DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NaCP60E and Cacna1b

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:XP_006497689.1 Gene:Cacna1b / 12287 MGIID:88296 Length:2351 Species:Mus musculus


Alignment Length:2877 Identity:635/2877 - (22%)
Similarity:1066/2877 - (37%) Gaps:889/2877 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    80 IYEETFCVVSKRFRKNYIHR--------FTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATI 136
            :|:::   :::|.|...::.        ||..:|||:|...:..|:....|.....|:|.::|||
Mouse    44 LYKQS---IAQRARTMALYNPIPVKQNCFTVNRSLFVFSEDNVVRKYAKRITEWPPFEYMILATI 105

  Fly   137 LFNCIFLA------------MTETVEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLD 189
            :.|||.||            |:|.:::.|..|:.|:..|..|||||.||:.:|.:||||.||.:|
Mouse   106 IANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHKGSYLRNGWNVMD 170

  Fly   190 FVVITSG-YATIGMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCL 253
            |||:.:| .||.|.:. :|..||..||||.||.||.:|.|:.::.:::.:...|.::..|..|.:
Mouse   171 FVVVLTGILATAGTDF-DLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAI 234

  Fly   254 MVFALFALQVYMGELRNKCVRQVPTDWTNVSHTDWQIWVNDTDNWLYDEDELPVLCGNLTGARHC 318
            ::||:..|:.|||:....|                  :.|.||.  ....:.|  ||....||.|
Mouse   235 LMFAIIGLEFYMGKFHKAC------------------FPNSTDT--EPVGDFP--CGKDPPARQC 277

  Fly   319 PFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENV-YNMVLATCGPMSVSFFTVVVFF 382
            ..:..|......||.|.|||||.::::||.||.||::.|.:: ||...|.....:..:|..::..
Mouse   278 DGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWLYFIPLIII 342

  Fly   383 GSFYLINLMLAVVALSYEEEAEITNEERKKDLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRK 447
            |||:::||:|.|::..:.:|.|  ..|.::..|..|......        ::|| ...:.|...:
Mouse   343 GSFFMLNLVLGVLSGEFAKERE--RVENRRAFLKLRRQQQIE--------RELN-GYLEWIFKAE 396

  Fly   448 GVLLASYSKKKTRRKKTKGGKEGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQA 512
            .|:||.                            :|..:...:|......| :||::        
Mouse   397 EVMLAE----------------------------EDKNAEEKSPLDAVLKR-AATKK-------- 424

  Fly   513 QKQYQQMEQQHKLAKSGSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQP- 576
                                |.|.:....:|...|.|                    :...|.| 
Mouse   425 --------------------SRNDLIHAEEGEDRFVD--------------------LCAVGSPF 449

  Fly   577 --SSNSSGVNRESSQDDSGVVDDHEEQDTTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNV 639
              :|..||....||                                                   
Mouse   450 ARASLKSGKTESSS--------------------------------------------------- 463

  Fly   640 YALHQEFSSEVVVIDDLPDRNCDRCVHWCTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAF 704
            |...:|                             ..|:..:.::|:...|...:...:.|||..
Mouse   464 YFRRKE-----------------------------KMFRFFIRRMVKAQSFYWVVLCVVALNTLC 499

  Fly   705 LAMEHHGMSESFRNALDVGNKVFTSIFTFECIVKLMALS-KDFFLCGWNIFDLLIVTASLLDIIF 768
            :||.|:...:....||.....||..:|..|..:|:..|. :.:|...:|.||..::..|:.::::
Mouse   500 VAMVHYNQPQRLTTALYFAEFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSIFEVVW 564

  Fly   769 ELVD-----GLSVLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGM 828
            ..:.     |:||||.|||||:.|:.:.|.:::.|:..:::::.::.:|..:|.:.|.:||::||
Mouse   565 AAIKPGTSFGISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGM 629

  Fly   829 QLFSKDYTPEKFDPDPVPRWNFNDFFHSFMMIFRILCGE-WIEPLWDCMRAE--EEQGASTCFAI 890
            |||...:..:    |..|..||:.|..:.:.:|:||.|| |...::..:.::  ..:|..:.|..
Mouse   630 QLFGGQFNFQ----DETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKGMFSSFYF 690

  Fly   891 FLPTLVMGNFMVLNLFLALLL-NSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRK 954
            .:.|| .||:.:||:|||:.: |..|::||...:||:.|.:....::::.::             
Mouse   691 IVLTL-FGNYTLLNVFLAIAVDNLANAQELTKDEEEMEEAANQKLALQKAKE------------- 741

  Fly   955 ERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGF 1019
                       |.:.....|..:|..|.|...||                      .||.|    
Mouse   742 -----------VAEVSPMSAANISIAAFVKQTRG----------------------TVSRS---- 769

  Fly  1020 QIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGT 1084
                                                                  .|.||||    
Mouse   770 ------------------------------------------------------SSVSSVN---- 776

  Fly  1085 CQNLTPFVQ---AERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCG 1146
                :|..|   ..|.:..|.:|.:..|...:..||.|:|            .||   ::|    
Mouse   777 ----SPRQQNSAKARSVWEQRASQLRLQNLRASCEALYSE------------MDP---EER---- 818

  Fly  1147 SFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEM 1211
                         .||.|..|..             |..:..:||                    
Mouse   819 -------------LRYASTRHVR-------------PDMKTHMDR-------------------- 837

  Fly  1212 RRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRR 1276
                             .|:.:.|  |:.|                                 |.
Mouse   838 -----------------PLVVEPG--RDGL---------------------------------RG 850

  Fly  1277 PSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHI 1341
            |.....:||.....|.::..             :|.....:|..::.:.|:....:.|::..   
Mouse   851 PVGSKSKPEGTEATESADLP-------------RRHHRHRDRDKTSATAPAGGEQDRTESTE--- 899

  Fly  1342 AIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSI 1406
               |||.|..|.                  ||||.|.........|:.:|.....:|...|: :.
Mouse   900 ---TGAREERAR------------------PRRSHSKETPGADTQVRCERSRRHHRRGSPEE-AT 942

  Fly  1407 SNEIRKICDQIHAPFVAMEAMAVA--------------ATSASQAQPNQSPF----LRRKVDPFT 1453
            ..|.|:.....||...:.|..|..              .|...:|:.|:.|.    .|.||.|  
Mouse   943 EREPRRHRAHRHAQDSSKEGTAPVLVPKGERRARHRGPRTGPREAENNEEPTRRHRARHKVPP-- 1005

  Fly  1454 VQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQ 1518
                   .|...||  |..|:|    :..:|.:|..|.  |.|.:...|..::..|         
Mouse  1006 -------TLQPPER--EAAEKE----SNAVEGDKETRN--HQPKEPHCDLEAIAVT--------- 1046

  Fly  1519 KQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHT 1583
                |:.   .:...|.|.|:...|.|..|               ::|:  :.|.:.:.|:...|
Mouse  1047 ----GVG---PLHMLPSTCLQKVDEQPEDA---------------DNQR--NVTRMGSQPSDPST 1087

  Fly  1584 HAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTA 1648
            ..|.........|:...:  |...::         .|..:.|..:|.:                 
Mouse  1088 TVHVPVTLTGPPGETPVV--PSGNMN---------LEGQAEGKKEAEA----------------- 1124

  Fly  1649 PDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQK 1713
                                     ||:...|          |.....|.:              
Mouse  1125 -------------------------DDVLRRG----------PRPIVPYSS-------------- 1140

  Fly  1714 CYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFED-INLD- 1776
                        |.|:...:.     :|.....:|....||..:||:|..|||.|..|| :..| 
Mouse  1141 ------------MFCLSPTNL-----LRRFCHYIVTMRYFEMVILVVIALSSIALAAEDPVRTDS 1188

  Fly  1777 -KNKTLKRVLYWINFSFCLIFVVEMILKWLALGF----SKYFTSFWTILDFIIV----FVSVFSL 1832
             :|..||    ::::.|..:|..||::|.:.||.    ..||...|.|||||:|    ....||.
Mouse  1189 FRNNALK----YMDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWNILDFIVVSGALVAFAFSS 1249

  Fly  1833 LI--EENENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIM 1895
            .:  .:.:::..::|||.||.||||:.|.|...::.|.:.::.::.::.|:|:|.::|..||:::
Mouse  1250 FMGGSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVI 1314

  Fly  1896 GVQFFGGKFFKCVNEMGELLPITEVNDKWDC-----------IE-QNYTWINSKITFDHVGMGYL 1948
            .||.|.||||.|.:|..||        :.||           :| |...|......:|:|....|
Mouse  1315 AVQLFKGKFFYCTDESKEL--------ERDCRGQYLDYEKEEVEAQPRQWKKYDFHYDNVLWALL 1371

  Fly  1949 ALLQVATFEGWMEVMADAVDARGVDLQP----QREANLYAYIYFVIFIVCGSFFTLNLFIGVIID 2009
            .|..|:|.|||..|:..:|||...:..|    :.|.:::..:|||:|    .||.:|:|:.:||.
Mouse  1372 TLFTVSTGEGWPMVLKHSVDATYEEQGPSPGFRMELSIFYVVYFVVF----PFFFVNIFVALIII 1432

  Fly  2010 NFNMLKKKYEGGVLEMFLTESQK---HYYTAMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRFE 2071
            .|   :::.:..:.|..|.::::   .:..:.|.|.|..||..     ..|....:....|..||
Mouse  1433 TF---QEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNK-----QSFQYKTWTFVVSPPFE 1489

  Fly  2072 IAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLR-YHYFTVPWNVFD 2135
            ..|..:|.||.:.:.::.||.|:....:|:..|..||::|.:|.|:||:... .:||...|||||
Mouse  1490 YFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECILKIIAFGVLNYFRDAWNVFD 1554

  Fly  2136 FLLVLASIFGILMEDI-----MIDLPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLP 2195
            |:.||.||..||:.:|     .|:|..       :|:||..|:::|::....||.||:..|.|..
Mouse  1555 FVTVLGSITDILVTEIAETNNFINLSF-------LRLFRAARLIKLLRQGYTIRILLWTFVQSFK 1612

  Fly  2196 ALFNIGALLGLITFIYAILGMSLFGNVKLQGALDDMV------NFQTFGRSMQLLFRLMTSAGWN 2254
            ||..:..|:.::.|||||:||.:|||:    ||||..      ||:||.:::.||||..|...|:
Mouse  1613 ALPYVCLLIAMLFFIYAIIGMQVFGNI----ALDDDTSINRHNNFRTFLQALMLLFRSATGEAWH 1673

  Fly  2255 DVLESLMIQPPDCDPFIHGHTNGN-CGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQE 2318
            :::.|.:.... |||    |.|.: ||.. .|..||.|||.:...:::|:::|:|::||....::
Mouse  1674 EIMLSCLGNRA-CDP----HANASECGSD-FAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRD 1732

  Fly  2319 EEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISK--PNNVA---LVSFNLP 2378
            ..| :....|:.|...|::|||.|...|.::.:.:.:..:.||||:.|  |..||   ||..|:|
Mouse  1733 SSI-LGPHHLDEFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMP 1796

  Fly  2379 ISKGN-KIHCLDILHALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPT------RKELEIVSSTR 2436
            ||..: .:|....|.||::..|.........|  |.|.|.:.:|:..:      :|.|:::....
Mouse  1797 ISNEDMTVHFTSTLMALIRTALEIKLAPAGTK--QHQCDAELRKEISSVWANLPQKTLDLLVPPH 1859

  Fly  2437 IWKRQEKAAKTIQTG---WKEYLRRKREKERSNSGDSATQTSSPGGWQSKLSALNFFH-LQVSRR 2497
              |..|.....:...   :..|.:.|..:::::        .:||| .|::..::.|| |:.:..
Mouse  1860 --KPDEMTVGKVYAALMIFDFYKQNKTTRDQTH--------QAPGG-LSQMGPVSLFHPLKATLE 1913

  Fly  2498 GTACSSRASSRKSSRASDASDLSELAGPWLNLPLMLVSGADEVVKDIKQQNDELGKRGSIFVEAP 2562
            .|..:....:|...|...|:.||.             .||        .|..|.|.:.|:.....
Mouse  1914 QTQPAVLRGARVFLRQKSATSLSN-------------GGA--------IQTQESGIKESLSWGTQ 1957

  Fly  2563 RASRRRSFYNFFLRHQDAVDDSLTSPSVHRKTAMNNTTNTTSNSASTSGT-ASSTATAPATGCGP 2626
            |.             |||         ::...|.....::.......||| |........|..||
Mouse  1958 RT-------------QDA---------LYEARAPLERGHSAEIPVGQSGTLAVDVQMQNMTLRGP 2000

  Fly  2627 AATSASDSDRHQAV-GGGSAPSRKRASSFIRKKP---PLERGLSAQSALRVNKNAFVSEASAPEV 2687
                  |.:....: ..|.|.|..|.::..:..|   |::|.:|. .|.|.:.....|      .
Mouse  2001 ------DGEPQPGLESQGRAASMPRLAAETQPAPNASPMKRSIST-LAPRPHGTQLCS------T 2052

  Fly  2688 IVTRPSPEQQTHPH-------------------SLSLRPDNATLVHV---LVH----------RE 2720
            ::.||.|.|.:|.|                   |||:.|:.|.....   |.|          |:
Mouse  2053 VLDRPPPSQASHHHHHRCHRRRDKKQRSLEKGPSLSVDPEGAPSTAAGPGLPHGEGSTACRRDRK 2117

  Fly  2721 SEEYKEEDESSPSVSGNGNGFGVGLDMLSKQPPPQIRITTGSVESSMDTCAMPTVQIMVDSPKDP 2785
            .|..:.::...||.|.:........|....:.|||:..:..|..:|      ||..:   .|...
Mouse  2118 QERGRSQERRQPSSSSSEKQRFYSCDRFGSREPPQLMPSLSSHPTS------PTAAL---EPAPH 2173

  Fly  2786 PRGDFSSAPIDDVGAPI 2802
            |:|   |..::  |:|:
Mouse  2174 PQG---SGSVN--GSPL 2185

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 77/220 (35%)
Ion_trans 705..902 CDD:278921 56/205 (27%)
Ion_trans 1768..2019 CDD:278921 85/279 (30%)
Na_channel_gate 2009..2063 CDD:240441 9/56 (16%)
Ion_trans 2085..2320 CDD:278921 86/247 (35%)
GPHH 2331..2386 CDD:293510 21/60 (35%)
Cacna1bXP_006497689.1 Ion_trans 94..367 CDD:366146 99/297 (33%)
Ion_trans 482..721 CDD:366146 69/243 (28%)
Granin <936..>1041 CDD:279595 27/122 (22%)
Ion_trans 1161..1395 CDD:366146 80/245 (33%)
Ion_trans 1485..1734 CDD:366146 93/265 (35%)
GPHH 1743..1796 CDD:374878 18/52 (35%)
Ca_chan_IQ 1808..1882 CDD:370105 14/77 (18%)
PHA03307 1959..>2326 CDD:223039 55/276 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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