DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ance-5 and Ace

DIOPT Version :9

Sequence 1:	NP_573392.2	Gene:	Ance-5 / 37980	FlyBaseID:	FBgn0035076	Length:	628	Species:	Drosophila melanogaster
Sequence 2:	NP_036676.1	Gene:	Ace / 24310	RGDID:	2493	Length:	1313	Species:	Rattus norvegicus

Alignment Length:	591	Identity:	157/591 - (26%)
Similarity:	276/591 - (46%)	Gaps:	56/591 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 WSLNRRIFVQLTAKGKSPLGGQVLNSKLEVEAETYRLFYDLAGNLSVVSVAELNDPLLRRRVQRM 108
            |..|..|.::         |.::|..| ..|...:.|.|....  ....|:...:..::|.::::
  Rat   678 WHYNTNITIE---------GSKILLQK-NKEVSNHTLKYGTWA--KTFDVSNFQNSTIKRIIKKV 730

  Fly   109 AKLQLQGLRPKDYEQAKDLLRQIHNFVNGPLVCPYEDCSARGSLAMYPQIMNKNMHTKLYEDLVI 173
            ..:....|.|.:.|:...:|..:....:...|| |.:.:.   |::.|.:.|....::.||:|:.
  Rat   731 QNVDRAVLPPNELEEYNQILLDMETTYSVANVC-YTNGTC---LSLEPDLTNIMATSRKYEELLW 791

  Fly   174 NWKAWRRAINEKDVAKNTFIGYVRLLRIAATYNGHVTPSRTWYLNYDTENFQAEMEAVVWEIMPL 238
            .||:||..:....:.  .|..||......|..||:.....:|..:|::::.:.::|.:..|:.||
  Rat   792 VWKSWRDKVGRAILP--FFPKYVDFSNKIAKLNGYSDAGDSWRSSYESDDLEQDLEKLYQELQPL 854

  Fly   239 YRELHAYLRREVQAAYPKADTKSDGAISAPIMDQILSQDW---------YPHQFFRTPHQGRQHQ 294
            |..||||:||.:...|.......||.|.|.::..:.:|.|         :|             .
  Rat   855 YLNLHAYVRRSLHRHYGSEYINLDGPIPAHLLGNMWAQTWSNIYDLVAPFP-------------S 906

  Fly   295 LPSVHRRLEEVLV----TPVKINRKAAEFFESLGLMVMPNIFYDR--FSRRMNDEEGGAECKSQV 353
            .||:.  ..|.::    ||.:|.::|..||.||||:.:|..|:::  ..:..:..|......:..
  Rat   907 APSID--ATEAMIKQGWTPRRIFKEADNFFTSLGLLPVPPEFWNKSMLEKPTDGREVVCHASAWD 969

  Fly   354 YYFPPDVALRYCPKLDYKKMMQIHGTMAELQYHLYKMQLPFGLDTEPCPGFGAAIAETVILASGT 418
            :|...|..::.|..::.::::..|..|..:||.:....||........|||..||.:.:.|:..|
  Rat   970 FYNGKDFRIKQCTSVNMEELVIAHHEMGHIQYFMQYKDLPVTFREGANPGFHEAIGDVLALSVST 1034

  Fly   419 PRHLHRLHILLNDSLTEEQSLNRLFRMGVHTLIAVPQYFINDKFLVDVMDGRIGVKDYNCAYWGL 483
            |:|||.|::|.::....|..:|.|.:|.:..:..:|..::.|::...|.||.|..::||..:|.|
  Rat  1035 PKHLHSLNLLSSEGSGYEHDINFLMKMALDKIAFIPFSYLIDQWRWRVFDGSITKENYNQEWWSL 1099

  Fly   484 QDKFAGVQPPLQRLNKDFDVDFKFYRGLNPETSNTKKFLAEILGFQFYRSFCLASGQYKPGDPNF 548
            :.|:.|:.||:.|...|||...||:...|  ....:.|::.|:.|||:.:.|.|:|.      ..
  Rat  1100 RLKYQGLCPPVPRSQGDFDPGSKFHVPAN--VPYIRYFISFIIQFQFHEALCRAAGH------TG 1156

  Fly   549 PLHNCDFYDSKEAGKKIRDMMQLGATRHWRDVMEIATGERKLSGRGILEYFAPLFTWLKERNKQL 613
            ||:.||.|.||||||.:.|.|:||.::.|.:.|:|.||:..:|...|:.||.||..||...|::.
  Rat  1157 PLYKCDIYQSKEAGKLLADAMKLGYSKQWPEAMKIITGQPNMSASAIMNYFKPLTEWLVTENRRH 1221

  Fly   614 DIEPGW 619
            ....||
  Rat  1222 GETLGW 1227

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ance-5	NP_573392.2	GluZincin	93..610	CDD:301352	145/531 (27%)
Ace	NP_036676.1	Peptidase M2 1	36..636
		Peptidase_M2	46..629	CDD:279709
		Peptidase M2 2	637..1238		157/591 (27%)
		Peptidase_M2	650..1227	CDD:279709	155/589 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3690
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D266227at33208
OrthoFinder	1	1.000	-	-		FOG0000442
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10514
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920