DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ance-5 and Ance-3

DIOPT Version :9

Sequence 1:	NP_573392.2	Gene:	Ance-5 / 37980	FlyBaseID:	FBgn0035076	Length:	628	Species:	Drosophila melanogaster
Sequence 2:	NP_001033904.1	Gene:	Ance-3 / 34808	FlyBaseID:	FBgn0032536	Length:	844	Species:	Drosophila melanogaster

Alignment Length:	548	Identity:	164/548 - (29%)
Similarity:	261/548 - (47%)	Gaps:	37/548 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 DPLLRRRVQRMAKLQLQ---GLRPKD-YEQAKDLLRQIHNFVNGPLVCPYE---DCSARGSLAMY 155
            |.:..||:.|...||.:   ...|.| .::...||.::....|...:|.|:   .|    .|...
  Fly   274 DLIFDRRLYRQLMLQSEVGPNALPLDVLDRYNRLLNEMLFLYNSAEICAYQQPFQC----DLHYI 334

  Fly   156 PQIMNKNMHTKLYEDLVINWKAWRRAINEKDVAKNTFIGYVRLLRIAATYNGHVTPSRTWYLNYD 220
            ||:.:....::.:::|...|..:.|.....  .::::...:.:::..|..|........|||.|:
  Fly   335 PQLKDIMAKSRDWDELQHTWVEYHRKAGRG--MRDSYEQLIDVMQEVAYVNNVTNGGEYWYLAYE 397

  Fly   221 TENFQAEMEAVVWE-IMPLYRELHAYLRREVQAAYPKADTKSDGAISAPIMDQILSQDWYPHQFF 284
            :.||:.:|: :||| |.|||..||||:||:::..|..........|.:.|:..:..|.|......
  Fly   398 SGNFRQDMD-IVWEQIRPLYEGLHAYVRRKLRDYYGPDRINRIAPIPSHILGNMYGQSWSNVLDI 461

  Fly   285 RTPHQGRQHQLPSVHRRLEEVLVTPVKINRKAAEFFESLGLMVM------PNIFYDRFSRRMNDE 343
            ..|:.||  :|..|..|:.|...||..:.:.|.|||.|:.:..:      .:||.....||:
  Fly   462 LIPYPGR--KLIDVTPRMVEQGYTPQLMFQLAEEFFTSINMSAVGPEFYRNSIFEQPLDRRV--- 521

  Fly   344 EGGAECKSQVYYF--PPDVALRYCPKLDYKKMMQIHGTMAELQYHLYKMQLPFGLDTEPCPGFGA 406
                .|:...:.|  ..|..::.|..::.:.::.:|..||.:||.|....||........|.|..
  Fly   522 ----LCEPSAWDFCNRHDFRVKICTDINQRSLISVHHEMAHIQYFLQYRHLPKIFRNGANPAFHQ 582

  Fly   407 AIAETVILASGTPRHLHRLHILLNDSLTEEQ-SLNRLFRMGVHTLIAVPQYFINDKFLVDVMDGR 470
            |:.:.:.|:..|||||..|. ||..||.|.. .:|.||.|.:..:..:|.....|.:..||..|.
  Fly   583 AVGDAIGLSVSTPRHLQTLG-LLQRSLDESSYDINYLFTMAIDKVAFLPFALSLDNWRYDVFSGN 646

  Fly   471 IGVKDYNCAYWGLQDKFAGVQPPLQRLNKDFDVDFKFYRGLNPETSNTKKFLAEILGFQFYRSFC 535
            ...:..||.||.|::|::|::||:.|..||||...|::...|  ....|.|.:.:|.||.||..|
  Fly   647 ANKRTMNCHYWNLREKYSGIKPPVLRSEKDFDPGAKYHIPAN--IPYIKYFFSTVLQFQIYRGLC 709

  Fly   536 LASGQYKPGDPNFPLHNCDFYDSKEAGKKIRDMMQLGATRHWRDVMEIATGERKLSGRGILEYFA 600
            ..||||.||||..|||.||.|....||..::.:|..||::.|::|:|....|.:|.|..:.||||
  Fly   710 RESGQYVPGDPRKPLHQCDIYRQPAAGNILKTLMSKGASQPWQEVLEETLREGRLDGTALREYFA 774

  Fly   601 PLFTWLKERNKQLDIEPGWDAD-ELCRR 627
            ||..||::.|.:.:...||:.| :.|:|
  Fly   775 PLEEWLRQENLRTNEYVGWNYDGDYCKR 802

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ance-5	NP_573392.2	GluZincin	93..610	CDD:301352	158/528 (30%)
Ance-3	NP_001033904.1	M2_ACE	216..784	CDD:188999	158/528 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3690
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5260
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D16282at33392
OrthoFinder	1	1.000	-	-		FOG0000442
OrthoInspector	1	1.000	-	-		otm14376
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10514
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.870