DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NaCP60E and scn5a

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:XP_031760488.1 Gene:scn5a / 100485924 XenbaseID:XB-GENE-6037407 Length:1989 Species:Xenopus tropicalis


Alignment Length:2605 Identity:832/2605 - (31%)
Similarity:1171/2605 - (44%) Gaps:827/2605 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 DDQATFNDEKAVAKHQVVAYTQRSQVKHENRHIQLVREYGFHPRTKASVEDGDVLPRKFEPFPEH 67
            |....|..|...|..:.:|..|....|.|||..:  ...|..||....:|.|..|||.:..||:|
 Frog    11 DSFRRFTPESLAAIEKRIAEEQARSAKQENRAEE--NNEGGKPRPHPDLEAGKQLPRIYGDFPKH 73

  Fly    68 MYGKPLEEIDTFI-YEETFCVVSKRFRKNYIHRFTGTKSLFLFYPWSPARRVCVYIATNQFFDYC 131
            :.|:|||:||.|. .::||.|::|   ...|.||:.|.:|::..|:.|.||..:.|..:..|...
 Frog    74 LIGQPLEDIDPFYRNKKTFIVLNK---GKTIFRFSATPALYIISPFHPIRRASIKILVHSLFSMF 135

  Fly   132 VMATILFNCIFLAMTET---VEEAEYIFLAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVI 193
            :|.|||.||:|:||:::   ::..||.|..||:.|.:|||:|:||.|..:|:||:|||||||.||
 Frog   136 IMCTILTNCVFMAMSDSSAWLKYVEYTFTGIYTFESMIKILARGFCLKPFTFLRDPWNWLDFSVI 200

  Fly   194 TSGYATIGMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFAL 258
            ...|||..:::||::.||||||||||||:|::||||||:.||:.|.|:||:||.||:|||.||||
 Frog   201 VMAYATEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVRKLADVMILTVFCLSVFAL 265

  Fly   259 FALQVYMGELRNKCVRQVP---------TDWTNVS-HTDWQIWVNDTDNWLYDED--ELPVLCGN 311
            ..||::||.|:.||||.:.         .||:|.| .:.::.:::|..| :|.:|  :..:||||
 Frog   266 TGLQLFMGHLKQKCVRDLDYFNATRMGMLDWSNESMWSSYEAFISDPAN-IYHKDGAKDALLCGN 329

  Fly   312 LTGARHCPFEYVCLCVGENPNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCGPMSVSFF 376
            .:.|..||..::|:..|.|||:|||:||.|.|:.|:.|:|:|.|||||:|...|...|...:.||
 Frog   330 SSDAGKCPDGFICMKTGRNPNYGYTSFDTFGWAFLSLFRLMTQDYWENLYQQTLRAAGKTYMIFF 394

  Fly   377 TVVVFFGSFYLINLMLAVVALSYEE--EAEITNEERKKDLLDHRDDSTFSFDPSVLNVKKLNKNN 439
            ..|:|.|||||:||:|||||::|||  :|.|...|.|:.          .|..::..:||     
 Frog   395 VFVIFLGSFYLVNLILAVVAMAYEEQNQATIAEAEAKER----------EFQQAMEQLKK----- 444

  Fly   440 KKKIDSRKGVLLASYS-------------KKKTRRKKTKGGKEGGTNGNGNGSNGDDNKSHSATP 491
            :::..:.||...||:|             :::.||||.|..:        ....|:|.|      
 Frog   445 EQEALASKGPDAASHSSCEMSPFSSKSAKERRNRRKKKKSSE--------TEEYGEDMK------ 495

  Fly   492 SPGPSPRHSATERPSALTMQAQKQYQQMEQQHKLAKSGSG---GSNNPMAPTPKGRISFQDS--G 551
                .||....|                |...|::..|.|   ||.       |.||| |.|  .
 Frog   496 ----PPRGEMDE----------------ESLRKMSILGIGFGPGSG-------KRRIS-QGSIFN 532

  Fly   552 MGVKNPNMLYPSDYKGQLIANSGQPSSNSSGVNRESSQDDSGVVDDHEEQDTTNDMGHVSTVELA 616
            ...:|.::...:::....::|:......|..|.|...:..:        |..|:.:...:|....
 Frog   533 FRFRNRDLCSETEFADDEVSNASDGHRGSLLVPRAGRRQST--------QSQTSPLSFANTPGYT 589

  Fly   617 LSPREVRLIKCNGNIARIKNHNVYA---------------------------------------- 641
            .:.:....:.|||.::.:.....|:                                        
 Frog   590 QNGKRNSSVDCNGVVSLVGGAGTYSNPTSPGGLLLPAVIVEKSGAEENASPTDLELSRMQLLMPH 654

  Fly   642 ------LHQEFSSEVVV---------IDDLPD--RNCDRC-VHWCTDY------ESWLQFQNCLY 682
                  :.|.|..:..|         :::|.:  :.|..| .|:...|      ..||..::.:.
 Frog   655 ALSVEYVDQPFQRQRAVSTVSVLTNALEELEESRQKCPPCWNHFAQSYLIWDCCSLWLDIKDGVK 719

  Fly   683 KVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFTSIFTFECIVKLMALSK-DF 746
            .||.||..:|.||:||||||.|:|:||:.|:..|...|.|||.|||.|||.|.:.|::||.. .:
 Frog   720 FVVMDPFIDLTITICIVLNTLFMALEHYKMTPEFEYMLSVGNYVFTGIFTAEMVFKIIALDPYYY 784

  Fly   747 FLCGWNIFDLLIVTASLLDIIFELVDGLSVLRGLRLLRVLKLAQSWTTMKVLLSIIISTIGALGN 811
            |..||||||.:||..||:::....:..|||||..|||||.|||:||.|:..|:.||.:::|||||
 Frog   785 FQQGWNIFDSIIVCLSLMELCLASMGNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGN 849

  Fly   812 LTLILVIVIYIFAVIGMQLFSKDYTPEKFD-------PDPVPRWNFNDFFHSFMMIFRILCGEWI 869
            |||:|.|:::||||:|:|||.::|    |:       ...:|||:.:||||||:::||:||||||
 Frog   850 LTLVLAIIVFIFAVVGVQLFGRNY----FECVCKISAECKLPRWHMHDFFHSFLIVFRVLCGEWI 910

  Fly   870 EPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLFLALLLNSFNSEELKSKKEEVGEESKLAR 934
            |.:||||   |..|...|..:|:..:|:||.:||||||||||:||:::.| |..:|.||.:.|..
 Frog   911 ETMWDCM---EVAGQPLCILVFMLVMVIGNLVVLNLFLALLLSSFSADNL-SAPDEDGEMNNLQI 971

  Fly   935 SIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKF 999
            :|.|::..||..::...|    .|...|                       .|.|||   |:...
 Frog   972 AIARIQRGIRFVKKAIVD----FFCNLF-----------------------TRPDKP---AQAFK 1006

  Fly  1000 HRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTY 1064
            ..||   :.|:.::                               .|.|..|             
 Frog  1007 SNLS---TKNQNIN-------------------------------NINLNNH------------- 1024

  Fly  1065 ESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISSGVSTQQYDSREEATYTESIELLGQ- 1128
                          :|.:.||:.                        |.||..:....|...|: 
 Frog  1025 --------------INMSNTCKE------------------------DFREGNSTNGGISKNGEK 1051

  Fly  1129 YNSTDTDPYANDQR-SGCGSFNRGDSLQDNSSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRL 1192
            |..:::|.|....| |.|.....|:|         ..|.|:|                       
 Frog  1052 YVVSESDDYMTSPRLSVCVPIALGES---------DVEYHEE----------------------- 1084

  Fly  1193 SQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQGNLREELLNCDQKELFQFLQEEE 1257
                                                                |::.:|       
 Frog  1085 ----------------------------------------------------DEQSIF------- 1090

  Fly  1258 ELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSN 1322
                                          |.||.|:        ||:.:.|             
 Frog  1091 ------------------------------TDVEISK--------EKQDDSI------------- 1104

  Fly  1323 LSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSV 1387
                                     ||.|..|                                 
 Frog  1105 -------------------------SECSTVD--------------------------------- 1111

  Fly  1388 KLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPF 1452
                  |.|.|                                                      
 Frog  1112 ------LRKSR------------------------------------------------------ 1116

  Fly  1453 TVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLI 1517
                         |.:|::||                                            
 Frog  1117 -------------ELIEQLPE-------------------------------------------- 1124

  Fly  1518 QKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAH 1582
                                             ||.:...|....||                  
 Frog  1125 ---------------------------------SSEEFADPEECFTE------------------ 1138

  Fly  1583 THAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSSGAADASSALALAMAQKTEQSQST 1647
                                                         ||:                 
 Frog  1139 ---------------------------------------------DAN----------------- 1141

  Fly  1648 APDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQ 1712
            .||.|                                                            
 Frog  1142 RPDGT------------------------------------------------------------ 1146

  Fly  1713 KCYDHFYFRCPWFMSC----MDTQSAKHWTRVRTAVLTVVDTPAFEWFVLVLIFASSITLCFEDI 1773
                    .|..:.||    :.|.:.|.|.::|.....:|:...||.|::.:|..||..|.||||
 Frog  1147 --------GCLRYCSCCRIDITTGAGKIWWKLRKTCFKIVEHNWFETFIIFMILLSSGALAFEDI 1203

  Fly  1774 NLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGFSKYFTSFWTILDFIIVFVSVFSLLIE--E 1836
            .:|:.|.:|.:|.:.:..|..:||:||:|||:|.||.||||:.|..|||.||.:||..|::.  .
 Frog  1204 YIDQKKVVKTILEYADKVFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFFIVDISVACLMVTTFS 1268

  Fly  1837 NENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFG 1901
            ..|:..::|||||||||||||:||::|||:|||||:.|||||.|||||||:||||||||||..|.
 Frog  1269 KGNVGSVKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFA 1333

  Fly  1902 GKFFKCVN-EMGELLPITEVNDKWDC---IEQNYTWINSKITFDHVGMGYLALLQVATFEGWMEV 1962
            |||.|||| ...|.|....|::|..|   |.....|..:|:.||:||.|||||||||||:|||::
 Frog  1334 GKFGKCVNATTKEELSYLTVDNKSMCNDFINTEAYWTKTKVNFDNVGAGYLALLQVATFKGWMDI 1398

  Fly  1963 MADAVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFL 2027
            |..|||:|.::.||..|.|.|.|:||||||:.||||||||||||||||||..|||..|  .::|:
 Frog  1399 MYAAVDSREIEQQPIYEINKYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGG--QDIFM 1461

  Fly  2028 TESQKHYYTAMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQ 2092
            ||.||.||.||||||.|||||.|.||:|.|....:|:...:.|:|.|.:||.|||:||.:|..||
 Frog  1462 TEEQKKYYNAMKKLGSKKPQKPIPRPLNKFQGFVFDIVTKQAFDIIIMILICLNMVTMMVETDDQ 1526

  Fly  2093 PHAVFFILEVSNAFFTTVFGLEAIVKIVGLRYHYFTVPWNVFDFLLVLASIFGILMEDIMIDLPI 2157
            ...:..:|...|..|..:|..|.|:||:.|||::||:.||:|||::|:.||.||::.||:....:
 Frog  1527 SKEIENLLYKINLAFVVLFSGECILKILALRYYFFTIGWNIFDFVVVILSIVGIVLSDIIEKYFV 1591

  Fly  2158 SPTLLRVVRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNV 2222
            ||||.||:|:.||||:||||:.|||||.|||||::|||||||||.||.|:.|||||.|||.|..|
 Frog  1592 SPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYV 1656

  Fly  2223 KLQGALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQ-PPDCDPFI---HGHTNGNCGHPL 2283
            |::..:|||.||||||.||..||::.|||||:.:|..::.. ||||||.|   ...|.||||:|.
 Frog  1657 KMESGIDDMFNFQTFGNSMICLFQITTSAGWDGLLNPILNSGPPDCDPDIANPGSPTLGNCGNPS 1721

  Fly  2284 LAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHF 2348
            :.|.:|.|:||||::||:|||||||||||:.|.:|....:.|||.||||..|.|:||.|||||.:
 Frog  1722 VGICFFVSYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFEMFYEVWEKFDPEATQFISY 1786

  Fly  2349 SQLSDFIASLDPPLGISKPNNVALVSFNLPISKGNKIHCLDILHALVKHVLGHVEETDNFKQLQE 2413
            |.||:|..:|..||.|:|||.:.|::.:||:..|::|||||||.|..|.|||...|.|   .|:.
 Frog  1787 SVLSNFADTLSEPLRIAKPNKIKLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMD---ALKV 1848

  Fly  2414 QMDVKFKKQFPTRKELEIVSSTRIWKRQEKAAKTIQTGWKEYLRRKREKERS------NSGDSAT 2472
            ||:.||....|::...|.:::|...|::|.:|..||..::.:|..:..|:.|      :..|:..
 Frog  1849 QMEEKFMAANPSKISYEPITTTLKRKQEEVSACVIQRAYRRHLLCRSMKQASFLYRHRSCDDNII 1913

  Fly  2473 QTSSP 2477
            :..:|
 Frog  1914 EEEAP 1918

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 114/230 (50%)
Ion_trans 705..902 CDD:278921 98/204 (48%)
Ion_trans 1768..2019 CDD:278921 151/256 (59%)
Na_channel_gate 2009..2063 CDD:240441 31/53 (58%)
Ion_trans 2085..2320 CDD:278921 131/238 (55%)
GPHH 2331..2386 CDD:293510 26/54 (48%)
scn5aXP_031760488.1 Ion_trans 129..424 CDD:395416 143/295 (48%)
Na_trans_cytopl 485..675 CDD:403218 33/239 (14%)
Ion_trans 724..937 CDD:395416 108/219 (49%)
Na_trans_assoc 963..1176 CDD:399489 77/825 (9%)
Ion_trans 1180..1453 CDD:395416 155/272 (57%)
Na_channel_gate 1445..1497 CDD:240441 31/53 (58%)
Ion_trans 1502..1757 CDD:395416 139/254 (55%)
GPHH 1769..1816 CDD:407139 23/46 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D37221at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR10037
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
33.110

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