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Protein Alignment Ance-5 and Ace2

DIOPT Version :9

Sequence 1:	NP_573392.2	Gene:	Ance-5 / 37980	FlyBaseID:	FBgn0035076	Length:	628	Species:	Drosophila melanogaster
Sequence 2:	NP_001012006.1	Gene:	Ace2 / 302668	RGDID:	728890	Length:	805	Species:	Rattus norvegicus

Alignment Length:	662	Identity:	153/662 - (23%)
Similarity:	268/662 - (40%)	Gaps:	109/662 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ILLLSVTFGIGQSSYELATKQILDRAKDRMRHV--------WSLNRRIFVQLTAKGKSPLGGQVL 67
            :||..|.....||..|...:..|::.......:        |:.|..|..:..
  Rat     7 LLLSLVAVATAQSLIEEKAESFLNKFNQEAEDLSYQSSLASWNYNTNITEENA------------ 59

  Fly    68 NSKLEVEAETYRLFYD----LAGNLSVVSVAELNDPLLRRRVQRMAKLQLQGLRPKDYEQAKDLL 128
             .|:...|..:..||:    :|.|.   |:.|:.:..::|:::.:.:.....|.|...:|...:|
  Rat    60 -QKMNEAAAKWSAFYEEQSKIAQNF---SLQEIQNATIKRQLKALQQSGSSALSPDKNKQLNTIL 120

  Fly   129 RQIHNFVNGPLVCPYEDCSARGSLAMYPQI-------MNKNMHTKL-YEDLVINWKAWRRAINEK 185
            ..:....:...||.          :|.||.       :::.|.|.. |...:..|:.||..:.::
  Rat   121 NTMSTIYSTGKVCN----------SMNPQECFLLEPGLDEIMATSTDYNRRLWAWEGWRAEVGKQ 175

  Fly   186 DVAKNTFIGYVRLLRIAATYNGHVTPSRTWYLNYDTENFQA----------EMEAVVWEIMPLYR 240
              .:..:..||.|....|..|.:......|..:|:.|..:.          ::|....||.|||.
  Rat   176 --LRPLYEEYVVLKNEMARANNYEDYGDYWRGDYEAEGVEGYNYNRNQLIEDVENTFKEIKPLYE 238

  Fly   241 ELHAYLRREVQAAYPKADTKSDGAISAPIMDQILSQDW---YPHQFFRTPHQGRQHQLPSVHRRL 302
            :||||:|.::...||...:.: |.:.|.::..:..:.|   ||   ..||..    |.|::.
  Rat   239 QLHAYVRTKLMEVYPSYISPT-GCLPAHLLGDMWGRFWTNLYP---LTTPFL----QKPNID--- 292

  Fly   303 EEVLVTPVKIN---------RKAAEFFESLGLMVMPNIFYDRFSRRMNDEEGGAECKSQVYYFPP 358
                ||...:|         ::|.:||.|:||..|...|:   :..|..|.|.   ..:|...|.
  Rat   293 ----VTDAMVNQSWDAERIFKEAEKFFVSVGLPQMTPGFW---TNSMLTEPGD---DRKVVCHPT 347

  Fly   359 -------DVALRYCPKLDYKKMMQIHGTMAELQYHLYKMQLPFGLDTEPCPGFGAAIAETVILAS 416
                   |..::.|.|:.....:..|..|..:||.:...:.||.|......||..|:.|.:.|::
  Rat   348 AWDLGHGDFRIKMCTKVTMDNFLTAHHEMGHIQYDMAYAKQPFLLRNGANEGFHEAVGEIMSLSA 412

  Fly   417 GTPRHLHRLHIL-LNDSLTEEQSLNRLFRMGVHTLIAVPQYFINDKFLVDVMDGRIGVKDYNCAY 480
            .||:||..:.:| .|.....|..:|.|.:..:..:..:|..::.:|:...|...:|..:.:...:
  Rat   413 ATPKHLKSIGLLPSNFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFQDKIPREQWTKKW 477

  Fly   481 WGLQDKFAGVQPPLQRLNKDFDVDFKFYRGLNPETSNTKKFLAEILGFQFYRSFCLASGQYKPGD 545
            |.::.:..||..||.......|....|:  ::.:.|..:.:...|..|||..:.|.|:..
  Rat   478 WEMKREIVGVVEPLPHDETYCDPASLFH--VSNDYSFIRYYTRTIYQFQFQEALCQAAKH----- 535

  Fly   546 PNFPLHNCDFYDSKEAGKKIRDMMQLGATRHWRDVMEIATGERKLSGRGILEYFAPLFTWLKERN 610
             :.|||.||..:|.|||:|:.:|:.||.:..|...:|...|.|.:..:.:|.||.|||.||||:|
  Rat   536 -DGPLHKCDISNSTEAGQKLLNMLSLGNSGPWTLALENVVGSRNMDVKPLLNYFQPLFVWLKEQN 599

  Fly   611 KQLDIEPGWDAD 622
            :...:  ||..|
  Rat   600 RNSTV--GWSTD 609

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.