DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NaCP60E and Cacna1g

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:XP_011246988.1 Gene:Cacna1g / 12291 MGIID:1201678 Length:2392 Species:Mus musculus


Alignment Length:3030 Identity:660/3030 - (21%)
Similarity:1092/3030 - (36%) Gaps:1070/3030 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   113 SPARRVCVYIATNQFFDYCVMATILFNCIFLAMTETVEEA--------------EYIFLAIYSIE 163
            |..|..|:....|.:|:...|..||.||:.|.|....|:.              ::|| |.:::|
Mouse    68 SRPRSWCLRTVCNPWFERVSMLVILLNCVTLGMFRPCEDIACDSQRCRILQAFDDFIF-AFFAVE 131

  Fly   164 MVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEVGNL--AGLRTFRVLRALKTVSIMP 226
            ||:|::|.| :..|..||.:.||.|||.::.:|.....:::.|:  :.:||.||||.|:.::.:|
Mouse   132 MVVKMVALG-IFGKKCYLGDTWNRLDFFIVIAGMLEYSLDLQNVSFSAVRTVRVLRPLRAINRVP 195

  Fly   227 GLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVPTDWTNVSHTDWQIW 291
            .::.::..||.:...|..|:.|..|...:|.:..:|::.|.|||:|.  :|.:::.....|.:.:
Mouse   196 SMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCF--LPENFSLPLSVDLEPY 258

  Fly   292 VNDTDNWLYDEDELPVLC------------------GNLTGARHCPFEYVC-------LCV---- 327
            . .|:|    |||.|.:|                  |...|...|..:|..       .||    
Mouse   259 Y-QTEN----EDESPFICSQPRENGMRSCRSVPTLRGEGGGGPPCGLDYEAYNSSSNTTCVNWNQ 318

  Fly   328 -------GE-NPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCGPMSVSFFTVVVFFGS 384
                   || ||..|..||||..::.:..||:|||:.|.::...|:......:..:|.:::..||
Mouse   319 YYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDAHSFYNFIYFILLIIVGS 383

  Fly   385 FYLINLMLAVVALSYEE----EAEITNEERKKDLLDHRDDSTFSFDPS----------VLNVKKL 435
            |::|||.|.|:|..:.|    |:::..|:|.:.|.:....::|| :|.          |..::|.
Mouse   384 FFMINLCLVVIATQFSETKQRESQLMREQRVRFLSNASTLASFS-EPGSCYEELLKYLVYILRKA 447

  Fly   436 NK---NNKKKIDSRKGVLLASYSKKKTRRKKTKGGKEGGTNGN---------------------- 475
            .:   ...:.:..|.|:|.:..:         :||:|...:|:                      
Mouse   448 ARRLAQVSRAVGVRAGLLSSPVA---------RGGQEPQPSGSCSRSHRRLSVHHLVHHHHHHHH 503

  Fly   476 ----GNGS-----------NGDDNKSH--------SATPSPGPSPR-----HS---ATERPSALT 509
                |||:           :.|.|.|.        :.|||.|| ||     ||   |......:.
Mouse   504 HYHLGNGTLRVPRASPEIQDRDANGSRWLMLPPPSTPTPSGGP-PRGAESVHSFYHADCHLEPVR 567

  Fly   510 MQAQKQYQQMEQQHKLAKSGSGGSNNPMAPTPKGRISFQDSGMGVKNPN---------MLYPSDY 565
            .||.......|...:...||........:|.|:   ..:|..:....|:         .:.|..:
Mouse   568 CQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPE---MLKDKALVEVAPSPGPPTLTSFNIPPGPF 629

  Fly   566 KGQLIANSGQPSSNSSG-------VNRESSQDDSGVVD------------------DHEEQDTTN 605
            .........|.:..|.|       ::...|:.|||...                  |||..|:.:
Mouse   630 SSMHKLLETQSTGESVGACHSSCKISSPCSKADSGACGPDSCPYCARTGAGEPESADHEMPDSDS 694

  Fly   606 DMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDRNCDRCVHWCTD 670
            :.                               ||...|:...     .||.|.:..|......|
Mouse   695 EA-------------------------------VYEFTQDAQH-----SDLRDPHRRRRPSLGPD 723

  Fly   671 YES------WLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFTS 729
            .|.      |....:...|:|....|...|.:.|::||..:.:|:|...|...|||::.|.||||
Mouse   724 AEPSSVLAFWRLICDTFRKIVDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTS 788

  Fly   730 IFTFECIVKLMALSKDFFLCG-WNIFDLLIVTASLLDIIFELVDGLSVLRGLRLLRVLKLAQSWT 793
            :|..|.::||:......::.. :||||.:||..|:.:|:.:...||||||..||:|||||.:...
Mouse   789 LFALEMLLKLLVYGPFGYIKNPYNIFDGVIVVISVWEIVGQQGGGLSVLRTFRLMRVLKLVRFLP 853

  Fly   794 TMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTPEKFDPDPVP-RWNFNDFFHSF 857
            .::..|.:::.|:..:....::|::.|:||:::||.||...:..|: |.|.:| |.||:....:.
Mouse   854 ALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASER-DGDTLPDRKNFDSLLWAI 917

  Fly   858 MMIFRILCGE-WIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLFLALLLNSFNSEELKS 921
            :.:|:||..| |.:.|::.|.:.....|    ..|:..:..||:::.||.:|:|:..|.:||:..
Mouse   918 VTVFQILTQEDWNKVLYNGMASTSSWAA----LYFIALMTFGNYVLFNLLVAILVEGFQAEEIGK 978

  Fly   922 KKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLE 986
            :::..|:.|.:                                               |..|..:
Mouse   979 REDTSGQLSCI-----------------------------------------------QLPVNSQ 996

  Fly   987 RGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAH 1051
            .||      .||                                                     
Mouse   997 GGD------ATK----------------------------------------------------- 1002

  Fly  1052 PLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREE 1116
                 |:|.|..:.           .||:|:|         ..::||                  
Mouse  1003 -----SESEPDFFS-----------PSVDGDG---------DRKKRL------------------ 1024

  Fly  1117 ATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTR 1181
                 ::..||                                      ||.|    .:|||   
Mouse  1025 -----ALVALG--------------------------------------EHSE----LRKSL--- 1039

  Fly  1182 SPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQ 1246
                   |..|...:..:..||.||....:     |::|.|                        
Mouse  1040 -------LPPLIIHTAATPMSLPKSSSTGV-----GEALGS------------------------ 1068

  Fly  1247 KELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKR 1311
                                      .|||.||                                
Mouse  1069 --------------------------GSRRTSS-------------------------------- 1075

  Fly  1312 STTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQ 1376
                     |..:||..|          |..:.:..|.||:      |.:|:             
Mouse  1076 ---------SGSAEPGTA----------HHEMKSPPSARSS------PHSPW------------- 1102

  Fly  1377 SVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQ 1441
              |||:...|.:..|.||                                             .:
Mouse  1103 --SAASSWTSRRSSRNSL---------------------------------------------GR 1120

  Fly  1442 SPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSL 1506
            :|.|:|: .|      ..:|.||:....:..::|:       ||.:..|....|.|.....||..
Mouse  1121 APSLKRR-SP------SGERRSLLSGEGQESQDEE-------ESSEEDRASPAGSDHRHRGSLER 1171

  Fly  1507 KSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHA 1571
            ::                              |||.:.|...|:..|                |.
Mouse  1172 EA------------------------------KSSFDLPDTLQVPGL----------------HR 1190

  Fly  1572 TSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALA 1636
            |:                     :|:....|| |....|:||.:.|||........|........
Mouse  1191 TA---------------------SGRSSASEH-QDCNGKSASGRLARTLRADDPPLDGDDGDDEG 1233

  Fly  1637 MAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATK 1701
            ...|.|:.:           |:.| ...|..|           ..|:|..||    .||      
Mouse  1234 NLSKGERLR-----------AWVR-ARLPACC-----------RERDSWSAY----IFP------ 1265

  Fly  1702 AAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSI 1766
                     ||                         :|.|.....::....|:..|||:||.:.|
Mouse  1266 ---------PQ-------------------------SRFRLLCHRIITHKMFDHVVLVIIFLNCI 1296

  Fly  1767 TLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGF----SKYFTSFWTILDFIIVFV 1827
            |:..|...:|.:...:..|...|:.|..:|:.||.:|.:|||:    ..|..|.|.:||.::|.:
Mouse  1297 TIAMERPKIDPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLI 1361

  Fly  1828 SVFSLLI-----EENENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLV 1887
            ||..:|:     ...:.|.:||.||.||.|||||.|||.||:::||..||.::..|.|::::|..
Mouse  1362 SVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCA 1426

  Fly  1888 FWLIFSIMGVQFFGGKFFKCVNEMGELLPITEVNDKWDCIEQNYTWINSKITFDHVGMGYLALLQ 1952
            |::||.|:|||.|.||||.|..|     ....:.:|.||.|.:|.|:..|..||::|...::|..
Mouse  1427 FFIIFGILGVQLFKGKFFVCQGE-----DTRNITNKSDCAEASYRWVRHKYNFDNLGQALMSLFV 1486

  Fly  1953 VATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKK 2017
            :|:.:||:::|.|.:||.|||.||....|.:..:||:.|::..:||.||:|:||:::||:..::.
Mouse  1487 LASKDGWVDIMYDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQH 1551

  Fly  2018 YEGGVLEMFLTESQKHYYTAMKKLGRKKPQK-----------VIK-------------RP----I 2054
            .|.       .|:::.....:|:|.:|:..|           ||.             :|    .
Mouse  1552 QEE-------EEARRREEKRLKRLEKKRRSKEKQMADLMLDDVIASGSSASAASEAQCKPYYSDY 1609

  Fly  2055 NHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKI 2119
            :.|..:.:.|..|...::.|..:|.||::||.:|||.||..:...|::.|..||.:|.||::.|:
Mouse  1610 SRFRLLVHHLCTSHYLDLFITGVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKL 1674

  Fly  2120 VGLRY-HYFTVPWNVFDFLLVLASIFGILMEDIMID--LPISPTLLRVVRVFRIGRILRLIKAAK 2181
            |...: .:|...||..|..:||.||.||.:|:|.::  |||:||::|::||.||.|:|:|:|.|.
Mouse  1675 VAFGFRRFFQDRWNQLDLAIVLLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAV 1739

  Fly  2182 GIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNVKLQ-----GALDDMVNFQTFGRSM 2241
            |:|.||..::.:||.:.|:|.|..|:.||:|.||:.|||:::..     ..|.....|:.||.:.
Mouse  1740 GMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAF 1804

  Fly  2242 QLLFRLMTSAGWNDVLESLMIQPPDCDPFIHGHTNGNCGHPLLAITYFTSFIIISYMIVINMYIA 2306
            ..|||:.|...||.:::..:   .|||      ....|.:.:::..||.||::.:..:::|:.||
Mouse  1805 LTLFRVSTGDNWNGIMKDTL---RDCD------QESTCYNTVISPIYFVSFVLTAQFVLVNVVIA 1860

  Fly  2307 IILENFNQAHQE--EEIGI-VEDDLEMFYIR------------WSKYD------------PHATQ 2344
            :::::..::::|  ||..: .|.:|||..:.            |...:            ||.|.
Mouse  1861 VLMKHLEESNKEAKEEAELEAELELEMKTLSPQPHSPLGSPFLWPGVEGVNSPDSPKPGAPHTTA 1925

  Fly  2345 FI-----HFS-------QLSDFIASL----------------------------------DP--P 2361
            .|     .||       ||.|.|:.|                                  ||  |
Mouse  1926 HIGAASSGFSLEHPTDRQLFDTISLLIQGSLEGELKLMDELAGPGGQPSAFPSAPSPGDSDPQIP 1990

  Fly  2362 LG-----------ISKPN-NVALVSFNLPISKGNKIHCLDILHALVKHVLGHVEETDNFKQLQEQ 2414
            |.           :|:|: ::||...:||    :..|.| :|.||..:::.|.||          
Mouse  1991 LAEMEALSLTSEIVSEPSCSLALTDDSLP----DDTHTL-LLSALESNMVPHTEE---------- 2040

  Fly  2415 MDVKFKKQFPTRKELEIVSSTRIWKRQEKAAKTIQTGWKEYLRRKREKERSNSGDSATQTSSPGG 2479
                  ...|...:|..|       |:...::|.......|:.|        :|.:|.::....|
Mouse  2041 ------GPVPLGPDLLTV-------RKSGVSRTHSLPNDSYMCR--------NGSTAERSLGHRG 2084

  Fly  2480 WQSKLSALNFFHLQVSRRGTACSSRASSRKSSRASDASDLSEL------------AGPWLNLPLM 2532
            |          .|..::.|:..|..      |:.:|.|.:.:|            |..|..:|.:
Mouse  2085 W----------GLPKAQSGSILSVH------SQPADTSCILQLPKDAHYLLQPHGAPTWGAIPKL 2133

  Fly  2533 LVSGADEVVKDIKQQNDELGKRGSIFVEAPRASRRRSFYNFFLRHQDAV-DDSLTSPSV-HRKTA 2595
            ...|                       .:|.|.|.       ||.|.|: .|||....: .|:..
Mouse  2134 PPPG-----------------------RSPLAQRP-------LRRQAAIRTDSLDVQGLGSREDL 2168

  Fly  2596 MNNTTN-----TTSNS---------ASTSGTASSTA-----TAPATGCGPA-------ATSASDS 2634
            ::..:.     |.|:|         ...||:.|..:     .||..|..|:       ..|:.:.
Mouse  2169 LSEVSGPSCPLTRSSSFWGGSSIQVQQRSGSQSKVSKHIRLPAPCPGLEPSWAKDPQETRSSLEL 2233

  Fly  2635 DRHQA-VGGGSAPSRKRASSFIRKKPPLERGLSAQSALRVNKNAFVSEASAPEVIVTRPS---PE 2695
            |...: :.|...||.       :::|...|.|         |..:..||.:..   .||.   .|
Mouse  2234 DTELSWISGDLLPSS-------QEEPLSPRDL---------KKCYSVEAQSCR---RRPGSWLDE 2279

  Fly  2696 QQTHPHSLSLRPDNATLVHVLVHRESEEYKEEDESSPSVSGNGNGFGVGLDMLSKQPPPQIRITT 2760
            |:.|..::|.. |:.:...:.             .|||..|.....|.|.....|..||.|.|..
Mouse  2280 QRRHSIAVSCL-DSGSQPRLC-------------PSPSSLGGQPLGGPGSRPKKKLSPPSISIDP 2330

  Fly  2761 GSVESSMDTCAMPTVQIMVDSPKDPPRGDFSSAPIDDVGA 2800
            ...:.....|: |.|.:...:|....:...:|:|:|...|
Mouse  2331 PESQGPRPPCS-PGVCLRRRAPASDSKDPSASSPLDSTAA 2369

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 71/271 (26%)
Ion_trans 705..902 CDD:278921 64/199 (32%)
Ion_trans 1768..2019 CDD:278921 95/259 (37%)
Na_channel_gate 2009..2063 CDD:240441 12/81 (15%)
Ion_trans 2085..2320 CDD:278921 82/244 (34%)
GPHH 2331..2386 CDD:293510 22/138 (16%)
Cacna1gXP_011246988.1 Ion_trans 80..406 CDD:366146 92/334 (28%)
Ion_trans 746..972 CDD:366146 73/230 (32%)
Ion_trans 1280..1552 CDD:366146 103/276 (37%)
Ion_trans 1622..1863 CDD:366146 87/249 (35%)
PHA03307 2110..>2389 CDD:223039 63/324 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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