DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ance-5 and Acer

DIOPT Version :9

Sequence 1:	NP_573392.2	Gene:	Ance-5 / 37980	FlyBaseID:	FBgn0035076	Length:	628	Species:	Drosophila melanogaster
Sequence 2:	NP_001260258.1	Gene:	Acer / 34189	FlyBaseID:	FBgn0016122	Length:	630	Species:	Drosophila melanogaster

Alignment Length:	637	Identity:	162/637 - (25%)
Similarity:	298/637 - (46%)	Gaps:	60/637 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LILLLSVTFGIGQSS------------YELATKQILDRAKDRM-------RHVWSLNRRIFVQLT 55
            |:::|.:..|:...:            :||..:|:..|..:..       .:|...||:..:::.
  Fly    11 LVIMLWLPHGLSMGNSCSASVLEARRFFELENEQLRRRFHEEFLSGYNYNTNVTEANRQAMIEVY 75

  Fly    56 AKGKSPLGGQVLNSKL--EVEAETYRLFYDLAGNLSVVSVAELNDPLLRRRVQRMAKLQLQGLRP 118
            |:...      ||.:|  ::::..|               .:..|..:||:.:.::||....|..
  Fly    76 ARNAE------LNKRLAQQIKSSDY---------------VQSEDADIRRQAEHLSKLGASALNA 119

  Fly   119 KDYEQAKDLLRQIHNFVNGPLVCPY---EDCSARGSLAMYPQIMNKNMHTKLYEDLVINWKAWRR 180
            .||...::.:..:........||.|   .||    ||.:.|.|..:..|::...:|...|:.|
  Fly   120 DDYLALQNAISSMQTNYATATVCSYTNRSDC----SLTLEPHIQERLSHSRDPAELAWYWREW-- 178

  Fly   181 AINEKD--VAKNTFIGYVRLLRIAATYNGHVTPSRTWYLNYDTENFQAEMEAVVWEIMPLYRELH 243
              ::|.  ..:..|..||||.|.|:..|||.:.:..|...|:..:|:.:::|...:::|.||:||
  Fly   179 --HDKSGTPMRQNFAEYVRLTRKASQLNGHRSYADYWVQFYEDPDFERQLDATFKQLLPFYRQLH 241

  Fly   244 AYLRREVQAAYPKADTKSDGAISAPIMDQILSQDWYPHQFFRTPHQGRQHQLPSVHRRLEEVLVT 308
            .|:|..::..|......::|.|...::..:..|.|.......||:.  :.....|...:|:...|
  Fly   242 GYVRFRLRQHYGPDVMPAEGNIPISLLGNMWGQSWNELLDLFTPYP--EKPFVDVKAEMEKQGYT 304

  Fly   309 PVKINRKAAEFFESLGLMVMPNIFYD-RFSRRMNDEEGGAECKSQVYYFPPDVALRYCPKLDYKK 372
            ..|:.....:||:|||:..:|..|:: ....|.:|........:..:|...||.::.|.::|...
  Fly   305 VQKLFELGDQFFQSLGMRALPPSFWNLSVLTRPDDRHVVCHASAWDFYQDSDVRIKMCTEVDSHY 369

  Fly   373 MMQIHGTMAELQYHLYKMQLPFGLDTEPCPGFGAAIAETVILASGTPRHLHRLHILLNDSLTEEQ 437
            ...:|..:..:||:|...|.|......|.|||..|:.:.:.|:..:.:||..:.::.|..|.|:.
  Fly   370 FYVVHHELGHIQYYLQYEQQPAVYRGAPNPGFHEAVGDVIALSVMSAKHLKAIGLIENGRLDEKS 434

  Fly   438 SLNRLFRMGVHTLIAVPQYFINDKFLVDVMDGRIGVKDYNCAYWGLQDKFAGVQPPLQRLNKDFD 502
            .:|:||:..:..::.:|..:..||:...|....:....:||.:|.::.:|.||:||:.|..||||
  Fly   435 RINQLFKQALSKIVFLPFGYAVDKYRYAVFRNELDESQWNCGFWQMRSEFGGVEPPVFRTEKDFD 499

  Fly   503 VDFKFYRGLNPETSNTKKFLAEILGFQFYRSFCLASGQYKPGDPNFPLHNCDFYDSKEAGKKIRD 567
            ...|::  ::.:....:.|.|.|..|||:::.|..:|||.|.:....|.|||.:.||.||:.:..
  Fly   500 PPAKYH--IDADVEYLRYFAAHIFQFQFHKALCRKAGQYAPNNSRLTLDNCDIFGSKAAGRSLSQ 562

  Fly   568 MMQLGATRHWRDVMEIATGERKLSGRGILEYFAPLFTWLKERNKQLDIEPGW 619
            .:..|.:|||::|:|..|||.::....:||||.||:.|||:.|.:|.:..||
  Fly   563 FLSKGNSRHWKEVLEEFTGETEMDPAALLEYFEPLYQWLKQENSRLGVPLGW 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ance-5	NP_573392.2	GluZincin	93..610	CDD:301352	143/522 (27%)
Acer	NP_001260258.1	M2_ACE	37..605	CDD:188999	155/600 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455772
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3690
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5260
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D16282at33392
OrthoFinder	1	1.000	-	-		FOG0000442
OrthoInspector	1	1.000	-	-		otm14376
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10514
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.800