DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NaCP60E and Cacna1c

DIOPT Version :9

Sequence 1:	NP_001261172.1	Gene:	NaCP60E / 37981	FlyBaseID:	FBgn0085434	Length:	2896	Species:	Drosophila melanogaster
Sequence 2:	XP_036021662.1	Gene:	Cacna1c / 12288	MGIID:	103013	Length:	2245	Species:	Mus musculus

Alignment Length:	3073	Identity:	632/3073 - (20%)
Similarity:	1008/3073 - (32%)	Gaps:	1319/3073 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 YGKPLEEIDTFIYEETFCVVSKRFRKNYIHRFTGT---KSLFLFYPWSPARRVCVYIATNQFFDY 130
            ||||.::..|                      |.|   ::|......:|.||.|:.|...:.|:.
Mouse   116 YGKPKKQGGT----------------------TATRPPRALLCLTLKNPIRRACISIVEWKPFEI 158

  Fly   131 CVMATILFNCIFLAM------------TETVEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRN 183
            .::.||..||:.||:            ...:|..||:||.|:::|..:|:||.|.|.:...||||
Mouse   159 IILLTIFANCVALAIYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRN 223

  Fly   184 PWNWLDFVVITSGYATIGMEV-----------GNLAG-----LRTFRVLRALKTVSIMPGLKTII 232
            .||.|||:::..|..:..:|.           |..||     ||.|||||.|:.||.:|.|:.::
Mouse   224 GWNLLDFIIVVVGLFSAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVL 288

  Fly   233 NALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQ-----VPTDWTNVSHTDWQIWV 292
            |:::.:...|..:..|.:|.::::|:..|:::||::...|..|     ||.
Mouse   289 NSIIKAMVPLLHIALLVLFVIIIYAIIGLELFMGKMHKTCYNQEGIIDVPA-------------- 339

  Fly   293 NDTDNWLYDEDELPVLCGNLTG-ARHCPFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDY 356
                    :||..|  |...|| .|.|....||....:.|.||.||||||.::|||.||.||::.
Mouse   340 --------EEDPSP--CALETGHGRQCQNGTVCKPGWDGPKHGITNFDNFAFAMLTVFQCITMEG 394

  Fly   357 WENV-YNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNEERKKDLLDHRDD 420
            |.:| |.|..|....:...:|..:|.||||:::||:|
Mouse   395 WTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVL---------------------------- 431

  Fly   421 STFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGKEGGTNGNGNGSNGDDNK 485
                                       |||...:||::.:.|                :.||
Mouse   432 ---------------------------GVLSGEFSKEREKAK----------------ARGD--- 450

  Fly   486 SHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQHKLAKSGSGGSNNPMAPTPKGRISFQDS 550
                                    .|..::.||:|:
Mouse   451 ------------------------FQKLREKQQLEE----------------------------- 462

  Fly   551 GMGVKNPNMLYPSDYKGQL----IANSGQPSSNSSGVNRESSQDDSGVVDDHEEQDTTND-MGHV 610
                         |.||.|    .|....|.:...|::.:..::.......|:::..... ..|.
Mouse   463 -------------DLKGYLDWITQAEDIDPENEDEGMDEDKPRNRGAPAGLHDQKKGKFAWFSHS 514

  Fly   611 STVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDRNCD-RCVH------WC 668
            :...:::...|.                     :..::|.|...|:...||. |..|      :.
Mouse   515 TETHVSMPTSET---------------------ESVNTENVAGGDIEGENCGARLAHRISKSKFS 558

  Fly   669 TDYESWLQFQNCLYK---VVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFTSI 730
            ..:..|.:|  |..|   .|:..:|...:...:.|||..:|.||:..........|..||...::
Mouse   559 RYWRRWNRF--CRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPHWLTEVQDTANKALLAL 621

  Fly   731 FTFECIVKLMALS-KDFFLCGWNIFDLLIVTASLLDIIFELVD-------GLSVLRGLRLLRVLK 787
            ||.|.::|:.:|. :.:|:..:|.||..||...:|:.|  ||:       |:||||.:||||:.|
Mouse   622 FTAEMLLKMYSLGLQAYFVSLFNRFDCFIVCGGILETI--LVETKIMSPLGISVLRCVRLLRIFK 684

  Fly   788 LAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTPEKFDPDPVPRWNFND 852
            :.:.|.::..|::.:::::.::.:|.|:|.:.|.||:::|||||...:   .||.....|..|::
Mouse   685 ITRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKF---NFDEMQTRRSTFDN 746

  Fly   853 FFHSFMMIFRILCGE-WIEPLWDCMRA---EEEQGASTCFAIFLPTLVMGNFMVLNLFLALLL-N 912
            |..|.:.:|:||.|| |...::|.:.|   ....|...|. .|:...:.||:::||:|||:.: |
Mouse   747 FPQSLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCI-YFIILFICGNYILLNVFLAIAVDN 810

  Fly   913 SFNSEELKSKKEEVGEESKLARSIERVRDLIRKK--RQERKDRKERKFAEKFQQIVLDAQQAHAQ 975
            ..::|.|.|.::|..||.:            |||  |..|....|:|     |:::
Mouse   811 LADAESLTSAQKEEEEEKE------------RKKLARPARTASPEKK-----QEVM--------- 849

  Fly   976 TLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTG 1040
                         :||.|           :||..
Mouse   850 -------------EKPAV-----------EESKE------------------------------- 859

  Fly  1041 DLPEQIQLQAHPLPPTSD-SMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISS 1104
               |:|:|::    .|:| ..|||.:..|                 .:|.|
Mouse   860 ---EKIELKS----ITADGESPPTTKINM-----------------DDLQP-------------- 886

  Fly  1105 GVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDE 1169
                    |..|                |..|::|...:|
Mouse   887 --------SENE----------------DKSPHSNPDTAG------------------------- 902

  Fly  1170 AFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQ 1234
                                                                    |:||
Mouse   903 --------------------------------------------------------EEDE----- 906

  Fly  1235 GNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNII 1299
                                ||.|:..|.:.|.:|
Mouse   907 --------------------EEPEMPVGPRPRPLS------------------------------ 921

  Fly  1300 QSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYD 1364
                             |..|...:.|.|   ||:...:
Mouse   922 -----------------ELHLKEKAVPMP---EASAFFI-------------------------- 940

  Fly  1365 SYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAV 1429
                                                   ||.:|..|..|.:|
Mouse   941 ---------------------------------------FSPNNRFRLQCHRI------------ 954

  Fly  1430 AATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLH 1494
                                    |....|..|.|.
Mouse   955 ------------------------VNDTIFTNLILF----------------------------- 966

  Fly  1495 GPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPL 1559
               .:.|.|:||
Mouse   967 ---FILLSSISL----------------------------------------------------- 975

  Fly  1560 AALTEHQQHFHATSIQAAPTPA-HTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHS 1623
                            ||..|. ||                             ||::
Mouse   976 ----------------AAEDPVQHT-----------------------------SFRN------- 988

  Fly  1624 SGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAY 1688
                                                       |.|
Mouse   989 -------------------------------------------HIL------------------- 991

  Fly  1689 NDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAF 1753
                                         |||.
Mouse   992 -----------------------------FYFD-------------------------------- 995

  Fly  1754 EWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGF----SKYFT 1814
              .|...||...|.|              ::|...::.|..||.:|:|||..|.|.    ..:..
Mouse   996 --IVFTTIFTIEIAL--------------KILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCR 1044

  Fly  1815 SFWTILDFIIVFVSVFSLLIEENENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIF 1879
            :::.|||.::|.||:.|..|:.:. :.|::.||.||.|||||||:|.:|::.||..:..||.:|.
Mouse  1045 NYFNILDLLVVSVSLISFGIQSSA-INVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIG 1108

  Fly  1880 NVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEMGELLPITEVNDKWDCIE-----------QNYTW 1933
            |:::|..:...:|:.:|||.|.||.:.|.:...:    ||...|.:.|.           |..:|
Mouse  1109 NIVIVTTLLQFMFACIGVQLFKGKLYTCSDSSKQ----TEAECKGNYITYKDGEVDHPIIQPRSW 1169

  Fly  1934 INSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAY-----IYFVIFIV 1993
            .|||..||:|....:||..|:|||||.|::..::|:...|..|     :|.|     |:|:|:|:
Mouse  1170 ENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGP-----IYNYRVEISIFFIIYII 1229

  Fly  1994 CGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPI---N 2055
            ..:||.:|:|:|.:|..|.      |.|..|....|..|:....::...:.:|   ::|.|   .
Mouse  1230 IIAFFMMNIFVGFVIVTFQ------EQGEQEYKNCELDKNQRQCVEYALKARP---LRRYIPKNQ 1285

  Fly  2056 HFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIV 2120
            |...::| :.||..||..:||||.||.:.:.::||.|.......:.:.|..||.:|.:|.|:|::
Mouse  1286 HQYKVWY-VVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLI 1349

  Fly  2121 GLR-YHYFTVPWNVFDFLLVLASIFGILMEDI-------------------MIDLPI-------- 2157
            ..: ..||:.||||||||:|:.||..:::.:.                   ::|:.|
Mouse  1350 AFKPKGYFSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVHPAEH 1414

  Fly  2158 ---SPTL---------LRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFI 2210
               ||::         :...|:||:.|:::|:...:|||.||:..:.|..||..:..|:.::.||
Mouse  1415 TQCSPSMSAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFI 1479

  Fly  2211 YAILGMSLFGNVKLQGALDDMV------NFQTFGRSMQLLFRLMTSAGWNDVLESLMIQP----- 2264
            ||::||.:||.:    ||:|..      |||||.:::.||||..|...|.|::  |...|
Mouse  1480 YAVIGMQVFGKI----ALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIM--LACMPGKKCA 1538

  Fly  2265 PDCDPFIHGHTNGN--CGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDD 2327
            |:.:|  ...|.|.  ||.. .|:.||.||.::...::||:::|:|::||:...::..| :....
Mouse  1539 PESEP--SNSTEGETPCGSS-FAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSI-LGPHH 1599

  Fly  2328 LEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISK--PNNVA---LVSFNLPISKGNKIHC 2387
            |:.|...|::|||.|...|....:...:..:.||||..|  |:.||   |||.|:|::....:..
Mouse  1600 LDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMF 1664

  Fly  2388 LDILHALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEK--------- 2443
            ...|.|||:..| .::...|.:|..|::....||               ||||...
Mouse  1665 NATLFALVRTAL-RIKTEGNLEQANEELRAIIKK---------------IWKRTSMKLLDQVVPP 1713

  Fly  2444 ------------AAKTIQTGWKEYLRR-KREKERSNSGDSATQTSSPGGWQSKLSALNFFHLQVS 2495
                        |...||    ||.|: |:.||:              |...|.|..|...||..
Mouse  1714 AGDDEVTVGKFYATFLIQ----EYFRKFKKRKEQ--------------GLVGKPSQRNALSLQAG 1760

  Fly  2496 RRGTACSSRASSRKSSRASDASDLSELAGPWLNLPLMLVSG----ADEVVKDIKQ------QNDE 2550
            .|                    .|.:: ||.:.   ..:||    .:|:.|.:|:      ::|.
Mouse  1761 LR--------------------TLHDI-GPEIR---RAISGDLTAEEELDKAMKEAVSAASEDDI 1801

  Fly  2551 LGKRGSIF---VEAPRASRRRSFYNFFL--------------------RHQDAVDDSLTSPSVHR 2592
            ..:.|.:|   |...::..|.:|...|.                    .|:..||.:.| ||.:.
Mouse  1802 FRRAGGLFGNHVTYYQSDSRGNFPQTFATQRPLHINKTGNNQADTESPSHEKLVDSTFT-PSSYS 1865

  Fly  2593 KTAMNNTTNTTSNSA-----STSGTASSTATAPATGCGPAATSASDSDRHQAVGGGSAPSRKRAS 2652
            .|..|...|..:|:|     ..:|.:|:.:|....|
Mouse  1866 STGSNANINNANNTALGRFPHPAGYSSTVSTVEGHG----------------------------- 1901

  Fly  2653 SFIRKKPPLERGLSAQSALRVNKNAFVSEASAPEVIVTRPSPEQQTHPHSLSLRPDNATLVHVLV 2717
                  |||      ..|:||.:.|:...:....      |.|.|....:..:.||....|
Mouse  1902 ------PPL------SPAVRVQEAAWKLSSKRCH------SRESQGATVNQEIFPDETRSV---- 1944

  Fly  2718 HRESEEYKEEDESSPSVSGNGNGFGVGLDMLSKQPPPQIRITTGSVESSMDTCAMPTVQIMVDSP 2782
             |.|||  .|..|.||:        :..||.|.|..          |....||.....:.:..||
Mouse  1945 -RMSEE--AEYCSEPSL--------LSTDMFSYQED----------EHRQLTCPEEDKREIQPSP 1988

  Fly  2783 KDPPRGDFSSAPIDDVGAPIDVNVQGDTSQVFYDYNPEKATDDQGNGQDETAQFESLPDR----- 2842
            |   |....||.:.              .:..:.....|...|||.   :.:|..:||..
Mouse  1989 K---RSFLRSASLG--------------RRASFHLECLKRQKDQGG---DISQKTALPLHLVHHQ 2033

  Fly  2843 -----------QR------------XPPV-----NTPLRDSEKRSSRGSRSSSSSTSSIRS--CS 2877
                       ||             |||     ..|||........|:.||....||..|  ||
Mouse  2034 ALAVAGLSPLLQRSHSPTTFPRPCPTPPVTPGSRGRPLRPIPTLRLEGAESSEKLNSSFPSIHCS 2098

  Fly  2878 S-SSSSSAASAAAPSARR 2894
            | |..::|.|.::..|||
Mouse  2099 SWSEETTACSGSSSMARR 2116

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	152..371	CDD:278921	80/241 (33%)
		Ion_trans	705..902	CDD:278921	63/208 (30%)
		Ion_trans	1768..2019	CDD:278921	85/270 (31%)
		Na_channel_gate	2009..2063	CDD:240441	10/56 (18%)
		Ion_trans	2085..2320	CDD:278921	83/287 (29%)
		GPHH	2331..2386	CDD:293510	20/59 (34%)
Cacna1c	XP_036021662.1	Ion_trans	153..446	CDD:395416	102/371 (27%)
		Ion_trans	578..819	CDD:395416	75/246 (30%)
		Ion_trans	957..1254	CDD:395416	110/588 (19%)
		Ion_trans	1296..1593	CDD:395416	92/305 (30%)
		GPHH	1602..1655	CDD:407139	19/52 (37%)
		Ca_chan_IQ	1666..1737	CDD:400901	20/90 (22%)
		CAC1F_C	1759..2194	CDD:407123	95/475 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R175
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840