Protein Alignment NaCP60E and SCN11A

DIOPT Version :9

• Sequence 1: NP_001261172.1
• Gene: NaCP60E / 37981
• FlyBaseID: FBgn0085434
• Length: 2896
• Species: Drosophila melanogaster
• Sequence 2: XP_016861136.1
• Gene: SCN11A / 11280
• HGNCID: 10583
• Length: 1916
• Species: Homo sapiens
• Alignment Length: 2543
• Identity: 758/2543 - (29%)
• Similarity: 1100/2543 - (43%)
• Gaps: 840/2543 - (33%)

  Fly     4 DQATF----NDEKAVAKHQVVAYTQRSQVKHENRHIQLVREYGFHPRTKASVEDGDVLPRKFEPF 64
            |:..|    :|..|..:.::....::.:.|.:...:.       .||.:..::....||:.:...
Human   137 DERNFRPFTSDSLAAIEKRIAIQKEKKKSKDQTGEVP-------QPRPQLDLKASRKLPKLYGDI 194

  Fly    65 PEHMYGKPLEEIDTFI-YEETFCVVSKRFRKNYIHRFTGTKSLFLFYPWSPARRVCVYIATNQFF 128
            |..:.|||||::|.|. ..:||.|::   ||..|:||:...:||:|.|::..|.:.:.::.:..|
Human   195 PRELIGKPLEDLDPFYRNHKTFMVLN---RKRTIYRFSAKHALFIFGPFNSIRSLAIRVSVHSLF 256

  Fly   129 DYCVMATILFNCIFLAM-------TETVEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWN 186
            ...::.|::.||:|:|.       :...:.||.:|..||..|.:|||:|:||:|:::::||:|||
Human   257 SMFIIGTVIINCVFMATGPAKNSNSNNTDIAECVFTGIYIFEALIKILARGFILDEFSFLRDPWN 321

  Fly   187 WLDFVVITSGYATIGMEVG---NLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTL 248
            |||.:||  |.|.:....|   .|..||||||.||||.:|::..||.|:.|||.|.::|..|:.|
Human   322 WLDSIVI--GIAIVSYIPGITIKLLPLRTFRVFRALKAISVVSRLKVIVGALLRSVKKLVNVIIL 384

  Fly   249 TIFCLMVFALFALQVYMGELRNKCVRQVPTDWTNVSHTDWQIWVNDTDNWLYDEDELP--VLCGN 311
            |.|||.:|||...|::||.|..||:.:   |..|:|:.:      ..|:....::..|  .:||.
Human   385 TFFCLSIFALVGQQLFMGSLNLKCISR---DCKNISNPE------AYDHCFEKKENSPEFKMCGI 440

  Fly   312 LTGARHCPFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCGPMSVSFF 376
            ..|...|..:|.|.....||::.|||||||.||.|..|:|:|.|.||.:|...|.|.|..||.||
Human   441 WMGNSACSIQYECKHTKINPDYNYTNFDNFGWSFLAMFRLMTQDSWEKLYQQTLRTTGLYSVFFF 505

  Fly   377 TVVVFFGSFYLINLMLAVVALSYEEE-----AEITNEER----KKDLLDHRDD----------ST 422
            .||:|.||||||||.||||.::|||:     |||..:|:    .:.||....:          |.
Human   506 IVVIFLGSFYLINLTLAVVTMAYEEQNKNVAAEIEAKEKMFQEAQQLLKEEKEALVAMGIDRSSL 570

  Fly   423 FSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGKEGGTNGNGNGSNGDDNKSH 487
            .|.:.|....||......||   ||...|                :|.|.: ...||:.|::
Human   571 TSLETSYFTPKKRKLFGNKK---RKSFFL----------------RESGKD-QPPGSDSDED--- 612

  Fly   488 SATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQHKLAKSGSGGSNNPMAPTPKGRISFQDSGM 552
                                    .||:.|.:||..:|:::.|
Human   613 ------------------------CQKKPQLLEQTKRLSQNLS---------------------- 631

  Fly   553 GVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQDDSGVVDDH-EEQDTTNDMGHVSTVELA 616
                      .|:                             .|:| :.......:..||.:.:.
Human   632 ----------LDH-----------------------------FDEHGDPLQRQRALSAVSILTIT 657

  Fly   617 LSPREVR---LIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDRNCDRCVHWCTDYESWLQFQ 678
            :..:|..   .:.|..|:|               |:.:|      .||  |..|.
Human   658 MKEQEKSQEPCLPCGENLA---------------SKYLV------WNC--CPQWL---------- 689

  Fly   679 NCLYKVVR----DPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIFTFECIVKL 739
             |:.||:|    ||..|||||:||::||.|||||||.|..||...|::||.||||||..|..:|:
Human   690 -CVKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKMEASFEKMLNIGNLVFTSIFIAEMCLKI 753

  Fly   740 MALSK-DFFLCGWNIFDLLIVTASLLDIIFELVDGLS--VLRGLRLLRVLKLAQSWTTMKVLLSI 801
            :||.. .:|..||||||.::...|..|::..::...|  .||..|:|||.|||:||.|:..|:.|
Human   754 IALDPYHYFRRGWNIFDSIVALLSFADVMNCVLQKRSWPFLRSFRVLRVFKLAKSWPTLNTLIKI 818

  Fly   802 IISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTPEKFDP---DP-------VPRWNFNDFFHS 856
            |.:::||||:||::|||||:||:|:|||||.:.:..:| .|   :|       :..|:..||:||
Human   819 IGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFNSQK-SPKLCNPTGPTVSCLRHWHMGDFWHS 882

  Fly   857 FMMIFRILCGEWIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLFLALLLNSFNSEELKS 921
            |:::||||||||||.:|:||: |....:|.|..:|:...|:|..:|||||:|||||||::||...
Human   883 FLVVFRILCGEWIENMWECMQ-EANASSSLCVIVFILITVIGKLVVLNLFIALLLNSFSNEERNG 946

  Fly   922 KKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLE 986
            ..|....::|:..:::|.|               |.|.  |.:          .||.|..
Human   947 NLEGEARKTKVQLALDRFR---------------RAFC--FVR----------HTLEHFC----- 979

  Fly   987 RGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAH 1051
                         |:...::                                  :||:
Human   980 -------------HKWCRKQ----------------------------------NLPQ------- 990

  Fly  1052 PLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREE 1116
                                                           |.:::.|.:.|
Human   991 -----------------------------------------------QKEVAGGCAAQ------- 1001

  Fly  1117 ATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTR 1181
                          |.|..|...:.:.                   |||..:|.      .:||.
Human  1002 --------------SKDIIPLVMEMKR-------------------GSETQEEL------GILTS 1027

  Fly  1182 SPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQ 1246
            .|   |:|.                     .||                              |.
Human  1028 VP---KTLG---------------------VRH------------------------------DW 1038

  Fly  1247 KELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKR 1311
            ..|....:||::                               ||.|..||
Human  1039 TWLAPLAEEEDD-------------------------------VEFSGEDN-------------- 1058

  Fly  1312 STTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQ 1376
                    ...:::|.|                    |:.|             |:|.
Human  1059 --------AQRITQPEP--------------------EQQA-------------YELH------- 1075

  Fly  1377 SVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQ 1441
                                                                         |.|:
Human  1076 -------------------------------------------------------------QENK 1079

  Fly  1442 SPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSL 1506
            .|..:|..   :|:.|.|             .|::|..|:     :.|||
Human  1080 KPTSQRVQ---SVEIDMF-------------SEDEPHLTI-----QDPRK--------------- 1108

  Fly  1507 KSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHA 1571
                                            ||.:
Human  1109 --------------------------------KSDV----------------------------- 1112

  Fly  1572 TSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALA 1636
            |||.:                           ..||:|....|
Human  1113 TSILS---------------------------ECSTIDLQDGF---------------------- 1128

  Fly  1637 MAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATK 1701
                     ...|:...|        ::|..||..                        .:|.
Human  1129 ---------GWLPEMVPK--------KQPERCLPK------------------------GFGC-- 1150

  Fly  1702 AAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSI 1766
                   |||  |......:.||.:          |..:|.....:|....||.|::.:|..||.
Human  1151 -------CFP--CCSVDKRKPPWVI----------WWNLRKTCYQIVKHSWFESFIIFVILLSSG 1196

  Fly  1767 TLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGFSKYFTSFWTILDFIIVFVSVFS 1831
            .|.|||::|:....::.:|...:..|..||::||:|||:|.||.|||||.|..||||||.|||.:
Human  1197 ALIFEDVHLENQPKIQELLNCTDIIFTHIFILEMVLKWVAFGFGKYFTSAWCCLDFIIVIVSVTT 1261

  Fly  1832 LLIEENENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMG 1896
            |:     ||..|:|.|||||||||||:|:::||::|||||:.|||:|.|||||||:|||:|.|:|
Human  1262 LI-----NLMELKSFRTLRALRPLRALSQFEGMKVVVNALIGAIPAILNVLLVCLIFWLVFCILG 1321

  Fly  1897 VQFFGGKFFKCVNEMGELLPITEVNDKWDCIEQNYTWINSKITFDHVGMGYLALLQVATFEGWME 1961
            |.||.|||.||:|....::..|.:.:|..|...|::|||.|:.||:||..||||||||||:|||:
Human  1322 VYFFSGKFGKCINGTDSVINYTIITNKSQCESGNFSWINQKVNFDNVGNAYLALLQVATFKGWMD 1386

  Fly  1962 VMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMF 2026
            ::..|||:...:.||:.|:|...|||||:||:.||||||||||||||||||..:||..|  .::|
Human  1387 IIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGG--QDIF 1449

  Fly  2027 LTESQKHYYTAMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYD 2091
            :||.||.||.||||||.|||||.|.||:|....:.:|:..|:.|:|.|..||.|||::|..|.|:
Human  1450 MTEEQKKYYNAMKKLGSKKPQKPIPRPLNKCQGLVFDIVTSQIFDIIIISLIILNMISMMAESYN 1514

  Fly  2092 QPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRYHYFTVPWNVFDFLLVLASIFGILMEDI--MID 2154
            ||.|:..||:..|..|..:|.||.::||..||.:|||..||:||.::||.||...::..:  ...
Human  1515 QPKAMKSILDHLNWVFVVIFTLECLIKIFALRQYYFTNGWNLFDCVVVLLSIVSTMISTLENQEH 1579

  Fly  2155 LPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLF 2219
            :|..|||.|:||:.||||||||::||:|||.|||||::|||:|||||.||.||.||||||||:.|
Human  1580 IPFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWF 1644

  Fly  2220 GNVKLQGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQPPDCDPFIHGHTNGNCGHPLL 2284
            ..|..:..:||:.||:||..||..||::.|||||:.:|..::.....|:     .::.||..|.:
Human  1645 SKVNPESGIDDIFNFKTFASSMLCLFQISTSAGWDSLLSPMLRSKESCN-----SSSENCHLPGI 1704

  Fly  2285 AITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHFS 2349
            |.:||.|:||||::||:|||||:||||||.|.:|.|..:.|||.::||..|.|:||.|||||.:|
Human  1705 ATSYFVSYIIISFLIVVNMYIAVILENFNTATEESEDPLGEDDFDIFYEVWEKFDPEATQFIKYS 1769

  Fly  2350 QLSDFIASLDPPLGISKPNNVALVSFNLPISKGNKIHCLDILHALVKHVLGHVEETDNFKQLQEQ 2414
            .||||..:|..||.::|||....:..:||:...:::||:|||.|....|||..:..|:.|.:.|:
Human  1770 ALSDFADALPEPLRVAKPNKYQFLVMDLPMVSEDRLHCMDILFAFTARVLGGSDGLDSMKAMMEE 1834

  Fly  2415 MDVKFKKQFPTRKELEIVSSTRIWKRQEKAAKTIQTGWKEYLRRKREKERSNSGDSATQTSSPGG 2479
               ||.:..|.:|..|.:.:|...|.:|:.|..||..:::|:.      :...||...|.....|
Human  1835 ---KFMEANPLKKLYEPIVTTTKRKEEERGAAIIQKAFRKYMM------KVTKGDQGDQNDLENG 1890

  Fly  2480 WQSKLSAL 2487
            ..|.|..|
Human  1891 PHSPLQTL 1898

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	152..371	CDD:278921	94/223 (42%)
		Ion_trans	705..902	CDD:278921	94/209 (45%)
		Ion_trans	1768..2019	CDD:278921	141/250 (56%)
		Na_channel_gate	2009..2063	CDD:240441	29/53 (55%)
		Ion_trans	2085..2320	CDD:278921	118/236 (50%)
		GPHH	2331..2386	CDD:293510	24/54 (44%)
SCN11A	XP_016861136.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D37221at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100419
Panther	1	1.100	-	-	O	PTHR10037
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820