Protein Alignment NaCP60E and cacna1hb

DIOPT Version :10

• Sequence 1: NP_001261172.1
• Gene: NaCP60E / 37981
• FlyBaseID: FBgn0085434
• Length: 2896
• Species: Drosophila melanogaster
• Sequence 2: XP_021331616.1
• Gene: cacna1hb / 100007317
• ZFINID: ZDB-GENE-090312-128
• Length: 2102
• Species: Danio rerio
• Alignment Length: 2975
• Identity: 645/2975 - (21%)
• Similarity: 1038/2975 - (34%)
• Gaps: 1106/2975 - (37%)

  Fly   133 MATILFNCIFLAMTETVEEAE--------------YIFLAIYSIEMVIKIIAKGFLLNKYTYLRN 183
            |..||.||:.|.|.:..::.|              :|| |.:::|||:|::|.| :.....||.:
Zfish     1 MLVILLNCVTLGMFQPCQDLECHTDRCSILQAFDDFIF-AFFAVEMVVKMVALG-VFGPKCYLGD 63

  Fly   184 PWNWLDFVVITSG---YATIGMEVGNLAGLRTFRVLRALKTVSIMPGLKTIINALLHSFRQLAEV 245
            .||.||..::.:|   |:..|..| :.:.:||.||||.|:.::.:|.::.::..||.:...|..|
Zfish    64 TWNRLDLFIVMAGMLEYSLDGHNV-SFSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNV 127

  Fly   246 MTLTIFCLMVFALFALQVYMGELRNKC-----VRQVPTDWTNVSHTDWQIW-VNDTDNWLYDEDE 304
            :.|..|...:|.:..:|::.|.|||:|     :|.:    .|||.:..:.: |::|       |:
Zfish   128 LLLCFFVFFIFGIVGVQLWAGLLRNRCFFDNNIRML----YNVSGSVSEYYRVDET-------DD 181

  Fly   305 LPVLCG----------------NLTGA--------------RHCP---------FEYVCLCVGEN 330
            :|.:|.                .:.||              :..|         :...|.....|
Zfish   182 IPFICSTNRENGMLRCSNVPKRRVAGADCELTADNVTELVFKEAPHHGCVNWNLYYNTCNASEHN 246

  Fly   331 PNHGYTNFDNFMWSMLTTFQLITLDYWENVYNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVV 395
            |::|..||||..::.:..||:|||:.|.::...|:......:..:|..::..|||::|||.|.|:
Zfish   247 PHNGAINFDNIGYAWIAIFQVITLEGWADIMYYVMDAHSFYNFIYFIFLIIVGSFFMINLCLVVI 311

  Fly   396 ALSYEE----EAEITNEERKKDLLDHRDDSTFS--FDPSVLNVKKLNKNNKKKIDSRKGVLLASY 454
            |..:.|    |.::..|:|.:   ...::||.:  .:|.....:.|.             .||..
Zfish   312 ATQFSETKQRENQLMQEQRAR---FRSNESTLASLAEPGSCYEEMLK-------------YLAHV 360

  Fly   455 SKKKTRR----------KKTKGGKEGGTNGNGNGSNG--DDNKSHSATPSPGPSP---RHSATER 504
            .:|..|.          |:.||....||:.:..|:||  .||.:     ..||:.   .|.....
Zfish   361 CRKLWRHVVRIYGDLCPKRRKGVANPGTSLSVGGTNGYWSDNGT-----KMGPTQYCMLHYHHPH 420

  Fly   505 PSALTMQAQKQYQQMEQQHKLAKSGSG-------------GSNNP-MAPTPKGRISFQDSGMGVK 555
            ...::...:.:..|:::...:||....             |.|.| :.|:   ::.......|||
Zfish   421 QHYISNGIEMKTLQLDRDAHIAKKTPSLPLALQNLKGLRLGMNYPTILPS---KMYTNSHARGVK 482

  Fly   556 NPNML-------------YPSDYKGQ------------LIANSGQPSSNSS----------GVNR 585
            .|...             |...||.|            :.:..|..||.||          |||.
Zfish   483 APAFHHGIYGRKISVCGGYHDTYKLQHGVYPGTCSSVCVDSRVGLVSSQSSSCPICAQEGDGVNC 547

  Fly   586 ESSQDDSGVVDDHEEQDTTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEV 650
            :|:.:     .|.|:|..  |:|                       :..:..|:.|  :|..||
Zfish   548 DSNGE-----SDPEKQGP--DVG-----------------------SEQRKTNLDA--EEKVSE- 579

  Fly   651 VVIDDLPDRNC-DRCVHWCTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSE 714
                   .||| ..|||:.         :..|.::|....|...|.:.|::||..:.:|:|...:
Zfish   580 -------KRNCVCMCVHYA---------RAVLKRIVDSKYFNRGIMIAILINTLSMGVEYHEQPD 628

  Fly   715 SFRNALDVGNKVFTSIFTFECIVKLMALSK-DFFLCGWNIFDLLIVTASLLDIIFELVDGLSVLR 778
            ...:.|::.|.||||:|..|.::||.|... |:....:||||.:||..|:.:|:.:...|.||||
Zfish   629 ELTDVLEISNIVFTSLFVLEMLLKLSACGLFDYISNPYNIFDGIIVIISVCEIVGQADGGFSVLR 693

  Fly   779 GLRLLRVLKLAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQLFSKDYTPEKFDPD 843
            ..||||||||.:....::..|.:::.|:..:....::|::.|:||:::||.||...:|....:.|
Zfish   694 TFRLLRVLKLVRFLPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFTLRLENGD 758

  Fly   844 PV-PRWNFNDFFHSFMMIFRILCGE-WIEPLWDCMRAEEEQGASTCFAIFLPTLVMGNFMVLNLF 906
            .| .|.||:....:.:.:|:||..| |...|::.|.:.....|    ..|:..:..||:::.||.
Zfish   759 TVSDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSPYAA----LYFVALMTFGNYVLFNLL 819

  Fly   907 LALLLNSFNSEELKSKKE-------EVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQ 964
            :|:|:..|.:|...|:.:       :.|:|.||       |:|:.
Zfish   820 VAILVEGFQAEGDASRSDTDDDMSSDYGDEDKL-------RELLN-------------------- 857

  Fly   965 IVLDAQQAHAQTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQ--IPLHDGL 1027
                                                            ||::...|  :|:.:|
Zfish   858 ------------------------------------------------SGTEMKMQTLMPISNG- 873

  Fly  1028 HTIVDGLEYDDTGDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFV 1092
                                   | |.|.: ||||                 |......|.||
Zfish   874 -----------------------H-LEPRA-SMPP-----------------NNTHVQFNSTP-- 894

  Fly  1093 QAERRLQHQISSGVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDN 1157
                                 |.|.::.                |:..:|:            .|
Zfish   895 ---------------------RTEVSHI----------------YSQSRRN------------SN 910

  Fly  1158 SSRRYGSEEHDEAFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNS 1222
            :|    :|.||      |:||.:...|.|.|.:.|..:...            :||..||
Zfish   911 TS----TELHD------QRSLSSLWGSRRSSWNSLGHAPNL------------LRRAQSG----- 948

  Fly  1223 MSIEQDELLSQQGNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENE 1287
               |::.|||..|.
Zfish   949 ---ERESLLSGPGR--------------------------------------------------- 959

  Fly  1288 TMVEHSEFDNIIQSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSA 1352
                    |:|.                     .||||                      .|:|:
Zfish   960 --------DSID---------------------DNLSE----------------------DEKSS 973

  Fly  1353 ADEVVLPLNPYDSYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQI 1417
            ...|.. |..:|..:|..|||
Zfish   974 LGGVSC-LGSFDFPELLQVPR-------------------------------------------- 993

  Fly  1418 HAPFVAMEAMAVAATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLR 1482
                                     |:|.
Zfish   994 -------------------------PYLE------------------------------------ 997

  Fly  1483 IESEKMPRKFLHGPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTL 1547
                      .:|    |||.    ..||..|:
Zfish   998 ----------CNG----RLDG----GYNSSPNI-------------------------------- 1012

  Fly  1548 AQISSLKTTPPLAALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAA 1612
                                                                  .||:.|
Zfish  1013 ------------------------------------------------------THPEPT----- 1018

  Fly  1613 SFQSARTESHSSGAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLT 1677
                     .:.||.|..                               .|:.| ||:
Zfish  1019 ---------STQGAEDDE-------------------------------FEESW-CLI------- 1035

  Fly  1678 VGGRRNSQGAYNDPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRT 1742
                                    ..::.:...||.|.||.    .|.:.....|:     ..|.
Zfish  1036 ------------------------LKRLLEPYKPQWCRDHE----DWSLYLFAPQN-----NFRM 1067

  Fly  1743 AVLTVVDTPAFEWFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLAL 1807
            ....|:....|:..||..||.:.||:..|..::..:.|.:..|...|:.|.:|||.||.:|.::|
Zfish  1068 RCQKVITHKMFDHIVLFFIFFNCITIALERPDIQPDSTERIFLKVSNYIFTVIFVAEMTVKVVSL 1132

  Fly  1808 GF----SKYFTSFWTILDFIIVFVSVFSLLIE-----ENENLKVLRSLRTLRALRPLRAISRWQG 1863
            |.    ..|..|.|.:||..:||||:..:|:.     .|..|.:||.||.||.|||||.|||..|
Zfish  1133 GLYAGPGSYLKSSWNVLDGFLVFVSIVDILVSLASSGGNRILGILRVLRLLRTLRPLRVISRAPG 1197

  Fly  1864 MRIVVNALMYAIPSIFNVLLVCLVFWLIFSIMGVQFFGGKFFKCVNEMGELLPITEVNDKWDCIE 1928
            :::||..|:.::..|.|::|:|..|:::|.|:|||.|.|||:.|     |......:.:|.:|::
Zfish  1198 LKLVVETLITSLRPIGNIVLICCAFFIVFGILGVQLFKGKFYHC-----EGFDTRNITNKSECLQ 1257

  Fly  1929 QNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMADAVDARGVDLQPQREANLYAYIYFVIFIV 1993
            ..|.||..|..||::|...::|..:::.:||:.:|.|.:||..||.||.|..|.:..:||:.|::
Zfish  1258 AKYKWIRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVAVDQQPIRNHNPWMLLYFISFLL 1322

  Fly  1994 CGSFFTLNLFIGVIIDNFNMLKKKYEGGVLEMFLTESQKHYYTAMKKLGRKKPQKVIKRPINHFL 2058
            ..|||.||:|:||:::||:..::..|.       .|:::......|:: .||.:|.::||   :.
Zfish  1323 IVSFFVLNMFVGVVVENFHKCRQDQEE-------EEARRREEKRQKRM-EKKRRKALQRP---YY 1376

  Fly  2059 AMF-------YDLSNSRRFEIAIFVLIFLNMLTMGIEHYDQPHAVFFILEVSNAFFTTVFGLEAI 2116
            |.:       :.|..|...::.|.::|.:|:|||.:|||.||..:...|:..|.|||.||.:||.
Zfish  1377 ADYSPTRLYIHTLCTSHYLDLFITIIIAINVLTMSMEHYRQPKYLDEGLKYCNYFFTLVFVIEAA 1441

  Fly  2117 VKIVGLRY-HYFTVPWNVFDFLLVLASIFGILMEDIMID--LPISPTLLRVVRVFRIGRILRLIK 2178
            :|:|...: .:|...||..|..:||.||.||.:|:|.::  |||:||::|::||.||.|:|:|:|
Zfish  1442 LKLVAFGFRRFFKERWNQLDLAIVLLSIMGITLEEIDLNASLPINPTIIRIMRVLRIARVLKLLK 1506

  Fly  2179 AAKGIRKLLFALVVSLPALFNIGALLGLITFIYAILGMSLFGNV------KLQGALDDMVNFQTF 2237
            .|.|:|.||..:|.:||.:.|:|.|..|:.||||.||:.|||.:      ..:| |.....||.|
Zfish  1507 MATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLDCTEENPCEG-LSRHATFQNF 1570

  Fly  2238 GRSMQLLFRLMTSAGWNDVLESLMIQPPDCDPFIHGHTNGNCGH--PLLAITYFTSFIIISYMIV 2300
            |.:...|||:.|...||.:::..:   .:|       .|..|..  |||:..||.:|::::..::
Zfish  1571 GMAFLTLFRVSTGDNWNGIMKDTL---REC-------KNDKCLSYLPLLSPLYFVTFVLMAQFVL 1625

  Fly  2301 INMYIAIILENFNQAHQEEEIGIVEDDLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGIS 2365
            :|:.:|::::
Zfish  1626 VNVVVAVLMK------------------------------------------------------- 1635

  Fly  2366 KPNNVALVSFNLPISKGNKIHCLDILHALVKHVLGHVEETDNFKQLQEQMDVKFKKQFPTRKELE 2430
                                               |:||::...:.:.:||.:.|        ||
Zfish  1636 -----------------------------------HLEESNIDAREEAEMDAELK--------LE 1657

  Fly  2431 IVSSTRIWKRQEKAAKTIQTGWK------EYLRRKREKERSNSGDSATQTSSPGGWQSKLSALNF 2489
            :.:.    :||..|:.....|.:      |.|...:.|: .|.|:..| ...| .....||..|.
Zfish  1658 LEAG----RRQSTASVGGAAGLEGTDAKIETLSHDQGKD-PNYGNFLT-VGRP-SISRMLSLPND 1715

  Fly  2490 FHLQVSRRGTACSSRASSRKSSRASDASDLSELAGPWLNLPLMLVSGADEVVKDIKQQNDELGKR 2554
            .::....:....|....|.|.......|.||....|..:..:|.|.||             ..:.
Zfish  1716 SYMLYPIKPLYGSIHERSSKQDCTLPGSSLSLGTQPSEDSAVMQVPGA-------------ASQT 1767

  Fly  2555 GSIFVEAPR-ASRRRSFYNFF--LRHQDAV-DDSLTSPSVHRKTAMNNTTNTTSNSASTSGTASS 2615
            ....|.||| .::|....|.|  ||.|.|: .||:.|.....:.|:    ...|...|:......
Zfish  1768 SLASVPAPRPLNQRARTSNAFRGLRRQQAIKSDSIDSTYADSRDAL----QIPSKPCSSDNLHLK 1828

  Fly  2616 TATAPATG----CGPAA---------TSASDSDRHQAVGGGSAPSRKRASSFIRKKPPLERGLSA 2667
            ..:.|..|    |.|..         |::..::|| .....|.|.|:.|   |:..|
Zfish  1829 VPSVPIGGRSAPCSPQTSPPPPLRNRTASVQTNRH-VYSQRSIPCRQTA---IKPHP-------- 1881

  Fly  2668 QSALRVNKNAFVSEASAPEVIVTRPSPEQQTHPHSLSLRPDNATLVHVLVHRESEEYKEEDESSP 2732
            .:|:|:|.|...|..|.        ||.   || |||....:...:||...|..:....:..|.
Zfish  1882 DAAVRLNTNRRASRHSL--------SPH---HP-SLSSDTQSQDSLHVGAPRHQDTSLRKYNSM- 1933

  Fly  2733 SVSGNGNGFGVGLDMLSKQPPPQIRITTG-SVESSMDTCAMPTVQIMVDSPKDPPRGDFSSAPID 2796
                ..|||      ||:...|:...|.| .:....|..:..:      |....|:.|..|.|..
Zfish  1934 ----ENNGF------LSQPQIPRRHSTHGEELRLQQDPSSSSS------SSSHTPKKDKMSPPCI 1982

  Fly  2797 DVGAPIDVN-VQGDTSQVFYDYNPEKATDDQGNGQDETAQFES--------LPDRQRXP--PVNT 2850
            .:..|.:.. |..:.|.|.               :..|..|:|        |||.|..|  |...
Zfish  1983 SIEPPAESEVVSQECSSVL---------------RRRTPSFDSALPRESLDLPDVQDEPHLPSRL 2032

  Fly  2851 PLR----DSEKRSSRGSRSS--SSSTSSIRSCSSSSSSSAASAAAPSARR 2894
            ||.    |....||..|.|.  |.|..|..|.:..|.|..|..||.|..|
Zfish  2033 PLPQFSFDQSDVSSLSSLSELLSDSDQSTHSIAHESRSGFAGDAAHSPLR 2082

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NaCP60E	NP_001261172.1	Ion_trans	125..371	CDD:459842	75/299 (25%)
		Ion_trans	687..902	CDD:459842	67/217 (31%)
		Ion_trans	1751..2019	CDD:459842	101/276 (37%)
		Na_channel_gate	2009..2063	CDD:240441	11/60 (18%)
		Ion_trans	2067..2320	CDD:459842	93/263 (35%)
		GPHH	2332..2378	CDD:465306	0/45 (0%)
cacna1hb	XP_021331616.1	Ion_trans	1..323	CDD:459842	86/335 (26%)
		Ion_trans	601..828	CDD:459842	71/230 (31%)
		Ion_trans	1075..1347	CDD:459842	101/276 (37%)
		Ion_trans	1392..1597	CDD:459842	82/208 (39%)
		Atrophin-1	1731..>2036	CDD:460830	86/377 (23%)