DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NaCP60E and Cacna1f

DIOPT Version :9

Sequence 1:	NP_001261172.1	Gene:	NaCP60E / 37981	FlyBaseID:	FBgn0085434	Length:	2896	Species:	Drosophila melanogaster
Sequence 2:	NP_446153.2	Gene:	Cacna1f / 114493	RGDID:	621535	Length:	1980	Species:	Rattus norvegicus

Alignment Length:	2827	Identity:	554/2827 - (19%)
Similarity:	907/2827 - (32%)	Gaps:	1225/2827 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 KSLFLFYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLAM------------TETVEEAEYIF 156
            ::||.....:|.||.|:.|...:.||..::.||..||:.|.:            ...:|:.||:|
  Rat    70 RALFCLTLTNPIRRSCISIVEWKPFDILILLTIFANCVALGVYIPFPEDDSNTANHNLEQVEYVF 134

  Fly   157 LAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEVG---------------- 205
            |.|:::|.|:||:|.|.:|:...|:||.||.|||:::..|..::.:|.|
  Rat   135 LVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGG 199

  Fly   206 -NLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELR 269
             ::..||.|||||.|:.||.:|.|..::|:::.:...|..:..|.:|.::::|:..|::::|.:.
  Rat   200 FDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMH 264

  Fly   270 NKCVRQVPTDWTNVSHTDWQIWVNDTDNWLYDEDELPVLCGNLTGARHCPFEYVCLCVGE--NPN 332
            ..|                  :...:|   .:.:|.|..|.:....|.|..... .|.|.  .||
  Rat   265 KTC------------------YFLGSD---MEAEEDPSPCASSGSGRSCTLNQT-ECRGRWPGPN 307

  Fly   333 HGYTNFDNFMWSMLTTFQLITLDYWENV-YNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVA 396
            .|.||||||.::|||.||.||::.|.:| |.|..|....:...:|..:|.||||:::||:|
  Rat   308 GGITNFDNFFFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVL---- 368

  Fly   397 LSYEEEAEITNEERKKDLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRR 461
                                                               |||...:||::.:.
  Rat   369 ---------------------------------------------------GVLSGEFSKEREKA 382

  Fly   462 KKTKGGKEGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQHK-- 524
            |                :.||                           .|..::.||||:..:
  Rat   383 K----------------ARGD---------------------------FQKLREKQQMEEDLRGY 404

  Fly   525 -----------------------LAKSGSGGSN---NPMAPTPKGRIS-FQDSGMGVKNPNMLYP 562
                                   ||:.|..|..   :.:....:||:. |..|.....:.:
  Rat   405 LDWITQAEELDLHDPSVDGNLASLAEEGRAGHRPQLSELTNRRRGRLRWFSHSTRSTHSTS---- 465

  Fly   563 SDYKGQLIANSGQPSSNSSGVNRESSQDDSGVVDDHEEQDTTNDMGHVSTVELALSPREVRLIK- 626
                    :::..|:|::..:.     |..|  |:.||:      |.:::..|.|:    :::|
  Rat   466 --------SHASLPASDTGSIT-----DTPG--DEDEEE------GTMASCTLCLN----KIMKT 505

  Fly   627 --CNGNIARIKNHNVYALHQEFSSEVVVIDDLPDRNCDRCVHWCTDYESWLQFQNCLYKVVRDPL 689
              |..  .|..|..:.|                  .|.|.|.           .|..|
  Rat   506 KVCRH--FRRANRGLRA------------------RCRRAVK-----------SNACY------- 532

  Fly   690 FELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIFTFECIVKLMALSKDFFLCG-WNI 753
              .|:.|.:.|||..:|.||||.........:..|||...:||.|.::||..|....::.. :|.
  Rat   533 --WAVLLLVFLNTLTIASEHHGQPVWLTQTQEYANKVLLCLFTVEMLLKLYGLGPSVYVASFFNR 595

  Fly   754 FDLLIVTASLLDIIFELVD-------GLSVLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGN 811
            ||..:|...:|:.  .||:       |:||||.:||||:.|:.:.|.::..|::.:::::.::.:
  Rat   596 FDCFVVCGGILET--TLVEVGAMQPLGISVLRCVRLLRIFKVTRHWASLSNLVASLLNSMKSIAS 658

  Fly   812 LTLILVIVIYIFAVIGMQLFSKDYTPEKFDPDPVPRWNFNDFFHSFMMIFRILCGE-WIEPLWDC 875
            |.|:|.:.|.||:::|||||...:   .||.....|..|:.|..:.:.:|:||.|| |...::|.
  Rat   659 LLLLLFLFIIIFSLLGMQLFGGKF---NFDQTHTKRSTFDTFPQALLTVFQILTGEDWNVVMYDG 720

  Fly   876 MRAEEE---QGASTCFAIFLPTLVMGNFMVLNLFLALLLNSFNSEELKSKKEEVGEESKLARSIE 937
            :.|...   .|...| ..|:...:.||:::||:|||:.:::..|.:..:.|::..|:|
  Rat   721 IMAYGGPFFPGMLVC-VYFIILFICGNYILLNVFLAIAVDNLASGDAGAAKDKGREKS------- 777

  Fly   938 RVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRL 1002
                                                            ..|:.|
  Rat   778 ------------------------------------------------SEGNPP----------- 783

  Fly  1003 SYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESA 1067
              ||:                    ..:|.|.|.:||
  Rat   784 --QEN--------------------KVLVPGGENEDT---------------------------- 798

  Fly  1068 MMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNST 1132
                                                            |.|.:|
  Rat   799 ------------------------------------------------EGTKSE----------- 804

  Fly  1133 DTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSG 1197
                       |...               |.||.:|
  Rat   805 -----------GAAP---------------GMEEEEE---------------------------- 815

  Fly  1198 QSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKG 1262
                                                                    :||||
  Rat   816 --------------------------------------------------------EEEEE---- 820

  Fly  1263 TKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPS 1327
                                  |.|....|.|.          |:|:
  Rat   821 ----------------------EEENGAGHVEL----------LQEV------------------ 835

  Fly  1328 PAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRR 1392
                                                       ||:
  Rat   836 -------------------------------------------VPK------------------- 838

  Fly  1393 SLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFD 1457

  Rat   839 ----------------------------------------------------------------- 838

  Fly  1458 RFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKL 1522
                    |:|..:||...                          ...|..||
  Rat   839 --------EKVVPIPEGSA--------------------------FFCLSQTN------------ 857

  Fly  1523 GMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHS 1587
                                                                     |.....|:
  Rat   858 ---------------------------------------------------------PLRKACHT 865

  Fly  1588 QAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDAT 1652
            ..|.|
  Rat   866 LIHHH------------------------------------------------------------ 870

  Fly  1653 QKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDH 1717
                .||.|
  Rat   871 ----VFTSL-------------------------------------------------------- 875

  Fly  1718 FYFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLK 1782
                                                   :||.|..||::|..|| .:..:....
  Rat   876 ---------------------------------------ILVFIILSSVSLAAED-PIRAHSFRN 900

  Fly  1783 RVLYWINFSFCLIFVVEMILKWLALGF----SKYFTSFWTILDFIIVFVSVFSLLIEENENLKVL 1843
            .:|.:.:::|..||.||::||....|.    ..:..|::.:||.::|.||:.|..|..:. :.|:
  Rat   901 HILGYFDYAFTSIFTVEILLKMTVFGAFLHQGSFCRSWFNLLDLLVVSVSLISFGIHSSA-ISVV 964

  Fly  1844 RSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCV 1908
            :.||.||.|||||||:|.:|::.||..:..||.:|.|:::|..:...:|:.:|||.|.|||:.|.
  Rat   965 KILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYSCT 1029

  Fly  1909 NEMGELL----------PITEVNDKWDCIEQNYTWINSKITFDHVGMGYLALLQVATFEGWMEVM 1963
            :|....|          |..:|:..   :.:...|:||...||:|....:||..|:|||||..::
  Rat  1030 DEAKHTLKECKGSFLIYPDGDVSRP---LVRERLWVNSDFNFDNVLSAMMALFTVSTFEGWPALL 1091

  Fly  1964 ADAVDARGVDLQPQREANLYAY-----IYFVIFIVCGSFFTLNLFIGVIIDNFNML-KKKYEGGV 2022
            ..|:||...|     |..:|.|     ::|:::|:..:||.:|:|:|.:|..|... :::|:...
  Rat  1092 YKAIDAHAED-----EGPIYNYHVEISVFFIVYIIIIAFFMMNIFVGFVIITFRAQGEQEYQNCE 1151

  Fly  2023 LEMFLTESQK---HYYTAMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLT 2084
            |:    ::|:   .|....:.|.|..|    |.|..:   ..:...||..||..:|:||.||.:.
  Rat  1152 LD----KNQRQCVEYALKAQPLRRYIP----KNPHQY---RVWATVNSAAFEYLMFLLILLNTVA 1205

  Fly  2085 MGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLR-YHYFTVPWNVFDFLLVLASIF---- 2144
            :.::||:|.....:.:::.|..||.:|.:|.::||:..: .|||...||.||.|:|:.|:.
  Rat  1206 LAMQHYEQTAPFNYAMDILNMVFTGLFTVEMVLKIIAFKPKHYFADAWNTFDALIVVGSVVDIAV 1270

  Fly  2145 ------GILMEDIMIDLPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGAL 2203
                  |.|.|.......||.|..   |:||:.|:::|:...:|||.||:..:.|..||..:..|
  Rat  1271 TEVNNGGHLGESSEDSSRISITFF---RLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALL 1332

  Fly  2204 LGLITFIYAILGMSLFGNVKLQGA--LDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQPPD 2266
            :.:|.||||::||.:||.|.||..  ::...|||||.:::.||||..|...|.:::  |...|.:
  Rat  1333 IAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTFPQAVLLLFRCATGEAWQEIM--LASLPGN 1395

  Fly  2267 -CDP---FIHGHTNGNCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDD 2327
             |||   |..|. ...||.. .||.||.||.::...::||:::|:|::||:...::..| :....
  Rat  1396 RCDPESDFGPGE-EFTCGSN-FAIVYFISFFMLCAFLIINLFVAVIMDNFDYLTRDWSI-LGPHH 1457

  Fly  2328 LEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISK--PNNVA---LVSFNLPISKGNKIHC 2387
            |:.|...||:|||.|...|....:...:..:.||||..|  |:.||   ||:.|:|::....:..
  Rat  1458 LDEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCPHRVACKRLVAMNVPLNSDGTVTF 1522

  Fly  2388 LDILHALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEK--------- 2443
            ...|.|||:..| .::...|..|..:::.:..||               ||||.::
  Rat  1523 NATLFALVRTSL-RIKTEGNLDQANQELRMVIKK---------------IWKRIKQKLLDEVIPP 1571

  Fly  2444 ------------AAKTIQTGWKEYLRR-KREKERSNSG-DSATQTSSPGGWQSKLSALNFFHLQV 2494
                        |...||    :|.|: :|.||:...| |:.|.|||.              ||.
  Rat  1572 PDEEEVTVGKFYATFLIQ----DYFRKFRRRKEKGLLGADAPTSTSSV--------------LQA 1618

  Fly  2495 SRRGTACSSRASSRKSSRASDASDLSELAGPWLNLPLMLVSGADEVVKDIKQQNDELGKRGSIFV 2559
            ..|                    .|.:| ||.:...|         ..|.:::.:|....|. ..
  Rat  1619 GLR--------------------SLQDL-GPEIRQAL---------TYDTEEEEEEEEAAGQ-EA 1652

  Fly  2560 EAPRASRRRSFYNFFLRHQDAVD-------DSLTSPSVHRKTAMNNTTNTTSNSASTSGTASSTA 2617
            |...|......|      :|::|       :|..|.|:..|..:                ..|.:
  Rat  1653 EEEEAENNPETY------KDSIDSQPQAQWNSRISVSLPVKEKL----------------PDSLS 1695

  Fly  2618 TAPATGCGPAATSASDSDRHQAVGGGSAPSRKRASSFIRKKPPLERGLSAQSAL--RVNKNAFVS 2680
            |.|:...|.|..|...|    .:..||.|.|:.:..|:...|  |.|.:....:  :.|:|   .
  Rat  1696 TGPSDDDGVAPNSRQPS----GLQAGSQPHRRSSGVFMFTIP--EEGSTQLKGVQGQDNQN---E 1751

  Fly  2681 EASAPEVIVTRPSPEQQTHPHSLSLRPDNATLVHVLVHRE----------------------SEE 2723
            |...|:  .|....||...|.:..|.|.:.:..||..|..                      ..:
  Rat  1752 EQEVPD--WTPNLDEQAGMPSNPVLLPPHWSQQHVNGHHVPRRRLLPPTPAGRKPSFTIQCLQRQ 1814

  Fly  2724 YKEEDESSPSVSGNGNGFGVGLDMLSKQPPPQ 2755
            ...||...|.....|...|.|....|...|||
  Rat  1815 GSCEDLPIPGTYHRGRTSGPGRAQGSWAAPPQ 1846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	152..371	CDD:278921	72/238 (30%)
		Ion_trans	705..902	CDD:278921	62/208 (30%)
		Ion_trans	1768..2019	CDD:278921	84/270 (31%)
		Na_channel_gate	2009..2063	CDD:240441	10/57 (18%)
		Ion_trans	2085..2320	CDD:278921	84/251 (33%)
		GPHH	2331..2386	CDD:293510	20/59 (34%)
Cacna1f	NP_446153.2	Ion_trans	91..383	CDD:395416	94/368 (26%)
		Ion_trans	532..763	CDD:395416	73/245 (30%)
		Ion_trans	869..1106	CDD:395416	82/405 (20%)
		Ion_trans	1188..1451	CDD:395416	92/269 (34%)
		GPHH	1460..1513	CDD:407139	19/52 (37%)
		Ca_chan_IQ	1524..1595	CDD:400901	18/90 (20%)
		CAC1F_C	1618..1977	CDD:407123	56/293 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810