DRSC/TRiP Functional Genomics Resources

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Protein Alignment NaCP60E and scn1a

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:XP_012826731.2 Gene:scn1a / 100488621 XenbaseID:XB-GENE-978019 Length:2020 Species:Xenopus tropicalis


Alignment Length:2677 Identity:849/2677 - (31%)
Similarity:1204/2677 - (44%) Gaps:842/2677 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 FNDEKAVAKHQVVAYTQRSQVKHENRHIQLVREYGFHPRTKASVEDGDVLPRKFEPFPEHMYGKP 72
            |:.|...|..:.:|..:..:.|.|:|...  .:.|  |:..:.:|.|..||..:...|..|..:|
 Frog    17 FSRESLEAIEKRIAEEKAKKPKQEHRDDD--DDNG--PKPSSDLEAGKSLPFIYGDIPPGMVSEP 77

  Fly    73 LEEIDT-FIYEETFCVVSKRFRKNYIHRFTGTKSLFLFYPWSPARRVCVYIATNQFFDYCVMATI 136
            ||::|. ::.::||.|::   |...|.||:.|.:|::..|::|.|:|.:.:..:..|...:|.||
 Frog    78 LEDLDPYYMNQKTFIVLN---RGKAIFRFSATSALYILTPFNPLRKVAIKVLVHSLFSMLIMCTI 139

  Fly   137 LFNCIFLAMT---ETVEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYA 198
            |.||:|:.|:   |..:..||.|..||:.|.:|||:|:||.|.|:|:||:|||||||.||...|.
 Frog   140 LTNCVFMTMSNPPEWTKNVEYTFTGIYTFESLIKILARGFCLEKFTFLRDPWNWLDFSVIVMAYV 204

  Fly   199 TIGMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQV 263
            |..:.:||::.||||||||||||:|::||||||:.||:.|.::|::||.||:|||.||||..||:
 Frog   205 TEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQL 269

  Fly   264 YMGELRNKCVRQVPTDW----------------------TNVSHTDWQIWVNDTDNWLYDEDELP 306
            :||.|||||::..|.|:                      |..|..||:.::.|.:::...|.:..
 Frog   270 FMGHLRNKCLQWPPIDYFPLINIPPILNGTMNIHDPFGNTTNSTFDWEEYITDKNHFYKLEGQKD 334

  Fly   307 -VLCGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCGP 370
             :||||.:.:..||..|:|:..|:|||:|||:||.|.|:.|:.|:|:|.|||||:|.:.|...|.
 Frog   335 FLLCGNSSDSGQCPKGYICVKTGKNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGK 399

  Fly   371 MSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNEERKKDLLDHRDDSTFSFDPSVLNVKK- 434
            ..:.||.:|:|.|||||:||:|||||::|||:.:.|.||        .:.....|...:..:|| 
 Frog   400 TYMIFFVLVIFLGSFYLVNLILAVVAMAYEEQNQATLEE--------AEQKEAEFQQMLEQLKKQ 456

  Fly   435 -----------LNKNNKKKIDSRKGVL---------LASYSKKKTR-RKKTKGGKEGGTNGNGNG 478
                       ||.:.:...|...|.|         |:|.|.|..| |||.:..||.|.    ..
 Frog   457 QEEAQAAAVAALNMSREYSEDGGFGPLSESSSEASKLSSKSAKDRRNRKKKRKQKELGE----EY 517

  Fly   479 SNGDDN---KSHSAT----------------------PSPGP----------SPRHSA-----TE 503
            ..|||.   ||.|.|                      .||..          |||.::     :.
 Frog   518 EKGDDEKFPKSESETSIKRKGFRFSIEGNRLTYENKFSSPHQSLLSIRGSLFSPRRNSRASLFSF 582

  Fly   504 RPSALTMQAQKQYQQMEQQHKLAKSGSGGSNNPMAPTPKG--------RISFQDSGMGV--KNPN 558
            |..|..:.::..:  .:.:|...:.......:...|...|        ::|.....|.|  .|..
 Frog   583 RNRAKDVGSENDF--ADDEHSTFEDNESRRGSLFVPNRHGERRNSNISQVSKSSKTMTVLPANGK 645

  Fly   559 MLYPSDYKGQLIANSGQPSSNSSGVN--------RESSQDDSGVVDDHEEQDTTNDMGHVSTVEL 615
            |....|..| :::..|.||..:|.|.        .:.:.||:|...:.|.:...:....| .::|
 Frog   646 MHSTVDCNG-VVSLLGGPSVPTSPVGLLLPEVIVDKPASDDNGTTTETEIRKRKSSCYQV-PMDL 708

  Fly   616 ALSP--REVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDRNCDRCVH--------W-CT 669
            ...|  |:..|     ::|.|..:.|..|.:.            .:.|..|.:        | |.
 Frog   709 LEDPTARQRAL-----SVASILTNTVEELEES------------RQKCPPCWYKFANTFLIWDCC 756

  Fly   670 DYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIFTFE 734
              |:||..::.:..:|.||..:||||:||||||.|:||||:.|::.|.:.|.:||.|||.|||.|
 Frog   757 --ENWLTVKHIVKLIVMDPFVDLAITICIVLNTLFMAMEHYPMTKEFNDVLSIGNLVFTGIFTAE 819

  Fly   735 CIVKLMALSK-DFFLCGWNIFDLLIVTASLLDIIFELVDGLSVLRGLRLLRVLKLAQSWTTMKVL 798
            .:.||:||.. .:|..||||||.:||:.||:::....|:||||||..|||||.|||:||.|:.:|
 Frog   820 MVFKLIALDPYYYFQEGWNIFDGIIVSLSLMELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNML 884

  Fly   799 LSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDY------TPEKFDPDPVPRWNFNDFFHSF 857
            :.||.:::||||||||:|.|:::||||:|||||.|.|      ..|..:   :|||:.|||||||
 Frog   885 IKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIAENCE---LPRWHMNDFFHSF 946

  Fly   858 MMIFRILCGEWIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLFLALLLNSFNSEELKSK 922
            :::||:|||||||.:||||   |..|.|.|..:|:..:|:||.:||||||||||:||:|:     
 Frog   947 LIVFRVLCGEWIETMWDCM---EVAGQSMCLLVFMLVMVIGNLVVLNLFLALLLSSFSSD----- 1003

  Fly   923 KEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLER 987
                                                                             
 Frog  1004 ----------------------------------------------------------------- 1003

  Fly   988 GDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHP 1052
                                                                             
 Frog  1004 ----------------------------------------------------------------- 1003

  Fly  1053 LPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEA 1117
                                              |||                            
 Frog  1004 ----------------------------------NLT---------------------------- 1006

  Fly  1118 TYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRS 1182
                         :||.|...|:.:...|...||......:.|    |...:||:|.||.|    
 Frog  1007 -------------ATDDDNEMNNLQIAVGRIQRGIDYVKKTIR----ECIQKAFVKKQKGL---- 1050

  Fly  1183 PSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDEL--LSQQGNLREELLNCD 1245
                                                         ||:  |.:..|.||..|   
 Frog  1051 ---------------------------------------------DEIKPLEELHNKRESCL--- 1067

  Fly  1246 QKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIK 1310
                  |.....|:.|                           ::::.:.||             
 Frog  1068 ------FNHNAVEINK---------------------------VLDYHKGDN------------- 1086

  Fly  1311 RSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRS 1375
             .|||                              |..  |:.::.::..|.|.|          
 Frog  1087 -GTTS------------------------------GVG--SSVEKYIIDENDYMS---------- 1108

  Fly  1376 QSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPN 1440
                                                                             
 Frog  1109 ----------------------------------------------------------------- 1108

  Fly  1441 QSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLS 1505
                                                               |:|.|         
 Frog  1109 ---------------------------------------------------FIHNP--------- 1113

  Fly  1506 LKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFH 1570
                                                          ||..|.|:|          
 Frog  1114 ----------------------------------------------SLTVTVPIA---------- 1122

  Fly  1571 ATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALAL 1635
                                    .|:              :.|::..||..||.:....|...|
 Frog  1123 ------------------------VGE--------------SDFENLNTEDFSSESDLEESKEKL 1149

  Fly  1636 AMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGAT 1700
            .|...:|.|.                           ||....|.....:|   :|:...|    
 Frog  1150 NMTSSSEGST---------------------------VDIRPPGVVAEGEG---EPIDIES---- 1180

  Fly  1701 KAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASS 1765
            :.|..||.||.:.|...|    |.....::....|.|...|....|:|:...||.|::.:|..||
 Frog  1181 EEALEPDACFTEGCVKRF----PICYVNIEENKGKLWWTFRKTCYTIVEHNWFETFIIFMILLSS 1241

  Fly  1766 ITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGFSKYFTSFWTILDFIIVFVSVF 1830
            ..|.||||.:::.||:|.:|.:.:..|..||::||:|||:|.||.||||:.|..|||:||.||:.
 Frog  1242 GALAFEDIYIEQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGFVKYFTNAWCWLDFLIVDVSLV 1306

  Fly  1831 SLLIEE--NENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFS 1893
            ||:...  ...|..::|||||||||||||:||::|||:|||||:.|||||.|||||||:||||||
 Frog  1307 SLVANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFS 1371

  Fly  1894 IMGVQFFGGKFFKCVN-EMGELLPITEVNDKWDCIEQNYT--WINSKITFDHVGMGYLALLQVAT 1955
            ||||..|.||::.||| ..||:|..|:||::.||:..|.:  |.|.|:.||:||.||||||||||
 Frog  1372 IMGVNLFAGKYYHCVNTTTGEMLLDTQVNNRSDCLHLNESARWKNVKVNFDNVGAGYLALLQVAT 1436

  Fly  1956 FEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEG 2020
            |:|||::|..|||:|.|:.||:.|.|||.|:||||||:.||||||||||||||||||..|||:.|
 Frog  1437 FKGWMDIMYAAVDSRKVEEQPRYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGG 1501

  Fly  2021 GVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTM 2085
              .::|:||.||.||.||||||.|||||.|.||.|.:..:.:|....:.|:|.|.:||.|||:||
 Frog  1502 --QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPPNKYQGLVFDFVTKQAFDIIIMILICLNMVTM 1564

  Fly  2086 GIEHYDQPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRYHYFTVPWNVFDFLLVLASIFGILMED 2150
            .||..:|...:...|...|..|..:|..|.|:||:.||::|||:.||:|||::|:.||.|:.:.|
 Frog  1565 MIETDEQSQDMENNLYWINLVFIILFTGECILKIISLRHYYFTIGWNIFDFVVVILSIVGMFLAD 1629

  Fly  2151 IMIDLPISPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILG 2215
            ::....:||||.||:|:.||||||||||.|||||.|||||::|||||||||.||.|:.|||||.|
 Frog  1630 MIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFG 1694

  Fly  2216 MSLFGNVKLQGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQ-PPDCDPFIH---GHTN 2276
            ||.|..||.:..:|||.||:|||.||..||::.|||||:.:|..::.. .|||||.:.   ....
 Frog  1695 MSNFAYVKKESGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGAPDCDPQMEHPGSSVK 1759

  Fly  2277 GNCGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPH 2341
            |:||:|.:.|.:|.|:||||:::|:|||||:|||||:.|.:|....:.|||.||||..|.|:||.
 Frog  1760 GDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLGEDDFEMFYEVWEKFDPD 1824

  Fly  2342 ATQFIHFSQLSDFIASLDPPLGISKPNNVALVSFNLPISKGNKIHCLDILHALVKHVLGHVEETD 2406
            |||||.:|:||:|..:|||||.|:|||.|.|::.:||:..|::|||||||.|..|.|||..:|.|
 Frog  1825 ATQFIEYSKLSNFADALDPPLRIAKPNRVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGEGDEMD 1889

  Fly  2407 NFKQLQEQMDVKFKKQFPTRKELEIVSSTRIWKRQEKAAKTIQTGWKEYLRR----------KRE 2461
               .|:..|:.:|....|::...|.::||...|::|.:...||..:::||.|          |:|
 Frog  1890 ---ALRLPMEERFMASNPSKASYEPITSTLRRKQEELSVVIIQRCFRKYLLRKTIKKASYLYKKE 1951

  Fly  2462 KERSNS-------------GDSATQ-------TSSPGGWQSKLSALNFFHLQVSRRGTACSSRAS 2506
            |...||             |:|.|:       |:||..:.|           |::.......:..
 Frog  1952 KLGVNSLPIKEDMVIDKLNGNSTTEKTDMTPSTTSPPSYDS-----------VTKPEKEKHEKDK 2005

  Fly  2507 SRKSSRASDASD 2518
            :.|.:::.||.:
 Frog  2006 AEKENKSKDARE 2017

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 112/241 (46%)
Ion_trans 705..902 CDD:278921 105/203 (52%)
Ion_trans 1768..2019 CDD:278921 156/255 (61%)
Na_channel_gate 2009..2063 CDD:240441 30/53 (57%)
Ion_trans 2085..2320 CDD:278921 124/238 (52%)
GPHH 2331..2386 CDD:293510 29/54 (54%)
scn1aXP_012826731.2 Ion_trans 128..435 CDD:395416 141/306 (46%)
Na_trans_cytopl 515..723 CDD:403218 38/220 (17%)
Ion_trans 772..985 CDD:395416 116/218 (53%)
Na_trans_assoc 1011..1222 CDD:399489 69/612 (11%)
Ion_trans 1226..1498 CDD:395416 160/271 (59%)
Na_channel_gate 1490..1542 CDD:240441 30/53 (57%)
Ion_trans 1547..1802 CDD:395416 132/254 (52%)
GPHH 1814..1861 CDD:407139 26/46 (57%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

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