DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NaCP60E and cacna1hb

DIOPT Version :9

Sequence 1:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster
Sequence 2:XP_021331616.1 Gene:cacna1hb / 100007317 ZFINID:ZDB-GENE-090312-128 Length:2102 Species:Danio rerio


Alignment Length:2975 Identity:645/2975 - (21%)
Similarity:1038/2975 - (34%) Gaps:1106/2975 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly   133 MATILFNCIFLAMTETVEEAE--------------YIFLAIYSIEMVIKIIAKGFLLNKYTYLRN 183
            |..||.||:.|.|.:..::.|              :|| |.:::|||:|::|.| :.....||.:
Zfish     1 MLVILLNCVTLGMFQPCQDLECHTDRCSILQAFDDFIF-AFFAVEMVVKMVALG-VFGPKCYLGD 63

  Fly   184 PWNWLDFVVITSG---YATIGMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEV 245
            .||.||..::.:|   |:..|..| :.:.:||.||||.|:.::.:|.::.::..||.:...|..|
Zfish    64 TWNRLDLFIVMAGMLEYSLDGHNV-SFSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNV 127

  Fly   246 MTLTIFCLMVFALFALQVYMGELRNKC-----VRQVPTDWTNVSHTDWQIW-VNDTDNWLYDEDE 304
            :.|..|...:|.:..:|::.|.|||:|     :|.:    .|||.:..:.: |::|       |:
Zfish   128 LLLCFFVFFIFGIVGVQLWAGLLRNRCFFDNNIRML----YNVSGSVSEYYRVDET-------DD 181

  Fly   305 LPVLCG----------------NLTGA--------------RHCP---------FEYVCLCVGEN 330
            :|.:|.                .:.||              :..|         :...|.....|
Zfish   182 IPFICSTNRENGMLRCSNVPKRRVAGADCELTADNVTELVFKEAPHHGCVNWNLYYNTCNASEHN 246

  Fly   331 PNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVV 395
            |::|..||||..::.:..||:|||:.|.::...|:......:..:|..::..|||::|||.|.|:
Zfish   247 PHNGAINFDNIGYAWIAIFQVITLEGWADIMYYVMDAHSFYNFIYFIFLIIVGSFFMINLCLVVI 311

  Fly   396 ALSYEE----EAEITNEERKKDLLDHRDDSTFS--FDPSVLNVKKLNKNNKKKIDSRKGVLLASY 454
            |..:.|    |.::..|:|.:   ...::||.:  .:|.....:.|.             .||..
Zfish   312 ATQFSETKQRENQLMQEQRAR---FRSNESTLASLAEPGSCYEEMLK-------------YLAHV 360

  Fly   455 SKKKTRR----------KKTKGGKEGGTNGNGNGSNG--DDNKSHSATPSPGPSP---RHSATER 504
            .:|..|.          |:.||....||:.:..|:||  .||.:     ..||:.   .|.....
Zfish   361 CRKLWRHVVRIYGDLCPKRRKGVANPGTSLSVGGTNGYWSDNGT-----KMGPTQYCMLHYHHPH 420

  Fly   505 PSALTMQAQKQYQQMEQQHKLAKSGSG-------------GSNNP-MAPTPKGRISFQDSGMGVK 555
            ...::...:.:..|:::...:||....             |.|.| :.|:   ::.......|||
Zfish   421 QHYISNGIEMKTLQLDRDAHIAKKTPSLPLALQNLKGLRLGMNYPTILPS---KMYTNSHARGVK 482

  Fly   556 NPNML-------------YPSDYKGQ------------LIANSGQPSSNSS----------GVNR 585
            .|...             |...||.|            :.:..|..||.||          |||.
Zfish   483 APAFHHGIYGRKISVCGGYHDTYKLQHGVYPGTCSSVCVDSRVGLVSSQSSSCPICAQEGDGVNC 547

  Fly   586 ESSQDDSGVVDDHEEQDTTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEV 650
            :|:.:     .|.|:|..  |:|                       :..:..|:.|  :|..|| 
Zfish   548 DSNGE-----SDPEKQGP--DVG-----------------------SEQRKTNLDA--EEKVSE- 579

  Fly   651 VVIDDLPDRNC-DRCVHWCTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSE 714
                   .||| ..|||:.         :..|.::|....|...|.:.|::||..:.:|:|...:
Zfish   580 -------KRNCVCMCVHYA---------RAVLKRIVDSKYFNRGIMIAILINTLSMGVEYHEQPD 628

  Fly   715 SFRNALDVGNKVFTSIFTFECIVKLMALSK-DFFLCGWNIFDLLIVTASLLDIIFELVDGLSVLR 778
            ...:.|::.|.||||:|..|.::||.|... |:....:||||.:||..|:.:|:.:...|.||||
Zfish   629 ELTDVLEISNIVFTSLFVLEMLLKLSACGLFDYISNPYNIFDGIIVIISVCEIVGQADGGFSVLR 693

  Fly   779 GLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTPEKFDPD 843
            ..||||||||.:....::..|.:::.|:..:....::|::.|:||:::||.||...:|....:.|
Zfish   694 TFRLLRVLKLVRFLPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFTLRLENGD 758

  Fly   844 PV-PRWNFNDFFHSFMMIFRILCGE-WIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLF 906
            .| .|.||:....:.:.:|:||..| |...|::.|.:.....|    ..|:..:..||:::.||.
Zfish   759 TVSDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPYAA----LYFVALMTFGNYVLFNLL 819

  Fly   907 LALLLNSFNSEELKSKKE-------EVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQ 964
            :|:|:..|.:|...|:.:       :.|:|.||       |:|:.                    
Zfish   820 VAILVEGFQAEGDASRSDTDDDMSSDYGDEDKL-------RELLN-------------------- 857

  Fly   965 IVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQ--IPLHDGL 1027
                                                            ||::...|  :|:.:| 
Zfish   858 ------------------------------------------------SGTEMKMQTLMPISNG- 873

  Fly  1028 HTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFV 1092
                                   | |.|.: ||||                 |......|.||  
Zfish   874 -----------------------H-LEPRA-SMPP-----------------NNTHVQFNSTP-- 894

  Fly  1093 QAERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDN 1157
                                 |.|.::.                |:..:|:            .|
Zfish   895 ---------------------RTEVSHI----------------YSQSRRN------------SN 910

  Fly  1158 SSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNS 1222
            :|    :|.||      |:||.:...|.|.|.:.|..:...            :||..||     
Zfish   911 TS----TELHD------QRSLSSLWGSRRSSWNSLGHAPNL------------LRRAQSG----- 948

  Fly  1223 MSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENE 1287
               |::.|||..|.                                                   
Zfish   949 ---ERESLLSGPGR--------------------------------------------------- 959

  Fly  1288 TMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSA 1352
                    |:|.                     .||||                      .|:|:
Zfish   960 --------DSID---------------------DNLSE----------------------DEKSS 973

  Fly  1353 ADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQI 1417
            ...|.. |..:|..:|..|||                                            
Zfish   974 LGGVSC-LGSFDFPELLQVPR-------------------------------------------- 993

  Fly  1418 HAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLR 1482
                                     |:|.                                    
Zfish   994 -------------------------PYLE------------------------------------ 997

  Fly  1483 IESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTL 1547
                      .:|    |||.    ..||..|:                                
Zfish   998 ----------CNG----RLDG----GYNSSPNI-------------------------------- 1012

  Fly  1548 AQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAA 1612
                                                                  .||:.|     
Zfish  1013 ------------------------------------------------------THPEPT----- 1018

  Fly  1613 SFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLT 1677
                     .:.||.|..                               .|:.| ||:       
Zfish  1019 ---------STQGAEDDE-------------------------------FEESW-CLI------- 1035

  Fly  1678 VGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRT 1742
                                    ..::.:...||.|.||.    .|.:.....|:     ..|.
Zfish  1036 ------------------------LKRLLEPYKPQWCRDHE----DWSLYLFAPQN-----NFRM 1067

  Fly  1743 AVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLAL 1807
            ....|:....|:..||..||.:.||:..|..::..:.|.:..|...|:.|.:|||.||.:|.::|
Zfish  1068 RCQKVITHKMFDHIVLFFIFFNCITIALERPDIQPDSTERIFLKVSNYIFTVIFVAEMTVKVVSL 1132

  Fly  1808 GF----SKYFTSFWTILDFIIVFVSVFSLLIE-----ENENLKVLRSLRTLRALRPLRAISRWQG 1863
            |.    ..|..|.|.:||..:||||:..:|:.     .|..|.:||.||.||.|||||.|||..|
Zfish  1133 GLYAGPGSYLKSSWNVLDGFLVFVSIVDILVSLASSGGNRILGILRVLRLLRTLRPLRVISRAPG 1197

  Fly  1864 MRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEMGELLPITEVNDKWDCIE 1928
            :::||..|:.::..|.|::|:|..|:::|.|:|||.|.|||:.|     |......:.:|.:|::
Zfish  1198 LKLVVETLITSLRPIGNIVLICCAFFIVFGILGVQLFKGKFYHC-----EGFDTRNITNKSECLQ 1257

  Fly  1929 QNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIV 1993
            ..|.||..|..||::|...::|..:::.:||:.:|.|.:||..||.||.|..|.:..:||:.|::
Zfish  1258 AKYKWIRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVAVDQQPIRNHNPWMLLYFISFLL 1322

  Fly  1994 CGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPINHFL 2058
            ..|||.||:|:||:::||:..::..|.       .|:::......|:: .||.:|.::||   :.
Zfish  1323 IVSFFVLNMFVGVVVENFHKCRQDQEE-------EEARRREEKRQKRM-EKKRRKALQRP---YY 1376

  Fly  2059 AMF-------YDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAI 2116
            |.:       :.|..|...::.|.::|.:|:|||.:|||.||..:...|:..|.|||.||.:||.
Zfish  1377 ADYSPTRLYIHTLCTSHYLDLFITIIIAINVLTMSMEHYRQPKYLDEGLKYCNYFFTLVFVIEAA 1441

  Fly  2117 VKIVGLRY-HYFTVPWNVFDFLLVLASIFGILMEDIMID--LPISPTLLRVVRVFRIGRILRLIK 2178
            :|:|...: .:|...||..|..:||.||.||.:|:|.::  |||:||::|::||.||.|:|:|:|
Zfish  1442 LKLVAFGFRRFFKERWNQLDLAIVLLSIMGITLEEIDLNASLPINPTIIRIMRVLRIARVLKLLK 1506

  Fly  2179 AAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNV------KLQGALDDMVNFQTF 2237
            .|.|:|.||..:|.:||.:.|:|.|..|:.||||.||:.|||.:      ..:| |.....||.|
Zfish  1507 MATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLDCTEENPCEG-LSRHATFQNF 1570

  Fly  2238 GRSMQLLFRLMTSAGWNDVLESLMIQPPDCDPFIHGHTNGNCGH--PLLAITYFTSFIIISYMIV 2300
            |.:...|||:.|...||.:::..:   .:|       .|..|..  |||:..||.:|::::..::
Zfish  1571 GMAFLTLFRVSTGDNWNGIMKDTL---REC-------KNDKCLSYLPLLSPLYFVTFVLMAQFVL 1625

  Fly  2301 INMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGIS 2365
            :|:.:|::::                                                       
Zfish  1626 VNVVVAVLMK------------------------------------------------------- 1635

  Fly  2366 KPNNVALVSFNLPISKGNKIHCLDILHALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPTRKELE 2430
                                               |:||::...:.:.:||.:.|        ||
Zfish  1636 -----------------------------------HLEESNIDAREEAEMDAELK--------LE 1657

  Fly  2431 IVSSTRIWKRQEKAAKTIQTGWK------EYLRRKREKERSNSGDSATQTSSPGGWQSKLSALNF 2489
            :.:.    :||..|:.....|.:      |.|...:.|: .|.|:..| ...| .....||..|.
Zfish  1658 LEAG----RRQSTASVGGAAGLEGTDAKIETLSHDQGKD-PNYGNFLT-VGRP-SISRMLSLPND 1715

  Fly  2490 FHLQVSRRGTACSSRASSRKSSRASDASDLSELAGPWLNLPLMLVSGADEVVKDIKQQNDELGKR 2554
            .::....:....|....|.|.......|.||....|..:..:|.|.||             ..:.
Zfish  1716 SYMLYPIKPLYGSIHERSSKQDCTLPGSSLSLGTQPSEDSAVMQVPGA-------------ASQT 1767

  Fly  2555 GSIFVEAPR-ASRRRSFYNFF--LRHQDAV-DDSLTSPSVHRKTAMNNTTNTTSNSASTSGTASS 2615
            ....|.||| .::|....|.|  ||.|.|: .||:.|.....:.|:    ...|...|:......
Zfish  1768 SLASVPAPRPLNQRARTSNAFRGLRRQQAIKSDSIDSTYADSRDAL----QIPSKPCSSDNLHLK 1828

  Fly  2616 TATAPATG----CGPAA---------TSASDSDRHQAVGGGSAPSRKRASSFIRKKPPLERGLSA 2667
            ..:.|..|    |.|..         |::..::|| .....|.|.|:.|   |:..|        
Zfish  1829 VPSVPIGGRSAPCSPQTSPPPPLRNRTASVQTNRH-VYSQRSIPCRQTA---IKPHP-------- 1881

  Fly  2668 QSALRVNKNAFVSEASAPEVIVTRPSPEQQTHPHSLSLRPDNATLVHVLVHRESEEYKEEDESSP 2732
            .:|:|:|.|...|..|.        ||.   || |||....:...:||...|..:....:..|. 
Zfish  1882 DAAVRLNTNRRASRHSL--------SPH---HP-SLSSDTQSQDSLHVGAPRHQDTSLRKYNSM- 1933

  Fly  2733 SVSGNGNGFGVGLDMLSKQPPPQIRITTG-SVESSMDTCAMPTVQIMVDSPKDPPRGDFSSAPID 2796
                ..|||      ||:...|:...|.| .:....|..:..:      |....|:.|..|.|..
Zfish  1934 ----ENNGF------LSQPQIPRRHSTHGEELRLQQDPSSSSS------SSSHTPKKDKMSPPCI 1982

  Fly  2797 DVGAPIDVN-VQGDTSQVFYDYNPEKATDDQGNGQDETAQFES--------LPDRQRXP--PVNT 2850
            .:..|.:.. |..:.|.|.               :..|..|:|        |||.|..|  |...
Zfish  1983 SIEPPAESEVVSQECSSVL---------------RRRTPSFDSALPRESLDLPDVQDEPHLPSRL 2032

  Fly  2851 PLR----DSEKRSSRGSRSS--SSSTSSIRSCSSSSSSSAASAAAPSARR 2894
            ||.    |....||..|.|.  |.|..|..|.:..|.|..|..||.|..|
Zfish  2033 PLPQFSFDQSDVSSLSSLSELLSDSDQSTHSIAHESRSGFAGDAAHSPLR 2082

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 68/280 (24%)
Ion_trans 705..902 CDD:278921 62/199 (31%)
Ion_trans 1768..2019 CDD:278921 94/259 (36%)
Na_channel_gate 2009..2063 CDD:240441 11/60 (18%)
Ion_trans 2085..2320 CDD:278921 87/245 (36%)
GPHH 2331..2386 CDD:293510 0/54 (0%)
cacna1hbXP_021331616.1 Ion_trans 1..323 CDD:306908 86/335 (26%)
Ion_trans 601..828 CDD:306908 71/230 (31%)
Ion_trans 1075..1347 CDD:306908 101/276 (37%)
Ion_trans 1392..1597 CDD:306908 82/208 (39%)
Herpes_TAF50 <1739..2026 CDD:308764 80/359 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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