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Protein Alignment Ance-5 and ACE2

DIOPT Version :9

Sequence 1:	NP_573392.2	Gene:	Ance-5 / 37980	FlyBaseID:	FBgn0035076	Length:	628	Species:	Drosophila melanogaster
Sequence 2:	NP_001358344.1	Gene:	ACE2 / 59272	HGNCID:	13557	Length:	805	Species:	Homo sapiens

Alignment Length:	672	Identity:	159/672 - (23%)
Similarity:	272/672 - (40%)	Gaps:	125/672 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SLILLLSVTFGIGQSSYELATKQILDRAKDRMRHVWSLNRRIFVQLTAKGKSPLGGQVLNSKLEV 73
            |.:||..|.....||:.|...|..||                                   |...
Human     5 SWLLLSLVAVTAAQSTIEEQAKTFLD-----------------------------------KFNH 34

  Fly    74 EAETYRLFY--DLAG-----NLSVVSVAELND-------------------PLLRRRVQRM-AKL 111
            |||.  |||  .||.     |::..:|..:|:                   ||  :.:|.: .||
Human    35 EAED--LFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPL--QEIQNLTVKL 95

  Fly   112 QLQGLRPKDYE-QAKDLLRQIHNFVN--------GPLVCP--YEDCSARGSLAMYPQIMNKNMHT 165
            |||.|:..... .::|..::::..:|        |.:..|  .::|     |.:.|. :|:.|..
Human    96 QLQALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQEC-----LLLEPG-LNEIMAN 154

  Fly   166 KL-YEDLVINWKAWRRAINEKDVAKNTFIGYVRLLRIAATYNGHVTPSRTWYLNYDTENFQA--- 226
            .| |.:.:..|::||..:.::  .:..:..||.|....|..|.:......|..:|:......
Human   155 SLDYNERLWAWESWRSEVGKQ--LRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDY 217

  Fly   227 -------EMEAVVWEIMPLYRELHAYLRREVQAAYPKADTKSDGAISAPIMDQILSQDWYPHQFF 284
                   ::|....||.|||..||||:|.::..||| :.....|.:.|.::..:..:.|......
Human   218 SRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYP-SYISPIGCLPAHLLGDMWGRFWTNLYSL 281

  Fly   285 RTPHQGRQHQLPSVHRRLEEVLVTPV----KINRKAAEFFESLGLMVMPNIFYDRFSRRMNDEEG 345
            ..|.    .|.|::.  :.:.:|...    :|.::|.:||.|:||   ||:....:...|..:.|
Human   282 TVPF----GQKPNID--VTDAMVDQAWDAQRIFKEAEKFFVSVGL---PNMTQGFWENSMLTDPG 337

  Fly   346 G---AECKSQVYYF-PPDVALRYCPKLDYKKMMQIHGTMAELQYHLYKMQLPFGLDTEPCPGFGA 406
            .   |.|....:.. ..|..:..|.|:.....:..|..|..:||.:.....||.|......||..
Human   338 NVQKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHE 402

  Fly   407 AIAETVILASGTPRHLHRLHILLNDSLTE-EQSLNRLFRMGVHTLIAVPQYFINDKFLVDVMDGR 470
            |:.|.:.|::.||:||..:.:|..|...: |..:|.|.:..:..:..:|..::.:|:...|..|.
Human   403 AVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGE 467

  Fly   471 IGVKDYNCAYWGLQDKFAGVQPPLQRLNKDFDVDFKFYRGLNPETSNTKKFLAEILGFQFYRSFC 535
            |....:...:|.::.:..||..|:.......|....|:  ::.:.|..:.:...:..|||..:.|
Human   468 IPKDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFH--VSNDYSFIRYYTRTLYQFQFQEALC 530

  Fly   536 LASGQYKPGDPNFPLHNCDFYDSKEAGKKIRDMMQLGATRHWRDVMEIATGERKLSGRGILEYFA 600
            .|:..      ..|||.||..:|.|||:|:.:|::||.:..|...:|...|.:.::.|.:|.||.
Human   531 QAAKH------EGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFE 589

  Fly   601 PLFTWLKERNKQLDIEPGWDAD 622
            |||||||::||...:  ||..|
Human   590 PLFTWLKDQNKNSFV--GWSTD 609

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.