|
Fly 104 KSLFLFYPWSPARRVCVYIATNQFFDYCVMATILFNC----IFLAMTET--------VEEAEYIF 156
::||.....:|.|:.|:.|...:.|:..::.||..|| ::|.|.|. :|:.||.|
Mouse 29 RALFCLTLQNPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDDNNTLNLGLEKLEYFF 93
Fly 157 LAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEVGNL------------AG 209
|.::|||..:||||.|||.::..|||:.||.|||:::..|..|:.:|..|: ||
Mouse 94 LIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFIIVFLGVFTVILEQVNIIQTNTAPMSSKGAG 158
Fly 210 -----LRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELR 269
||.|||||.|:.||.:|.|:.::|::..:...|..:..|.:|.::::|:..|:::.|::.
Mouse 159 LDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKMH 223
Fly 270 NKCVRQVPTDWTNVSHTDWQIWVNDTDNWLYDEDELPVLCGNLTGARHCPFE-YVCLCVGENPNH 333
..| :...||.....|:|.|..|......|.|... ..|......|||
Mouse 224 KTC------------------YFIGTDIVATVENEKPSPCARTGSGRPCTINGSECRGGWPGPNH 270
Fly 334 GYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCG---PMSVSFFTVVVFFGSFYLINLMLAVV 395
|.|:||||.:||||.:|.|:::.|.:|...|....| |. .:|..::..|||:::||:|
Mouse 271 GITHFDNFGFSMLTVYQCISMEGWTDVLYWVNDAIGNEWPW--IYFVTLILLGSFFILNLVL--- 330
Fly 396 ALSYEEEAEITNEERKKDLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTR 460
|||...::|::.:
Mouse 331 ----------------------------------------------------GVLSGEFTKEREK 343
Fly 461 RKKTKGGKEGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQHKL 525
.| |.| |.|..::.||:|:
Mouse 344 AK----------------SRG---------------------------TFQKLREKQQLEE---- 361
Fly 526 AKSGSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQD 590
|.:|.: |.:.:....|
Mouse 362 --------------------------------------DLRGYM-----------SWITQGEVMD 377
Fly 591 DSGVVDDHEEQDTTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDD 655
|||..|...:.|.|...|..| :.:..|:: :|..
Mouse 378 ----VDDLREGKLSLDEGGSDTESL---------------------YEIEGLNK-------IIQF 410
Fly 656 LPD-RNCDRCVHW-CTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRN 718
:.. |..:|...| |.| :|:..:|...:.|.:.|||..:|.|||.......:
Mouse 411 IRHWRQWNRVFRWKCHD-------------LVKSKVFYWLVILIVALNTLSIASEHHNQPLWLTH 462
Fly 719 ALDVGNKVFTSIFTFECIVKLMALS-KDFFLCGWNIFDLLIVTASLLDIIFELVD-------GLS 775
..||.|:|..::||.|.::|:..|. :.:|:..:|.||..:|.:.:|:|: ||: |:|
Mouse 463 LQDVANRVLLTLFTIEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGILEIL--LVESGAMSPLGIS 525
Fly 776 VLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTPEKF 840
|||.:||||:.|:.:.||::..|::.::::|.::.:|.|:|.:.|.|||::|||||...| .|
Mouse 526 VLRCIRLLRLFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIIIFALLGMQLFGGRY---DF 587
Fly 841 DPDPVPRWNFNDFFHSFMMIFRILCGE-WIEPLWDCMRA---EEEQGASTCFAIFLPTLVMGNFM 901
:...|.|.||::|..:.:.:|::|.|| |...:::.:.| ....|...|. .|:...|.||::
Mouse 588 EDTEVRRSNFDNFPQALISVFQVLTGEDWNSVMYNGIMAYGGPTYPGVLVCI-YFIILFVCGNYI 651
Fly 902 VLNLFLALLL-NSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQI 965
:||:|||:.: |...:|.|.|.: :.|.:|||.||
Mouse 652 LLNVFLAIAVDNLAEAESLTSAQ--------------------KAKAEERKRRK----------- 685
Fly 966 VLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTI 1030
:.:|
Mouse 686 -------------------MSKG------------------------------------------ 689
Fly 1031 VDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAE 1095
||..|:
Mouse 690 ----------------------LPDKSE------------------------------------- 695
Fly 1096 RRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSR 1160
.|.||.|
Mouse 696 ------------------EERATVT---------------------------------------- 702
Fly 1161 RYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSI 1225
|.|::.|:..|....:.||.:|
Mouse 703 --------------------------KKLEQKSKGEGIPTTAKLKIDE----------------- 724
Fly 1226 EQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMV 1290
Mouse 725 ----------------------------------------------------------------- 724
Fly 1291 EHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADE 1355
||..:.|:| :|.|:|| ..|..|. ||
Mouse 725 -----------FESNVNEVK--------------DPYPSAD------------FPGDDEE---DE 749
Fly 1356 VVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAP 1420
..:|::|
Mouse 750 PEIPVSP---------------------------------------------------------- 756
Fly 1421 FVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIES 1485
..:|::.|::
Mouse 757 -----------------------------------------------------RPRPLAELQL-- 766
Fly 1486 EKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQI 1550
|:|
Mouse 767 ---------------------------------KEK----------------------------- 769
Fly 1551 SSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQ 1615
|.|.|
Mouse 770 -------------------------AVPIP----------------------------------- 774
Fly 1616 SARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGG 1680
:|||
Mouse 775 ------------EASS------------------------------------------------- 778
Fly 1681 RRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVL 1745
|:...| ..::|....
Mouse 779 -------------------------------------FFIFSP-------------TNKIRVLCH 793
Fly 1746 TVVDTPAFEWFVLVLIFASSITLCFED-INLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGF 1809
.:|:...|..|:|:.|..||..|..|| |..|..: .::|.:.::.|..:|.||::||....|.
Mouse 794 RIVNATWFTNFILLFILLSSAALAAEDPIRADSMR--NQILEYFDYVFTAVFTVEIVLKMTTYGA 856
Fly 1810 ----SKYFTSFWTILDFIIVFVSVFSLLIEENENLKVLRSLRTLRALRPLRAISRWQGMRIVVNA 1870
..:..:::.|||.::|.||:.|:.:|.:. :.|::.||.||.|||||||:|.:|::.||..
Mouse 857 FLHKGSFCRNYFNILDLLVVAVSLISMGLESSA-ISVVKILRVLRVLRPLRAINRAKGLKHVVQC 920
Fly 1871 LMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEMGELLPITEVNDKWDCIEQNY---- 1931
:..||.:|.|::||..:...:|:.:|||.|.|||:.| .:|..:||. :|....|
Mouse 921 VFVAIRTIGNIVLVTTLLQFMFACIGVQLFKGKFYSC----NDLSKMTEE----ECRGYYYIYKD 977
Fly 1932 -----------TWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAY 1985
.||::...||:|....::|..|:|||||.:::..|:|:...|..|.....:...
Mouse 978 GDPTQIELRPRQWIHNDFHFDNVLSAMMSLFTVSTFEGWPQLLYKAIDSNEEDTGPVYNNRVEMA 1042
Fly 1986 IYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQK-- 2048
|:|:|:|:..:||.:|:|:|.:|..|. |.|..|....|..|:....::...:.:|.:
Mouse 1043 IFFIIYIILIAFFMMNIFVGFVIVTFQ------EQGETEYKNCELDKNQRQCVQYALKARPLRCY 1101
Fly 2049 VIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGL 2113
:.|.|..: .::|.:::| .||..:|.||.||.:.:|::||:|...:..|.::.|..||.:|.|
Mouse 1102 IPKNPYQY--QVWYVVTSS-YFEYLMFALIMLNTICLGMQHYNQSEQMNHISDILNVAFTIIFTL 1163
Fly 2114 EAIVKIVGLRYH-YFTVPWNVFDFLLVLASIFGILMEDIMIDLPISPTL---------------L 2162
|.::|::..:.. ||..||||||||:|:.||..:::.:|...|..|..| .
Mouse 1164 EMVLKLIAFKPRGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGLYCLGGGCGNVDPDESA 1228
Fly 2163 RV----VRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVK 2223
|: .|:||:.|:::|:..|:|:|.||:..:.|..||..:..|:.::.||||::||.:||.:.
Mouse 1229 RISSAFFRLFRVMRLVKLLNRAEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQMFGKIA 1293
Fly 2224 LQGA--LDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQPPDCDP---FIHG--HTNGNCGH 2281
:... ::...|||||.:::.||||..|...|.::|.:...... ||| :..| || ||
Mouse 1294 MVDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKL-CDPESDYAPGEEHT---CG- 1353
Fly 2282 PLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFI 2346
...|..||.||.::...::||:::|:|::||:...::..| :....|:.|...|::|||.|...|
Mouse 1354 TNFAYYYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSI-LGPHHLDEFKAIWAEYDPEAKGRI 1417
Fly 2347 HFSQLSDFIASLDPPLGISK--PNNVA---LVSFNLPISKGNKIHCLDILHALVKHVLGHVEETD 2406
....:...:..:.||||..| |:.|| ||..|:|::....:.....|.|||:..| .::...
Mouse 1418 KHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLFALVRTAL-KIKTEG 1481
Fly 2407 NFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEK---------------------AAKTIQT 2450
||:|..|::....|| ||||... |...||.
Mouse 1482 NFEQANEELRAIIKK---------------IWKRTSMKLLDQVIPPIGDDEVTVGKFYATFLIQE 1531
Fly 2451 GWKEYLRRKREKERSNSGDSATQTSSPGGWQSKLSALNFFHLQVSRRGTACSSRASSRKSSRASD 2515
.::::::|:.|.. |::.|...: .:|...|
Mouse 1532 HFRKFMKRQEEYY---------------GYRPKKDTV---QIQAGLR------------------ 1560
Fly 2516 ASDLSELAGPWLNLPLMLVSG----ADEVVKDIKQQNDELG---KRGSIFVEA-----------P 2562
.:.|.|.|.:: ..:|| .:|:.:.:.:...|.| :.|.:|.:. |
Mouse 1561 --TIEEEAAPEIH---RAISGDLTAEEELERAMVEAAMEEGIFRRTGGLFGQVDNFLERTNSLPP 1620
Fly 2563 RASRRR--SFYNFFLRHQDA---VDDSLTSPSVHRKTAMNNTTNTTSNSASTSGTAS-------- 2614
..:.:| .|....:...:: ::|...:|..| ..|..||.|..:|.| .|.:|
Mouse 1621 VMANQRPLQFAEIEMEELESPVFLEDFPQNPGTH-PLARANTNNANANVA--YGNSSHRNNPVFS 1682
Fly 2615 ---------STATAPATGCGPAATSASDSDRHQAVGGGSAPSRKRASSFIRKKPPLERGLSAQSA 2670
..|..|.|..||.:.....|..| ||...... |:|..:||:
Mouse 1683 SICYEREFLGEADMPVTREGPLSQPCRASGPH---------SRSHVDKL--KRPMTQRGM----- 1731
Fly 2671 LRVNKNAFVSEASAPEVIVTRPSPEQQT-----HPHSLSLRPDNATLVHVLVHRESEEYKEEDE- 2729
.|...| |||.|.| ||.....:...:..:.....|..||:...:.
Mouse 1732 ---------PEGQVP------PSPCQVTGAKAEHPVQKEGKGPTSRFLETPNSRNFEEHVPRNSA 1781
Fly 2730 ---SSPS---------VSGNGNGFGVGLDMLSKQPPPQIRITTGSVESSMDTCAMPTVQIMVDS- 2781
::|: |.| |||.|:.. ....:.|| ::..|.|.|...::.|.:
Mouse 1782 HRCTAPATAMLIQEALVRG-------GLDSLAAD--ANFVMATG--QALADACQMEPEEVEVAAT 1835
Fly 2782 ---PKDPPRG 2788
.::.|.|
Mouse 1836 ELLKQESPEG 1845
| 
