DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ance-5 and Ace2

DIOPT Version :10

Sequence 1:NP_573392.2 Gene:Ance-5 / 37980 FlyBaseID:FBgn0035076 Length:628 Species:Drosophila melanogaster
Sequence 2:NP_081562.2 Gene:Ace2 / 70008 MGIID:1917258 Length:805 Species:Mus musculus


Alignment Length:658 Identity:155/658 - (23%)
Similarity:272/658 - (41%) Gaps:97/658 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 SLILLLSVTFGIGQSSYELATKQILDRAKDRMRHV--------WSLNRRIFVQLTAKGKSPLGGQ 65
            |.:||..|.....||..|...|..|:........:        |:.|..|..:..          
Mouse     5 SWLLLSLVAVTTAQSLTEENAKTFLNNFNQEAEDLSYQSSLASWNYNTNITEENA---------- 59

  Fly    66 VLNSKLEVEAETYRLFY-DLAGNLSVVSVAELNDPLLRRRVQRMAKLQLQGLRPKDYEQAKDLLR 129
               .|:...|..:..|| :.:......|:.|:..|:::|::|.:.:.....|.....:|...:|.
Mouse    60 ---QKMSEAAAKWSAFYEEQSKTAQSFSLQEIQTPIIKRQLQALQQSGSSALSADKNKQLNTILN 121

  Fly   130 QIHNFVNGPLVC----PYEDCSARGSLAMYPQIMNKNMHTKL-YEDLVINWKAWRRAINEKDVAK 189
            .:....:...||    | ::|     |.:.|. :::.|.|.. |...:..|:.||..:.::  .:
Mouse   122 TMSTIYSTGKVCNPKNP-QEC-----LLLEPG-LDEIMATSTDYNSRLWAWEGWRAEVGKQ--LR 177

  Fly   190 NTFIGYVRLLRIAATYNGHVTPSRTWYLNYDTE-----NFQ-----AEMEAVVWEIMPLYRELHA 244
            ..:..||.|....|..|.:......|..:|:.|     |:.     .::|....||.|||..|||
Mouse   178 PLYEEYVVLKNEMARANNYNDYGDYWRGDYEAEGADGYNYNRNQLIEDVERTFAEIKPLYEHLHA 242

  Fly   245 YLRREVQAAYPKADTKSDGAISAPIMDQILSQDW---YPHQFFRTPHQGRQHQLPSVHRRLEEVL 306
            |:||::...||...:.: |.:.|.::..:..:.|   ||   ...|..    |.|::.       
Mouse   243 YVRRKLMDTYPSYISPT-GCLPAHLLGDMWGRFWTNLYP---LTVPFA----QKPNID------- 292

  Fly   307 VTPVKIN---------RKAAEFFESLGLMVMPNIFYDRFSRRMNDEEGGAECKSQVYYFPP---- 358
            ||...:|         ::|.:||.|:||   |::....::..|..|.....   :|...|.    
Mouse   293 VTDAMMNQGWDAERIFQEAEKFFVSVGL---PHMTQGFWANSMLTEPADGR---KVVCHPTAWDL 351

  Fly   359 ---DVALRYCPKLDYKKMMQIHGTMAELQYHLYKMQLPFGLDTEPCPGFGAAIAETVILASGTPR 420
               |..::.|.|:.....:..|..|..:||.:...:.||.|......||..|:.|.:.|::.||:
Mouse   352 GHGDFRIKMCTKVTMDNFLTAHHEMGHIQYDMAYARQPFLLRNGANEGFHEAVGEIMSLSAATPK 416

  Fly   421 HLHRLHILLNDSLTE-EQSLNRLFRMGVHTLIAVPQYFINDKFLVDVMDGRIGVKDYNCAYWGLQ 484
            ||..:.:|.:|...: |..:|.|.:..:..:..:|..::.:|:...|..|.|..:.:...:|.::
Mouse   417 HLKSIGLLPSDFQEDSETEINFLLKQALTIVGTLPFTYMLEKWRWMVFRGEIPKEQWMKKWWEMK 481

  Fly   485 DKFAGVQPPLQRLNKDFDVDFKFYRGLNPETSNTKKFLAEILGFQFYRSFCLASGQYKPGDPNFP 549
            .:..||..||.......|....|:  ::.:.|..:.:...|..|||..:.|.|: :|     |..
Mouse   482 REIVGVVEPLPHDETYCDPASLFH--VSNDYSFIRYYTRTIYQFQFQEALCQAA-KY-----NGS 538

  Fly   550 LHNCDFYDSKEAGKKIRDMMQLGATRHWRDVMEIATGERKLSGRGILEYFAPLFTWLKERNKQLD 614
            ||.||..:|.|||:|:..|:.||.:..|...:|...|.|.:..:.:|.||.|||.||||:|:...
Mouse   539 LHKCDISNSTEAGQKLLKMLSLGNSEPWTKALENVVGARNMDVKPLLNYFQPLFDWLKEQNRNSF 603

  Fly   615 IEPGWDAD 622
            :  ||:.:
Mouse   604 V--GWNTE 609

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ance-5NP_573392.2 M2_ACE 67..610 CDD:341055 140/578 (24%)
Ace2NP_081562.2 Peptidase_M2 21..606 CDD:460196 147/637 (23%)
Collectrin 617..770 CDD:465322
Essential for cleavage by ADAM17. /evidence=ECO:0000250 652..659
Essential for cleavage by TMPRSS11D and TMPRSS2. /evidence=ECO:0000250 697..716
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 771..805
LIR. /evidence=ECO:0000250|UniProtKB:Q9BYF1 778..786
SH2-binding. /evidence=ECO:0000250|UniProtKB:Q9BYF1 781..785
Endocytic sorting signal. /evidence=ECO:0000250|UniProtKB:Q9BYF1 781..784
PTB. /evidence=ECO:0000250|UniProtKB:Q9BYF1 792..795
PDZ-binding. /evidence=ECO:0000250|UniProtKB:Q9BYF1 803..805
Blue background indicates that the domain is not in the aligned region.

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