DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NaCP60E and Scn4a

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:NP_573462.2 Gene:Scn4a / 110880 MGIID:98250 Length:1841 Species:Mus musculus


Alignment Length:2595 Identity:799/2595 - (30%)
Similarity:1132/2595 - (43%) Gaps:896/2595 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 DEKAVAKHQVVAYTQRSQVKHENRHIQLVREYGFHPRTKASVEDGDVLPRKFEPFPEHMYGKPLE 74
            :::|:.:...:...::.:::...|            :.::.:|.|..||..:...|..:.|.|||
Mouse    29 EQRAMEEEARLQRNKQMEIEEPER------------KPRSDLEAGKNLPLIYGDPPPEVIGVPLE 81

  Fly    75 EIDTFIYE-ETFCVVSKRFRKNYIHRFTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATILF 138
            ::|.:..: :||.|::|   ...|.||:.|.:|::..|:|..|||.:.:..:..|...:|.|||.
Mouse    82 DLDPYYSDKKTFIVLNK---GKAIFRFSATPALYMLSPFSIVRRVAIKVLIHALFSMFIMITILT 143

  Fly   139 NCIFLAMTET---VEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATI 200
            ||:|:.|:..   .::.||.|..||:.|.:||::|:||.::.:|:||:|||||||.|||..|.|.
Mouse   144 NCVFMTMSNPPSWSKDVEYTFTGIYTFESLIKMLARGFCIDDFTFLRDPWNWLDFSVITMAYVTE 208

  Fly   201 GMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYM 265
            .:::||::.||||||||||||::::||||||:.||:.|.::|::||.||:|||.||||..||::|
Mouse   209 FVDLGNISALRTFRVLRALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFM 273

  Fly   266 GELRNKCVRQVP------------------------------------TDWTNVSHTDWQIWVND 294
            |.||.||||..|                                    ..|.:.|..||:.::||
Mouse   274 GNLRQKCVRWPPPMNDTNTTWYGNDTWYGNDTWYGNDTWYGNDTWNSQESWVSNSTFDWEAYIND 338

  Fly   295 TDNWLYDE---DELPVLCGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDY 356
            ..|:.:.|   |.|  ||||.:.|.|||..|.|:..|.|||:|||::|.|.|:.|..|:|:|.||
Mouse   339 EGNFYFLEGSNDAL--LCGNSSDAGHCPEGYECMKAGRNPNYGYTSYDTFSWAFLALFRLMTQDY 401

  Fly   357 WENVYNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNEERKKDLLDHRDDS 421
            |||::.:.|...|...:.||.|::|.||||||||:|||||::|.|:.|.|..|      |...:.
Mouse   402 WENLFQLTLRAAGKTYMIFFVVIIFLGSFYLINLILAVVAMAYAEQNEATLAE------DQEKEE 460

  Fly   422 TFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGK--EGGTNGNGNGSNGDDN 484
            .|.                        .:|..:.|.:...:|.|..:  |||...:|:       
Mouse   461 EFQ------------------------QMLEKFKKHQEELEKAKAAQALEGGEEADGD------- 494

  Fly   485 KSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQHKLAKSGSGGSNNPMAPTPKGRISFQD 549
                        |.||                                                 
Mouse   495 ------------PTHS------------------------------------------------- 498

  Fly   550 SGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQDDSGVVDDHEEQDTTNDMGHVSTVE 614
                         .|..|.|      .:|...|..|.|...:|.:.|..||.:..          
Mouse   499 -------------KDCNGSL------DTSGEKGPPRPSCSAESAISDAMEELEEA---------- 534

  Fly   615 LALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDRNCD----RCVH----W--CT 669
                                        ||:               |.    :|.|    |  |.
Mouse   535 ----------------------------HQK---------------CPPWWYKCAHKVLIWNCCA 556

  Fly   670 DYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIFTFE 734
               .|::|::.:..:|.||..:|.||:||||||.|:||||:.|:|.|.|.|.|||.|||.|||.|
Mouse   557 ---PWVKFKHIILLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLSVGNLVFTGIFTAE 618

  Fly   735 CIVKLMALSK-DFFLCGWNIFDLLIVTASLLDIIFELVDGLSVLRGLRLLRVLKLAQSWTTMKVL 798
            .::||:|:.. ::|..||||||..|||.||:::....|.||||||..|||||.|||:||.|:.:|
Mouse   619 MVLKLIAMDPYEYFQQGWNIFDSFIVTLSLVELGLANVQGLSVLRSFRLLRVFKLAKSWPTLNML 683

  Fly   799 LSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTP--EKFDPD-PVPRWNFNDFFHSFMMI 860
            :.||.:::||||||||:|.|:::||||:|||||.|.|..  .|...| .:|||:.:||||||:::
Mouse   684 IKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIASDCSLPRWHMHDFFHSFLIV 748

  Fly   861 FRILCGEWIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLFLALLLNSFNSEELKSKKEE 925
            ||||||||||.:||||   |..|.:.|..:||..:|:||.:||||||||||:||:::.|.:..|:
Mouse   749 FRILCGEWIETMWDCM---EVAGQAMCLTVFLMVMVIGNLVVLNLFLALLLSSFSADSLAASDED 810

  Fly   926 VGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDK 990
             ||.:.|..:|.|::..|             .||:.|                   .:||     
Mouse   811 -GEMNNLQIAIGRIKWGI-------------AFAKTF-------------------LLGL----- 837

  Fly   991 PGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPP 1055
                                            ||..:.::.|                       
Mouse   838 --------------------------------LHGKILSLKD----------------------- 847

  Fly  1056 TSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEATYT 1120
                        :|.:.|                                               
Mouse   848 ------------IMLSLG----------------------------------------------- 853

  Fly  1121 ESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSY 1185
                                :..|.|.                                      
Mouse   854 --------------------EPGGAGE-------------------------------------- 860

  Fly  1186 RKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELF 1250
                                               |..|..:||                     
Mouse   861 -----------------------------------NGESPPEDE--------------------- 869

  Fly  1251 QFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTS 1315
                                   .:.|..:.|                    .|||::       
Mouse   870 -----------------------KKEPPPEDG--------------------NKELKD------- 884

  Fly  1316 LERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSA 1380
                               ..|:.|:.:..|.......|.:....|||.:               
Mouse   885 -------------------NHILNHVGLTDGPRSSIEMDHLNFINNPYLT--------------- 915

  Fly  1381 AAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFL 1445
                                                ||.|..:.|:..                 
Mouse   916 ------------------------------------IHVPIASEESDL----------------- 927

  Fly  1446 RRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTN 1510
                                    |:|.||:..:....|..|.|.:.|:..:.      |:.||.
Mouse   928 ------------------------EMPTEEETDTFSEPEDIKKPLQPLYDGNS------SVCSTA 962

  Fly  1511 SYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQ 1575
            .|                              :||.                             
Mouse   963 DY------------------------------KPPE----------------------------- 968

  Fly  1576 AAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQK 1640
                                      |.|:                                   
Mouse   969 --------------------------EDPE----------------------------------- 972

  Fly  1641 TEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKV 1705
             ||::                                    .|.:|                 ::
Mouse   973 -EQAE------------------------------------ENPEG-----------------EL 983

  Fly  1706 PDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCF 1770
            |::||.:.|..    |||.....:.....|.|..:|.|...:|:...||.|::.:|..||..|.|
Mouse   984 PEECFTEACVK----RCPCLYVDISQGRGKMWWTLRRACFKIVEHNWFETFIVFMILLSSGALAF 1044

  Fly  1771 EDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGFSKYFTSFWTILDFIIVFVSVFSLLIE 1835
            |||.:::.:.::.:|.:.:..|..||::||:|||:|.||..|||:.|..|||:||.||:.||:..
Mouse  1045 EDIYIEQRRVIQTILEYADKVFTYIFILEMLLKWVAYGFKVYFTNAWCWLDFLIVDVSIISLVAN 1109

  Fly  1836 --ENENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQ 1898
              ....|..::|||||||||||||:||::|||:|||||:.|||||.|||||||:||||||||||.
Mouse  1110 WLGYSELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVN 1174

  Fly  1899 FFGGKFFKCVN-EMGELLPITEVNDKWDCIEQNYT----WINSKITFDHVGMGYLALLQVATFEG 1958
            .|.|||:.|:| ...|...|:.||:|.:|....||    |:|.|:.:|:||:|||:|||||||:|
Mouse  1175 LFAGKFYYCINTTTSERFDISVVNNKSECESLMYTGQVRWMNVKVNYDNVGLGYLSLLQVATFKG 1239

  Fly  1959 WMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVL 2023
            ||::|..|||:|..:.||..|.|||.|:||||||:.||||||||||||||||||..|||:.|  .
Mouse  1240 WMDIMYAAVDSREKEEQPDYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGG--K 1302

  Fly  2024 EMFLTESQKHYYTAMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIE 2088
            ::|:||.||.||.||||||.|||||.|.||.|....|.||....:.|:|:|.:||.|||:||.:|
Mouse  1303 DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKIQGMVYDFVTKQVFDISIMILICLNMVTMMVE 1367

  Fly  2089 HYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRYHYFTVPWNVFDFLLVLASIFGILMEDIMI 2153
            ..||......||...|..|..||..|.::|:..||::|||:.||:|||::|:.||.|:.:.|::.
Mouse  1368 TDDQSQLKVDILYNINMVFIIVFTGECVLKMFALRHYYFTIGWNIFDFVVVILSIVGLALSDLIQ 1432

  Fly  2154 DLPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSL 2218
            ...:||||.||:|:.||||:||||:.|||||.|||||::|||||||||.||.|:.|||:|.|||.
Mouse  1433 KYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSN 1497

  Fly  2219 FGNVKLQGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQ-PPDCDPFIHG---HTNGNC 2279
            |..||.:..:|||.||:|||.|:..||.:.|||||:.:|..::.. ||||||.:..   :..|:|
Mouse  1498 FAYVKKESGIDDMFNFETFGNSIICLFEITTSAGWDGLLNPILNSGPPDCDPTLENPGTNIKGDC 1562

  Fly  2280 GHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQ 2344
            |:|.:.|.:|.|:||||::||:||||||||||||.|.:|....:.|||.||||..|.|:||.|||
Mouse  1563 GNPSIGICFFCSYIIISFLIVVNMYIAIILENFNVATEESSEPLCEDDFEMFYETWEKFDPDATQ 1627

  Fly  2345 FIHFSQLSDFIASLDPPLGISKPNNVALVSFNLPISKGNKIHCLDILHALVKHVLGHVEETDNFK 2409
            ||.:|:||||:.:|..||.|:|||.:.|::.:||:..|:||||||||.||.|.|||...|.|..|
Mouse  1628 FIDYSRLSDFVDTLQEPLKIAKPNKIKLITLDLPMVPGDKIHCLDILFALTKEVLGDSGEMDALK 1692

  Fly  2410 QLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEKAAKTIQTGWKEYLRRKREKERS--------N 2466
            |..|:   ||....|::...|.:::|...|::|..|..||..::.:|.::..|:.|        .
Mouse  1693 QTMEE---KFMAANPSKVSYEPITTTLKRKQEEVCAIKIQRAYRRHLLQRSVKQASYMYRHSQEG 1754

  Fly  2467 SGDSATQTSSPGGWQSKLSALNFFHLQVS-RRGTACSSRASSRKSSRASDASDLSELAGP 2525
            :||.|.:       :..|.|.....:..| :......|:....|.| ..||...:|:..|
Mouse  1755 NGDGAPE-------KEGLLANTMNKMYGSEKEDNGVQSQGEKEKDS-TEDAGPTTEVTAP 1806

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 113/257 (44%)
Ion_trans 705..902 CDD:278921 109/200 (55%)
Ion_trans 1768..2019 CDD:278921 148/257 (58%)
Na_channel_gate 2009..2063 CDD:240441 31/53 (58%)
Ion_trans 2085..2320 CDD:278921 124/238 (52%)
GPHH 2331..2386 CDD:293510 28/54 (52%)
Scn4aNP_573462.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 32..63 4/42 (10%)
I. /evidence=ECO:0000305 113..448 146/336 (43%)
Ion_trans 130..451 CDD:395416 142/322 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 484..522 14/124 (11%)
II. /evidence=ECO:0000305 554..826 144/278 (52%)
Ion_trans 571..784 CDD:395416 119/215 (55%)
Na_trans_assoc 810..1020 CDD:399489 69/820 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 854..896 13/204 (6%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 925..983 20/278 (7%)
III. /evidence=ECO:0000305 1007..1320 170/314 (54%)
Ion_trans 1024..1298 CDD:395416 152/273 (56%)
Na_channel_gate 1290..1342 CDD:240441 31/53 (58%)
Important for rapid channel inactivation. /evidence=ECO:0000250|UniProtKB:P15390 1304..1306 0/1 (0%)
IV. /evidence=ECO:0000305 1329..1627 152/297 (51%)
Ion_trans 1347..1603 CDD:395416 133/255 (52%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1776..1841 8/32 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100419
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.720

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