Protein Alignment NaCP60E and CATSPER1

DIOPT Version :9

• Sequence 1: NP_001261172.1
• Gene: NaCP60E / 37981
• FlyBaseID: FBgn0085434
• Length: 2896
• Species: Drosophila melanogaster
• Sequence 2: NP_444282.3
• Gene: CATSPER1 / 117144
• HGNCID: 17116
• Length: 780
• Species: Homo sapiens
• Alignment Length: 540
• Identity: 118/540 - (21%)
• Similarity: 185/540 - (34%)
• Gaps: 181/540 - (33%)

  Fly  1565 HQQHFHATSIQA----------------APTPAHTH--------AHSQAHAHSMAGQRRRMEHPQ 1605
            |..:.|...:|:                ||.||.:.        ||.:..||||......:....
Human   310 HSSYLHGDYVQSTSQLSIPHTSRSLIHDAPGPAASRTGVFPYHVAHPRGSAHSMTRSSSTIRSRV 374

  Fly  1606 STLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLV 1670
            :.:.|....|...|: ||.   |..........:||.:.|     .|:|....|.|.:..|
Human   375 TQMSKKVHTQDISTK-HSE---DWGKEEGQFQKRKTGRLQ-----RTRKKGHSTNLFQWLW---- 426

  Fly  1671 SYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAK 1735
                               :.:||...|..:..:   :......::.|.|    |:.|::|
Human   427 -------------------EKLTFLIQGFREMIR---NLTQSLAFETFIF----FVVCLNT---- 461

  Fly  1736 HWTRVRTAVLTVVDTPA-----FEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLI 1795
                    |:.|..|.|     .||:.:.|   .||..|                         |
Human   462 --------VMLVAQTFAEVEIRGEWYFMAL---DSIFFC-------------------------I 490

  Fly  1796 FVVEMILKWLALGFSKYFTSFWTILDFIIVFVSVFSLLIEENEN-----------LKVLRSLRTL 1849
            :|||.:||.:|||.| ||..||..|||.|:.::|...|:.:..:           |||.:|||.|
Human   491 YVVEALLKIIALGLS-YFFDFWNNLDFFIMAMAVLDFLLMQTHSFAIYHQSLFRILKVFKSLRAL 554

  Fly  1850 RALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEMGEL 1914
            ||:|.||.:|....::.|...|..::|||..:|::......:||.:                  |
Human   555 RAIRVLRRLSFLTSVQEVTGTLGQSLPSIAAILILMFTCLFLFSAV------------------L 601

  Fly  1915 LPITEVNDKWDCIEQNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQRE 1979
            ..:...:|              ...|.::......|..:.|.:.|..:..|:          :.:
Human   602 RALFRKSD--------------PKRFQNIFTTIFTLFTLLTLDDWSLIYMDS----------RAQ 642

  Fly  1980 ANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNF------NMLKKKYEGG------VLEMFLTESQ- 2031
            ...|.....||:|:...|..|||.|.|::|:|      .:.|.|.|..      :||..|||.:
Human   643 GAWYIIPILVIYIIIQYFIFLNLVITVLVDSFQTALFKGLEKAKQERAARIQEKLLEDSLTELRA 707

  Fly  2032 ------KHYYTAMKKLGRKK 2045
                  ....|.:|:|..||
Human   708 AEPKEVASEGTMLKRLIEKK 727

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	152..371	CDD:278921
		Ion_trans	705..902	CDD:278921
		Ion_trans	1768..2019	CDD:278921	63/267 (24%)
		Na_channel_gate	2009..2063	CDD:240441	15/56 (27%)
		Ion_trans	2085..2320	CDD:278921
		GPHH	2331..2386	CDD:293510
CATSPER1	NP_444282.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..37
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	71..306
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	376..412		9/44 (20%)
		Ion_trans	483..677	CDD:278921	64/264 (24%)
		7TMR-DISM_7TM	486..629	CDD:284997	47/200 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810