIFYFVSFYMLCAFLIINLFVAVIMDNFDYLTRDWSI-LGPHHLDEFKRIWAEYDPEAKGR 1551

  Fly  2346 IHFSQLSDFIASLDPPLGISK--PNNVA---LVSFNLPISKGNKIHCLDILHALVKHVLGHVEET 2405
            |....:...:..:.||||..|  |:.||   |||.|:|::....:.....|.|||:..| .::..
Zfish  1552 IKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTAL-RIKTE 1615

  Fly  2406 DNFKQLQEQMDVKFKK--------------------------------------QFPTRKELEIV 2432
            .|.:|..|::....||                                      :|..|||..:|
Zfish  1616 GNLEQANEELRAIVKKIWKRTSMKLLDQVVPPAGDDEVTVGKFYATFLIQEYFRKFKKRKEQGLV 1680

  Fly  2433 SSTRIWKRQEKAAKTIQTGWKEYLRRKREKERSNSGDSATQTSSPGGWQSKLSA----------- 2486
            :     |...|.|.::|.|.:.......|..|:.|||...:.......:..:.|           
Zfish  1681 A-----KIPPKTALSLQAGLRTLHDMGPEIRRAISGDLTVEEELERAMKETVCAASEDDIFRVKR 1740

  Fly  2487 --------LNFFH-----------------LQVSRRGTACSSRASSRK---------SSRASDAS 2517
                    :|::|                 |.:|:.|:...:.:.|.:         ||.:|..|
Zfish  1741 SGGLFGNHVNYYHQSDGHVSFPQSFTTQRPLHISKSGSPGEAESPSHQKLVDSTFTPSSYSSSGS 1805

  Fly  2518 DLSELAGPWLN----------LPLMLVSGADEVVKDIKQQNDELGKRGS--IFVEAPR-----AS 2565
            :.:      :|          .|...||..|             |:.|.  ..:..||     .:
Zfish  1806 NAN------INNANNTAIGHRYPKPTVSTVD-------------GQTGPPLTTIPLPRPTWCFPN 1851

  Fly  2566 RRRSFYNFFLRHQDAVDDSLTSPSVHRKTAMNNTTNTTS-----NSASTSGTASSTATAPATGCG 2625
            :|..||:.|:| .|:.|..|  |.:.|:.|..:.|...:     :.|..|..........:....
Zfish  1852 KRSCFYDTFMR-SDSSDSRL--PIIRREEASTDETYDETFLDERDQAMLSMDMLEFQDEESKQLA 1913

  Fly  2626 PAATSASDSDRHQAVGGGSAPSRK---------RASSF------------IRKKPPLERGLSAQS 2669
            |...:....:|..    ..:|.|:         |.|||            :.:|..|...|....
Zfish  1914 PMVEAEVGEERRP----WQSPRRRAFLCPTALGRRSSFHLECLRKHNRPDVSQKTALPLHLVHHQ 1974

  Fly  2670 ALRVNKNAFVSEASAPEVIVTR--------PS------PEQQTHPHSLSLRPDNATLVHVLVHRE 2720
            ||.|...:.:...|....:.||        ||      |..|..|   |||.:.           
Zfish  1975 ALAVAGLSPLLRRSHSPTLFTRLCSTPPASPSGRSGGGPCYQPVP---SLRLEG----------- 2025

  Fly  2721 SEEYKEEDESSPSVS-------GNGNGFGVGLDMLSKQPPP-----QIRITTGSVESSM------ 2767
            |..|::.:.|.|||:       .|||..|.....:|...||     .|.:..||..|.:      
Zfish  2026 SGSYEKLNSSMPSVNCSSWYSDSNGNHSGRAQRPVSLTVPPVTRRDSISLAHGSAGSLVEAVLIS 2090

  Fly  2768 ---------------------DTCAMPTVQIMVDSPKD------PPRGDFSSAPI---DDVGAPI 2802
                                 :.|.| |::.|.::..:      ||..:.:..|.   .|.|:  
Zfish  2091 EGLGRYAHDPSFIQVAKQEIAEACDM-TMEEMENAADNILNANAPPNANGNLLPFIQCRDTGS-- 2152

  Fly  2803 DVNVQGDTSQVFYDYNPEKATDDQGNGQDETAQFESLPDRQRXPPVNTPLRDSE 2856
                |.....:....:|  ||...|..:.|..:.|....|      |:||.:.|
Zfish  2153 ----QESRCSLSLGLSP--ATGSDGALEAELEESEGAGQR------NSPLMEDE 2194

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 77/245 (31%)
Ion_trans 705..902 CDD:278921 67/208 (32%)
Ion_trans 1768..2019 CDD:278921 86/270 (32%)
Na_channel_gate 2009..2063 CDD:240441 10/55 (18%)
Ion_trans 2085..2320 CDD:278921 79/258 (31%)
GPHH 2331..2386 CDD:293510 20/59 (34%)
cacna1cXP_021330579.1 Ion_trans 156..452 CDD:306908 99/375 (26%)
Ion_trans 559..798 CDD:306908 81/297 (27%)
Ion_trans 934..1211 CDD:306908 97/440 (22%)
Ion_trans 1253..1527 CDD:306908 87/276 (32%)
GPHH 1528..1598 CDD:318993 22/70 (31%)
Ca_chan_IQ 1600..1671 CDD:312334 10/71 (14%)
CAC1F_C 1694..2129 CDD:318975 86/475 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.940

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