back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NaCP60E and Scn2a

DIOPT Version :9

Sequence 1:	NP_001261172.1	Gene:	NaCP60E / 37981	FlyBaseID:	FBgn0085434	Length:	2896	Species:	Drosophila melanogaster
Sequence 2:	NP_001092768.1	Gene:	Scn2a / 110876	MGIID:	98248	Length:	2006	Species:	Mus musculus

Alignment Length:	2642	Identity:	828/2642 - (31%)
Similarity:	1191/2642 - (45%)	Gaps:	869/2642 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FNDEKAVAKHQVVAYTQRSQVKHENRHIQLVREYGFHPRTKASVEDGDVLPRKFEPFPEHMYGKP 72
            |..|...|..|.:|..:..:.|.|.:...  .|.|  |:..:.:|.|..||..:...|..|..:|
Mouse    17 FTRESLAAIEQRIAEEKAKRPKQERKDED--DENG--PKPNSDLEAGKSLPFIYGDIPPEMVSEP 77

  Fly    73 LEEIDT-FIYEETFCVVSKRFRKNYIHRFTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATI 136
            ||::|. :|.::||.|::|   ...|.||:.|.:|::..|::|.|::.:.|..:..|:..:|.||
Mouse    78 LEDLDPYYINKKTFIVLNK---GKAISRFSATSALYILTPFNPIRKLAIKILVHSLFNVLIMCTI 139

  Fly   137 LFNCIFLAMT---ETVEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYA 198
            |.||:|:.|:   :..:..||.|..||:.|.:|||:|:||.|..:|:||:|||||||.|||..|.
Mouse   140 LTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYV 204

  Fly   199 TIGMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQV 263
            |..:.:||::.||||||||||||:|::||||||:.||:.|.::|::||.||:|||.||||..||:
Mouse   205 TEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQL 269

  Fly   264 YMGELRNKCVRQVP----------------TDWTNVSHT------DWQIWVNDTDNWLYDEDEL- 305
            :||.|||||::..|                .||...:..      :|..::.|..::.:.|.:.
Mouse   270 FMGNLRNKCLQWPPDNSTFEINITSFFNNSLDWNGTAFNRTMNMFNWDEYIEDKSHFYFLEGQND 334

  Fly   306 PVLCGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCGP 370
            .:||||.:.|..||..|:|:..|.|||:|||:||.|.|:.|:.|:|:|.|:|||:|.:.|...|.
Mouse   335 ALLCGNSSDAGQCPEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGK 399

  Fly   371 MSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNEERK------KDLLDH------------ 417
            ..:.||.:|:|.||||||||:|||||::|||:.:.|.||.:      :.:|:.
Mouse   400 TYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAA 464

  Fly   418 -------RDDS------TFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGKE 469
                   ||.|      .||...||  ..||:..::|::              |.||||.|..::
Mouse   465 AAASAESRDFSGAGGIGVFSESSSV--ASKLSSKSEKEL--------------KNRRKKKKQKEQ 513

  Fly   470 GGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATE------------RPSALTMQAQKQYQQMEQQ 522
            .          |::.|..:.        |.||:|            ..|.||.:     ::....
Mouse   514 A----------GEEEKEDAV--------RKSASEDSIRKKGFRFSLEGSRLTYE-----KRFSSP 555

  Fly   523 HKLAKSGSGGSNNPMAPTP------KGRI---------------SFQDSGMGVKNPNMLYPSDYK 566
            |:...|..|...:|...:.      |||:               :|:|:..  :..::..|..:.
Mouse   556 HQSLLSIRGSLFSPRRNSRASLFSFKGRVKDIGSENDFADDEHSTFEDNDS--RRDSLFVPHRHG 618

  Fly   567 GQLIANSGQPSSNSSGV-------NRESSQDDSGVVD----------------------DHEEQD 602
            .:..:|..|.|..|.|:       ...|:.|.:|||.                      :.|.:.
Mouse   619 ERRPSNVSQASRASRGIPTLPMNGKMHSAVDCNGVVSLVGGPSALTSPVGQLLPEGTTTETEIRK 683

  Fly   603 TTNDMGHVSTVELALSP--REVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDRNC---- 661
            ..:...||| ::|...|  |:..:     ::|.|..:.:..|.:.            .:.|
Mouse   684 RRSSSYHVS-MDLLEDPTSRQRAM-----SMASILTNTMEELEES------------RQKCPPCW 730

  Fly   662 ----DRCVHW-CTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALD 721
                :.|:.| |.  :.||:.::.:..||.||..:||||:||||||.|:||||:.|:|.|.:.|.
Mouse   731 YKFANMCLIWDCC--KPWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLS 793

  Fly   722 VGNKVFTSIFTFECIVKLMALSK-DFFLCGWNIFDLLIVTASLLDIIFELVDGLSVLRGLRLLRV 785
            |||.|||.|||.|..:|::|:.. .:|..||||||..||:.||:::....|:||||||..|||||
Mouse   794 VGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVEGLSVLRSFRLLRV 858

  Fly   786 LKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTP--EKFDPD-PVPR 847
            .|||:||.|:.:|:.||.:::||||||||:|.|:::||||:|||||.|.|..  .|...| .:||
Mouse   859 FKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPR 923

  Fly   848 WNFNDFFHSFMMIFRILCGEWIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLFLALLLN 912
            |:.:||||||:::||:|||||||.:||||   |..|.:.|..:|:..:|:||.:||||||||||:
Mouse   924 WHMHDFFHSFLIVFRVLCGEWIETMWDCM---EVAGQTMCLTVFMMVMVIGNLVVLNLFLALLLS 985

  Fly   913 SFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTL 977
            ||:|:.|.:..:: .|.:.|..::.|:        |:..|..:||..|..|:..:..|:|
Mouse   986 SFSSDNLAATDDD-NEMNNLQIAVGRM--------QKGIDFVKRKIREFIQKAFVRKQKA----- 1036

  Fly   978 SHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDL 1042
                            |.|.|                       ||.|
Mouse  1037 ----------------LDEIK-----------------------PLED----------------- 1045

  Fly  1043 PEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVS 1107

Mouse  1046 ----------------------------------------------------------------- 1045

  Fly  1108 TQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFL 1172
                                          .|:::..|        :.::::...|
Mouse  1046 ------------------------------LNNKKDSC--------ISNHTTIEIG--------- 1063

  Fly  1173 KYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNL 1237
                          |.|:.|...:|.:.              ..|.|:....:::.:.:|...|
Mouse  1064 --------------KDLNYLKDGNGTTS--------------GIGSSVEKYVVDESDYMSFINN- 1099

  Fly  1238 REELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQ-- 1300
                                                   ||..:..|   ..|..|:|:|:..
Mouse  1100 ---------------------------------------PSLTVTVP---IAVGESDFENLNTEE 1122

  Fly  1301 -SFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYD 1364
             |.|.::||.|....:                             |.:||.|..|
Mouse  1123 FSSESDMEESKEKLNA-----------------------------TSSSEGSTVD---------- 1148

  Fly  1365 SYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAV 1429
                                                                |.||
Mouse  1149 ----------------------------------------------------IGAP--------- 1152

  Fly  1430 AATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLH 1494
                |...||                             |..|||
Mouse  1153 ----AEGEQP-----------------------------EAEPEE-------------------- 1164

  Fly  1495 GPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPL 1559
                                                          |:|
Mouse  1165 ----------------------------------------------SLE---------------- 1167

  Fly  1560 AALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSS 1624

Mouse  1168 ----------------------------------------------------------------- 1167

  Fly  1625 GAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYN 1689

Mouse  1168 ----------------------------------------------------------------- 1167

  Fly  1690 DPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSC---MDTQSAKHWTRVRTAVLTVVDTP 1751
                            |:.||.:.|...  |:|     |   ::....|.|..:|.....:|:..
Mouse  1168 ----------------PEACFTEDCVRK--FKC-----CQISIEEGKGKLWWNLRKTCYKIVEHN 1209

  Fly  1752 AFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGFSKYFTSF 1816
            .||.|::.:|..||..|.||||.:::.||:|.:|.:.:..|..||::||:|||:|.||..|||:.
Mouse  1210 WFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFQMYFTNA 1274

  Fly  1817 WTILDFIIVFVSVFSLLIEE--NENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIF 1879
            |..|||:||.||:.||....  ...|..::|||||||||||||:||::|||:|||||:.|||||.
Mouse  1275 WCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIM 1339

  Fly  1880 NVLLVCLVFWLIFSIMGVQFFGGKFFKCVN-EMGELLPITEVNDKWDC---IEQNYT--WINSKI 1938
            |||||||:||||||||||..|.|||:.|:| ..||:..::.||:..:|   ||.|.|  |.|.|:
Mouse  1340 NVLLVCLIFWLIFSIMGVNLFAGKFYHCINYTTGEMFDVSVVNNYSECQALIESNQTARWKNVKV 1404

  Fly  1939 TFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLF 2003
            .||:||:|||:|||||||:|||::|..|||:|.|:|||:.|.|||.|:||||||:.|||||||||
Mouse  1405 NFDNVGLGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLF 1469

  Fly  2004 IGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPINHFLAMFYDLSNSR 2068
            |||||||||..|||:.|  .::|:||.||.||.||||||.|||||.|.||.|.|..|.:|....:
Mouse  1470 IGVIIDNFNQQKKKFGG--QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQ 1532

  Fly  2069 RFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRYHYFTVPWNV 2133
            .|:|:|.:||.|||:||.:|..||...:..||...|..|..:|..|.::|::.||::|||:.||:
Mouse  1533 VFDISIMILICLNMVTMMVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRHYYFTIGWNI 1597

  Fly  2134 FDFLLVLASIFGILMEDIMIDLPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALF 2198
            |||::|:.||.|:.:.:::....:||||.||:|:.||||||||||.|||||.|||||::||||||
Mouse  1598 FDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALF 1662

  Fly  2199 NIGALLGLITFIYAILGMSLFGNVKLQGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQ 2263
            |||.||.|:.|||||.|||.|..||.:..:|||.||:|||.||..||::.|||||:.:|..::..
Mouse  1663 NIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNS 1727

  Fly  2264 -PPDCDP---FIHGHTNGNCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIV 2324
             ||||||   .......|:||:|.:.|.:|.|:||||:::|:|||||:|||||:.|.:|....:.
Mouse  1728 GPPDCDPEKDHPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLS 1792

  Fly  2325 EDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISKPNNVALVSFNLPISKGNKIHCLD 2389
            |||.||||..|.|:||.|||||.|.:||||.|:|||||.|:|||.|.|::.:||:..|::|||||
Mouse  1793 EDDFEMFYEVWEKFDPDATQFIEFCKLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLD 1857

  Fly  2390 ILHALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEKAAKTIQTGWKE 2454
            ||.|..|.|||...|.|   .|:.||:.:|....|::...|.:::|...|::|.:|..||..::.
Mouse  1858 ILFAFTKRVLGESGEMD---ALRIQMEERFMASNPSKVSYEPITTTLKRKQEEVSAIVIQRAYRR 1919

  Fly  2455 YLRR----------KREKERSNSG---------DSATQTSSP 2477
            ||.:          |::|.:.:.|         |...:.|:|
Mouse  1920 YLLKQKVKKVSSIYKKDKGKEDEGTPIKEDIITDKLNENSTP 1961

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.