DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NaCP60E and scn4a

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:XP_017944811.2 Gene:scn4a / 100492371 XenbaseID:XB-GENE-982767 Length:1849 Species:Xenopus tropicalis


Alignment Length:2537 Identity:811/2537 - (31%)
Similarity:1138/2537 - (44%) Gaps:815/2537 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 PRTKASVEDGDVLPRKFEPFPEHMYGKPLEEIDTFI-YEETFCVVSKRFRKNYIHRFTGTKSLFL 108
            |..|..:|.|..||..:...|..:.|.|:||:|:|. .::||.|::|   ...|.|||.||:|:|
 Frog    47 PTPKNGLEAGKNLPLIYGDPPPELIGIPIEELDSFYSNQKTFIVLNK---GKAIFRFTATKALYL 108

  Fly   109 FYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLAMTET---VEEAEYIFLAIYSIEMVIKIIA 170
            ..|::|.||..:.:..:..|...:|.|||.||:|:.|::.   .:..||.|..||:.|.:|||:|
 Frog   109 LDPFNPIRRGAIKVLIHSLFSLFIMFTILTNCVFMTMSDPPPWSKNVEYTFTGIYTFESLIKILA 173

  Fly   171 KGFLLNKYTYLRNPWNWLDFVVITSGYATIGMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINAL 235
            :||.::.:|:||:|||||||.||...|.|..:::||::.||||||||||||::::||||||:.||
 Frog   174 RGFCIDSFTFLRDPWNWLDFCVIVMAYTTEFVDLGNVSALRTFRVLRALKTITVIPGLKTIVGAL 238

  Fly   236 LHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVPTD--------------------- 279
            :.|.::||:||.||:|||.||||..||::||.||:||||..|.|                     
 Frog   239 IQSVKKLADVMILTLFCLAVFALIGLQLFMGNLRHKCVRWPPPDDYFMLYDNSTLNSTLYNDTMI 303

  Fly   280 ------WTNV---SHTDWQIWVNDTDNWLY-DEDELPVLCGNLTGARHCPFEYVCLCVGENPNHG 334
                  .|||   ...||..::||..|:.: |.....:||||.:.|..||..|.|:..|.|||:|
 Frog   304 NSTLSNSTNVFDNDTIDWGAYLNDEANFYFLDGANDALLCGNSSDAGKCPESYTCMKTGRNPNYG 368

  Fly   335 YTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSY 399
            ||::|:|.|:.|:.|:|:|.|:|||::.:.|...|...:.||.||:|.||||||||:|||||::|
 Frog   369 YTSYDSFNWAFLSLFRLMTQDFWENLFQLTLRAAGKTYMVFFVVVIFLGSFYLINLILAVVAMAY 433

  Fly   400 EEEAEIT-NEERKKDLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKK 463
            .|:.|.| .||.:|:.         .|...:|.:||..:...::..|...|.|.:..||....:.
 Frog   434 AEQNEATLQEEIEKEK---------EFQELLLQLKKHQEEQARRKSSVASVGLLNAEKKNALSEN 489

  Fly   464 TKGGKEGGTNGNGNGSNGDDNKSHSATPSPGPSPRHSATERPSAL-TMQAQKQYQQMEQQHKLAK 527
            |..| :|..|.:.||..               .|:......||.. |..||...|          
 Frog   490 TLSG-DGTENMDCNGRT---------------VPKVIIERAPSMEDTSSAQSDQQ---------- 528

  Fly   528 SGSGGSNNPMAPTPKGRISFQDSGMGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQDDS 592
                                ::|.:.::.|.:               |..:.|:           
 Frog   529 --------------------RNSKVYLEEPTL---------------QKRAEST----------- 547

  Fly   593 GVVDDHEEQDTTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLP 657
                            |....|:||...|....||.            ....:|::..::.|   
 Frog   548 ----------------HSVLSEVALEELEEAHQKCP------------PWWYKFANTFLIWD--- 581

  Fly   658 DRNCDRCVHWCTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDV 722
                      |.|.  |::|:..:..||.||..:|.||:||||||.|:||||:.|:|.|...|:|
 Frog   582 ----------CCDL--WVKFKEFVRFVVMDPFVDLGITICIVLNTLFMAMEHYPMTEQFEGVLNV 634

  Fly   723 GNKVFTSIFTFECIVKLMALSK-DFFLCGWNIFDLLIVTASLLDIIFELVDGLSVLRGLRLLRVL 786
            ||.|||.||..|...|::||.. .:|..||||||.:|||.||:::....|:||||||..|||||.
 Frog   635 GNLVFTGIFAAEMFFKIIALDPYYYFQVGWNIFDSIIVTLSLVELGLANVEGLSVLRSFRLLRVF 699

  Fly   787 KLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTP--EKFDPD-PVPRW 848
            |||:||.|:.:|:.||.:::||||||||:|.|:::||||:|||||.|.|..  .|...| .:|||
 Frog   700 KLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIASDCELPRW 764

  Fly   849 NFNDFFHSFMMIFRILCGEWIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLFLALLLNS 913
            :.:||||||:::||||||||||.:||||   |..|.:.|..:|:..:|:||.:||||||||||:|
 Frog   765 HMHDFFHSFLIVFRILCGEWIETMWDCM---EVAGQAMCLVVFMMVMVIGNLVVLNLFLALLLSS 826

  Fly   914 FNSEELKSKKEEVGEESKLARSIERVR---DLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQ 975
            |:::.| |..::.||.:.|..:|.|:.   |.::|                              
 Frog   827 FSADNL-SASDDDGEMNNLQIAIGRITRGIDFVKK------------------------------ 860

  Fly   976 TLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTG 1040
                                 |.|..|.|:..                                 
 Frog   861 ---------------------TFFSILHYKRK--------------------------------- 871

  Fly  1041 DLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSG 1105
                                                               .:||:         
 Frog   872 ---------------------------------------------------AKAEQ--------- 876

  Fly  1106 VSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEA 1170
                    .||....|:|.|    |..:|:|                                  
 Frog   877 --------EEEDPNKENIAL----NHVETEP---------------------------------- 895

  Fly  1171 FLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQG 1235
                                                                             
 Frog   896 ----------------------------------------------------------------- 895

  Fly  1236 NLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQ 1300
                              :.:.||:..|                   :||.:             
 Frog   896 ------------------EPKIELEPRT-------------------EPEPK------------- 910

  Fly  1301 SFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDS 1365
                                   .|| |..|..||             :|...||       :|.
 Frog   911 -----------------------KEP-PLIDGVTK-------------KRYYMDE-------FDH 931

  Fly  1366 YDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVA 1430
            .:..:.|.....|..|::                 :.||.|.:                      
 Frog   932 ANFFNNPHMRIEVPIASE-----------------ESDFDIPD---------------------- 957

  Fly  1431 ATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHG 1495
                              .|.|:.|          ..|||.....|...                
 Frog   958 ------------------TDEFSTQ----------SEVEEGILHHKKYD---------------- 978

  Fly  1496 PDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLA 1560
                  |..|:.||..|:                    ||       ||                
 Frog   979 ------DGSSVCSTADYK--------------------PP-------EP---------------- 994

  Fly  1561 ALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSG 1625
              .|.::.|                                ||                      
 Frog   995 --EEEEEAF--------------------------------EH---------------------- 1003

  Fly  1626 AADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYND 1690
                                                                    :..:|    
 Frog  1004 --------------------------------------------------------KEDEG---- 1008

  Fly  1691 PMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEW 1755
                           |::||...|..    |||.....:.|:..|.|..:|.....:|:...||.
 Frog  1009 ---------------PEECFTADCVR----RCPCLYVDITTEKGKIWWNIRKTCFQIVEHNWFET 1054

  Fly  1756 FVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGFSKYFTSFWTIL 1820
            |::.:|..||..|.||||.:::.:.:|.:|.:.:..|..|||.||:|||.|.||..|||:.|..|
 Frog  1055 FIIFMILLSSGALAFEDIYIEQRQVIKTILEYADKVFTYIFVFEMLLKWTAYGFKIYFTNAWCWL 1119

  Fly  1821 DFIIVFVSVFSLLIE--ENENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLL 1883
            ||:||.||:.||...  ....|..::|||||||||||||:||::|||:|||||:.|||||.||||
 Frog  1120 DFLIVDVSLISLTANWLGYSELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLL 1184

  Fly  1884 VCLVFWLIFSIMGVQFFGGKFFKCVN-EMGELLPITEVNDKWDCIEQNYT----WINSKITFDHV 1943
            |||:||||||||||..|.||:::|:| ...||..|..||::.||:..|.:    |:|.|:.||:|
 Frog  1185 VCLIFWLIFSIMGVNLFAGKYYRCINTTTSELFEIDVVNNRSDCLALNNSEQVRWVNVKVNFDNV 1249

  Fly  1944 GMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVII 2008
            |:|||:|||||||:|||::|..|||:|.::.|||.|.|||.|:||||||:.|:||||||||||||
 Frog  1250 GLGYLSLLQVATFKGWMDIMYAAVDSRNIEDQPQYEINLYMYLYFVIFIIFGAFFTLNLFIGVII 1314

  Fly  2009 DNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRFEIA 2073
            ||||..|||:.|  .::|:||.||.||.||||||.|||||.|.||.|....:.||....:.|:|.
 Frog  1315 DNFNQQKKKFGG--KDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPTNKIQGLVYDFVTKQLFDIV 1377

  Fly  2074 IFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRYHYFTVPWNVFDFLL 2138
            |.:||.|||:||.||..||......||...|..|..:|..|.::|:..|||::||:.||:|||::
 Frog  1378 IMILICLNMVTMMIETDDQSQEKTDILFKINLVFIVIFTAECVLKMFALRYYFFTIGWNIFDFVV 1442

  Fly  2139 VLASIFGILMEDIMIDLPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGAL 2203
            |:.||.||::.|::.:..:||||.||:|:.||||:||||:.|||||.|||||::|||||||||.|
 Frog  1443 VILSIVGIVLSDLIAEYFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLL 1507

  Fly  2204 LGLITFIYAILGMSLFGNVKLQGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQ-PPDC 2267
            |.|:.|||:|.|||.|..||.:..:||:.||:|||.|:..||::.|||||:.:|..::.. ||||
 Frog  1508 LFLVMFIYSIFGMSNFAYVKKESGIDDIFNFETFGNSIICLFQITTSAGWDGLLNPILNSGPPDC 1572

  Fly  2268 DPFIH--GHT-NGNCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLE 2329
            ||.:.  |.| .|:||:|.:.|.:|.|:||||::||:||||||||||||.|.:|....:.|||.|
 Frog  1573 DPHLENFGTTVTGDCGNPAIGIVFFCSYIIISFLIVVNMYIAIILENFNVATEESGEPLCEDDFE 1637

  Fly  2330 MFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISKPNNVALVSFNLPISKGNKIHCLDILHAL 2394
            |||..|.|:||.||||:.:|::|||:.:|..||.|.|||.:.|::.:||:..|:||||||||.||
 Frog  1638 MFYETWEKFDPDATQFVEYSRMSDFVDTLQDPLRIPKPNKIKLITLDLPMVTGDKIHCLDILFAL 1702

  Fly  2395 VKHVLGHVEETDNFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEKAAKTIQTGWKEYLRRK 2459
            .|.|||...|.|   .|:..|:.||....|::...|.:::|...|::|.....||..::.:|.|:
 Frog  1703 TKEVLGDSGEMD---ALKASMEEKFMMANPSKVSYEPITTTLKRKQEEVCVIKIQRAFRRHLLRR 1764

  Fly  2460 REKERS----NSGDSATQTSSP----GGWQSKLSALNFFHLQVSRRGTACSSRASSRKSSRASDA 2516
            ..|..|    .|.|..:....|    |....:::|....:::..:.|.....|:::|.|..:.|.
 Frog  1765 SVKHASYIFRQSNDEESSVEEPPEKEGLIAERINAAYGKYVEEGQNGGTHRPRSTNRTSHSSIDY 1829

  Fly  2517 SD 2518
            .|
 Frog  1830 DD 1831

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 112/249 (45%)
Ion_trans 705..902 CDD:278921 106/200 (53%)
Ion_trans 1768..2019 CDD:278921 150/257 (58%)
Na_channel_gate 2009..2063 CDD:240441 30/53 (57%)
Ion_trans 2085..2320 CDD:278921 126/238 (53%)
GPHH 2331..2386 CDD:293510 26/54 (48%)
scn4aXP_017944811.2 Ion_trans 125..440 CDD:395416 142/314 (45%)
Ion_trans 599..812 CDD:395416 116/215 (54%)
Na_trans_assoc 838..1045 CDD:399489 74/822 (9%)
Ion_trans 1049..1323 CDD:395416 154/273 (56%)
Na_channel_gate 1315..1367 CDD:240441 30/53 (57%)
Ion_trans 1372..1628 CDD:395416 135/255 (53%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.010

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